Eras (ES cell expressed Ras) - Rat Genome Database

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Gene: Eras (ES cell expressed Ras) Rattus norvegicus
Analyze
Symbol: Eras
Name: ES cell expressed Ras
RGD ID: 1585907
Description: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human ERAS (ES cell expressed Ras); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; 5-fluorouracil (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTPase ERas; hypothetical protein LOC679682; LOC108348138; LOC679682; similar to ES cell-expressed Ras
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,245,915 - 17,250,301 (+)NCBIGRCr8
mRatBN7.2X14,573,987 - 14,578,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,573,987 - 14,578,374 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,387,537 - 19,391,924 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,691,188 - 20,695,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,956,357 - 16,960,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,318,215 - 15,322,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,321,713 - 15,322,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,419,028 - 15,423,414 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,098,270 - 16,102,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,608,537 - 26,612,923 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,658,743 - 14,663,129 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:26884329  


Genomics

Comparative Map Data
Eras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,245,915 - 17,250,301 (+)NCBIGRCr8
mRatBN7.2X14,573,987 - 14,578,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,573,987 - 14,578,374 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,387,537 - 19,391,924 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,691,188 - 20,695,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,956,357 - 16,960,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,318,215 - 15,322,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,321,713 - 15,322,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,419,028 - 15,423,414 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,098,270 - 16,102,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,608,537 - 26,612,923 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,658,743 - 14,663,129 (+)NCBICelera
Cytogenetic MapXq12NCBI
ERAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,826,513 - 48,829,869 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,826,513 - 48,830,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,684,923 - 48,688,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,572,227 - 48,573,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,443,531 - 48,444,797NCBI
CeleraX52,974,981 - 52,976,246 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,344,561 - 46,347,994 (+)NCBIHuRef
CHM1_1X48,716,067 - 48,719,421 (+)NCBICHM1_1
T2T-CHM13v2.0X48,237,009 - 48,240,364 (+)NCBIT2T-CHM13v2.0
Eras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,790,515 - 7,794,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,790,515 - 7,794,846 (-)EnsemblGRCm39 Ensembl
GRCm38X7,924,276 - 7,928,607 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,924,276 - 7,928,607 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,501,402 - 7,505,733 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,081,235 - 7,085,566 (-)NCBIMGSCv36mm8
CeleraX3,540,725 - 3,545,056 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.58NCBI
Eras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955543381,756 - 383,093 (+)NCBIChiLan1.0ChiLan1.0
ERAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,317,880 - 50,319,208 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,321,353 - 50,322,574 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,125,895 - 41,127,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,984,189 - 48,987,653 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,986,812 - 48,987,513 (+)Ensemblpanpan1.1panPan2
ERAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,024,867 - 42,029,649 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,028,711 - 42,029,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,401,245 - 16,405,081 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,162,000 - 42,165,837 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,164,899 - 42,165,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,148,247 - 42,152,082 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,136,523 - 42,140,359 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,230,679 - 42,234,515 (+)NCBIUU_Cfam_GSD_1.0
Eras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,539,541 - 34,543,018 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721782,525 - 783,208 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721782,343 - 783,591 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,941,664 - 42,946,524 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,942,033 - 42,946,715 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,883,777 - 47,888,037 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,955,444 - 45,957,170 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,955,803 - 45,956,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,434,706 - 11,436,678 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624893631,033 - 632,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eras
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:146
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000042140, ENSRNOT00000071835
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
RH134245  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,572,163 - 14,572,372 (+)MAPPERmRatBN7.2
Rnor_6.0X15,417,205 - 15,417,413NCBIRnor6.0
Rnor_6.0X15,316,392 - 15,316,600NCBIRnor6.0
Rnor_5.0X16,198,440 - 16,198,648UniSTSRnor5.0
Rnor_5.0X16,096,633 - 16,096,841UniSTSRnor5.0
RGSC_v3.4X26,606,714 - 26,606,922UniSTSRGSC3.4
CeleraX14,656,920 - 14,657,128UniSTS
RH 3.4 MapX164.6UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 6 13
Below cutoff 1 1 1 1 57 27 18 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042140   ⟹   ENSRNOP00000047699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,573,987 - 14,578,374 (+)Ensembl
Rnor_6.0 EnsemblX15,419,028 - 15,423,414 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071835   ⟹   ENSRNOP00000066895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX15,321,713 - 15,322,396 (+)Ensembl
RefSeq Acc Id: NM_001109375   ⟹   NP_001102845
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,245,915 - 17,250,301 (+)NCBI
mRatBN7.2X14,573,987 - 14,578,374 (+)NCBI
Rnor_6.0X15,318,215 - 15,322,601 (+)NCBI
Rnor_5.0X16,098,270 - 16,102,842 (+)NCBI
RGSC_v3.4X26,608,537 - 26,612,923 (+)RGD
CeleraX14,658,743 - 14,663,129 (+)RGD
Sequence:
RefSeq Acc Id: XM_017602155   ⟹   XP_017457644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,245,921 - 17,250,294 (+)NCBI
mRatBN7.2X14,573,993 - 14,578,455 (+)NCBI
Rnor_6.0X15,318,221 - 15,322,595 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102845 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457644 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83810 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047699
  ENSRNOP00000047699.3
Reference Protein Sequences
RefSeq Acc Id: NP_001102845   ⟸   NM_001109375
- UniProtKB: D3ZTE4 (UniProtKB/TrEMBL),   A6KP62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457644   ⟸   XM_017602155
- Peptide Label: isoform X1
- UniProtKB: D3ZTE4 (UniProtKB/TrEMBL),   A6KP62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047699   ⟸   ENSRNOT00000042140
RefSeq Acc Id: ENSRNOP00000066895   ⟸   ENSRNOT00000071835

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTE4-F1-model_v2 AlphaFold D3ZTE4 1-227 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585907 AgrOrtholog
BioCyc Gene G2FUF-2932 BioCyc
Ensembl Genes ENSRNOG00000042470 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000048396 Ensembl
Ensembl Transcript ENSRNOT00000042140 ENTREZGENE
  ENSRNOT00000042140.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  Ras_small_GTPase UniProtKB/TrEMBL
  Small_GTP-bd UniProtKB/TrEMBL
KEGG Report rno:679682 UniProtKB/TrEMBL
NCBI Gene 679682 ENTREZGENE
PANTHER GTPASE ERAS UniProtKB/TrEMBL
  PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Eras PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042470 RatGTEx
  ENSRNOG00000048396 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A6KP62 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTE4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Eras  ES cell expressed Ras  LOC108348138  GTPase ERas  Data merged from RGD:11427050 737654 PROVISIONAL
2016-08-02 LOC108348138  GTPase ERas      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-05-27 Eras  ES cell expressed Ras  LOC679682  similar to ES cell-expressed Ras  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679682  similar to ES cell-expressed Ras  LOC682898  similar to ES cell-expressed Ras  Data merged from RGD:1593951 1643240 APPROVED
2006-11-20 LOC682898  similar to ES cell-expressed Ras      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679682  similar to ES cell-expressed Ras      Symbol and Name status set to provisional 70820 PROVISIONAL