Rex2l2 (reduced expression 2 like 2) - Rat Genome Database

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Gene: Rex2l2 (reduced expression 2 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rex2l2 (Ensembl: Rex2)
Name: reduced expression 2 like 2 (Ensembl:reduced expression 2)
RGD ID: 1586249
Description: Predicted to enable metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100362123; LOC102557083; LOC691261; reduced expression 2; reduced expression 2 like 3; Rex2; Rex2l3; zinc finger protein 2 homolog; zinc finger protein 480-like; zinc finger protein 53-like; zinc finger protein 605-like; zinc finger protein 665-like; zinc finger protein 883; zinc finger protein 883-like; zinc finger protein 888-like; zinc finger protein ZFP2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,183,186 - 163,202,283 (-)NCBIGRCr8
mRatBN7.25157,884,460 - 157,919,072 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5157,899,999 - 157,919,004 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05164,222,515 - 164,235,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05167,893,993 - 167,911,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45164,502,433 - 164,515,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5156,133,639 - 156,154,167 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Rex2l2
464 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000109883   ⟹   ENSRNOP00000080924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5157,899,999 - 157,919,004 (-)Ensembl
RefSeq Acc Id: XM_039111340   ⟹   XP_038967268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,183,186 - 163,202,283 (-)NCBI
mRatBN7.25157,899,996 - 157,919,072 (-)NCBI
RefSeq Acc Id: XM_039111342   ⟹   XP_038967270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,184,323 - 163,202,283 (-)NCBI
mRatBN7.25157,901,130 - 157,919,072 (-)NCBI
RefSeq Acc Id: XM_063288650   ⟹   XP_063144720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85163,183,186 - 163,202,283 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038967268 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967270 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144720 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080924.1
RefSeq Acc Id: XP_038967268   ⟸   XM_039111340
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967270   ⟸   XM_039111342
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000080924   ⟸   ENSRNOT00000109883
RefSeq Acc Id: XP_063144720   ⟸   XM_063288650
- Peptide Label: isoform X2
Protein Domains
C2H2-type   KRAB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-39222 BioCyc
Ensembl Genes ENSRNOG00000062461 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000109883.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel_C2H2_ZnF UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Rex2l2 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Rex2l2 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062461 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZRD4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-22 Rex2l2  reduced expression 2 like 2  Rex2l3  reduced expression 2 like 3  Name and Symbol changed 629549 APPROVED
2023-10-13 Rex2l3  reduced expression 2 like 3  Rex2l2  reduced expression 2 like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-04-03 Rex2l2  reduced expression 2 like 2  Rex2  reduced expression 2  Name and Symbol changed 629549 APPROVED
2022-06-02 Rex2  reduced expression 2  Rex2  reduced expression 2  Data merged from RGD:149736224 737654 PROVISIONAL
2021-08-09 Rex2  reduced expression 2      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Rex2  reduced expression 2  LOC102557083  zinc finger protein 665-like  Data merged from RGD:7713042 737654 PROVISIONAL
2014-07-08 Rex2  reduced expression 2  LOC100362123  zinc finger protein 53-like  Data merged from RGD:2318760 737654 APPROVED
2013-12-18 LOC102557083  zinc finger protein 665-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100362123  zinc finger protein 53-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Rex2  reduced expression 2  LOC691261  similar to reduced expression 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691261  similar to reduced expression 2      Symbol and Name status set to provisional 70820 PROVISIONAL