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Gene: Adam19 (ADAM metallopeptidase domain 19) Rattus norvegicus

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Symbol:

Adam19

Name:

ADAM metallopeptidase domain 19

RGD ID:

1585017

Description:

Predicted to enable SH3 domain binding activity and metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in several processes, including amyloid precursor protein catabolic process; positive regulation of cell-cell adhesion mediated by cadherin; and proteolysis. Predicted to act upstream of or within heart development. Predicted to be located in Golgi apparatus and nucleus. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

a disintegrin and metallopeptidase domain 19 (meltrin beta); a disintegrin and metalloproteinase domain 19 (meltrin beta); a disintegrin and metalloproteinase domain 19 (meltrin beta) (mapped); Adam19_mapped; disintegrin and metalloproteinase domain-containing protein 19; LOC303068; meltrin beta; Sox30; SRY-box containing gene 30

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADAM19 (ADAM metallopeptidase domain 19)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Adam19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adam19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADAM19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADAM19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adam19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADAM19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADAM19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adam19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Adam19 (ADAM metallopeptidase domain 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZFP62 (ZFP62 zinc finger protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ADAM19 (ADAM metallopeptidase domain 19)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Adam19 (ADAM metallopeptidase domain 19)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adam19b (ADAM metallopeptidase domain 19b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Meltrin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Meltrin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	adm-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	adm-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	adam19	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	30,992,713 - 31,084,455 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	30,992,754 - 31,084,455 (+)	Ensembl				GRCr8
mRatBN7.2	10	30,491,362 - 30,583,115 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,491,405 - 30,583,105 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	35,218,634 - 35,310,362 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	3,757,069 - 3,848,808 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	30,193,020 - 30,284,822 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	31,146,107 - 31,240,582 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,146,107 - 31,240,582 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	30,966,982 - 31,059,793 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	31,190,242 - 31,282,773 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	29,944,988 - 30,036,150 (+)	NCBI		Celera
RGSC_v3.1	10	31,117,503 - 31,279,676 (+)	NCBI
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital heart disease (ISO)

lung adenocarcinoma (ISO)

squamous cell carcinoma (ISO)

ureteral obstruction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methoxyethanol (EXP)

3,3',5-triiodo-L-thyronine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

bisphenol F (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

camptothecin (ISO)

cantharidin (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diquat (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

fructose (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

glyphosate (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

indometacin (ISO)

inulin (ISO)

irinotecan (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

menadione (ISO)

methyl methanesulfonate (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

nicotine (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

oxaliplatin (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

PD 0325901 (ISO)

pentanal (ISO)

pentane-2,3-dione (EXP)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

propanal (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

toluene (ISO)

Tributyltin oxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid precursor protein catabolic process (ISO)

biological_process (ND)

heart development (ISO)

membrane protein ectodomain proteolysis (IBA,ISO)

placenta development (ISO)

positive regulation of cell-cell adhesion mediated by cadherin (ISO)

positive regulation of gene expression (ISO)

protein processing (ISO)

proteolysis (IEA)

Cellular Component

Golgi apparatus (ISO)

membrane (IEA)

nucleus (ISO)

Molecular Function

metal ion binding (IEA)

metalloendopeptidase activity (IBA,IEA,ISO)

metalloendopeptidase activity involved in amyloid precursor protein catabolic process (ISO)

metallopeptidase activity (IEA)

protein binding (ISO)

SH3 domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ADAMs: key components in EGFR signalling and development.	Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
2.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Meltrin beta (ADAM19) gene: cloning, mapping, and analysis of the regulatory region.	Kurohara K, etal., Biochem Biophys Res Commun 2000 Apr 13;270(2):522-7.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Canonical transforming growth factor-ß signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.	Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Roles of Meltrin beta /ADAM19 in the processing of neuregulin.	Shirakabe K, etal., J Biol Chem. 2001 Mar 23;276(12):9352-8. Epub 2000 Dec 14.
11.	Essential role for ADAM19 in cardiovascular morphogenesis.	Zhou HM, etal., Mol Cell Biol. 2004 Jan;24(1):96-104.

Additional References at PubMed

PMID:11162584	PMID:12615925	PMID:14975714	PMID:19727588

Genomics

Comparative Map Data

Adam19
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	30,992,713 - 31,084,455 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	30,992,754 - 31,084,455 (+)	Ensembl				GRCr8
mRatBN7.2	10	30,491,362 - 30,583,115 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,491,405 - 30,583,105 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	35,218,634 - 35,310,362 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	3,757,069 - 3,848,808 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	30,193,020 - 30,284,822 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	31,146,107 - 31,240,582 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,146,107 - 31,240,582 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	30,966,982 - 31,059,793 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	31,190,242 - 31,282,773 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	29,944,988 - 30,036,150 (+)	NCBI		Celera
RGSC_v3.1	10	31,117,503 - 31,279,676 (+)	NCBI
Cytogenetic Map	10	q21	NCBI

ADAM19
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	157,477,304 - 157,575,775 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	157,395,534 - 157,575,858 (-)	Ensembl			hg38	GRCh38
GRCh37	5	156,904,312 - 157,002,783 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	156,836,890 - 156,935,346 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	156,836,890 - 156,935,346	NCBI
Celera	5	152,930,875 - 153,029,355 (-)	NCBI		Celera
Cytogenetic Map	5	q33.3	NCBI
HuRef	5	151,992,608 - 152,091,126 (-)	NCBI		HuRef
CHM1_1	5	156,337,034 - 156,435,579 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	157,996,322 - 158,094,808 (-)	NCBI		T2T-CHM13v2.0

Adam19
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	45,945,329 - 46,038,174 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	45,946,819 - 46,038,170 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	46,054,502 - 46,147,347 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	46,055,992 - 46,147,343 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	45,869,489 - 45,960,845 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	45,899,475 - 45,990,766 (+)	NCBI		MGSCv36	mm8
Celera	11	50,642,938 - 50,736,472 (+)	NCBI		Celera
Cytogenetic Map	11	B1.1	NCBI
cM Map	11	27.54	NCBI

Adam19
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	11,654,630 - 11,745,262 (-)	Ensembl
ChiLan1.0	NW_004955408	11,651,298 - 11,746,391 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADAM19
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	152,633,941 - 152,767,369 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	150,773,489 - 150,906,918 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	152,839,326 - 152,972,741 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	159,494,786 - 159,593,171 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	159,494,786 - 159,593,171 (-)	Ensembl			panPan2	panpan1.1

ADAM19
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	52,650,077 - 52,733,299 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	52,650,162 - 52,729,843 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	52,541,667 - 52,625,395 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	53,085,204 - 53,169,651 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	53,085,156 - 53,169,615 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	52,912,670 - 52,996,321 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	53,019,009 - 53,102,828 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	53,536,728 - 53,619,997 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adam19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	107,151,126 - 107,234,001 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936515	5,594,546 - 5,683,726 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936515	5,603,095 - 5,683,347 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAM19
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	65,715,517 - 65,814,758 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	65,715,445 - 65,814,761 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	71,570,083 - 71,669,354 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAM19
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	59,867,949 - 59,966,873 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	59,867,596 - 59,966,802 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	17,663,866 - 17,762,545 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adam19
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	31,858,450 - 31,944,893 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	31,857,795 - 31,944,252 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Adam19
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	28,777,995 - 28,868,181 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Adam19
1156 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	480
Count of miRNA genes:	240
Interacting mature miRNAs:	319
Transcripts:	ENSRNOT00000008184
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35730538	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38832698	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	23422121	32490778	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6661118	35509383	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	29377046	52699134	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

D10Got50

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	30,493,139 - 30,493,350 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,147,834 - 31,148,044	NCBI	Rnor6.0
Rnor_5.0	10	30,968,709 - 30,968,919	UniSTS	Rnor5.0
RGSC_v3.4	10	31,191,968 - 31,192,179	RGD	RGSC3.4
RGSC_v3.4	10	31,191,969 - 31,192,179	UniSTS	RGSC3.4
Celera	10	29,946,715 - 29,946,939	UniSTS
RGSC_v3.1	10	31,193,018 - 31,193,228	RGD
RH 3.4 Map	10	339.01	UniSTS
RH 3.4 Map	10	339.01	RGD
RH 2.0 Map	10	343.7	RGD
Cytogenetic Map	10	q21	UniSTS

RH128156

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	30,582,820 - 30,583,032 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,240,289 - 31,240,500	NCBI	Rnor6.0
Rnor_5.0	10	31,059,500 - 31,059,711	UniSTS	Rnor5.0
RGSC_v3.4	10	31,282,480 - 31,282,691	UniSTS	RGSC3.4
Celera	10	30,035,857 - 30,036,068	UniSTS
RH 3.4 Map	10	318.8	UniSTS
Cytogenetic Map	10	q21	UniSTS

RH128894

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	30,577,761 - 30,577,960 (+)	MAPPER	mRatBN7.2
mRatBN7.2	17	43,538,399 - 43,538,598 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	45,613,981 - 45,614,179	NCBI	Rnor6.0
Rnor_6.0	10	31,235,230 - 31,235,428	NCBI	Rnor6.0
Rnor_5.0	17	57,856,187 - 57,856,385	UniSTS	Rnor5.0
Rnor_5.0	10	31,054,441 - 31,054,639	UniSTS	Rnor5.0
RGSC_v3.4	10	31,277,421 - 31,277,619	UniSTS	RGSC3.4
RGSC_v3.4	17	51,192,709 - 51,192,907	UniSTS	RGSC3.4
Celera	17	52,940,820 - 52,941,018	UniSTS
Celera	10	30,030,798 - 30,030,996	UniSTS
Cytogenetic Map	10	q21	UniSTS
Cytogenetic Map	17	q11	UniSTS

AI431060

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	30,582,806 - 30,583,032 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,240,275 - 31,240,500	NCBI	Rnor6.0
Rnor_5.0	10	31,059,486 - 31,059,711	UniSTS	Rnor5.0
RGSC_v3.4	10	31,282,466 - 31,282,691	UniSTS	RGSC3.4
Celera	10	30,035,843 - 30,036,068	UniSTS
Cytogenetic Map	10	q21	UniSTS

BF410193

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	30,568,386 - 30,568,499 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,225,855 - 31,225,967	NCBI	Rnor6.0
Rnor_5.0	10	31,045,066 - 31,045,178	UniSTS	Rnor5.0
RGSC_v3.4	10	31,268,046 - 31,268,158	UniSTS	RGSC3.4
Celera	10	30,021,422 - 30,021,534	UniSTS
Cytogenetic Map	10	q21	UniSTS

AU049292

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	30,546,952 - 30,547,231 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,204,426 - 31,204,704	NCBI	Rnor6.0
Rnor_5.0	10	31,023,637 - 31,023,915	UniSTS	Rnor5.0
RGSC_v3.4	10	31,246,616 - 31,246,894	UniSTS	RGSC3.4
Celera	10	29,999,995 - 30,000,273	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	355	192	11	142	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001160228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008184 ⟹ ENSRNOP00000008184

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	30,992,754 - 31,084,452 (+)	Ensembl
mRatBN7.2 Ensembl	10	30,491,446 - 30,583,105 (+)	Ensembl
Rnor_6.0 Ensembl	10	31,146,107 - 31,240,582 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108861 ⟹ ENSRNOP00000077829

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	30,993,274 - 31,084,455 (+)	Ensembl
mRatBN7.2 Ensembl	10	30,491,405 - 30,582,988 (+)	Ensembl

RefSeq Acc Id:

NM_001160228 ⟹ NP_001153700

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	30,992,761 - 31,084,455 (+)	NCBI
mRatBN7.2	10	30,491,412 - 30,583,114 (+)	NCBI
Rnor_6.0	10	31,146,107 - 31,240,582 (+)	NCBI
Rnor_5.0	10	30,966,982 - 31,059,793 (+)	NCBI
RGSC_v3.4	10	31,190,242 - 31,282,773 (+)	RGD
Celera	10	29,944,988 - 30,036,150 (+)	RGD

Sequence:

show sequence

CGTTTGCTTGAAAACCGCCGCCGCCGCTAGGCCGGGGGCAGGCAATGGCAGGGGATGTGTGATT
GCGGACAGTGAGAGGGCCATTGCTATCATGCCCGGGCGCGCGGGCGTCGCCCGGTTCTGCTTGC
TGGCTCTCGCTCTGCAGCTACAGTGGCCGCTGGCGGCATGCGAACCGGAATGGACCACAAGAGG
AAGCAAAGAAGACAGCCCTCCACTACAACATGAACTCATAATACCTCAGTGGAGGACTTCAGAA
AGCCCCAGGGGAGGAAAGCATCCACTCACGGCAGAGCTCAGGGTCATGGCTGAAGGGCGAGAGC
TGATCCTGGACCTGGAGAAGAACGAGCACCTTTTTGCTCCAGCCTACACAGAGACCTGCTACAC
CGCAAGTGGCAATCCTCAGACCACCACGCTGAAATCTGAGGATCACTGCTTTTACCACGGGACT
GTGAGGAAAGTGGATGAGTCCAGCGTCACTCTCAGCACCTGCCGGGGAATTAGAGGACTGATTA
TAGTGAGAAGTAACCTCAGCTACATCATCGAGCCCGTCCCTAACAGCGACAACCAACACCGTAT
TTACAGATCCGAACATCTCAAGCTGCCCCCGGGGAACTGTGGGTTCGAGCACTCCAGGCCCACC
TCTAAGGACTGGACCCTTCAGTTTACACATCAGACCAAAAAGCAACCTCGCAGAATGAAACGGG
AAGATTTACACTCTATGAAGTACGTGGAGCTTTATCTGGTGGCTGATTACGCAGAGTTTCAGAA
GAACCGGCATGACCAGGATGCCACCAAACACAAGCTCATGGAGATTGCCAACTATGTTGATAAG
TTTTACCGCTCCCTGAGCATCCGGATTGCGCTTGTCGGCTTGGAGGTGTGGACACACGGGGATA
AGTGTGAAGTCTCAGAGAATCCGTACTCTACCCTCTGGTCCTTTCTCAGTTGGAGGCGCAAGCT
GCTCACCCAGAAGAGCCATGACAATGCCCAGCTAATCACGGGCAGGTCCTTCCAAGGCACCACC
ATTGGCCTGGCCCCCCTCATGGCCATGTGTTCTGTGTACCAGTCCGGAGGAGTTAGCATGGACC
ACTCCGAGAATGCCATCGGTGTAGCCTCCACCGTGGCCCACGAGATTGGCCACAACTTTGGCAT
GAGCCATGATTCTGCACACTGCTGTTCTACCAGCGCAGCCGATGGTGGGTGCATCATGGCTGCT
GCTACGGGGCACCCTTTCCCCAAAGTGTTCAGTTCGTGCAACAGGAAGGAGCTGGACAGGTATC
TGCAGTCAGGAGGTGGGATGTGTCTCTCCAACATGCCAGATACGAGGACTCTGTATGGAGGCCG
GAGGTGTGGCAATGGGTACCTGGAAGACGGTGAAGAATGTGACTGCGGAGAAGAGGACGAATGT
AAGAACCCTTGCTGCAATGCCTCCAACTGCACTCTGAAGGAAGGGGCCGAGTGTGCCCATGGCT
CCTGCTGCCACCAGTGTAAGCTGGTGGCTCCTGGAACCCAGTGTCGTGAGCAGGTGCGGCAGTG
TGATCTCCCCGAGTTCTGCACGGGCAAGTCCCCCCACTGCCCCACCAACTATTACCAGATGGAT
GGCACCCCCTGCGAGGGTGGCCAGGCCTACTGCTACAATGGCATGTGCCTCACTTATCAGGAGC
AGTGCCAGCAGCTGTGGGGACCTGGAGCCAGGCCTGCTCTTGATCTTTGCTTCGAGAGGGTGAA
TGCTGCTGGTGACACCTATGGTAACTGCGGCAAAGGCTTGAATGGCAAATACAGGAAGTGCAGC
CCCAGGGATGCCAAGTGTGGGAAGATCCAGTGTCAGAGCACCCAGGCCAGGCCCCTGGAATCCA
ACGCAGTATCTATTGACACCACCATTACCTTGAACGGGAGGCGGATCCACTGTCGGGGCACCCA
TGTCTACCGGGGTCCTGAGGAGGAAGAAGGGGAGGGTGACATGCTGGACCCAGGGCTGGTGATG
ACCGGGACCAAGTGTGGCCACAACCATATTTGCTTCGAGGGGCAATGCAGGAACACCTCCTTCT
TTGAGACGGAAGGCTGTGGGAAAAAGTGCAATGGTCATGGGGTCTGCAACAACAACAAGAACTG
TCATTGCTTCCCTGGCTGGGCTCCACCTTTCTGTAACACCCCAGGAGATGGCGGCAGCATTGAC
AGTGGGCCTTTGCCCCCTAAGAGTGCGGGTCCTGTGATTGCTGGGGTGTTTTCTGCCCTCTTCG
TGTTGGCAGTCCTGGTGCTATTGTGTCATTGCTACAGACAGAGCCACAAACTGGGCAAGCCCTC
AGCTCTCCCTTTTAAGCTGCGGCAACAGTTCAGTTGTCCCTTCAGGGTGTCTCAGAATGGTGGA
ACTGGCCACGCCAACCCAACTTTCAAGTTGCAGACACCCCAGGGCAAGCGAAAGGTGACTAACA
CCCCTGAAACTCTCCGGAAGCCCTCCCACCCTCCTCCCCGGCCCCCTCCGGACTACCTACGAGT
TGAATCCCATCCTGCACCACTGCCAGCACATCTGAACAGGGCTGCTGGGAGCTCACCAGAAGCT
GGAGCTCAGATAGAAAGAAAGGAATCAGCCAGAAGACCTCCCCCAAGCCGGCCCATGCCCCCTG
CACCGAACTGCCTACTGTCCCAGGATTTCTCCAGGCCTCGACCACCTCAGAAGGCACTCCCAGC
GAATCCTGTGCCGGGCCAAAGGACTGTTCCCAGGCCAGGAGGCACCTCCCTGTTTCATCCCCCT
ACTACTGGTCCTCAGCCTCCCAGGCCTCCAGCAGTGTCTGTTCCAAAGCTTCCTGAGTACCGAT
CACAGAGGATTGGAGGGATAACCAGCTCCAAGATCTAGACGTGTCTAGAAGTTTCTTGTTTCGC
TTGAAGACTCCGGATGCCATGGAAGGTCCAGAAGGAAGAAGCCTGCTTGGCCACCCTGAAGCTT
CTGCAGCCTTCTGGAACCCACCTCATCCCCAGAATCTCCCTTCTTGCCCTAGTGCCTCCTGCTT
CCTCTGAGACCCAGAGGGTCTCATAGCCGATGGCTTCTAAGTGTTGTCCTGTGCAATATACAGT
CCGGGTAGGAAAGGGAAACATGTGGAGGAGGTTTGGGGAAGATTCTCCCTCAGCCCGCTAGCCA
AGAGCTACCAACAATGTTCAGGGAAGTCTTGAGCTGGGGTCCTCCTGTGCCGAGCTTGGAGAAG
GTATCCATCTGGGTCCTCTGCTGGCAGGTACACACAGGAGCTTCAGTGATTGGCCTCCCAGGCT
GGGCCTTACTGTCTCTTAGCTTTTATGGCCCGAGGAAGCTGCATCCCTGCCCCAAGGCTTGGTC
AAGGTGCCTGTTCCCGGCTATGTGGCTGCATGTGACAAGCCATGCTCCCTCACCCCCCGCCATT
CTTCACATTCCCACTCCCATATTTACATGGGTCACTCTGACTCAGACAGGTACTATTTGTAAGT
AGTGTAGACAGCAGGGGGGAGCGGTCAGCCTGTGTCCCCTCTGAGCCGTGATGCCAAAGGTTGC
TAAGGACTTTTAGAATCCCCAGCCGTACATCCCAGTGTTCCATGTGTCCCCTTCTCCTCCTCTT
TCAGCATCCCTAGCCTATGGTGCTTTGGTGGTGGACCACTGCAGTCCTGACTTGCTGGTGACTA
TATGCTAGTGACCTCCAAATCAGGATCCTGCCTCATGGGGTAGCCACTGGACTTTCTGCACTGG
ATCGCAAGAGCATTGAGCCGAGTGGGCGTGTGTGTGTGTGTGTGTGTGTGTGACAGAGACAGTG
AGAGAGAGACAGGCAGGCAGACAGACAGACAGACAGCTCTGCGTGTACTTGTATTTTATGGCCT
CAAACAGGATAAGGGGCCTCCTTCCTTATTCCTGACCTATATCTAAGTAAGGTTCTCCAGGACA
GCCACAGTTATACTGAGGGGGGACTGACATGTTTGGAATCCTGGCTATTAGTAACGTCTATGCA
GGGGCACCAGCCCCTCCCTGGTGGTCAGCTCTGAGGTGAGATTGTTGACTATGAACAGATCACA
GTTGACAGTCACAGTTAACTCTCTTCAACCAAGCACTTCCATCAGTTCTCTCCTGGTTACTGCT
CCTATGTGATTGTCTTGGAAGATGCTGGGAGGTGGGAATGGGACTGGCATGGACCTCCTCTTGC
TTGGTGCTCTGCCTCCTAGAACAGTTTTCACACATTTGCCAGGCCTGGCCTCGAAGAGGCCATC
TTCCACCCCCAAAAAAGGTGCTAATAGCACTCCAGAGGGCTCTCTAGGGGCCTTCCTGCCAACC
GTGGCGAGCGGTTGTTAGCTCTTGGAACCCTCCAGAGGAAGAGGCAAGCTTTTGACTCCCCATT
ACCACCCCGAGGCCTCCTTCTATCTCCTCACAGAGACAAGTGAGAGATACAGCATACATGGCTG
GCGGGTAGAAAGATCTCAGGAAAACATCTCTTTTCTTTTCAGGGTAACTGTGCCGTTCACACTC
TCTGAGTGTGATCCAAAATCTTACTTAAGGCCTTGGTCCATCTCCTGTGTCAGTGTCTCATTTC
TGTGCTTTACCAGATGCCCAGTAACTACAGCTTGGGCCCTAGAGACAGAGGCCACCCCGATTCT
CACCACAAAGTTAGAAACCCTCCACTTTCTTTCCCTTGAGCCACATCAGAAAAAAGACCCATTT
CCTTGCTCATTGGCAATCACTTCGGCTTTTTTCTCTTTCGTTACTCTCGTACCACCTCCATCCC
ATAAAACTATACTGTGAACCGTAAGAGGGCAGGATTTTTTAACTCGGTAGAAATGCTGGCAGCT
ACTCTCCAAAAGCCAGGGAGGCTGTCACAGGTAGGAATCCCTTCCCGTCTGCATTGTGAAGGGT
CCCGTACAGGTGTACCTAGGCTTCAAAGACAGGGCTCGTCCCAAAGGATTGTCACTTAGGAGAT
GAAAGAATATTACCACATGGGGAGGAGGGGGCGCTTGCAACAGAACACTTTGGTCTACCTACAC
CAAGTCTGTGAGGGCATGCAAGACTGAAAAGGCCTTTTCTTATGCATAGAAAGTGAGCAAGACT
AGAAATAACTGTCCAAGGCGTCTCTGTTCCTGGCCACTGAAGAGAGATGTCAGAAGGCGTTGGA
ATAGGTCGAAGCCAAGGCTCCAGTGGGCTGAGGGAAGGTTTGGAGCTGGATTTCGTGGTGTACA
CCTTTAGTCCCAGGAGAGGTAGGTGAATCTCTTGAGTATGAGGGTAGCCTGGTCTAAAAAGGAA
GTTCCAGGACAGCCAGGGCCACACCGAGAAAAAAAAAATCAACTCTACAAAAACAAGTAAAAAT
TAAGACAGGATCTCAAGTATCCTAGGTTGGCCTTCAAGTCACTTCAAAAGTAGAGAAAGAAAAC
TGAGGGTGACCTTTGAACTCCTGAGTGCTGGCTTCTTCCCGCGTGCTCAGACTGCCAGTGTGTG
CTACCATGCTTCATGTGGTCCTGGGTTCAAACACAGACCTTCATGTGTCTATAGGCAACCACCC
TACCAACTGATCTACATCCCTCAGCCACAGCCCCTGCCAACCTTAGAACTGCAAAGCCATTTCT
GACCTGTAAACCTCAGCTCCCAATCTCTGTAAGATGTGTAGCCTTGGCTAATCCCTTCCACATT
GCAACTCCCTGCTTGCTTCCTATTCCTTCTAGCCTTGGTGACTTCCACCCGTAAGAGAAAAGCC
CCTTTTAACCCCTGCTCCAAAACATTGTAGATGTTAGGGTCTGGATGCTCTCTGCAATTCAACA
GTCCCTTCTGTTGCAGTAGCTCCCTGCCACGCTCCAGTAATCCTTCAGTGTCTCCTCTGGGCTC
AATGAATTTGCTTATTTGACAAAGTGGGCGTGAGACTTGTATTCTTAAAATTGGAGGTTAGTCA
TTTTGTCAAATGCGTGTCATGACAGACCCAAAAGGACTCCACACACAAGCCAGGGACACCAACT
GGAAAGGTGCCCCTCTCCCAGGGAAGCCTGCTAGGGAGAGGTTCTGTAGAACCCAAGCCCAGCA
GCCCAAAGTCATGCACCCAGTGTCCTCTTGTATGACTGTGTATATGTCTGTCTGGGATCCAGGG
CAAATGTGAATTTTCTTTTGATTCGGGAGATTGTTCACAGGAAATAGTCCTCTCCTCTCATGTC
CTCCTATTGATTGTTTACAATATTTGTACATCTATGCAAAATACTTGAATGGGCCGTGGTGCCT
TGTTTTGTTTTTTCTTGTTTTTTGTTTTTTTTTTTCCTCCTTGTTTGTATTTAATTAAAACAAA
TTGTCATTAGGAAA

hide sequence

RefSeq Acc Id:

XM_039085915 ⟹ XP_038941843

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	31,022,891 - 31,084,455 (+)	NCBI
mRatBN7.2	10	30,521,552 - 30,583,115 (+)	NCBI

RefSeq Acc Id:

XM_039085916 ⟹ XP_038941844

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	30,992,713 - 31,068,673 (+)	NCBI
mRatBN7.2	10	30,491,362 - 30,567,341 (+)	NCBI

RefSeq Acc Id:

XM_039085917 ⟹ XP_038941845

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	31,064,112 - 31,084,455 (+)	NCBI
mRatBN7.2	10	30,562,771 - 30,583,115 (+)	NCBI

RefSeq Acc Id:

XM_063268971 ⟹ XP_063125041

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	30,992,713 - 31,075,973 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001153700	(Get FASTA)	NCBI Sequence Viewer
	XP_038941843	(Get FASTA)	NCBI Sequence Viewer
	XP_038941844	(Get FASTA)	NCBI Sequence Viewer
	XP_038941845	(Get FASTA)	NCBI Sequence Viewer
	XP_063125041	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM04164	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008184
	ENSRNOP00000008184.6
	ENSRNOP00000077829.2

RefSeq Acc Id:	NP_001153700 ⟸ NM_001160228
- Peptide Label:	precursor
- UniProtKB:	A0A8I5Y236 (UniProtKB/TrEMBL), A6HDQ9 (UniProtKB/TrEMBL), D3ZPM7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPGRAGVARFCLLALALQLQWPLAACEPEWTTRGSKEDSPPLQHELIIPQWRTSESPRGGKHPL TAELRVMAEGRELILDLEKNEHLFAPAYTETCYTASGNPQTTTLKSEDHCFYHGTVRKVDESSV TLSTCRGIRGLIIVRSNLSYIIEPVPNSDNQHRIYRSEHLKLPPGNCGFEHSRPTSKDWTLQFT HQTKKQPRRMKREDLHSMKYVELYLVADYAEFQKNRHDQDATKHKLMEIANYVDKFYRSLSIRI ALVGLEVWTHGDKCEVSENPYSTLWSFLSWRRKLLTQKSHDNAQLITGRSFQGTTIGLAPLMAM CSVYQSGGVSMDHSENAIGVASTVAHEIGHNFGMSHDSAHCCSTSAADGGCIMAAATGHPFPKV FSSCNRKELDRYLQSGGGMCLSNMPDTRTLYGGRRCGNGYLEDGEECDCGEEDECKNPCCNASN CTLKEGAECAHGSCCHQCKLVAPGTQCREQVRQCDLPEFCTGKSPHCPTNYYQMDGTPCEGGQA YCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCGKGLNGKYRKCSPRDAKCGKI QCQSTQARPLESNAVSIDTTITLNGRRIHCRGTHVYRGPEEEEGEGDMLDPGLVMTGTKCGHNH ICFEGQCRNTSFFETEGCGKKCNGHGVCNNNKNCHCFPGWAPPFCNTPGDGGSIDSGPLPPKSA GPVIAGVFSALFVLAVLVLLCHCYRQSHKLGKPSALPFKLRQQFSCPFRVSQNGGTGHANPTFK LQTPQGKRKVTNTPETLRKPSHPPPRPPPDYLRVESHPAPLPAHLNRAAGSSPEAGAQIERKES ARRPPPSRPMPPAPNCLLSQDFSRPRPPQKALPANPVPGQRTVPRPGGTSLFHPPTTGPQPPRP PAVSVPKLPEYRSQRIGGITSSKI hide sequence

Ensembl Acc Id:

ENSRNOP00000008184 ⟸ ENSRNOT00000008184

RefSeq Acc Id:	XP_038941844 ⟸ XM_039085916
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038941843 ⟸ XM_039085915
- Peptide Label:	isoform X1
- UniProtKB:	D3ZPM7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038941845 ⟸ XM_039085917
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000077829 ⟸ ENSRNOT00000108861

RefSeq Acc Id:	XP_063125041 ⟸ XM_063268971
- Peptide Label:	isoform X2

Protein Domains

Disintegrin EGF-like Peptidase M12B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZPM7-F1-model_v2	AlphaFold	D3ZPM7	1-920	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697123

Promoter ID:

EPDNEW_R7648

Type:

initiation region

Name:

Adam19_1

Description:

ADAM metallopeptidase domain 19

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	31,146,146 - 31,146,206	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1585017	AgrOrtholog
BioCyc Gene	G2FUF-25376	BioCyc
Ensembl Genes	ENSRNOG00000042980	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008184	ENTREZGENE
	ENSRNOT00000008184.8	UniProtKB/TrEMBL
	ENSRNOT00000108861.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.390.10	UniProtKB/TrEMBL
	4.10.70.10	UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/TrEMBL
InterPro	ADAM_Cys-rich	UniProtKB/TrEMBL
	Blood-coag_inhib_Disintegrin	UniProtKB/TrEMBL
	Disintegrin_CS	UniProtKB/TrEMBL
	Disintegrin_dom_sf	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	MetalloPept_cat_dom	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	Reprolysin_adamalysin	UniProtKB/TrEMBL
KEGG Report	rno:303068	UniProtKB/TrEMBL
NCBI Gene	Adam19	ENTREZGENE
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/TrEMBL
	PTHR11905:SF19	UniProtKB/TrEMBL
Pfam	ADAM_CR	UniProtKB/TrEMBL
	Disintegrin	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
PhenoGen	Adam19	PhenoGen
PRINTS	DISINTEGRIN	UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	DISINTEGRIN_1	UniProtKB/TrEMBL
	DISINTEGRIN_2	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000042980	RatGTEx
SMART	ACR	UniProtKB/TrEMBL
	DISIN	UniProtKB/TrEMBL
Superfamily-SCOP	Disintegrin	UniProtKB/TrEMBL
	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
UniProt	A0A8I5Y236	ENTREZGENE, UniProtKB/TrEMBL
	A6HDQ9	ENTREZGENE, UniProtKB/TrEMBL
	D3ZPM7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-01-06	Adam19	ADAM metallopeptidase domain 19	Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-02	Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	Sox30_predicted	SRY-box containing gene 30 (predicted)	Data merged from RGD:1305717	737654	APPROVED
2008-02-26	Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	Adam19	a disintegrin and metalloproteinase domain 19 (meltrin beta)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-10	Adam19	a disintegrin and metalloproteinase domain 19 (meltrin beta)	Adam19_mapped	a disintegrin and metalloproteinase domain 19 (meltrin beta) (mapped)	Data merged from RGD:620406	737654	APPROVED
2006-11-19	Adam19_mapped	a disintegrin and metalloproteinase domain 19 (meltrin beta)(mapped)	Adam19	a disintegrin and metalloproteinase domain 19 (meltrin beta)	Symbol set to symbol_mapped, name set to name (mapped)	1582166	APPROVED
2006-11-19	Adam19	a disintegrin and metalloproteinase domain 19 (meltrin beta)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Sox30_predicted	SRY-box containing gene 30 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2004-02-26	Adam19	a disintegrin and metalloproteinase domain 19 (meltrin beta)			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Adam19	a disintegrin and metalloproteinase domain 19 (meltrin beta)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_homology	highly homologous to mouse Adam19	632493

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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