Polr2sl1 (RNA polymerase II, I and III subunit like 1) - Rat Genome Database

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Gene: Polr2sl1 (RNA polymerase II, I and III subunit like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Polr2sl1 (Ensembl: LOC681193)
Name: RNA polymerase II, I and III subunit like 1 (Ensembl:similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5))
RGD ID: 1583498
Description: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Predicted to be involved in DNA-templated transcription. Predicted to be part of DNA-directed RNA polymerase complex.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07061871.2; Ab1-108-like; DNA-directed RNA polymerases I, II, and III subunit RPABC5-like; LOC681193; similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr846,418,202 - 6,418,405 (+)NCBIGRCr8
mRatBN7.245,743,067 - 5,743,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,743,067 - 5,743,270 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.042,512,018 - 2,514,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4150,301,854 - 150,302,052 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.042,564,836 - 2,566,484 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44985,235 - 985,438 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera44,575,514 - 4,578,458 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Variants

.
Variants in Polr2sl1
1 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034180   ⟹   ENSRNOP00000077851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl45,743,067 - 5,743,270 (+)Ensembl
RefSeq Acc Id: XM_039108547   ⟹   XP_038964475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr846,418,202 - 6,418,405 (+)NCBI
mRatBN7.245,743,067 - 5,743,270 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038964475 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077851
  ENSRNOP00000077851.1
Reference Protein Sequences
RefSeq Acc Id: XP_038964475   ⟸   XM_039108547
- UniProtKB: A0A8I5Y7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077851   ⟸   ENSRNOT00000034180

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583498 AgrOrtholog
BioCyc Gene G2FUF-46169 BioCyc
Ensembl Genes ENSRNOG00000042507 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034180 ENTREZGENE
  ENSRNOT00000034180.5 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro RNA_pol_su_RPB10 UniProtKB/TrEMBL
  RNA_pol_suN_Zn-BS UniProtKB/TrEMBL
  RPABC5/Rpb10 UniProtKB/TrEMBL
NCBI Gene 681193 ENTREZGENE
PANTHER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 UniProtKB/TrEMBL
  PTHR23431 UniProtKB/TrEMBL
Pfam RNA_pol_N UniProtKB/TrEMBL
PhenoGen Polr2sl1 PhenoGen
PIRSF RNA_pol_N/8_sub UniProtKB/TrEMBL
PROSITE RNA_POL_N_8KD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042507 RatGTEx
Superfamily-SCOP SSF46924 UniProtKB/TrEMBL
UniProt A0A8I5Y7Y5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Polr2sl1  RNA polymerase II, I and III subunit like 1  LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  Symbol and Name Changed 1299863 APPROVED
2022-06-02 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  AABR07061871.2    Data merged from RGD:15004601 737654 PROVISIONAL
2019-11-08 AABR07061871.2        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-05-24 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  LOC100365067  Ab1-108-like  Data merged from RGD:2319803 1643240 APPROVED
2010-05-05 LOC100365067  Ab1-108-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  LOC681480  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)  Data merged from RGD:1595352 1643240 APPROVED
2006-11-20 LOC681480  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC681193  similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5)      Symbol and Name status set to provisional 70820 PROVISIONAL