Gpr84 (G protein-coupled receptor 84) - Rat Genome Database

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Gene: Gpr84 (G protein-coupled receptor 84) Rattus norvegicus
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Symbol: Gpr84
Name: G protein-coupled receptor 84
RGD ID: 1585277
Description: Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human GPR84 (G protein-coupled receptor 84); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G-protein coupled receptor 84; LOC688730; similar to G protein-coupled receptor 84
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,322,374 - 136,324,648 (-)NCBIGRCr8
mRatBN7.27134,443,904 - 134,446,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,443,936 - 134,446,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,199,092 - 136,201,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,428,460 - 138,430,629 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,414,679 - 138,416,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,934,606 - 144,937,194 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,934,610 - 144,936,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,714,628 - 142,716,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,217,811 - 142,220,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7130,867,597 - 130,869,790 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23382219   PMID:23449982  


Genomics

Comparative Map Data
Gpr84
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,322,374 - 136,324,648 (-)NCBIGRCr8
mRatBN7.27134,443,904 - 134,446,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,443,936 - 134,446,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,199,092 - 136,201,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,428,460 - 138,430,629 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,414,679 - 138,416,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,934,606 - 144,937,194 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,934,610 - 144,936,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,714,628 - 142,716,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,217,811 - 142,220,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7130,867,597 - 130,869,790 (-)NCBICelera
Cytogenetic Map7q36NCBI
GPR84
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,350,698 - 54,364,486 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1254,362,445 - 54,364,487 (-)EnsemblGRCh38hg38GRCh38
GRCh371254,756,229 - 54,758,270 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,042,496 - 53,044,525 (-)NCBINCBI36Build 36hg18NCBI36
Build 341253,042,496 - 53,044,525NCBI
Celera1254,408,078 - 54,410,119 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1251,795,357 - 51,797,398 (-)NCBIHuRef
CHM1_11254,722,928 - 54,724,969 (-)NCBICHM1_1
T2T-CHM13v2.01254,317,281 - 54,331,118 (-)NCBIT2T-CHM13v2.0
Gpr84
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915103,216,660 - 103,219,050 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15103,216,662 - 103,219,039 (-)EnsemblGRCm39 Ensembl
GRCm3815103,308,233 - 103,310,670 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15103,308,235 - 103,310,612 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715103,138,666 - 103,140,869 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615103,136,269 - 103,138,472 (-)NCBIMGSCv36mm8
Celera15105,472,798 - 105,474,993 (-)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1558.88NCBI
Gpr84
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554581,602,241 - 1,604,492 (-)NCBIChiLan1.0ChiLan1.0
GPR84
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21039,806,935 - 39,809,032 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11239,803,704 - 39,805,801 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01234,379,654 - 34,381,761 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11235,105,480 - 35,107,520 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1235,106,114 - 35,107,304 (+)Ensemblpanpan1.1panPan2
GPR84
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127952,320 - 954,091 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27952,886 - 954,067 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2745,300,898 - 45,302,916 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.027949,619 - 951,636 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl27950,248 - 951,429 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.127941,272 - 943,288 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.027950,255 - 952,271 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02745,704,777 - 45,706,795 (-)NCBIUU_Cfam_GSD_1.0
Gpr84
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,608,164 - 61,611,706 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651211,554,324 - 11,555,508 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651211,554,161 - 11,555,525 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR84
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,552,806 - 19,554,823 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,552,828 - 19,554,848 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2520,410,012 - 20,411,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR84
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,478,503 - 50,481,476 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1150,478,719 - 50,479,909 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037195,558,692 - 195,560,739 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr84
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249042,384,088 - 2,386,816 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249042,377,214 - 2,386,845 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr84
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:44
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000055279
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
BE108474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27134,443,925 - 134,444,091 (+)MAPPERmRatBN7.2
Rnor_6.07144,934,628 - 144,934,793NCBIRnor6.0
Rnor_5.07142,714,650 - 142,714,815UniSTSRnor5.0
RGSC_v3.47142,217,829 - 142,217,994UniSTSRGSC3.4
Celera7130,867,615 - 130,867,780UniSTS
RH 3.4 Map71065.6UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 1 31 105 60 63 34 25 34 2 148 68 93 40 44 29

Sequence


Ensembl Acc Id: ENSRNOT00000055279   ⟹   ENSRNOP00000052154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,443,936 - 134,446,178 (-)Ensembl
Rnor_6.0 Ensembl7144,934,610 - 144,936,803 (-)Ensembl
RefSeq Acc Id: NM_001109509   ⟹   NP_001102979
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,322,378 - 136,324,573 (-)NCBI
mRatBN7.27134,443,908 - 134,446,101 (-)NCBI
Rnor_6.07144,934,610 - 144,936,803 (-)NCBI
Rnor_5.07142,714,628 - 142,716,875 (-)NCBI
RGSC_v3.47142,217,811 - 142,220,004 (-)RGD
Celera7130,867,597 - 130,869,790 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242448   ⟹   XP_006242510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,322,374 - 136,324,626 (-)NCBI
mRatBN7.27134,443,904 - 134,446,154 (-)NCBI
Rnor_6.07144,934,606 - 144,937,194 (-)NCBI
Rnor_5.07142,714,628 - 142,716,875 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242449   ⟹   XP_006242511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,322,374 - 136,324,648 (-)NCBI
mRatBN7.27134,443,904 - 134,446,173 (-)NCBI
Rnor_6.07144,934,606 - 144,937,194 (-)NCBI
Rnor_5.07142,714,628 - 142,716,875 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102979 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242510 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242511 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86786 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052154.2
RefSeq Acc Id: NP_001102979   ⟸   NM_001109509
- UniProtKB: D4ACK0 (UniProtKB/TrEMBL),   A6KD06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242511   ⟸   XM_006242449
- Peptide Label: isoform X1
- UniProtKB: D4ACK0 (UniProtKB/TrEMBL),   A6KD06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242510   ⟸   XM_006242448
- Peptide Label: isoform X1
- UniProtKB: D4ACK0 (UniProtKB/TrEMBL),   A6KD06 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052154   ⟸   ENSRNOT00000055279
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACK0-F1-model_v2 AlphaFold D4ACK0 1-396 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585277 AgrOrtholog
BioCyc Gene G2FUF-31878 BioCyc
Ensembl Genes ENSRNOG00000036834 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055279.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:688730 UniProtKB/TrEMBL
NCBI Gene 688730 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 84 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr84 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036834 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6KD06 ENTREZGENE, UniProtKB/TrEMBL
  D4ACK0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Gpr84  G protein-coupled receptor 84  LOC688730  similar to G protein-coupled receptor 84  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688730  similar to G protein-coupled receptor 84      Symbol and Name status set to provisional 70820 PROVISIONAL