Serpine3 (serpin family E member 3) - Rat Genome Database

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Gene: Serpine3 (serpin family E member 3) Rattus norvegicus
Analyze
Symbol: Serpine3
Name: serpin family E member 3
RGD ID: 1585042
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Orthologous to human SERPINE3 (serpin family E member 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC691375; RGD1310515; serpin E3; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; similar to serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,084,819 - 41,109,006 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,084,620 - 41,108,853 (+)EnsemblGRCr8
mRatBN7.21536,908,816 - 36,931,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,907,131 - 36,933,150 (+)EnsemblmRatBN7.2
Rnor_6.01545,827,983 - 45,855,952 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,834,302 - 45,858,335 (+)Ensemblrn6Rnor6.0
Rnor_5.01549,600,587 - 49,622,250 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41541,917,864 - 41,942,032 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1536,588,819 - 36,616,791 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Serpine3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,084,819 - 41,109,006 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,084,620 - 41,108,853 (+)EnsemblGRCr8
mRatBN7.21536,908,816 - 36,931,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,907,131 - 36,933,150 (+)EnsemblmRatBN7.2
Rnor_6.01545,827,983 - 45,855,952 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,834,302 - 45,858,335 (+)Ensemblrn6Rnor6.0
Rnor_5.01549,600,587 - 49,622,250 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41541,917,864 - 41,942,032 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1536,588,819 - 36,616,791 (+)NCBICelera
Cytogenetic Map15p12NCBI
SERPINE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,339,691 - 51,364,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,335,773 - 51,364,735 (+)Ensemblhg38GRCh38
GRCh371351,913,827 - 51,938,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,813,169 - 50,834,240 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1332,964,335 - 32,985,406 (+)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1332,704,249 - 32,725,482 (+)NCBIHuRef
CHM1_11351,882,676 - 51,903,771 (+)NCBICHM1_1
T2T-CHM13v2.01350,554,612 - 50,579,655 (+)NCBIT2T-CHM13v2.0
Serpine3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,900,743 - 62,929,692 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,901,116 - 62,929,692 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381462,663,298 - 62,692,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,663,667 - 62,692,243 (+)Ensemblmm10GRCm38
MGSCv371463,282,504 - 63,311,080 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361461,617,777 - 61,647,749 (+)NCBIMGSCv36mm8
Celera1460,422,453 - 60,450,997 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.23NCBI
Serpine3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554314,694,654 - 4,727,080 (+)Ensembl
ChiLan1.0NW_0049554314,694,654 - 4,727,080 (+)NCBIChiLan1.0ChiLan1.0
SERPINE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21452,778,733 - 52,799,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11351,416,083 - 51,443,938 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01332,475,429 - 32,496,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,220,434 - 51,244,077 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,220,735 - 51,241,791 (+)EnsemblpanPan2panpan1.1
SERPINE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122637,600 - 666,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22636,466 - 663,695 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha22670,052 - 697,870 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.022618,307 - 646,209 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22621,442 - 644,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.122539,560 - 567,633 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022588,743 - 616,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022607,030 - 635,107 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serpine3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945160,683,068 - 160,711,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,168,895 - 4,197,662 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,167,734 - 4,198,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1116,466,475 - 16,500,541 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11116,465,521 - 16,500,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,805,221 - 16,839,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,227,812 - 29,251,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,228,049 - 29,249,397 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605714,575,894 - 14,597,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpine3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247482,833,748 - 2,860,303 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Serpine3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,724,687 - 61,746,079 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serpine3
217 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:86
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000051307
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
BF403479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21536,922,987 - 36,923,077 (+)MAPPERmRatBN7.2
Rnor_6.01545,848,472 - 45,848,561NCBIRnor6.0
Rnor_5.01549,614,770 - 49,614,859UniSTSRnor5.0
RGSC_v3.41541,932,034 - 41,932,123UniSTSRGSC3.4
Celera1536,609,309 - 36,609,398UniSTS
RH 3.4 Map15258.6UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 11 34 98 51 50 19 36 19 5 145 95 3 77 15 50 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000051307   ⟹   ENSRNOP00000045922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1541,084,620 - 41,108,853 (+)Ensembl
mRatBN7.2 Ensembl1536,907,131 - 36,933,150 (+)Ensembl
Rnor_6.0 Ensembl1545,834,302 - 45,858,335 (+)Ensembl
RefSeq Acc Id: XM_063274875   ⟹   XP_063130945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,084,819 - 41,109,006 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063130945 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85301 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045922
  ENSRNOP00000045922.3
Ensembl Acc Id: ENSRNOP00000045922   ⟸   ENSRNOT00000051307
RefSeq Acc Id: XP_063130945   ⟸   XM_063274875
- UniProtKB: D4A9F7 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9F7-F1-model_v2 AlphaFold D4A9F7 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585042 AgrOrtholog
BioCyc Gene G2FUF-13455 BioCyc
Ensembl Genes ENSRNOG00000009814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051307 ENTREZGENE
  ENSRNOT00000051307.6 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene 691375 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  PTHR11461:SF129 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpine3 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009814 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt D4A9F7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpine3  serpin family E member 3  Serpine3  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Serpine3  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3  LOC691375  similar to serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691375  similar to serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  LOC683254  similar to serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2  Data merged from RGD:1589229 1643240 APPROVED
2006-11-19 LOC691375  similar to serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683254  similar to serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL