Tomm20l (translocase of outer mitochondrial membrane 20 like) - Rat Genome Database

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Gene: Tomm20l (translocase of outer mitochondrial membrane 20 like) Rattus norvegicus
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Symbol: Tomm20l
Name: translocase of outer mitochondrial membrane 20 like
RGD ID: 1586305
Description: Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix and tRNA import into mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM20L (translocase of outer mitochondrial membrane 20 like); INTERACTS WITH bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog); aldehydo-D-glucose (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC128303.1; LOC689996; similar to translocase of outer mitochondrial membrane 20 homolog; TOMM20-like protein 1; Tomm20l1; translocase of outer mitochondrial membrane 20 homolog (yeast)-like; translocase of outer mitochondrial membrane 20 homolog-like; translocase of outer mitochondrial membrane 20 like 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8695,335,681 - 95,346,116 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl695,335,840 - 95,347,299 (+)EnsemblGRCr8
mRatBN7.2689,594,016 - 89,612,070 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl689,599,873 - 89,610,147 (+)EnsemblmRatBN7.2
Rnor_6.0693,538,377 - 93,549,533 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl693,539,271 - 93,651,154 (+)NCBIrn6Rnor6.0
Rnor_5.06103,004,605 - 103,015,121 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4693,208,302 - 93,218,521 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera688,083,111 - 88,094,268 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tomm20l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8695,335,681 - 95,346,116 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl695,335,840 - 95,347,299 (+)EnsemblGRCr8
mRatBN7.2689,594,016 - 89,612,070 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl689,599,873 - 89,610,147 (+)EnsemblmRatBN7.2
Rnor_6.0693,538,377 - 93,549,533 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl693,539,271 - 93,651,154 (+)NCBIrn6Rnor6.0
Rnor_5.06103,004,605 - 103,015,121 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4693,208,302 - 93,218,521 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera688,083,111 - 88,094,268 (+)NCBICelera
Cytogenetic Map6q24NCBI
TOMM20L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381458,395,930 - 58,417,080 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1458,395,928 - 58,408,702 (+)Ensemblhg38GRCh38
GRCh371458,862,648 - 58,875,420 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361457,932,385 - 57,945,172 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1438,912,616 - 38,925,391 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1439,027,270 - 39,040,037 (+)NCBIHuRef
CHM1_11458,801,207 - 58,813,988 (+)NCBICHM1_1
T2T-CHM13v2.01452,602,950 - 52,624,123 (+)NCBIT2T-CHM13v2.0
Tomm20l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391271,158,202 - 71,169,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1271,158,202 - 71,169,995 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381271,111,428 - 71,123,222 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1271,111,428 - 71,123,221 (+)Ensemblmm10GRCm38
MGSCv371272,212,415 - 72,224,209 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1272,211,475 - 72,223,254 (+)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1229.39NCBI
TOMM20L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21559,517,614 - 59,531,404 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11458,728,289 - 58,748,838 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01438,987,239 - 39,001,441 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11457,255,851 - 57,268,343 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1457,255,851 - 57,268,343 (+)EnsemblpanPan2panpan1.1
TOMM20L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1833,747,643 - 33,761,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl833,747,284 - 33,755,880 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha833,508,932 - 33,517,299 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0833,989,091 - 33,997,455 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl833,989,091 - 33,997,435 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1833,601,633 - 33,609,978 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0833,669,762 - 33,678,101 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0834,044,093 - 34,052,460 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tomm20l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864071,392,612 - 71,412,432 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364952,779,851 - 2,786,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM20L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1187,475,006 - 187,486,729 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11187,474,745 - 187,496,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21208,367,169 - 208,408,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM20L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12435,578,996 - 35,591,613 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2435,579,540 - 35,591,495 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605323,859,161 - 23,881,058 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm20l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1784,747,003 - 84,756,992 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tomm20l
22 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat

Markers in Region
RH141247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2689,610,241 - 89,610,424 (+)MAPPERmRatBN7.2
Rnor_6.0693,549,632 - 93,549,814NCBIRnor6.0
Rnor_5.06103,015,220 - 103,015,402UniSTSRnor5.0
RGSC_v3.4693,218,665 - 93,218,847UniSTSRGSC3.4
Celera688,094,367 - 88,094,549UniSTS
RH 3.4 Map6639.2UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 50 67 138 95 11 49 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078791   ⟹   ENSRNOP00000068942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl695,335,840 - 95,347,299 (+)Ensembl
mRatBN7.2 Ensembl689,599,873 - 89,610,147 (+)Ensembl
RefSeq Acc Id: XM_001072851   ⟹   XP_001072851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8695,335,681 - 95,346,116 (+)NCBI
mRatBN7.2689,594,016 - 89,612,070 (+)NCBI
Rnor_6.0693,538,383 - 93,549,533 (+)NCBI
Rnor_5.06103,004,605 - 103,015,121 (+)NCBI
RGSC_v3.4693,208,302 - 93,218,521 (+)RGD
Sequence:
RefSeq Acc Id: XM_039113236   ⟹   XP_038969164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8695,335,681 - 95,337,512 (+)NCBI
mRatBN7.2689,594,016 - 89,601,536 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419105 (Get FASTA)   NCBI Sequence Viewer  
  XP_001072851 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969164 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03567 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068942.2
RefSeq Acc Id: XP_001072851   ⟸   XM_001072851
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038969164   ⟸   XM_039113236
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000068942   ⟸   ENSRNOT00000078791

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JU30-F1-model_v2 AlphaFold A0A0G2JU30 1-143 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694655
Promoter ID:EPDNEW_R5172
Type:initiation region
Name:AC128303_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0693,539,251 - 93,539,311EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586305 AgrOrtholog
BioCyc Gene G2FUF-37184 BioCyc
Ensembl Genes ENSRNOG00000054663 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078791.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.960.10 UniProtKB/TrEMBL
InterPro MAS20 UniProtKB/TrEMBL
  MAS20_rcpt_metazoan UniProtKB/TrEMBL
  Tom20_dom_sf UniProtKB/TrEMBL
NCBI Gene 689996 ENTREZGENE
PANTHER PTHR12430 UniProtKB/TrEMBL
  TOMM20-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam MAS20 UniProtKB/TrEMBL
PhenoGen Tomm20l PhenoGen
PIRSF MAS20_rcpt UniProtKB/TrEMBL
PRINTS EUOM20RECPTR UniProtKB/TrEMBL
  OM20RECEPTOR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054663 RatGTEx
Superfamily-SCOP SSF47157 UniProtKB/TrEMBL
UniProt A0A0G2JU30 ENTREZGENE, UniProtKB/TrEMBL
  A6HC12 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Tomm20l  translocase of outer mitochondrial membrane 20 like  AC128303.1    Data merged from RGD:15008855 737654 PROVISIONAL
2019-11-08 AC128303.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-03-01 Tomm20l  translocase of outer mitochondrial membrane 20 like  Tomm20l  translocase of outer mitochondrial membrane 20 homolog (yeast)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-31 Tomm20l  translocase of outer mitochondrial membrane 20 homolog (yeast)-like   LOC689996  similar to translocase of outer mitochondrial membrane 20 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689996  similar to translocase of outer mitochondrial membrane 20 homolog  LOC687901  similar to translocase of outer mitochondrial membrane 20 homolog  Data merged from RGD:1594947 1643240 APPROVED
2006-11-20 LOC687901  similar to translocase of outer mitochondrial membrane 20 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689996  similar to translocase of outer mitochondrial membrane 20 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL