Erfe (erythroferrone) - Rat Genome Database

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Gene: Erfe (erythroferrone) Rattus norvegicus
Analyze
Symbol: Erfe
Name: erythroferrone
RGD ID: 1584688
Description: Predicted to enable hormone activity and identical protein binding activity. Involved in negative regulation of apoptotic process and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human ERFE (erythroferrone); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement C1q tumor necrosis factor-related protein 15; Fam132b; family with sequence similarity 132, member B; hypothetical protein LOC681056; LOC681056; myonectin; rCG55642-like; uncharacterized protein LOC681056
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,404,512 - 99,412,383 (+)NCBIGRCr8
mRatBN7.2991,956,971 - 91,964,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,956,977 - 91,964,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,383,741 - 100,391,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,519,499 - 105,527,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,883,090 - 103,890,962 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,505,136 - 98,513,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,505,259 - 98,511,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,181,281 - 98,189,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,593,588 - 90,599,489 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera989,497,999 - 89,505,868 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (ISO,ISS)
extracellular space  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury. Otaka N, etal., Circ Res. 2018 Dec 7;123(12):1326-1338. doi: 10.1161/CIRCRESAHA.118.313777.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22351773   PMID:24880340   PMID:28282554  


Genomics

Comparative Map Data
Erfe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,404,512 - 99,412,383 (+)NCBIGRCr8
mRatBN7.2991,956,971 - 91,964,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,956,977 - 91,964,846 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,383,741 - 100,391,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,519,499 - 105,527,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,883,090 - 103,890,962 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,505,136 - 98,513,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,505,259 - 98,511,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,181,281 - 98,189,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,593,588 - 90,599,489 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera989,497,999 - 89,505,868 (+)NCBICelera
Cytogenetic Map9q36NCBI
ERFE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,158,970 - 238,168,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,158,970 - 238,168,900 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,067,611 - 239,077,531 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,734,413 - 238,740,434 (+)NCBINCBI36Build 36hg18NCBI36
Celera2232,785,225 - 232,790,057 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,862,858 - 230,868,712 (+)NCBIHuRef
CHM1_12239,072,755 - 239,082,636 (+)NCBICHM1_1
T2T-CHM13v2.02238,648,711 - 238,658,631 (+)NCBIT2T-CHM13v2.0
Erfe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,293,033 - 91,301,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,294,152 - 91,301,939 (+)EnsemblGRCm39 Ensembl
GRCm38191,366,305 - 91,374,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,366,430 - 91,374,217 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,263,007 - 93,270,794 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,196,866 - 93,204,619 (+)NCBIMGSCv36mm8
Celera194,303,580 - 94,311,360 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.1NCBI
Erfe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,409,988 - 2,415,522 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555422,408,504 - 2,415,522 (-)NCBIChiLan1.0ChiLan1.0
ERFE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,789,655 - 140,801,423 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,804,893 - 140,816,390 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,390,190 - 125,401,677 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,239,611 - 244,252,426 (+)NCBIpanpan1.1PanPan1.1panPan2
ERFE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,656,576 - 48,665,620 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,152,543 - 49,161,544 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,042,670 - 49,051,697 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,044,193 - 49,049,952 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,917,878 - 48,926,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,706,502 - 48,715,494 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,938,500 - 48,947,540 (+)NCBIUU_Cfam_GSD_1.0
Erfe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,609,629 - 190,614,861 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525323,090 - 329,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936525324,814 - 330,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERFE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,728,478 - 137,738,676 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,728,507 - 137,738,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,139,615 - 152,146,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERFE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,180,014 - 124,190,445 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,180,126 - 124,188,669 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,226,385 - 75,236,886 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erfe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248473,313,214 - 3,319,050 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Erfe
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:66
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000051810
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 44 105 76 75 44 25 44 6 196 92 85 45 56 31

Sequence


Ensembl Acc Id: ENSRNOT00000051810   ⟹   ENSRNOP00000045074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,956,977 - 91,964,846 (+)Ensembl
Rnor_6.0 Ensembl998,505,259 - 98,511,160 (+)Ensembl
RefSeq Acc Id: NM_001377080   ⟹   NP_001364009
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,404,514 - 99,412,383 (+)NCBI
mRatBN7.2991,956,977 - 91,964,846 (+)NCBI
RefSeq Acc Id: XM_063267726   ⟹   XP_063123796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,404,512 - 99,408,774 (+)NCBI
RefSeq Acc Id: XR_005488963
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,404,513 - 99,410,502 (+)NCBI
mRatBN7.2991,956,971 - 91,962,966 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001364009 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123796 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AB34 (Get FASTA)   NCBI Sequence Viewer  
  EDL92028 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045074.2
Ensembl Acc Id: ENSRNOP00000045074   ⟸   ENSRNOT00000051810
RefSeq Acc Id: NP_001364009   ⟸   NM_001377080
- Peptide Label: precursor
- UniProtKB: D4AB34 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123796   ⟸   XM_063267726
- Peptide Label: isoform X1
Protein Domains
C1q

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AB34-F1-model_v2 AlphaFold D4AB34 1-341 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696874
Promoter ID:EPDNEW_R7383
Type:initiation region
Name:Erfe_1
Description:erythroferrone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,505,238 - 98,505,298EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584688 AgrOrtholog
BioCyc Gene G2FUF-26718 BioCyc
Ensembl Genes ENSRNOG00000024688 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051810.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot
InterPro Adipolin/Erythroferrone-rel UniProtKB/Swiss-Prot
  C1q_dom UniProtKB/Swiss-Prot
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot
NCBI Gene 681056 ENTREZGENE
PANTHER ADIPOLIN UniProtKB/Swiss-Prot
  ERYTHROFERRONE UniProtKB/Swiss-Prot
PhenoGen Erfe PhenoGen
PROSITE C1Q UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024688 RatGTEx
  ENSRNOG00055009467 RatGTEx
  ENSRNOG00060008604 RatGTEx
  ENSRNOG00065021144 RatGTEx
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot
UniProt D4AB34 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Erfe  erythroferrone  Fam132b  family with sequence similarity 132, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Fam132b  family with sequence similarity 132, member B  LOC100364890  rCG55642-like  Data merged from RGD:2320175 1643240 APPROVED
2010-05-05 LOC100364890  rCG55642-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Fam132b  family with sequence similarity 132, member B  LOC681056  hypothetical protein LOC681056  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681056  hypothetical protein LOC681056      Symbol and Name status set to provisional 70820 PROVISIONAL