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Gene: Draxin (dorsal inhibitory axon guidance protein) Rattus norvegicus

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Symbol:

Draxin

Name:

dorsal inhibitory axon guidance protein

RGD ID:

1585098

Description:

Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Predicted to be active in extracellular region. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein); INTERACTS WITH bisphenol A; Cuprizon; paracetamol.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hypothetical protein LOC691317; LOC691317

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,813,308 - 163,846,609 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	163,816,502 - 163,855,174 (-)	Ensembl				GRCr8
mRatBN7.2	5	158,530,149 - 158,563,457 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,530,342 - 158,564,483 (-)	Ensembl				mRatBN7.2
Rnor_6.0	5	164,913,085 - 164,943,012 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,913,906 - 164,927,869 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	168,571,192 - 168,604,145 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	165,179,954 - 165,193,917 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	156,813,054 - 156,842,895 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Parkinson's disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

camptothecin (ISO)

cisplatin (ISO)

clobetasol (ISO)

Cuprizon (EXP)

diallyl disulfide (ISO)

Diallyl sulfide (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

GSK-J4 (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-Nitrosopyrrolidine (ISO)

nitrates (ISO)

Nutlin-3 (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP)

PCB138 (ISO)

phenylmercury acetate (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior commissure morphogenesis (ISO)

axon guidance (IEA,ISO)

commissural neuron differentiation in spinal cord (IEA,ISO)

dorsal spinal cord development (IEA,ISO)

forebrain development (IEA,ISO)

negative regulation of axon extension (ISO)

negative regulation of canonical Wnt signaling pathway (IEA,ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of neuron projection development (ISO)

Wnt signaling pathway (IEA)

Cellular Component

extracellular region (IEA,ISO)

Molecular Function

molecular adaptor activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19150847	PMID:19808066	PMID:19857465	PMID:20621059

Genomics

Comparative Map Data

Draxin
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,813,308 - 163,846,609 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	163,816,502 - 163,855,174 (-)	Ensembl				GRCr8
mRatBN7.2	5	158,530,149 - 158,563,457 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,530,342 - 158,564,483 (-)	Ensembl				mRatBN7.2
Rnor_6.0	5	164,913,085 - 164,943,012 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,913,906 - 164,927,869 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	168,571,192 - 168,604,145 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	165,179,954 - 165,193,917 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	156,813,054 - 156,842,895 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

DRAXIN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	11,686,635 - 11,725,857 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	11,690,958 - 11,725,857 (+)	Ensembl			hg38	GRCh38
GRCh37	1	11,751,767 - 11,785,914 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	11,674,368 - 11,702,923 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	10,863,842 - 10,892,408 (+)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	10,905,872 - 10,934,449 (+)	NCBI		HuRef
CHM1_1	1	11,739,788 - 11,768,348 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	11,230,691 - 11,269,932 (+)	NCBI		T2T-CHM13v2.0

Draxin
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	148,182,894 - 148,215,582 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	148,182,894 - 148,215,155 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	148,098,437 - 148,131,139 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	148,098,437 - 148,130,698 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	147,472,546 - 147,504,807 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	146,944,456 - 146,974,498 (-)	NCBI		MGSCv36	mm8
Celera	4	150,340,046 - 150,392,279 (-)	NCBI		Celera
Cytogenetic Map	4	E1- E2	NCBI
cM Map	4	78.67	NCBI

Draxin
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,161,913 - 2,174,013 (-)	Ensembl
ChiLan1.0	NW_004955486	2,161,927 - 2,185,230 (-)	NCBI	ChiLan1.0	ChiLan1.0

DRAXIN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	216,496,154 - 216,533,049 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	215,142,280 - 215,179,165 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	10,453,708 - 10,488,391 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	11,670,651 - 11,700,012 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	11,670,651 - 11,700,012 (+)	Ensembl			panPan2	panpan1.1

DRAXIN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	84,515,881 - 84,525,797 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	84,515,811 - 84,526,387 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	81,048,566 - 81,058,406 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	85,179,300 - 85,189,152 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	85,177,345 - 85,201,605 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	81,928,122 - 81,937,956 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	82,928,734 - 82,938,550 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	83,991,540 - 84,001,382 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Draxin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	34,735,958 - 34,748,926 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	561,822 - 571,622 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	561,822 - 571,817 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DRAXIN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	71,786,800 - 71,814,679 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	71,786,806 - 71,814,946 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	65,729,472 - 65,740,651 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DRAXIN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	120,073,073 - 120,099,835 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	120,073,430 - 120,085,279 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	23,934,170 - 23,968,426 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Draxin
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	1,256,169 - 1,263,904 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624818	1,253,968 - 1,274,418 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Draxin
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	12,663,686 - 12,677,700 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Draxin
230 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	105
Count of miRNA genes:	96
Interacting mature miRNAs:	104
Transcripts:	ENSRNOT00000012080
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	160111176	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	160071170	172129029	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	156396728	167181764	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	156289283	171137955	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	6	23	151	62	63	38	80	38	6	246	127	11	132	62	91	25	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006225621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012080 ⟹ ENSRNOP00000012079

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	158,530,342 - 158,564,483 (-)	Ensembl
Rnor_6.0 Ensembl	5	164,913,906 - 164,927,869 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000143892 ⟹ ENSRNOP00000106947

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	163,817,437 - 163,855,174 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000149539 ⟹ ENSRNOP00000112195

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	163,816,502 - 163,847,145 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000157458 ⟹ ENSRNOP00000100484

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	163,819,349 - 163,849,259 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167890 ⟹ ENSRNOP00000101863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	163,817,472 - 163,836,331 (-)	Ensembl

RefSeq Acc Id:

XM_006239423 ⟹ XP_006239485

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,813,308 - 163,846,609 (-)	NCBI
mRatBN7.2	5	158,534,342 - 158,563,457 (-)	NCBI
Rnor_6.0	5	164,913,085 - 164,943,012 (-)	NCBI
Rnor_5.0	5	168,571,192 - 168,604,145 (-)	NCBI

Sequence:

show sequence

GCCGTCCCCGCCCCTCGCTCACTCCCTCCTTTGCAGCCGGAGCAGCCTCCCGCCACCCGTGCAC
CTCTCCCTCCGCCCTCAGCTGCGCTCGGCTCCCGCAGGCGCTCGGCCCTGCGCCCTCCGTCCCC
TCCCCGTCCGCCCGACAGGGAGAGCCAATGGCAGGGTCCGTCCTCAGGGTCCCCATGCTGTTCC
TGATCCTCCTGCTATTTCCAGAGCTCTACATGACAGGCACCCTGGCCTCTGGATCCTCTGCCCG
GAACCTGCCCGAAACCCACTCCCACCTCCCCAGCTCTGCACTATGGGTGCCTCAGACAAGCCAT
CACGGTCGTCGAGGCCTGGGGAAGAAGGACAGGGGCCCAGGCAGACCTCGCCGGACCCAGGAGG
GAGCCGTGGTCACTGCCACCAGGCAGGCTTCCCAGATGACACCTGGACAGCCCCCTGCTGGCCT
TCTGCAGAACAAGGAGCTGCTTCTGGGGCTGGCATTGCCCTACCCGGAGAAGGAGGCCCGGTCT
CCTGGTTGGGAGAGGGTGAAGAAACGTGGCAGAGAACACAAGAGGCGCAGGGACCGTCTGCGGC
TGCATCGAGGCCGGCCTGCCATCCGTGGACCCAGCTCCCTCATGAAGAAGGTGGAACCCTCTGA
AGACCGGATGCTGGAGAGTACCATGGAGGAGTCTTCCACTAGCCTGGCCCCTACCATGTTCTTC
CTAACCACAGCCGACGGTGCCATGCCTACTGTGGAAGAGTCCCGGATCCTGCCCGTCACCTCCC
TGCGGCCCCAGACACAGCCCACGTCTGATGGGGAGGTGATGCCCACACTGGACATGGCCCTATT
TGATTGGACGGATTATGAAGACTTAAAGCCAGAGGTTTGGCCTTCTGCAAAGAAAAAAGAGAAA
CACTGGAGTCATTTTACCAGTGATGGTAACGAGACATCACCTGCTGAGGGAGAGCCGTGTGACC
ATCACCAGGACTGCTTGCCAGGAACTTGCTGTGACCTCCGGGAACATCTCTGCACACCCCACAA
CCGCGGCCTCAACAACAAATGTTTCGATGACTGCATGTGCACGGAAGGGCTGCGCTGCTATGCC
AAATTCCACCGGAACCGCAGGGTCACTCGAAGGAAGGGGCGCTGCGTGGAACCTGAGACAGCCA
ACGGGGACGAGGGATCTTTCATCAACATCTAGCGCCCTAGTGGTGCCTCCCCACCGGCCCGGGG
TCTGAGCCAAGGAGGTTTAGGACAAACAGGGCGTGTTAGTAACTAGCTCAACTTGAGGCTGAGT
GGGGAATCAATGGTTGAGGCTGTAGGTGCAGGCCCAATTCCCTCACCCCCAAAGCAGGAAGGCC
GCTTGGCTGAGAGCAGTGCGCCTGCGCCCGCCCGCTTGCAGACCGCAGCCAGGGACGGGGCGGG
GCCGGTCCCCAGCCAGGACCCGGCTCAGCTAAGGGATCCTGCTAAACTCGGTGGCTGTGTGGAG
CGCACCCTCTTCTGCTCTACGCCAGCACTGCAACAGTTTCAATTTGTGAAATCAAGAAGGCTCC
CTTGACTGGAAAGGGTTGGAAAGAGAGGGGACACCTGACAGGCGTGCATCTGGAATGCTGTGTT
CCAGGCTAACGCCAAGCACCACGTGTATTTTTACTGAATTTCCACAGAGACCGTGGTAAGAGAT
CACTGACGCGCACCCGAGGTGCATGATCGTCGTGCAGGGTCCCACGTCATCCATGGTCCTCCAG
TTCTGGCAGCAGAGACAGCTTGACTGTCTTCAGCCTTTCCCAAGAGAGACTTACGTCTTTTTGA
TGGACCGAGTCTTACTCTTTGGCCAAGCTGGCAACTCAGACAATCCTCCTGCCTCGGTCTTCCA
AATGCTGGAATTATAGGCATGGGTCGGCATAATTCGGCAGGTGTATCTTCCTTAAAAACAAAAC
ATTGGGGTTGGGGATTTAGCTCAGTGGTAGAGCACTTGCCTAGCAAGCGCAAGGTCCTGGGTTC
GGTCCCCAGCTCCGAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039111355 ⟹ XP_038967283

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	163,813,308 - 163,836,862 (-)	NCBI
mRatBN7.2	5	158,530,149 - 158,553,704 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_006239485	(Get FASTA)	NCBI Sequence Viewer
	XP_038967283	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000100484.1
	ENSRNOP00000101863
	ENSRNOP00000101863.1
	ENSRNOP00000106947.1
	ENSRNOP00000112195
	ENSRNOP00000112195.1

RefSeq Acc Id:	XP_006239485 ⟸ XM_006239423
- Peptide Label:	isoform X2
- UniProtKB:	D3ZDG4 (UniProtKB/TrEMBL), A6IU48 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGSVLRVPMLFLILLLFPELYMTGTLASGSSARNLPETHSHLPSSALWVPQTSHHGRRGLGKK DRGPGRPRRTQEGAVVTATRQASQMTPGQPPAGLLQNKELLLGLALPYPEKEARSPGWERVKKR GREHKRRRDRLRLHRGRPAIRGPSSLMKKVEPSEDRMLESTMEESSTSLAPTMFFLTTADGAMP TVEESRILPVTSLRPQTQPTSDGEVMPTLDMALFDWTDYEDLKPEVWPSAKKKEKHWSHFTSDG NETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGLNNKCFDDCMCTEGLRCYAKFHRNRRVT RRKGRCVEPETANGDEGSFINI hide sequence

Ensembl Acc Id:

ENSRNOP00000012079 ⟸ ENSRNOT00000012080

RefSeq Acc Id:	XP_038967283 ⟸ XM_039111355
- Peptide Label:	isoform X1
- UniProtKB:	A6IU48 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000112195 ⟸ ENSRNOT00000149539

Ensembl Acc Id:

ENSRNOP00000106947 ⟸ ENSRNOT00000143892

Ensembl Acc Id:

ENSRNOP00000101863 ⟸ ENSRNOT00000167890

Ensembl Acc Id:

ENSRNOP00000100484 ⟸ ENSRNOT00000157458

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZDG4-F1-model_v2	AlphaFold	D3ZDG4	1-342	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1585098	AgrOrtholog
BioCyc Gene	G2FUF-39177	BioCyc
Ensembl Genes	ENSRNOG00000008911	Ensembl
	ENSRNOG00000077899	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000143892.1	UniProtKB/TrEMBL
	ENSRNOT00000149539	ENTREZGENE
	ENSRNOT00000149539.1	UniProtKB/TrEMBL
	ENSRNOT00000157458.1	UniProtKB/TrEMBL
	ENSRNOT00000167890	ENTREZGENE
	ENSRNOT00000167890.1	UniProtKB/TrEMBL
InterPro	Draxin	UniProtKB/TrEMBL
NCBI Gene	691317	ENTREZGENE
PANTHER	DRAXIN	UniProtKB/TrEMBL
	PTHR28610	UniProtKB/TrEMBL
Pfam	Draxin	UniProtKB/TrEMBL
PhenoGen	Draxin	PhenoGen
RatGTEx	ENSRNOG00000008911	RatGTEx
	ENSRNOG00000077899	RatGTEx
UniProt	A0ABK0KZ10_RAT	UniProtKB/TrEMBL
	A0ABK0L9T1_RAT	UniProtKB/TrEMBL
	A0ABK0LX29_RAT	UniProtKB/TrEMBL
	A0ABK0M877_RAT	UniProtKB/TrEMBL
	A6IU48	ENTREZGENE, UniProtKB/TrEMBL
	D3ZDG4	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-02	Draxin	dorsal inhibitory axon guidance protein	LOC691317	hypothetical protein LOC691317	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC691317	hypothetical protein LOC691317	LOC686619	hypothetical protein LOC686619	Data merged from RGD:1595029	1643240	APPROVED
2006-11-20	LOC686619	hypothetical protein LOC686619			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC691317	hypothetical protein LOC691317			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD