Slc2a7 (solute carrier family 2 member 7) - Rat Genome Database

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Gene: Slc2a7 (solute carrier family 2 member 7) Rattus norvegicus
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Symbol: Slc2a7
Name: solute carrier family 2 member 7
RGD ID: 1583902
Description: Predicted to enable D-glucose transmembrane transporter activity and fructose transmembrane transporter activity. Predicted to be involved in D-glucose import; dehydroascorbic acid transport; and fructose transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC2A7 (solute carrier family 2 member 7); INTERACTS WITH acrylamide; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glucose transporter type 7; GLUT-7; LOC100362644; LOC691471; similar to intestinal facilitative glucose transporter 7; solute carrier family 2 (facilitated glucose transporter), member 7; solute carrier family 2, facilitated glucose transporter member 7
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,907,721 - 165,927,277 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5165,907,721 - 165,926,891 (+)EnsemblGRCr8
mRatBN7.25160,624,793 - 160,643,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,624,793 - 160,643,514 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5163,341,254 - 163,360,451 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,163,127 - 165,182,312 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,119,812 - 165,139,016 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,195,981 - 167,211,613 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,195,981 - 167,211,391 (+)Ensemblrn6Rnor6.0
Rnor_5.05170,826,294 - 170,839,549 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45167,287,943 - 167,318,833 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5158,885,103 - 158,901,022 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28083649  


Genomics

Comparative Map Data
Slc2a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,907,721 - 165,927,277 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5165,907,721 - 165,926,891 (+)EnsemblGRCr8
mRatBN7.25160,624,793 - 160,643,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,624,793 - 160,643,514 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5163,341,254 - 163,360,451 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,163,127 - 165,182,312 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,119,812 - 165,139,016 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,195,981 - 167,211,613 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,195,981 - 167,211,391 (+)Ensemblrn6Rnor6.0
Rnor_5.05170,826,294 - 170,839,549 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45167,287,943 - 167,318,833 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5158,885,103 - 158,901,022 (+)NCBICelera
Cytogenetic Map5q36NCBI
SLC2A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818,992,534 - 9,026,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,002,973 - 9,026,423 (-)Ensemblhg38GRCh38
GRCh3719,063,032 - 9,086,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3618,985,946 - 9,008,991 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3418,997,624 - 9,020,670NCBI
Celera18,172,056 - 8,195,080 (-)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef18,213,158 - 8,236,183 (-)NCBIHuRef
CHM1_119,053,282 - 9,076,303 (-)NCBICHM1_1
T2T-CHM13v2.018,526,240 - 8,560,063 (-)NCBIT2T-CHM13v2.0
Slc2a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,233,293 - 150,253,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,233,429 - 150,252,939 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384150,148,834 - 150,169,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,148,972 - 150,168,482 (+)Ensemblmm10GRCm38
MGSCv374149,523,081 - 149,542,591 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364148,992,772 - 149,012,282 (+)NCBIMGSCv36mm8
Celera4152,423,736 - 152,443,348 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.04NCBI
SLC2A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21219,203,957 - 219,228,946 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,848,716 - 217,873,683 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017,760,357 - 7,784,105 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.118,994,787 - 9,017,922 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl18,994,787 - 9,017,922 (-)EnsemblpanPan2panpan1.1
Slc2a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,717,310 - 32,735,227 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,205,532 - 3,221,030 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366233,205,237 - 3,221,639 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,484,227 - 69,503,732 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1669,483,736 - 69,503,758 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC2A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,724,595 - 122,749,456 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,725,001 - 122,748,899 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605426,742,129 - 26,771,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1110,588,194 - 10,606,953 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc2a7
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000055520
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
D5Got113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,621,260 - 160,621,545 (+)MAPPERmRatBN7.2
Rnor_6.05167,184,438 - 167,184,722NCBIRnor6.0
Rnor_5.05170,818,262 - 170,818,546UniSTSRnor5.0
RGSC_v3.45167,296,841 - 167,297,126RGDRGSC3.4
RGSC_v3.45167,296,842 - 167,297,126UniSTSRGSC3.4
RGSC_v3.15167,307,030 - 167,307,314RGD
RH 3.4 Map51118.9RGD
RH 3.4 Map51118.9UniSTS
RH 2.0 Map51108.4RGD
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 26 17 8 9 6 6 6 42 28 1 10 6 45 3 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000055520   ⟹   ENSRNOP00000052384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5165,907,721 - 165,926,891 (+)Ensembl
mRatBN7.2 Ensembl5160,624,793 - 160,643,514 (+)Ensembl
Rnor_6.0 Ensembl5167,195,981 - 167,211,391 (+)Ensembl
RefSeq Acc Id: NM_001393692   ⟹   NP_001380621
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,907,721 - 165,926,921 (+)NCBI
mRatBN7.25160,624,793 - 160,643,994 (+)NCBI
RefSeq Acc Id: XM_039111576   ⟹   XP_038967504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,907,721 - 165,927,277 (+)NCBI
mRatBN7.25160,624,793 - 160,643,994 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380621 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967504 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A4ZYQ5 (Get FASTA)   NCBI Sequence Viewer  
  ABP68403 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052384
Ensembl Acc Id: ENSRNOP00000052384   ⟸   ENSRNOT00000055520
RefSeq Acc Id: XP_038967504   ⟸   XM_039111576
- Peptide Label: isoform X1
- UniProtKB: A6IUD0 (UniProtKB/TrEMBL),   F1M868 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380621   ⟸   NM_001393692
- UniProtKB: A6IUD0 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A4ZYQ5-F1-model_v2 AlphaFold A4ZYQ5 1-512 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583902 AgrOrtholog
BioCyc Gene G2FUF-39079 BioCyc
Ensembl Genes ENSRNOG00000036951 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000055520 ENTREZGENE
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro GLUT UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Sugar/inositol_transpt UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
NCBI Gene Slc2a7 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 7 UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc2a7 PhenoGen
PRINTS SUGRTRNSPORT UniProtKB/Swiss-Prot
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036951 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A4ZYQ5 ENTREZGENE
  A6IUD0 ENTREZGENE, UniProtKB/TrEMBL
  F1M868 ENTREZGENE, UniProtKB/TrEMBL
  GTR7_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a7  solute carrier family 2 member 7  Slc2a7  solute carrier family 2 (facilitated glucose transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-18 Slc2a7  solute carrier family 2 (facilitated glucose transporter), member 7  LOC100362644  solute carrier family 2 (facilitated glucose transporter), member 7  Data merged from RGD:2324314 737654 APPROVED
2010-05-06 LOC100362644  solute carrier family 2 (facilitated glucose transporter), member 7      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-09 Slc2a7  solute carrier family 2 (facilitated glucose transporter), member 7   LOC691471  similar to intestinal facilitative glucose transporter 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691471  similar to intestinal facilitative glucose transporter 7      Symbol and Name status set to provisional 70820 PROVISIONAL