Dok7 (docking protein 7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dok7 (docking protein 7) Rattus norvegicus
Analyze
Symbol: Dok7
Name: docking protein 7
RGD ID: 1566416
Description: Predicted to enable phosphatidylinositol binding activity; protein kinase binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including neuromuscular junction development; positive regulation of Rac protein signal transduction; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Predicted to act upstream of or within Rac protein signal transduction; neurotransmitter receptor localization to postsynaptic specialization membrane; and receptor clustering. Predicted to be located in plasma membrane and synapse. Predicted to be active in neuromuscular junction and postsynaptic membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: downstream of tyrosine kinase 7; LOC305448; protein Dok-7; RGD1566416; similar to hypothetical protein A930013K19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,890,051 - 79,924,081 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,891,367 - 79,932,252 (-)EnsemblGRCr8
mRatBN7.21475,665,444 - 75,699,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,666,744 - 75,699,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1480,120,121 - 80,152,223 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,360,981 - 81,392,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,805,970 - 77,838,072 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,925,409 - 80,963,454 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,926,654 - 80,958,478 (-)Ensemblrn6Rnor6.0
Rnor_5.01481,615,342 - 81,647,642 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,308,034 - 81,339,858 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,593,247 - 74,625,071 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
Additional References at PubMed
PMID:15632090   PMID:16794080   PMID:20603078   PMID:27658713  


Genomics

Comparative Map Data
Dok7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,890,051 - 79,924,081 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,891,367 - 79,932,252 (-)EnsemblGRCr8
mRatBN7.21475,665,444 - 75,699,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,666,744 - 75,699,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1480,120,121 - 80,152,223 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,360,981 - 81,392,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,805,970 - 77,838,072 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,925,409 - 80,963,454 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,926,654 - 80,958,478 (-)Ensemblrn6Rnor6.0
Rnor_5.01481,615,342 - 81,647,642 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,308,034 - 81,339,858 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,593,247 - 74,625,071 (-)NCBICelera
Cytogenetic Map14q21NCBI
DOK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3843,463,306 - 3,501,482 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl43,463,306 - 3,501,473 (+)Ensemblhg38GRCh38
GRCh3743,465,033 - 3,503,209 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,434,831 - 3,466,007 (+)NCBIBuild 36Build 36hg18NCBI36
Celera43,375,833 - 3,406,924 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef43,402,183 - 3,435,804 (+)NCBIHuRef
CHM1_143,462,601 - 3,494,163 (+)NCBICHM1_1
T2T-CHM13v2.043,463,090 - 3,501,240 (+)NCBIT2T-CHM13v2.0
Dok7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,213,922 - 35,245,183 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,214,110 - 35,245,183 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38535,056,571 - 35,087,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,056,766 - 35,087,839 (+)Ensemblmm10GRCm38
MGSCv37535,399,733 - 35,430,480 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36535,373,945 - 35,404,692 (+)NCBIMGSCv36mm8
Celera532,531,870 - 32,562,455 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map518.0NCBI
Dok7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,166,079 - 2,190,128 (+)Ensembl
ChiLan1.0NW_0049555142,166,263 - 2,190,211 (+)NCBIChiLan1.0ChiLan1.0
DOK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,807,930 - 3,848,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,741,379 - 3,781,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,613,018 - 3,653,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,607,986 - 3,629,550 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,605,185 - 3,628,570 (+)EnsemblpanPan2panpan1.1
DOK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,873,298 - 60,897,047 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,869,206 - 60,897,318 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha363,517,049 - 63,547,646 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0361,342,232 - 61,373,037 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,342,015 - 61,372,581 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,836,025 - 60,866,592 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,042,097 - 61,072,308 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,398,035 - 61,428,824 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
DOK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,089,670 - 2,122,685 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.182,089,645 - 2,119,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,853,134 - 1,879,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,240,766 - 45,271,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2745,241,817 - 45,269,021 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660511,587,466 - 1,624,518 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dok7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,457,652 - 24,478,250 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475524,454,458 - 24,478,257 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dok7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11169,990,758 - 70,022,885 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dok7
136 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:218
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000035385
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH131279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,673,661 - 75,673,843 (+)MAPPERmRatBN7.2
Rnor_6.01480,933,572 - 80,933,753NCBIRnor6.0
Rnor_5.01481,622,260 - 81,622,441UniSTSRnor5.0
RGSC_v3.41481,314,952 - 81,315,133UniSTSRGSC3.4
Celera1474,600,165 - 74,600,346UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 67 132 48 53 23 35 23 6 248 129 11 114 74 89 30 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000035385   ⟹   ENSRNOP00000036262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,891,367 - 79,924,079 (-)Ensembl
mRatBN7.2 Ensembl1475,666,744 - 75,699,164 (-)Ensembl
Rnor_6.0 Ensembl1480,926,654 - 80,958,478 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098833   ⟹   ENSRNOP00000083030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,898,208 - 79,924,017 (-)Ensembl
mRatBN7.2 Ensembl1475,673,579 - 75,699,386 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118992   ⟹   ENSRNOP00000096459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,898,208 - 79,932,252 (-)Ensembl
mRatBN7.2 Ensembl1475,673,579 - 75,699,386 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136750   ⟹   ENSRNOP00000104998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,898,208 - 79,929,830 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161564   ⟹   ENSRNOP00000112374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,898,113 - 79,931,989 (-)Ensembl
RefSeq Acc Id: NM_001130062   ⟹   NP_001123534
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,891,367 - 79,924,017 (-)NCBI
mRatBN7.21475,666,736 - 75,699,386 (-)NCBI
Rnor_6.01480,926,654 - 80,958,478 (-)NCBI
Rnor_5.01481,615,342 - 81,647,642 (-)NCBI
RGSC_v3.41481,308,034 - 81,339,858 (-)RGD
Celera1474,593,247 - 74,625,071 (-)RGD
Sequence:
RefSeq Acc Id: NM_001414957   ⟹   NP_001401886
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,898,208 - 79,924,017 (-)NCBI
mRatBN7.21475,673,577 - 75,699,386 (-)NCBI
RefSeq Acc Id: XM_017599205   ⟹   XP_017454694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,890,078 - 79,924,023 (-)NCBI
mRatBN7.21475,665,448 - 75,699,391 (-)NCBI
Rnor_6.01480,925,409 - 80,963,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599206   ⟹   XP_017454695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,890,051 - 79,924,045 (-)NCBI
mRatBN7.21475,665,444 - 75,699,413 (-)NCBI
Rnor_6.01480,925,409 - 80,963,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091972   ⟹   XP_038947900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,890,077 - 79,923,717 (-)NCBI
mRatBN7.21475,665,448 - 75,699,086 (-)NCBI
RefSeq Acc Id: XM_039091973   ⟹   XP_038947901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,890,051 - 79,923,972 (-)NCBI
mRatBN7.21475,665,444 - 75,699,326 (-)NCBI
RefSeq Acc Id: XM_063273153   ⟹   XP_063129223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,898,207 - 79,924,081 (-)NCBI
RefSeq Acc Id: NP_001123534   ⟸   NM_001130062
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: XP_017454694   ⟸   XM_017599205
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454695   ⟸   XM_017599206
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000036262   ⟸   ENSRNOT00000035385
RefSeq Acc Id: XP_038947901   ⟸   XM_039091973
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947900   ⟸   XM_039091972
- Peptide Label: isoform X2
- UniProtKB: D3ZDW9 (UniProtKB/TrEMBL),   A6IK09 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096459   ⟸   ENSRNOT00000118992
Ensembl Acc Id: ENSRNOP00000083030   ⟸   ENSRNOT00000098833
RefSeq Acc Id: NP_001401886   ⟸   NM_001414957
- Peptide Label: isoform 2
- UniProtKB: A0A8I6GLL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129223   ⟸   XM_063273153
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZVQ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112374   ⟸   ENSRNOT00000161564
Ensembl Acc Id: ENSRNOP00000104998   ⟸   ENSRNOT00000136750
Protein Domains
IRS-type PTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDW9-F1-model_v2 AlphaFold D3ZDW9 1-569 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566416 AgrOrtholog
BioCyc Gene G2FUF-15313 BioCyc
Ensembl Genes ENSRNOG00000022419 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035385 ENTREZGENE
  ENSRNOT00000035385.6 UniProtKB/TrEMBL
  ENSRNOT00000098833 ENTREZGENE
  ENSRNOT00000098833.2 UniProtKB/TrEMBL
  ENSRNOT00000118992 ENTREZGENE
  ENSRNOT00000118992.2 UniProtKB/TrEMBL
  ENSRNOT00000136750.1 UniProtKB/TrEMBL
  ENSRNOT00000161564.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro Dok-7 UniProtKB/TrEMBL
  Dok-7_PH UniProtKB/TrEMBL
  Dok-7_PTB UniProtKB/TrEMBL
  Insln_rcpt_S1 UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
KEGG Report rno:305448 UniProtKB/TrEMBL
NCBI Gene 305448 ENTREZGENE
PANTHER PROTEIN DOK-7 UniProtKB/TrEMBL
  PTHR21636 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
PhenoGen Dok7 PhenoGen
PROSITE IRS_PTB UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022419 RatGTEx
SMART IRS UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A8I5ZVQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLL7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJC2_RAT UniProtKB/TrEMBL
  A0ABK0M4Y0_RAT UniProtKB/TrEMBL
  A6IK09 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDW9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Dok7  docking protein 7  RGD1566416_predicted  similar to hypothetical protein A930013K19 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566416_predicted  similar to hypothetical protein A930013K19 (predicted)  LOC305448  similar to hypothetical protein A930013K19  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305448  similar to hypothetical protein A930013K19      Symbol and Name status set to provisional 70820 PROVISIONAL