Polr2sl1 (RNA polymerase II, I and III subunit like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Polr2sl1 (RNA polymerase II, I and III subunit like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Polr2sl1
Name: RNA polymerase II, I and III subunit like 1
RGD ID: 1583498
Description: Predicted to enable zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Orthologous to human POLR2L (RNA polymerase II, I and III subunit L).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07061871.2; Ab1-108-like; DNA-directed RNA polymerases I, II, and III subunit RPABC5-like; LOC681193; similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr846,418,202 - 6,418,405 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl46,418,202 - 6,418,405 (+)EnsemblGRCr8
mRatBN7.245,743,067 - 5,743,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,743,067 - 5,743,270 (+)EnsemblmRatBN7.2
Rnor_6.042,512,018 - 2,514,962 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,301,854 - 150,302,052 (-)NCBIrn6Rnor6.0
Rnor_5.042,564,836 - 2,566,484 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44985,235 - 985,438 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera44,575,514 - 4,578,458 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat


Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
5 3 12 3 12 9 1 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000034180   ⟹   ENSRNOP00000077851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl46,418,202 - 6,418,405 (+)Ensembl
mRatBN7.2 Ensembl45,743,067 - 5,743,270 (+)Ensembl
RefSeq Acc Id: XM_039108547   ⟹   XP_038964475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr846,418,202 - 6,418,405 (+)NCBI
mRatBN7.245,743,067 - 5,743,270 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038964475 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077851
  ENSRNOP00000077851.1
RefSeq Acc Id: XP_038964475   ⟸   XM_039108547
- UniProtKB: A0A8I5Y7Y5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077851   ⟸   ENSRNOT00000034180

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583498 AgrOrtholog
BioCyc Gene G2FUF-46169 BioCyc
Ensembl Genes ENSRNOG00000042507 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034180 ENTREZGENE
  ENSRNOT00000034180.6 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro RNA_pol_su_RPB10 UniProtKB/TrEMBL
  RNA_pol_suN_Zn-BS UniProtKB/TrEMBL
  RPABC5/Rpb10 UniProtKB/TrEMBL
NCBI Gene 681193 ENTREZGENE
PANTHER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 UniProtKB/TrEMBL
  PTHR23431 UniProtKB/TrEMBL
Pfam RNA_pol_N UniProtKB/TrEMBL
PhenoGen Polr2sl1 PhenoGen
PIRSF RNA_pol_N/8_sub UniProtKB/TrEMBL
PROSITE RNA_POL_N_8KD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042507 RatGTEx
Superfamily-SCOP SSF46924 UniProtKB/TrEMBL
UniProt A0A8I5Y7Y5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Polr2sl1  RNA polymerase II, I and III subunit like 1  LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  Symbol and Name Changed 1299863 APPROVED
2022-06-02 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  AABR07061871.2    Data merged from RGD:15004601 737654 PROVISIONAL
2019-11-08 AABR07061871.2        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-05-24 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  LOC100365067  Ab1-108-like  Data merged from RGD:2319803 1643240 APPROVED
2010-05-05 LOC100365067  Ab1-108-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  LOC681480  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  Data merged from RGD:1595352 1643240 APPROVED
2006-11-20 LOC681480  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)      Symbol and Name status set to provisional 70820 PROVISIONAL