Vom2r77 (vomeronasal 2 receptor, 77) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Vom2r77 (vomeronasal 2 receptor, 77) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r77
Name: vomeronasal 2 receptor, 77
RGD ID: 1582883
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane; INTERACTS WITH cadmium dichloride; valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690227; similar to vomeronasal 2, receptor, 1; vomeronasal 2 receptor 77
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr899,900,049 - 9,966,052 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl99,900,049 - 9,966,052 (-)EnsemblGRCr8
mRatBN7.299,572,874 - 9,638,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl99,572,073 - 9,639,044 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx912,602,845 - 12,668,854 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0916,841,351 - 16,907,362 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0915,603,324 - 15,669,329 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd912,626,657 - 12,692,685 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive911,862,240 - 11,928,261 (-)NCBILyon_Normotensive
Lyon_Hypertensive912,303,154 - 12,369,175 (-)NCBILyon_Hypertensive
F344_StmMcwi97,331,948 - 7,399,766 (+)NCBIF344_StmMcwi
Rnor_6.097,749,090 - 7,815,144 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl97,749,090 - 7,815,144 (-)Ensemblrn6Rnor6.0
Rnor_5.096,788,535 - 6,854,589 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera95,348,088 - 5,414,088 (-)NCBICelera
Cytogenetic Map9q11-q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17382427  


Genomics

Variants

.
Variants in Vom2r77
3176 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:83
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000072966
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
21 2 2 1 2 9 2 18 7 14 2 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001099519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000072966   ⟹   ENSRNOP00000066193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl99,900,049 - 9,966,052 (-)Ensembl
mRatBN7.2 Ensembl99,572,073 - 9,639,044 (-)Ensembl
Rnor_6.0 Ensembl97,749,090 - 7,815,144 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095714   ⟹   ENSRNOP00000090732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl99,572,073 - 9,577,191 (-)Ensembl
RefSeq Acc Id: NM_001099519   ⟹   NP_001092989
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,900,049 - 9,966,052 (-)NCBI
mRatBN7.299,572,874 - 9,638,896 (-)NCBI
Dahl_SR_JrHsd912,626,657 - 12,692,685 (-)NCBI
Lyon_Normotensive911,862,240 - 11,928,261 (-)NCBI
Lyon_Hypertensive912,303,154 - 12,369,175 (-)NCBI
F344_StmMcwi97,331,948 - 7,399,766 (+)NCBI
Rnor_6.097,749,090 - 7,815,144 (-)NCBI
Rnor_5.096,788,535 - 6,854,589 (-)NCBI
Celera95,348,088 - 5,414,088 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001092989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066193
  ENSRNOP00000066193.1
RefSeq Acc Id: NP_001092989   ⟸   NM_001099519
- Peptide Label: precursor
- UniProtKB: M0R9L8 (UniProtKB/TrEMBL),   A6KQA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066193   ⟸   ENSRNOT00000072966
Ensembl Acc Id: ENSRNOP00000090732   ⟸   ENSRNOT00000095714
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R9L8-F1-model_v2 AlphaFold M0R9L8 1-849 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582883 AgrOrtholog
BioCyc Gene G2FUF-28370 BioCyc
Ensembl Genes ENSRNOG00000049443 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072966 ENTREZGENE
  ENSRNOT00000072966.3 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
KEGG Report rno:690227 UniProtKB/TrEMBL
NCBI Gene 690227 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
  VOMERONASAL 2, RECEPTOR 118-RELATED UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r77 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
  VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049443 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A6KQA7 ENTREZGENE, UniProtKB/TrEMBL
  M0R9L8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Vom2r77  vomeronasal 2 receptor, 77  LOC681780  similar to vomeronasal 2, receptor, 1  Data merged from RGD:1591625 1643240 APPROVED
2008-07-23 Vom2r77  vomeronasal 2 receptor, 77  LOC690227  similar to vomeronasal 2, receptor, 1  Symbol and Name updated 1299863 APPROVED
2006-11-20 LOC681780  similar to vomeronasal 2, receptor, 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690227  similar to vomeronasal 2, receptor, 1      Symbol and Name status set to provisional 70820 PROVISIONAL