Dnase1l2 (deoxyribonuclease 1 like 2) - Rat Genome Database

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Gene: Dnase1l2 (deoxyribonuclease 1 like 2) Rattus norvegicus
Analyze
Symbol: Dnase1l2
Name: deoxyribonuclease 1 like 2
RGD ID: 1583566
Description: Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to act upstream of or within corneocyte development and hair follicle development. Predicted to be located in extracellular region. Predicted to be active in nucleus. Orthologous to human DNASE1L2 (deoxyribonuclease 1 like 2); INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deoxyribonuclease 1-like 2; deoxyribonuclease I-like 2; deoxyribonuclease-1-like 2; LOC681124; rCG35247-like; similar to Deoxyribonuclease I-like 2 precursor (DNase I-like 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,976,012 - 13,978,574 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,976,012 - 13,978,366 (-)EnsemblGRCr8
mRatBN7.21013,471,850 - 13,473,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,471,479 - 13,473,763 (-)EnsemblmRatBN7.2
Rnor_6.01013,812,335 - 13,814,514 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,812,707 - 13,814,304 (-)Ensemblrn6Rnor6.0
Rnor_5.01013,629,321 - 13,631,498 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,698,596 - 13,701,079 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,151,976 - 13,154,155 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21307874  


Genomics

Comparative Map Data
Dnase1l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,976,012 - 13,978,574 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,976,012 - 13,978,366 (-)EnsemblGRCr8
mRatBN7.21013,471,850 - 13,473,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,471,479 - 13,473,763 (-)EnsemblmRatBN7.2
Rnor_6.01013,812,335 - 13,814,514 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,812,707 - 13,814,304 (-)Ensemblrn6Rnor6.0
Rnor_5.01013,629,321 - 13,631,498 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,698,596 - 13,701,079 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,151,976 - 13,154,155 (-)NCBICelera
Cytogenetic Map10q12NCBI
DNASE1L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,236,444 - 2,238,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,235,816 - 2,238,711 (+)Ensemblhg38GRCh38
GRCh37162,286,445 - 2,288,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,226,469 - 2,228,713 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34162,226,468 - 2,228,712NCBI
Celera162,500,889 - 2,503,133 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,212,560 - 2,214,798 (+)NCBIHuRef
CHM1_1162,286,417 - 2,288,661 (+)NCBICHM1_1
T2T-CHM13v2.0162,258,893 - 2,261,160 (+)NCBIT2T-CHM13v2.0
Dnase1l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,659,054 - 24,662,075 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,659,055 - 24,662,079 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381724,440,087 - 24,443,763 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,440,081 - 24,443,105 (-)Ensemblmm10GRCm38
MGSCv371724,577,713 - 24,580,046 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361724,168,165 - 24,170,684 (-)NCBIMGSCv36mm8
Celera1724,955,439 - 24,957,592 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.39NCBI
Dnase1l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,028,168 - 15,031,110 (-)Ensembl
ChiLan1.0NW_00495544215,028,168 - 15,031,110 (-)NCBIChiLan1.0ChiLan1.0
DNASE1L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,737,754 - 2,740,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,518,655 - 6,522,535 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,093,669 - 1,096,123 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,336,203 - 2,338,684 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,336,768 - 2,338,391 (+)EnsemblpanPan2panpan1.1
DNASE1L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha639,979,265 - 39,982,569 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0639,048,460 - 39,051,772 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,048,500 - 39,052,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,733,481 - 38,736,785 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,705,790 - 38,709,109 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,184,517 - 39,187,829 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnase1l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,898,483 - 104,901,279 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,808,463 - 1,810,019 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,808,184 - 1,810,735 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE1L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,757,296 - 39,761,080 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1339,757,725 - 39,761,497 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,418,925 - 42,423,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNASE1L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,130,879 - 2,133,817 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,131,854 - 2,133,524 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606828,925,769 - 28,928,101 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnase1l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462482449,949 - 53,375 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462482449,877 - 53,383 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dnase1l2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v191,730,572 - 1,732,767 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnase1l2
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:48
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000012203
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
BF401693  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,471,743 - 13,471,834 (+)MAPPERmRatBN7.2
Rnor_6.01013,812,601 - 13,812,691NCBIRnor6.0
Rnor_5.01013,629,587 - 13,629,677UniSTSRnor5.0
RGSC_v3.41013,698,862 - 13,698,952UniSTSRGSC3.4
Celera1013,152,242 - 13,152,332UniSTS
RH 3.4 Map10190.7UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 51 131 91 90 59 41 59 6 263 117 2 110 67 89 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000012203   ⟹   ENSRNOP00000012203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,976,012 - 13,978,297 (-)Ensembl
mRatBN7.2 Ensembl1013,471,479 - 13,473,763 (-)Ensembl
Rnor_6.0 Ensembl1013,812,707 - 13,814,304 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118986   ⟹   ENSRNOP00000081688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,976,012 - 13,978,366 (-)Ensembl
mRatBN7.2 Ensembl1013,471,479 - 13,473,763 (-)Ensembl
RefSeq Acc Id: NM_001427102   ⟹   NP_001414031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,976,012 - 13,978,297 (-)NCBI
RefSeq Acc Id: XM_063269828   ⟹   XP_063125898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,976,012 - 13,978,574 (-)NCBI
RefSeq Acc Id: XM_063269829   ⟹   XP_063125899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,976,012 - 13,978,574 (-)NCBI
RefSeq Acc Id: XM_063269830   ⟹   XP_063125900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,976,012 - 13,978,574 (-)NCBI
RefSeq Acc Id: XM_063269831   ⟹   XP_063125901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,976,012 - 13,978,574 (-)NCBI
Ensembl Acc Id: ENSRNOP00000012203   ⟸   ENSRNOT00000012203
Ensembl Acc Id: ENSRNOP00000081688   ⟸   ENSRNOT00000118986
RefSeq Acc Id: XP_063125901   ⟸   XM_063269831
- Peptide Label: isoform X4
- UniProtKB: A6HCS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125900   ⟸   XM_063269830
- Peptide Label: isoform X3
- UniProtKB: A6HCS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125899   ⟸   XM_063269829
- Peptide Label: isoform X2
- UniProtKB: A6HCS1 (UniProtKB/TrEMBL),   A0A8I5ZT23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125898   ⟸   XM_063269828
- Peptide Label: isoform X1
- UniProtKB: A6HCS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414031   ⟸   NM_001427102
- Peptide Label: precursor
- UniProtKB: A6HCS2 (UniProtKB/TrEMBL),   D3ZF29 (UniProtKB/TrEMBL)
Protein Domains
Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF29-F1-model_v2 AlphaFold D3ZF29 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583566 AgrOrtholog
BioCyc Gene G2FUF-25858 BioCyc
Ensembl Genes ENSRNOG00000042352 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012203 ENTREZGENE
  ENSRNOT00000012203.7 UniProtKB/TrEMBL
  ENSRNOT00000118986 ENTREZGENE
  ENSRNOT00000118986.2 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
InterPro Deoxyribonuclease-1_AS UniProtKB/TrEMBL
  DNase_I-like UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/TrEMBL
  Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
NCBI Gene 681124 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE UniProtKB/TrEMBL
  DEOXYRIBONUCLEASE-1-LIKE 2 UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/TrEMBL
PhenoGen Dnase1l2 PhenoGen
PIRSF DNase_I_euk UniProtKB/TrEMBL
PRINTS DNASEI UniProtKB/TrEMBL
PROSITE DNASE_I_1 UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042352 RatGTEx
SMART DNaseIc UniProtKB/TrEMBL
Superfamily-SCOP Exo_endo_phos UniProtKB/TrEMBL
UniProt A0A8I5ZT23 ENTREZGENE, UniProtKB/TrEMBL
  A6HCS1 ENTREZGENE, UniProtKB/TrEMBL
  A6HCS2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZF29 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Dnase1l2  deoxyribonuclease 1 like 2  Dnase1l2  deoxyribonuclease I-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Dnase1l2  deoxyribonuclease I-like 2  LOC100364462  rCG35247-like  Data merged from RGD:2320998 1643240 APPROVED
2012-01-24 Dnase1l2  deoxyribonuclease I-like 2  Dnase1l2  deoxyribonuclease 1-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100364462  rCG35247-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Dnase1l2  deoxyribonuclease 1-like 2  LOC681124  similar to Deoxyribonuclease I-like 2 precursor (DNase I-like 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681124  similar to Deoxyribonuclease I-like 2 precursor (DNase I-like 2)      Symbol and Name status set to provisional 70820 PROVISIONAL