Spaca5 (sperm acrosome associated 5) - Rat Genome Database

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Gene: Spaca5 (sperm acrosome associated 5) Rattus norvegicus
Analyze
Symbol: Spaca5
Name: sperm acrosome associated 5
RGD ID: 1584964
Description: Predicted to enable lysozyme activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be active in acrosomal vesicle and sperm flagellum. Orthologous to several human genes including SPACA5 (sperm acrosome associated 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314431; similar to PNPK6288; sperm acrosome-associated protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,472,369 - 3,475,552 (-)NCBIGRCr8
mRatBN7.2X918,817 - 922,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX918,817 - 922,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX946,948 - 950,132 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,422,640 - 4,425,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X743,174 - 746,359 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X912,770 - 915,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX912,770 - 915,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X907,618 - 910,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX1,488,462 - 1,491,645 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Spaca5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,472,369 - 3,475,552 (-)NCBIGRCr8
mRatBN7.2X918,817 - 922,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX918,817 - 922,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX946,948 - 950,132 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,422,640 - 4,425,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X743,174 - 746,359 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X912,770 - 915,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX912,770 - 915,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X907,618 - 910,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX1,488,462 - 1,491,645 (-)NCBICelera
Cytogenetic MapXq11NCBI
SPACA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,004,336 - 48,009,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,004,336 - 48,009,733 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,863,734 - 47,869,130 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,748,678 - 47,754,074 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX52,182,559 - 52,187,955 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX45,698,884 - 45,704,280 (+)NCBIHuRef
CHM1_1X47,894,879 - 47,900,324 (+)NCBICHM1_1
T2T-CHM13v2.0X47,414,513 - 47,419,909 (+)NCBIT2T-CHM13v2.0
Spaca5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,934,669 - 20,944,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,934,645 - 20,944,202 (+)EnsemblGRCm39 Ensembl
GRCm38X21,068,430 - 21,077,958 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX21,068,406 - 21,077,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,645,532 - 20,655,089 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,225,447 - 20,234,847 (+)NCBIMGSCv36mm8
CeleraX19,202,482 - 19,211,886 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.59NCBI
Spaca5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955516103,674 - 106,082 (-)NCBIChiLan1.0ChiLan1.0
SPACA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,628,747 - 49,631,850 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,632,342 - 49,635,222 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,435,554 - 40,441,190 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,328,726 - 48,334,106 (+)NCBIpanpan1.1PanPan1.1panPan2
ZNF81
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,590,329 - 41,612,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,353,440 - 41,593,082 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,968,120 - 15,989,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,727,776 - 41,749,559 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,727,802 - 41,731,591 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,715,021 - 41,736,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,703,102 - 41,724,897 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,796,676 - 41,818,457 (+)NCBIUU_Cfam_GSD_1.0
SPACA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,476,587 - 42,478,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,476,719 - 42,478,783 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,046,163 - 47,048,227 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231905
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,170,226 - 45,175,615 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607610,436,318 - 10,441,371 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Spaca5
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:7
Interacting mature miRNAs:7
Transcripts:ENSRNOT00000075264
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 10 2
Low 1 8 20 11 18 11 8 8 11 10 3 9 8
Below cutoff 2 3 2 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075264   ⟹   ENSRNOP00000067235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX918,817 - 922,049 (-)Ensembl
Rnor_6.0 EnsemblX912,770 - 915,953 (-)Ensembl
RefSeq Acc Id: NM_001108058   ⟹   NP_001101528
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,472,369 - 3,475,552 (-)NCBI
mRatBN7.2X918,817 - 922,000 (-)NCBI
Rnor_6.0X912,770 - 915,953 (-)NCBI
Rnor_5.0X907,618 - 910,801 (-)NCBI
CeleraX1,488,462 - 1,491,645 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101528 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97736 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067235
  ENSRNOP00000067235.1
Reference Protein Sequences
RefSeq Acc Id: NP_001101528   ⟸   NM_001108058
- Peptide Label: precursor
- UniProtKB: M0RCC1 (UniProtKB/TrEMBL),   A6JZP9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067235   ⟸   ENSRNOT00000075264

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCC1-F1-model_v2 AlphaFold M0RCC1 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584964 AgrOrtholog
BioCyc Gene G2FUF-3207 BioCyc
Ensembl Genes ENSRNOG00000045622 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075264 ENTREZGENE
  ENSRNOT00000075264.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.530.10 UniProtKB/TrEMBL
InterPro Glyco_hydro_22 UniProtKB/TrEMBL
  Glyco_hydro_22_lys UniProtKB/TrEMBL
  Lysozyme-like_dom UniProtKB/TrEMBL
KEGG Report rno:314431 UniProtKB/TrEMBL
NCBI Gene 314431 ENTREZGENE
PANTHER PTHR11407 UniProtKB/TrEMBL
  PTHR11407:SF31 UniProtKB/TrEMBL
Pfam Lys UniProtKB/TrEMBL
PhenoGen Spaca5 PhenoGen
PRINTS LYSOZYME UniProtKB/TrEMBL
  LYZLACT UniProtKB/TrEMBL
PROSITE LACTALBUMIN_LYSOZYME_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045622 RatGTEx
SMART LYZ1 UniProtKB/TrEMBL
Superfamily-SCOP SSF53955 UniProtKB/TrEMBL
UniProt A6JZP9 ENTREZGENE, UniProtKB/TrEMBL
  M0RCC1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Spaca5  sperm acrosome associated 5  LOC314431  similar to PNPK6288  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC314431  similar to PNPK6288      Symbol and Name status set to provisional 70820 PROVISIONAL