Acp7 (acid phosphatase 7, tartrate resistant) - Rat Genome Database

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Gene: Acp7 (acid phosphatase 7, tartrate resistant) Rattus norvegicus
Analyze
Symbol: Acp7
Name: acid phosphatase 7, tartrate resistant
RGD ID: 1585399
Description: Predicted to enable acid phosphatase activity and metal ion binding activity. Orthologous to human ACP7 (acid phosphatase 7, tartrate resistant (putative)); INTERACTS WITH gentamycin; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acid phosphatase type 7; acid phosphatase type 7-like; hypothetical protein LOC687403; iron/zinc purple acid phosphatase; iron/zinc purple acid phosphatase-like; iron/zinc purple acid phosphatase-like protein; iron/zinc purple acid phosphatase-like protein-like; LOC100911458; LOC687403; Papl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,022,801 - 93,048,484 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,024,991 - 93,048,873 (-)EnsemblGRCr8
mRatBN7.2183,896,485 - 83,923,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,898,153 - 83,920,634 (-)EnsemblmRatBN7.2
Rnor_6.0185,141,383 - 85,162,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,143,789 - 85,153,210 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,357,115 - 86,406,398 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera178,283,514 - 78,314,164 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Acp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,022,801 - 93,048,484 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,024,991 - 93,048,873 (-)EnsemblGRCr8
mRatBN7.2183,896,485 - 83,923,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,898,153 - 83,920,634 (-)EnsemblmRatBN7.2
Rnor_6.0185,141,383 - 85,162,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,143,789 - 85,153,210 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,357,115 - 86,406,398 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera178,283,514 - 78,314,164 (-)NCBICelera
Cytogenetic Map1q21NCBI
ACP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,083,788 - 39,111,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,083,913 - 39,111,497 (+)Ensemblhg38GRCh38
GRCh371939,575,008 - 39,602,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,266,785 - 44,293,318 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1936,377,378 - 36,404,537 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,021,747 - 36,049,070 (+)NCBIHuRef
CHM1_11939,575,308 - 39,602,545 (+)NCBICHM1_1
T2T-CHM13v2.01941,887,741 - 41,915,473 (+)NCBIT2T-CHM13v2.0
Acp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,304,055 - 28,330,755 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,306,701 - 28,330,757 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,607,322 - 28,631,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,607,276 - 28,631,332 (-)Ensemblmm10GRCm38
MGSCv37729,392,656 - 29,416,034 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,316,397 - 28,339,775 (-)NCBIMGSCv36mm8
Celera723,172,719 - 23,196,100 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.86NCBI
Acp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468434,769 - 446,477 (-)Ensembl
ChiLan1.0NW_004955468432,907 - 452,848 (-)NCBIChiLan1.0ChiLan1.0
ACP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,374,843 - 45,406,669 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,237,020 - 47,282,622 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,182,793 - 36,211,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,731,722 - 44,758,298 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,733,177 - 44,757,204 (+)EnsemblpanPan2panpan1.1
ACP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,059,670 - 114,077,208 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,062,005 - 114,076,079 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1113,462,897 - 113,478,352 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,660,903 - 114,676,388 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,660,889 - 114,675,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,218,966 - 114,234,219 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,852,118 - 113,867,525 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,847,529 - 114,862,976 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,562,753 - 13,577,076 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,990,638 - 2,004,359 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,991,033 - 2,004,359 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,840,213 - 47,859,834 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1647,839,504 - 47,860,629 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,413,251 - 43,432,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,677,191 - 33,703,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,678,672 - 33,701,889 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607311,704,010 - 11,730,294 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,421,101 - 12,437,696 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,420,419 - 12,440,210 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acp7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,375,652 - 167,395,101 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acp7
195 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000071691
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat

Markers in Region
RH131797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,501,042 - 83,501,257 (+)MAPPERmRatBN7.2
Rnor_6.0185,134,714 - 85,134,928NCBIRnor6.0
Rnor_5.0186,350,446 - 86,350,660UniSTSRnor5.0
RGSC_v3.4183,302,657 - 83,302,871UniSTSRGSC3.4
Celera177,900,979 - 77,901,193UniSTS
RH 3.4 Map1841.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 1 3 88 4 10 1 3 1 6 28 9 3 79 7 63 9 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000071691   ⟹   ENSRNOP00000067221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,024,991 - 93,048,808 (-)Ensembl
mRatBN7.2 Ensembl183,898,153 - 83,920,634 (-)Ensembl
Rnor_6.0 Ensembl185,143,789 - 85,153,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167520   ⟹   ENSRNOP00000110707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,024,991 - 93,048,873 (-)Ensembl
RefSeq Acc Id: XM_039100849   ⟹   XP_038956777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,022,801 - 93,048,484 (-)NCBI
mRatBN7.2183,896,485 - 83,923,436 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001419521 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067221.4
  ENSRNOP00000110707
  ENSRNOP00000110707.1
Ensembl Acc Id: ENSRNOP00000067221   ⟸   ENSRNOT00000071691
RefSeq Acc Id: XP_038956777   ⟸   XM_039100849
Ensembl Acc Id: ENSRNOP00000110707   ⟸   ENSRNOT00000167520
Protein Domains
Calcineurin-like phosphoesterase   Purple acid phosphatase C-terminal   Purple acid phosphatase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCA8-F1-model_v2 AlphaFold M0RCA8 1-399 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585399 AgrOrtholog
BioCyc Gene G2FUF-60234 BioCyc
BioCyc Pathway PWY-6348 [phosphate acquisition] BioCyc
BioCyc Pathway Image PWY-6348 BioCyc
Ensembl Genes ENSRNOG00000047901 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071691.4 UniProtKB/TrEMBL
  ENSRNOT00000167520 ENTREZGENE
  ENSRNOT00000167520.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
  Purple acid phosphatase-like, N-terminal UniProtKB/TrEMBL
InterPro Metallo-depent_PP-like UniProtKB/TrEMBL
  Metallo_PEstase_dom UniProtKB/TrEMBL
  MPP_PAP UniProtKB/TrEMBL
  Purple_acid_Pase-like_N UniProtKB/TrEMBL
  Purple_acid_Pase_N UniProtKB/TrEMBL
  Purple_acid_PPase_C_dom UniProtKB/TrEMBL
NCBI Gene 687403 ENTREZGENE
PANTHER ACID PHOSPHATASE TYPE 7 UniProtKB/TrEMBL
  PURPLE ACID PHOSPHATASE UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
  Metallophos_C UniProtKB/TrEMBL
  Pur_ac_phosph_N UniProtKB/TrEMBL
PhenoGen Acp7 PhenoGen
RatGTEx ENSRNOG00000047901 RatGTEx
Superfamily-SCOP Purple_Pase_N UniProtKB/TrEMBL
  SSF56300 UniProtKB/TrEMBL
UniProt A0ABK0M1A2_RAT UniProtKB/TrEMBL
  A6J9J9 ENTREZGENE, UniProtKB/TrEMBL
  M0RCA8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Acp7  acid phosphatase 7, tartrate resistant  LOC100911458  iron/zinc purple acid phosphatase-like protein-like  Data merged from RGD:6492696 737654 PROVISIONAL
2015-11-30 Acp7  acid phosphatase 7, tartrate resistant  Papl  iron/zinc purple acid phosphatase-like protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-12-01 Papl  iron/zinc purple acid phosphatase-like protein  Papl  iron/zinc purple acid phosphatase-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-22 Papl  iron/zinc purple acid phosphatase-like  Papl  iron/zinc purple acid phosphatase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-16 Papl  iron/zinc purple acid phosphatase  LOC687403  hypothetical protein LOC687403  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911458  iron/zinc purple acid phosphatase-like protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687403  hypothetical protein LOC687403      Symbol and Name status set to provisional 70820 PROVISIONAL