Nalf2 (NALCN channel auxiliary factor 2) - Rat Genome Database

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Gene: Nalf2 (NALCN channel auxiliary factor 2) Rattus norvegicus
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Symbol: Nalf2
Name: NALCN channel auxiliary factor 2
RGD ID: 1584125
Description: Predicted to contribute to stretch-activated, monoatomic cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human NALF2 (NALCN channel auxiliary factor 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam155b; family with sequence similarity 155, member B; LOC688841; similar to transmembrane protein 28; Tmem28l; transmembrane protein 28-like; transmembrane protein FAM155B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X68,965,327 - 68,991,201 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX68,965,327 - 68,991,201 (+)EnsemblGRCr8
mRatBN7.2X64,925,100 - 64,951,074 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX64,925,051 - 64,951,077 (+)EnsemblmRatBN7.2
Rnor_6.0X69,579,968 - 69,605,032 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX69,580,015 - 69,605,032 (+)Ensemblrn6Rnor6.0
Rnor_5.0X70,452,229 - 70,477,252 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X87,823,433 - 87,845,963 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX65,289,397 - 65,314,753 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Nalf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X68,965,327 - 68,991,201 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX68,965,327 - 68,991,201 (+)EnsemblGRCr8
mRatBN7.2X64,925,100 - 64,951,074 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX64,925,051 - 64,951,077 (+)EnsemblmRatBN7.2
Rnor_6.0X69,579,968 - 69,605,032 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX69,580,015 - 69,605,032 (+)Ensemblrn6Rnor6.0
Rnor_5.0X70,452,229 - 70,477,252 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X87,823,433 - 87,845,963 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX65,289,397 - 65,314,753 (+)NCBICelera
Cytogenetic MapXq22NCBI
NALF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X69,504,326 - 69,532,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX69,504,326 - 69,532,508 (+)Ensemblhg38GRCh38
GRCh37X68,724,169 - 68,752,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X68,641,803 - 68,669,076 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X68,508,098 - 68,535,370NCBI
CeleraX69,078,407 - 69,105,680 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX62,546,646 - 62,572,751 (+)NCBIHuRef
CHM1_1X68,618,438 - 68,645,717 (+)NCBICHM1_1
T2T-CHM13v2.0X67,937,741 - 67,965,930 (+)NCBIT2T-CHM13v2.0
Nalf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X98,863,770 - 98,892,395 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX98,864,627 - 98,892,396 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X99,820,164 - 99,848,789 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX99,821,021 - 99,848,790 (+)Ensemblmm10GRCm38
MGSCv37X97,016,408 - 97,041,684 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X96,023,788 - 96,049,064 (+)NCBIMGSCv36mm8
MGSCv36X82,660,766 - 82,686,328 (+)NCBIMGSCv36mm8
CeleraX86,754,906 - 86,780,428 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.59NCBI
Nalf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,025,628 - 9,052,438 (+)Ensembl
ChiLan1.0NW_0049554759,024,816 - 9,052,394 (+)NCBIChiLan1.0ChiLan1.0
NALF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X69,179,357 - 69,207,541 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X69,182,960 - 69,211,144 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X58,770,612 - 58,798,803 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NALF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X53,969,675 - 53,998,274 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX53,969,665 - 53,997,140 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX44,795,303 - 44,823,793 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X54,935,550 - 54,964,053 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX54,935,676 - 54,962,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X52,903,387 - 52,931,870 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X54,232,158 - 54,260,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,156,091 - 54,184,582 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nalf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X48,090,547 - 48,134,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367771,116,759 - 1,143,766 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367771,100,109 - 1,143,753 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NALF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX55,631,037 - 55,658,303 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X55,631,149 - 55,658,309 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X62,829,412 - 62,856,570 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NALF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X59,343,731 - 59,370,975 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX59,343,823 - 59,368,426 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660651,198,929 - 1,227,061 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nalf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624891649,561 - 676,976 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624891649,825 - 677,539 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nalf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X58,450,839 - 58,474,547 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nalf2
87 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:78
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000057920
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 6 39 152 42 41 14 23 14 6 193 87 3 134 72 92 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000057920   ⟹   ENSRNOP00000054729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX68,965,327 - 68,991,201 (+)Ensembl
mRatBN7.2 EnsemblX64,925,051 - 64,951,077 (+)Ensembl
Rnor_6.0 EnsemblX69,580,015 - 69,605,032 (+)Ensembl
RefSeq Acc Id: NM_001427609   ⟹   NP_001414538
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,965,327 - 68,991,201 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414538 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054729
  ENSRNOP00000054729.2
Ensembl Acc Id: ENSRNOP00000054729   ⟸   ENSRNOT00000057920
RefSeq Acc Id: NP_001414538   ⟸   NM_001427609
- UniProtKB: D4A4E6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4E6-F1-model_v2 AlphaFold D4A4E6 1-471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701865
Promoter ID:EPDNEW_R12385
Type:single initiation site
Name:Fam155b_1
Description:family with sequence similarity 155, member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X69,580,107 - 69,580,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584125 AgrOrtholog
BioCyc Gene G2FUF-2143 BioCyc
Ensembl Genes ENSRNOG00000038066 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057920 ENTREZGENE
  ENSRNOT00000057920.5 UniProtKB/TrEMBL
InterPro NALCN_aux_factor_1/2 UniProtKB/TrEMBL
NCBI Gene 688841 ENTREZGENE
PANTHER PTHR15819:SF8 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN FAM155 UniProtKB/TrEMBL
PhenoGen Nalf2 PhenoGen
RatGTEx ENSRNOG00000038066 RatGTEx
UniProt D4A4E6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-04-29 Nalf2  NALCN channel auxiliary factor 2  Fam155b  family with sequence similarity 155, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Fam155b  family with sequence similarity 155, member B  Tmem28l  transmembrane protein 28-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Tmem28l  transmembrane protein 28-like  LOC688841  similar to transmembrane protein 28  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC688841  similar to transmembrane protein 28  LOC684154  similar to transmembrane protein 28  Data merged from RGD:1593901 1643240 APPROVED
2006-11-20 LOC684154  similar to transmembrane protein 28      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC688841  similar to transmembrane protein 28      Symbol and Name status set to provisional 70820 PROVISIONAL