Eya1 (EYA transcriptional coactivator and phosphatase 1) - Rat Genome Database

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Gene: Eya1 (EYA transcriptional coactivator and phosphatase 1) Rattus norvegicus
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Symbol: Eya1
Name: EYA transcriptional coactivator and phosphatase 1
RGD ID: 1584849
Description: Predicted to enable RNA binding activity; histone H2AXY142 phosphatase activity; and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of nucleobase-containing compound metabolic process; and protein sumoylation. Predicted to act upstream of or within several processes, including embryonic organ morphogenesis; kidney development; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH acrylamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eyes absent 1; eyes absent 1 homolog; eyes absent 1 homolog (Drosophila); eyes absent homolog 1; eyes absent homolog 1 (Drosophila); LOC108350919; LOC502935; similar to eyes absent 1 isoform a; uncharacterized LOC108350919
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr859,646,599 - 9,884,609 (+)NCBIGRCr8
mRatBN7.254,863,501 - 5,101,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl54,955,543 - 5,101,483 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.054,275,728 - 4,495,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl54,373,626 - 4,513,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.054,252,745 - 4,487,853 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.454,132,825 - 4,276,837 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera54,454,356 - 4,554,997 (+)NCBICelera
Celera54,581,829 - 4,692,568 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Eya1Ratbranchiootorenal syndrome  ISOEYA1 (Homo sapiens)8554880DNA:deletion more ...RGD 
Eya1Ratbranchiootorenal syndrome  ISOEYA1 (Homo sapiens)1598917 RGD 
Eya1Ratbranchiootorenal syndrome  ISOEYA1 (Homo sapiens)8554897DNA:mutations:exons and introns:multipleRGD 
Eya1RatCardiovascular Abnormalities  ISOEya1 (Mus musculus)11561941 RGD 
Eya1RatLung Agenesis  IEP 8554873mRNA and protein:decreased expression:lung epithelium:RGD 
Eya1Ratmitochondrial myopathy  ISOEYA1 (Homo sapiens)8694159mRNA:increased expression:muscle:RGD 
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Original Reference(s)
Eya1Ratanterior segment dysgenesis  ISOEYA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655545
Eya1Ratbranchiooculofacial syndrome  ISOEYA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10464653 more ...
Eya1Ratbranchiootic syndrome  ISOEYA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10464653 more ...
Eya1RatBranchiootic Syndrome 1  ISOEYA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10464653 more ...
Eya1Ratbranchiootorenal syndrome  ISOEYA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10429368 more ...
Eya1Ratbranchiootorenal syndrome 1  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Branchiootorenal syndrome 1ClinVarPMID:10464653 more ...
Eya1Ratcataract  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital cataractClinVarPMID:15146463 more ...
Eya1Ratfocal segmental glomerulosclerosis  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Glomerulosclerosis and focalClinVarPMID:10991693 more ...
Eya1Ratfocal segmental glomerulosclerosis 1  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Focal sclerosis with hyalinosisClinVarPMID:10991693 more ...
Eya1Ratgenetic disease  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10464653 more ...
Eya1RatHearing Loss  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hearing impairmentClinVarPMID:23552953 more ...
Eya1RatOtofaciocervical Syndrome 1  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Otofaciocervical syndrome 1ClinVarPMID:10464653 more ...
Eya1Ratprostate cancer  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
Eya1Ratrenal agenesis  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bilateral renal agenesisClinVarPMID:25741868 and PMID:35005812
Eya1Ratrenal hypoplasia  ISOEYA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Renal hypoplasiaClinVarPMID:28492532
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Original Reference(s)
Eya1Ratbranchiootic syndrome  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Eya1Ratbranchiootorenal syndrome  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12834866
Eya1RatCayler Cardiofacial Syndrome  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15493068
Eya1RatConductive Hearing Loss  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10471511
Eya1RatCongenital Abnormalities  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10471511
Eya1Ratcongenital heart disease  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15493068
Eya1RatCraniofacial Abnormalities  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10471511
Eya1RatOtofaciocervical Syndrome 1  ISOEYA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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Original Reference(s)
Eya1Ratbranchiootorenal syndrome  ISSEya1 (Mus musculus)13592920 MouseDO 
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Original Reference(s)
Eya1RatBranchiootic Syndrome 1  ISOEYA1 (Homo sapiens)7240710 OMIM 
Eya1Ratbranchiootorenal syndrome 1  ISOEYA1 (Homo sapiens)7240710 OMIM 
Eya1RatOtofaciocervical Syndrome 1  ISOEYA1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Eya1Rat17beta-estradiol multiple interactionsISOEYA1 (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of EYA1 mRNACTDPMID:20823114
Eya1Rat3,4-methylenedioxymethamphetamine increases expressionISOEya1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of EYA1 mRNACTDPMID:20188158
Eya1Rat4,4'-sulfonyldiphenol increases expressionISOEya1 (Mus musculus)6480464bisphenol S results in increased expression of EYA1 mRNACTDPMID:30951980
Eya1Rat4-hydroperoxycyclophosphamide decreases expressionISOEya1 (Mus musculus)6480464perfosfamide results in decreased expression of EYA1 mRNACTDPMID:19429390
Eya1Rat5-azacytidine decreases expressionISOEYA1 (Homo sapiens)6480464Azacitidine results in decreased expression of EYA1 mRNACTDPMID:20823114
Eya1Ratabacavir decreases expressionISOEYA1 (Homo sapiens)6480464abacavir results in decreased expression of EYA1 mRNACTDPMID:31711903
Eya1Ratacrolein multiple interactionsISOEYA1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] affects the expression of EYA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which affects the expression of EYA1 mRNACTDPMID:32699268
Eya1Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of EYA1 mRNACTDPMID:28959563
Eya1Rataflatoxin B1 decreases methylationISOEYA1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of EYA1 geneCTDPMID:27153756
Eya1Rataflatoxin B1 increases methylationISOEYA1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of EYA1 intronCTDPMID:30157460
Eya1RatAflatoxin B2 alpha decreases methylationISOEYA1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of EYA1 intronCTDPMID:30157460
Eya1Ratall-trans-retinoic acid increases expressionISOEYA1 (Homo sapiens)6480464Tretinoin results in increased expression of EYA1 mRNACTDPMID:21934132
Eya1Ratall-trans-retinoic acid multiple interactionsISOEYA1 (Homo sapiens)6480464Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA1 mRNA]CTDPMID:31711903
Eya1Ratall-trans-retinoic acid decreases expressionISOEYA1 (Homo sapiens)6480464Tretinoin results in decreased expression of EYA1 mRNACTDPMID:23724009 and PMID:31711903
Eya1Ratalpha-pinene multiple interactionsISOEYA1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] affects the expression of EYA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which affects the expression of EYA1 mRNACTDPMID:32699268
Eya1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of EYA1 mRNACTDPMID:35163327
Eya1Ratalpha-Zearalanol decreases expressionEXP 6480464Zeranol results in decreased expression of EYA1 mRNACTDPMID:35163327
Eya1Ratarsenite(3-) multiple interactionsISOEYA1 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to EYA1 mRNA]CTDPMID:32406909
Eya1Ratbenzo[a]pyrene increases methylationISOEYA1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of EYA1 3' UTR and Benzo(a)pyrene results in increased methylation of EYA1 promoterCTDPMID:27901495
Eya1Ratbenzo[a]pyrene decreases methylationISOEYA1 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of EYA1 5' UTRCTDPMID:27901495

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Biological Process
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Original Reference(s)
Eya1Ratanimal organ morphogenesis acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:2150426 PMID:12070080RGDPMID:12070080
Eya1Rataorta morphogenesis acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:102780 more ...RGDPMID:21364285
Eya1Ratbiological_process  ND 159840712/2006: no relevant rat dataRGD 
Eya1Ratbranching involved in ureteric bud morphogenesis acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:102780 PMID:12783782RGDPMID:12783782
Eya1Ratcell differentiation involved_inIBAFB:FBgn0000320 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Eya1Ratcell fate commitment acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:1857803 more ...RGDPMID:15817220 and PMID:16018995
Eya1Ratchromatin remodeling involved_inIEAGO:01407931600115GO_REF:0000108GOCGO_REF:0000108
Eya1Ratcochlea morphogenesis acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:1857803 PMID:10072433RGDPMID:10072433
Eya1RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Eya1RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Eya1Ratdouble-strand break repair involved_inISOEYA1 (Homo sapiens)1624291 PMID:19234442RGDPMID:19234442
Eya1Ratembryonic skeletal system morphogenesis acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:2150426 PMID:10471511RGDPMID:10471511
Eya1Ratepithelial cell proliferation acts_upstream_ofISOEya1 (Mus musculus)1624291MGI:2150426 PMID:16916509RGDPMID:16916509
Eya1Ratextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_ofISOEya1 (Mus musculus)1624291MGI:1857803 PMID:15817220RGDPMID:15817220
Eya1Ratinner ear morphogenesis acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:1857803 more ...RGDPMID:10471511 more ...
Eya1Ratmesodermal cell fate specification involved_inISOEya1 (Mus musculus)1624291 PMID:17785448RGDPMID:17785448
Eya1Ratmetanephros development acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:1857803 more ...RGDPMID:10072433 and PMID:16018995
Eya1Ratmiddle ear morphogenesis acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:2150426 PMID:10471511RGDPMID:10471511
Eya1Ratnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand involved_inIBAMGI:109344 and PANTHER:PTN0000226411600115GO_REF:0000033GO_CentralGO_REF:0000033
Eya1Ratnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinISOEya1 (Mus musculus)1624291MGI:1857803 PMID:15817220RGDPMID:15817220
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Cellular Component
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Molecular Function
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RGD Manual Annotations


  
Object Symbol
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Reference
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Source
Original Reference(s)
Eya1Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISOEYA1 (Homo sapiens)8661242 RGD 

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Reference Title
Reference Citation
1. Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1. Abdelhak S, etal., Hum Mol Genet. 1997 Dec;6(13):2247-55.
2. Expression of Eya1 and Six1 is decreased in distal airways of rats with experimental pulmonary hypoplasia. Friedmacher F, etal., J Pediatr Surg. 2014 Feb;49(2):301-4. doi: 10.1016/j.jpedsurg.2013.11.043. Epub 2013 Nov 18.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. Guo C, etal., J Clin Invest. 2011 Apr;121(4):1585-95. doi: 10.1172/JCI44630.
5. EYA1 and SIX1 gene mutations in Japanese patients with branchio-oto-renal (BOR) syndrome and related conditions. Okada M, etal., Pediatr Nephrol. 2006 Apr;21(4):475-81. Epub 2006 Feb 21.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses. Sanggaard KM, etal., Eur J Hum Genet. 2007 Nov;15(11):1121-31. Epub 2007 Jul 18.
13. Muscle-fiber transdifferentiation in an experimental model of respiratory chain myopathy. Venhoff N, etal., Arthritis Res Ther. 2012 Oct 29;14(5):R233.
1 to 13 of 13 rows
PMID:10072433   PMID:10471511   PMID:12070080   PMID:12783782   PMID:14628052   PMID:15496442   PMID:15817220   PMID:16018995   PMID:16024294   PMID:16530750   PMID:16916509   PMID:16990542  
PMID:17098221   PMID:17785448   PMID:19234442   PMID:19497856   PMID:21936910   PMID:22513373  



Eya1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr859,646,599 - 9,884,609 (+)NCBIGRCr8
mRatBN7.254,863,501 - 5,101,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl54,955,543 - 5,101,483 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.054,275,728 - 4,495,525 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl54,373,626 - 4,513,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.054,252,745 - 4,487,853 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.454,132,825 - 4,276,837 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera54,454,356 - 4,554,997 (+)NCBICelera
Celera54,581,829 - 4,692,568 (+)NCBICelera
Cytogenetic Map5q11NCBI
EYA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38871,197,433 - 71,548,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl871,197,433 - 71,592,025 (-)EnsemblGRCh38hg38GRCh38
GRCh37872,109,668 - 72,460,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36872,272,222 - 72,437,021 (-)NCBINCBI36Build 36hg18NCBI36
Build 34872,272,221 - 72,437,021NCBI
Celera868,106,627 - 68,271,433 (-)NCBICelera
Cytogenetic Map8q13.3NCBI
HuRef867,603,371 - 67,768,504 (-)NCBIHuRef
CHM1_1872,164,260 - 72,329,031 (-)NCBICHM1_1
T2T-CHM13v2.0871,626,530 - 71,983,583 (-)NCBIT2T-CHM13v2.0
Eya1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,239,177 - 14,381,259 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,239,178 - 14,380,459 (-)EnsemblGRCm39 Ensembl
GRCm38114,168,953 - 14,311,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,168,954 - 14,310,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,159,039 - 14,300,280 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,154,172 - 14,295,413 (-)NCBIMGSCv36mm8
Celera114,109,695 - 14,251,151 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map14.31NCBI
Eya1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554448,495,530 - 8,655,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554448,336,071 - 8,655,041 (+)NCBIChiLan1.0ChiLan1.0
EYA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2786,938,623 - 87,280,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1862,568,011 - 62,730,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0867,728,057 - 68,060,069 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1869,387,769 - 69,551,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl869,387,769 - 69,551,829 (-)Ensemblpanpan1.1panPan2
EYA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12920,176,306 - 20,595,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2920,177,014 - 20,525,653 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2920,436,698 - 20,855,121 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02920,275,380 - 20,693,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2920,274,650 - 20,771,147 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12920,325,900 - 20,743,158 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02920,378,421 - 20,796,035 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02920,660,077 - 21,078,705 (-)NCBIUU_Cfam_GSD_1.0
Eya1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530358,739,647 - 59,053,061 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936648395,524 - 546,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936648395,526 - 546,705 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EYA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl463,970,807 - 64,328,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1463,970,939 - 64,328,107 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2469,915,648 - 69,943,761 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EYA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1866,902,961 - 67,238,149 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl866,902,972 - 67,060,567 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603974,161,305 - 74,511,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eya1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474419,782,790 - 19,977,335 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474419,782,174 - 19,975,496 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Eya1
2020 total Variants

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:50
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000064946
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)519895442Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)5706553510687501Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat

RH131160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,101,167 - 5,101,387 (+)MAPPERmRatBN7.2
Rnor_6.054,514,798 - 4,515,017NCBIRnor6.0
Rnor_5.054,487,538 - 4,487,757UniSTSRnor5.0
RGSC_v3.454,278,492 - 4,278,711UniSTSRGSC3.4
Celera54,692,253 - 4,692,472UniSTS
Cytogenetic Map5q11UniSTS
BE118841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,087,195 - 5,087,397 (+)MAPPERmRatBN7.2
Rnor_6.054,501,555 - 4,501,756NCBIRnor6.0
Rnor_5.054,474,004 - 4,474,205UniSTSRnor5.0
RGSC_v3.454,261,648 - 4,261,849UniSTSRGSC3.4
Celera54,677,816 - 4,678,017UniSTS
RH 3.4 Map50.0UniSTS
Cytogenetic Map5q11UniSTS
Eya1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,013,761 - 5,014,209 (+)MAPPERmRatBN7.2
Rnor_6.054,424,872 - 4,425,319NCBIRnor6.0
Rnor_5.054,401,233 - 4,401,680UniSTSRnor5.0
Celera54,604,211 - 4,604,658UniSTS
Cytogenetic Map5q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 49 113 62 61 30 25 30 6 187 97 93 45 60 31


1 to 29 of 29 rows
RefSeq Transcripts NM_001427021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001843561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001843562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010066461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 29 of 29 rows

Ensembl Acc Id: ENSRNOT00000064946   ⟹   ENSRNOP00000063439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl54,955,543 - 5,101,483 (+)Ensembl
Rnor_6.0 Ensembl54,373,626 - 4,513,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082717   ⟹   ENSRNOP00000070005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl54,961,075 - 5,101,483 (+)Ensembl
Rnor_6.0 Ensembl54,393,472 - 4,513,142 (+)Ensembl
RefSeq Acc Id: NM_001427021   ⟹   NP_001413950
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,515 - 9,884,609 (+)NCBI
RefSeq Acc Id: XM_039110905   ⟹   XP_038966833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,501 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110906   ⟹   XP_038966834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,506 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110907   ⟹   XP_038966835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,599 - 9,884,609 (+)NCBI
mRatBN7.254,863,501 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110908   ⟹   XP_038966836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,505 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110909   ⟹   XP_038966837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
mRatBN7.254,863,504 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110911   ⟹   XP_038966839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,780 - 9,884,609 (+)NCBI
mRatBN7.254,955,650 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110912   ⟹   XP_038966840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,743,980 - 9,884,609 (+)NCBI
mRatBN7.254,960,842 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110913   ⟹   XP_038966841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,737,254 - 9,884,609 (+)NCBI
mRatBN7.254,955,487 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110914   ⟹   XP_038966842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,766,336 - 9,884,609 (+)NCBI
mRatBN7.254,983,203 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_039110916   ⟹   XP_038966844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,766,336 - 9,884,609 (+)NCBI
mRatBN7.254,983,203 - 5,101,483 (+)NCBI
RefSeq Acc Id: XM_063288306   ⟹   XP_063144376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,744,094 - 9,884,609 (+)NCBI
RefSeq Acc Id: XM_063288307   ⟹   XP_063144377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,744,110 - 9,884,609 (+)NCBI
RefSeq Acc Id: XM_063288308   ⟹   XP_063144378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,780 - 9,870,577 (+)NCBI
RefSeq Acc Id: XM_063288309   ⟹   XP_063144379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,738,780 - 9,884,609 (+)NCBI
RefSeq Acc Id: XR_010066461
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr859,646,619 - 9,884,609 (+)NCBI
1 to 5 of 17 rows
1 to 5 of 17 rows
Ensembl Acc Id: ENSRNOP00000070005   ⟸   ENSRNOT00000082717
Ensembl Acc Id: ENSRNOP00000063439   ⟸   ENSRNOT00000064946
RefSeq Acc Id: XP_038966833   ⟸   XM_039110905
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966835   ⟸   XM_039110907
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966837   ⟸   XM_039110909
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JWT3 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVI5-F1-model_v2 AlphaFold D3ZVI5 1-592 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42274 BioCyc
Ensembl Genes ENSRNOG00000007590 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064946 ENTREZGENE
  ENSRNOT00000064946.4 UniProtKB/TrEMBL
  ENSRNOT00000082717 ENTREZGENE
  ENSRNOT00000082717.2 UniProtKB/TrEMBL
  ENSRNOT00000120692 ENTREZGENE
  ENSRNOT00000120693 ENTREZGENE
  ENSRNOT00000120694 ENTREZGENE
  ENSRNOT00000120695 ENTREZGENE
Gene3D-CATH 3.40.50.12350 UniProtKB/TrEMBL
InterPro EYA_dom UniProtKB/TrEMBL
  EYA_dom_metazoan UniProtKB/TrEMBL
  EYA_dom_sf UniProtKB/TrEMBL
  EYA_fam UniProtKB/TrEMBL
NCBI Gene 502935 ENTREZGENE
PANTHER PTHR10190 UniProtKB/TrEMBL
  PTHR10190:SF11 UniProtKB/TrEMBL
Pfam Hydrolase UniProtKB/TrEMBL
PhenoGen Eya1 PhenoGen
RatGTEx ENSRNOG00000007590 RatGTEx
UniProt A0A0G2JWT3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVI5 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Eya1  EYA transcriptional coactivator and phosphatase 1  LOC108350919  uncharacterized LOC108350919  Data merged from RGD:11376464 737654 PROVISIONAL
2016-08-02 LOC108350919  uncharacterized LOC108350919      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-06-25 Eya1  EYA transcriptional coactivator and phosphatase 1  Eya1  eyes absent homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-29 Eya1  eyes absent homolog 1 (Drosophila)  Eya1  eyes absent 1 homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Eya1  eyes absent 1 homolog (Drosophila)  LOC502935  similar to eyes absent 1 isoform a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC502935  similar to eyes absent 1 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL