Atf7ip2 (activating transcription factor 7 interacting protein 2) - Rat Genome Database

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Gene: Atf7ip2 (activating transcription factor 7 interacting protein 2) Rattus norvegicus
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Symbol: Atf7ip2
Name: activating transcription factor 7 interacting protein 2
RGD ID: 1583744
Description: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human ATF7IP2 (activating transcription factor 7 interacting protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; gentamycin; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activating transcription factor 7-interacting protein 2; LOC497859; similar to activating transcription factor 7 interacting protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,909,898 - 5,952,844 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl105,909,658 - 5,952,995 (-)EnsemblGRCr8
mRatBN7.2105,403,099 - 5,445,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,403,105 - 5,446,142 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1010,099,399 - 10,142,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,620,576 - 9,663,387 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0105,258,752 - 5,301,500 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,476,205 - 5,519,893 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,476,966 - 5,511,955 (-)Ensemblrn6Rnor6.0
Rnor_5.0104,297,228 - 4,340,498 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4105,356,438 - 5,399,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera104,419,013 - 4,461,981 (-)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:31904090  


Genomics

Comparative Map Data
Atf7ip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,909,898 - 5,952,844 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl105,909,658 - 5,952,995 (-)EnsemblGRCr8
mRatBN7.2105,403,099 - 5,445,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,403,105 - 5,446,142 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1010,099,399 - 10,142,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,620,576 - 9,663,387 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0105,258,752 - 5,301,500 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,476,205 - 5,519,893 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,476,966 - 5,511,955 (-)Ensemblrn6Rnor6.0
Rnor_5.0104,297,228 - 4,340,498 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4105,356,438 - 5,399,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera104,419,013 - 4,461,981 (-)NCBICelera
Cytogenetic Map10q11NCBI
ATF7IP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381610,386,061 - 10,483,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1610,326,434 - 10,483,640 (+)Ensemblhg38GRCh38
GRCh371610,479,918 - 10,577,495 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361610,430,226 - 10,484,996 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341610,430,225 - 10,484,995NCBI
Celera1610,690,093 - 10,744,829 (+)NCBICelera
Cytogenetic Map16p13.2-p13.13NCBI
HuRef1610,399,242 - 10,496,846 (+)NCBIHuRef
CHM1_11610,479,841 - 10,577,424 (+)NCBICHM1_1
T2T-CHM13v2.01610,421,735 - 10,519,259 (+)NCBIT2T-CHM13v2.0
Atf7ip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,010,513 - 10,068,595 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,010,576 - 10,069,342 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381610,192,649 - 10,250,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,192,712 - 10,251,478 (+)Ensemblmm10GRCm38
MGSCv371610,192,999 - 10,243,144 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361610,106,290 - 10,156,629 (+)NCBIMGSCv36mm8
Celera1610,826,131 - 10,876,320 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.5NCBI
Atf7ip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554427,894,518 - 7,941,580 (-)Ensembl
ChiLan1.0NW_0049554427,896,626 - 7,975,579 (-)NCBIChiLan1.0ChiLan1.0
ATF7IP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21810,850,826 - 11,018,846 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11614,626,607 - 14,794,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0169,314,019 - 9,411,940 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11610,545,087 - 10,642,209 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1610,589,012 - 10,642,209 (+)EnsemblpanPan2panpan1.1
ATF7IP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1632,078,700 - 32,128,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl632,079,186 - 32,118,658 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha633,460,859 - 33,516,213 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0632,261,952 - 32,317,341 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl632,261,957 - 32,317,506 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1632,074,922 - 32,130,345 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,947,684 - 32,002,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0632,373,245 - 32,428,680 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atf7ip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344110,949,807 - 110,990,344 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365308,796,077 - 8,830,847 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365308,795,303 - 8,832,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF7IP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,523,463 - 32,598,855 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1332,523,462 - 32,598,946 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,324,469 - 33,378,479 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF7IP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.159,880,656 - 9,972,528 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl59,924,868 - 9,973,606 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606820,193,373 - 20,286,510 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf7ip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248247,783,337 - 7,855,024 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248247,779,900 - 7,880,243 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atf7ip2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1912,084,991 - 12,131,598 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atf7ip2
342 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:69
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000039429
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 6 39 121 79 79 48 37 48 6 244 97 6 101 78 91 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000039429   ⟹   ENSRNOP00000032259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl105,909,658 - 5,952,864 (-)Ensembl
mRatBN7.2 Ensembl105,403,105 - 5,446,142 (-)Ensembl
Rnor_6.0 Ensembl105,476,966 - 5,511,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097686   ⟹   ENSRNOP00000083576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl105,926,537 - 5,952,714 (-)Ensembl
mRatBN7.2 Ensembl105,412,919 - 5,445,878 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109058   ⟹   ENSRNOP00000079052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl105,919,375 - 5,952,995 (-)Ensembl
mRatBN7.2 Ensembl105,412,919 - 5,446,142 (-)Ensembl
RefSeq Acc Id: NM_001017471   ⟹   NP_001017471
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,909,933 - 5,952,742 (-)NCBI
mRatBN7.2105,403,134 - 5,445,945 (-)NCBI
Rnor_6.0105,476,240 - 5,519,816 (-)NCBI
Rnor_5.0104,297,228 - 4,340,498 (-)NCBI
RGSC_v3.4105,356,438 - 5,399,673 (-)RGD
Celera104,419,013 - 4,461,981 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245728   ⟹   XP_006245790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,919,258 - 5,952,844 (-)NCBI
mRatBN7.2105,412,397 - 5,445,989 (-)NCBI
Rnor_6.0105,485,474 - 5,519,890 (-)NCBI
Rnor_5.0104,297,228 - 4,340,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245732   ⟹   XP_006245794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,919,258 - 5,952,842 (-)NCBI
mRatBN7.2105,412,397 - 5,445,989 (-)NCBI
Rnor_6.0105,485,474 - 5,519,890 (-)NCBI
Rnor_5.0104,297,228 - 4,340,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767495   ⟹   XP_008765717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,909,898 - 5,952,826 (-)NCBI
mRatBN7.2105,403,099 - 5,445,989 (-)NCBI
Rnor_6.0105,476,205 - 5,519,893 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767496   ⟹   XP_008765718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,919,258 - 5,952,834 (-)NCBI
mRatBN7.2105,413,861 - 5,445,989 (-)NCBI
Rnor_6.0105,487,011 - 5,519,889 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005489903
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8105,920,656 - 5,952,834 (-)NCBI
mRatBN7.2105,413,857 - 5,445,989 (-)NCBI
RefSeq Acc Id: NP_001017471   ⟸   NM_001017471
- UniProtKB: Q5XIL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245794   ⟸   XM_006245732
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006245790   ⟸   XM_006245728
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008765717   ⟸   XM_008767495
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008765718   ⟸   XM_008767496
- Peptide Label: isoform X4
- UniProtKB: A6K4K8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032259   ⟸   ENSRNOT00000039429
Ensembl Acc Id: ENSRNOP00000079052   ⟸   ENSRNOT00000109058
Ensembl Acc Id: ENSRNOP00000083576   ⟸   ENSRNOT00000097686
Protein Domains
ATF7-interacting protein protein binding   Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIL7-F1-model_v2 AlphaFold Q5XIL7 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583744 AgrOrtholog
BioCyc Gene G2FUF-26126 BioCyc
Ensembl Genes ENSRNOG00000025522 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039429 ENTREZGENE
  ENSRNOT00000039429.6 UniProtKB/TrEMBL
  ENSRNOT00000097686.2 UniProtKB/TrEMBL
  ENSRNOT00000109058 ENTREZGENE
  ENSRNOT00000109058.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135436 IMAGE-MGC_LOAD
InterPro ATF7-int UniProtKB/TrEMBL
  ATF7IP_BD UniProtKB/TrEMBL
  Fn3_ATF7IP UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
KEGG Report rno:497859 UniProtKB/TrEMBL
MGC_CLONE MGC:94500 IMAGE-MGC_LOAD
NCBI Gene 497859 ENTREZGENE
PANTHER PTHR23210 UniProtKB/TrEMBL
  PTHR23210:SF23 UniProtKB/TrEMBL
Pfam ATF7IP_BD UniProtKB/TrEMBL
  fn3_4 UniProtKB/TrEMBL
PhenoGen Atf7ip2 PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025522 RatGTEx
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt A0A8I5ZM83 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXG6 ENTREZGENE, UniProtKB/TrEMBL
  A6K4K8 ENTREZGENE, UniProtKB/TrEMBL
  F7EMW9 ENTREZGENE
  Q5XIL7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7EMW9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Atf7ip2  activating transcription factor 7 interacting protein 2  LOC497859  similar to activating transcription factor 7 interacting protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC497859  similar to activating transcription factor 7 interacting protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL