Rex2l2 (reduced expression 2 like 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rex2l2 (reduced expression 2 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rex2l2
Name: reduced expression 2 like 2
RGD ID: 1586249
Description: Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100362123; LOC102557083; LOC691261; reduced expression 2; reduced expression 2 like 3; Rex2; Rex2l3; zinc finger protein 2 homolog; zinc finger protein 480-like; zinc finger protein 53-like; zinc finger protein 605-like; zinc finger protein 665-like; zinc finger protein 883; zinc finger protein 883-like; zinc finger protein 888-like; zinc finger protein ZFP2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,183,186 - 163,202,283 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5163,183,189 - 163,202,194 (-)EnsemblGRCr8
mRatBN7.25157,884,460 - 157,919,072 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5157,899,999 - 157,919,004 (-)EnsemblmRatBN7.2
Rnor_6.05164,222,515 - 164,235,267 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05167,893,993 - 167,911,900 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45164,502,433 - 164,515,847 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5156,133,639 - 156,154,167 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Rex2l2
60 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000109883   ⟹   ENSRNOP00000080924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5163,183,189 - 163,202,194 (-)Ensembl
mRatBN7.2 Ensembl5157,899,999 - 157,919,004 (-)Ensembl
RefSeq Acc Id: XM_039111340   ⟹   XP_038967268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,183,186 - 163,202,283 (-)NCBI
mRatBN7.25157,899,996 - 157,919,072 (-)NCBI
RefSeq Acc Id: XM_039111342   ⟹   XP_038967270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,184,323 - 163,202,283 (-)NCBI
mRatBN7.25157,901,130 - 157,919,072 (-)NCBI
RefSeq Acc Id: XM_063288650   ⟹   XP_063144720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,183,186 - 163,202,283 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038967268 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967270 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144720 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080924
  ENSRNOP00000080924.2
RefSeq Acc Id: XP_038967268   ⟸   XM_039111340
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967270   ⟸   XM_039111342
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000080924   ⟸   ENSRNOT00000109883
RefSeq Acc Id: XP_063144720   ⟸   XM_063288650
- Peptide Label: isoform X2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586249 AgrOrtholog
BioCyc Gene G2FUF-39222 BioCyc
Ensembl Genes ENSRNOG00000062461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000109883 ENTREZGENE
  ENSRNOT00000109883.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Rex2l2 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 484 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Rex2l2 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062461 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZRD4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-22 Rex2l2  reduced expression 2 like 2  Rex2l3  reduced expression 2 like 3  Name and Symbol changed 629549 APPROVED
2023-10-13 Rex2l3  reduced expression 2 like 3  Rex2l2  reduced expression 2 like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-04-03 Rex2l2  reduced expression 2 like 2  Rex2  reduced expression 2  Name and Symbol changed 629549 APPROVED
2022-06-02 Rex2  reduced expression 2  Rex2  reduced expression 2  Data merged from RGD:149736224 737654 PROVISIONAL
2021-08-09 Rex2  reduced expression 2      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Rex2  reduced expression 2  LOC102557083  zinc finger protein 665-like  Data merged from RGD:7713042 737654 PROVISIONAL
2014-07-08 Rex2  reduced expression 2  LOC100362123  zinc finger protein 53-like  Data merged from RGD:2318760 737654 APPROVED
2013-12-18 LOC102557083  zinc finger protein 665-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100362123  zinc finger protein 53-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Rex2  reduced expression 2  LOC691261  similar to reduced expression 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691261  similar to reduced expression 2      Symbol and Name status set to provisional 70820 PROVISIONAL