Krt87 (keratin 87) - Rat Genome Database

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Gene: Krt87 (keratin 87) Rattus norvegicus
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Symbol: Krt87
Name: keratin 87
RGD ID: 1583565
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to human KRT81 (keratin 81); KRT83 (keratin 83); and KRT86 (keratin 86); INTERACTS WITH dimethylarsinic acid; aristolochic acid A (ortholog); bleomycin A2 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: keratin 83; keratin 83, type II; keratin complex 2, basic, gene 25; keratin, type II cuticular Hb3; Krt83; LOC681126; similar to keratin complex 2, basic, gene 25
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,426,567 - 134,433,740 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,426,567 - 134,433,740 (-)EnsemblGRCr8
mRatBN7.27132,547,388 - 132,555,005 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,548,141 - 132,554,978 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,349,963 - 134,356,799 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,579,469 - 136,586,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,489,258 - 136,496,114 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,078,996 - 143,085,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,078,996 - 143,085,833 (-)Ensemblrn6Rnor6.0
Rnor_5.07140,880,242 - 140,887,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,178,781 - 140,185,794 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,012,194 - 129,019,994 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes. Nanashima N, etal., J Biol Chem. 2008 Jun 13;283(24):16868-75. Epub 2008 Apr 16.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:15085952   PMID:21916889   PMID:23580065  


Genomics

Comparative Map Data
Krt87
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,426,567 - 134,433,740 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,426,567 - 134,433,740 (-)EnsemblGRCr8
mRatBN7.27132,547,388 - 132,555,005 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,548,141 - 132,554,978 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,349,963 - 134,356,799 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,579,469 - 136,586,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,489,258 - 136,496,114 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,078,996 - 143,085,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,078,996 - 143,085,833 (-)Ensemblrn6Rnor6.0
Rnor_5.07140,880,242 - 140,887,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,178,781 - 140,185,794 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,012,194 - 129,019,994 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT87P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,250,544 - 52,258,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,250,466 - 52,258,553 (-)Ensemblhg38GRCh38
GRCh371252,644,328 - 52,652,292 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,929,672 - 50,939,395 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1251,445,848 - 51,455,571 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,676,862 - 49,686,585 (-)NCBIHuRef
CHM1_11252,609,760 - 52,619,483 (-)NCBICHM1_1
T2T-CHM13v2.01252,214,188 - 52,222,152 (-)NCBIT2T-CHM13v2.0
Krt87
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,329,371 - 101,336,685 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,328,919 - 101,336,685 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,431,490 - 101,438,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,431,038 - 101,438,804 (-)Ensemblmm10GRCm38
MGSCv3715101,261,921 - 101,269,235 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,259,828 - 101,266,804 (-)NCBIMGSCv36mm8
Celera15103,579,946 - 103,587,260 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.9NCBI

Variants

.
Variants in Krt87
64 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:51
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000031257
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 4 4 31 25 30 11 52 11 4 111 62 5 22 21 61 19 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000031257   ⟹   ENSRNOP00000029805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,426,567 - 134,433,740 (-)Ensembl
mRatBN7.2 Ensembl7132,548,141 - 132,554,978 (-)Ensembl
Rnor_6.0 Ensembl7143,078,996 - 143,085,833 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077286   ⟹   ENSRNOP00000069234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,548,141 - 132,554,978 (-)Ensembl
Rnor_6.0 Ensembl7143,078,996 - 143,085,833 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098871   ⟹   ENSRNOP00000090562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,548,141 - 132,554,978 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108728   ⟹   ENSRNOP00000081533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,548,214 - 132,554,978 (-)Ensembl
RefSeq Acc Id: NM_001101675   ⟹   NP_001095145
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,426,567 - 134,433,740 (-)NCBI
mRatBN7.27132,547,832 - 132,555,005 (-)NCBI
Rnor_6.07143,078,996 - 143,085,833 (-)NCBI
Rnor_5.07140,880,242 - 140,887,079 (-)NCBI
RGSC_v3.47140,178,781 - 140,185,794 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264250   ⟹   XP_063120320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,426,949 - 134,433,713 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001095145 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120320 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAF75713 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029805
  ENSRNOP00000029805.3
RefSeq Acc Id: NP_001095145   ⟸   NM_001101675
- UniProtKB: A7M746 (UniProtKB/TrEMBL),   D4ABK6 (UniProtKB/TrEMBL),   A0A8I6A9T4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029805   ⟸   ENSRNOT00000031257
Ensembl Acc Id: ENSRNOP00000069234   ⟸   ENSRNOT00000077286
Ensembl Acc Id: ENSRNOP00000090562   ⟸   ENSRNOT00000098871
Ensembl Acc Id: ENSRNOP00000081533   ⟸   ENSRNOT00000108728
RefSeq Acc Id: XP_063120320   ⟸   XM_063264250
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSZ3 (UniProtKB/TrEMBL)
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A7M746-F1-model_v2 AlphaFold A7M746 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695671
Promoter ID:EPDNEW_R6196
Type:single initiation site
Name:Krt83_1
Description:keratin 83
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,085,860 - 143,085,920EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583565 AgrOrtholog
BioCyc Gene G2FUF-31985 BioCyc
Ensembl Genes ENSRNOG00000032859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031257 ENTREZGENE
  ENSRNOT00000031257.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_rod_dom UniProtKB/TrEMBL
  Intermediate_filament_CS UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
  Keratin_II UniProtKB/TrEMBL
KEGG Report rno:681126 UniProtKB/TrEMBL
NCBI Gene 681126 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KERATIN, TYPE II CUTICULAR HB5 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
PharmGKB KRT83 RGD
PhenoGen Krt87 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  PS00226 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032859 RatGTEx
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt A0A8I5ZSZ3 ENTREZGENE
  A0A8I6A9T4 ENTREZGENE
  A7M746 ENTREZGENE, UniProtKB/TrEMBL
  D4ABK6 ENTREZGENE
UniProt Secondary D4ABK6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-21 Krt87  keratin 87  Krt83  keratin 83  Name and Symbol changed 629549 APPROVED
2016-03-16 Krt83  keratin 83  Krt83  keratin 83, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt83  keratin 83, type II  Krt83  keratin 83  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Krt83  keratin 83   LOC681126  similar to keratin complex 2, basic, gene 25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681126  similar to keratin complex 2, basic, gene 25      Symbol and Name status set to provisional 70820 PROVISIONAL