Cep72 (centrosomal protein 72) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cep72 (centrosomal protein 72) Rattus norvegicus
Analyze
Symbol: Cep72
Name: centrosomal protein 72
RGD ID: 1566336
Description: Predicted to enable identical protein binding activity. Predicted to be involved in gamma-tubulin complex localization; microtubule cytoskeleton organization; and regulation of protein localization to centrosome. Predicted to be located in centrosome. Predicted to be active in centriolar satellite. Orthologous to human CEP72 (centrosomal protein 72); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: centrosomal protein 72kDa; centrosomal protein of 72 kDa; LOC308064; RGD1566336; similar to RIKEN cDNA 4933440J22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,053,884 - 31,083,863 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,053,914 - 31,083,863 (+)EnsemblGRCr8
mRatBN7.2129,225,312 - 29,255,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,225,361 - 29,255,271 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,027,020 - 29,056,963 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,026,875 - 35,056,816 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,227,635 - 29,257,577 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,834,977 - 31,864,938 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,835,000 - 31,864,628 (+)Ensemblrn6Rnor6.0
Rnor_5.0133,259,539 - 33,289,662 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,031,815 - 30,061,725 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,876,610 - 27,906,505 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriolar satellite  (IBA,IEA,ISO)
centrosome  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11591653   PMID:19536135   PMID:21399614   PMID:24415959   PMID:26297806  


Genomics

Comparative Map Data
Cep72
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,053,884 - 31,083,863 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,053,914 - 31,083,863 (+)EnsemblGRCr8
mRatBN7.2129,225,312 - 29,255,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,225,361 - 29,255,271 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,027,020 - 29,056,963 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,026,875 - 35,056,816 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,227,635 - 29,257,577 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,834,977 - 31,864,938 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,835,000 - 31,864,628 (+)Ensemblrn6Rnor6.0
Rnor_5.0133,259,539 - 33,289,662 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,031,815 - 30,061,725 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,876,610 - 27,906,505 (+)NCBICelera
Cytogenetic Map1p11NCBI
CEP72
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385612,340 - 676,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5612,330 - 667,168 (+)Ensemblhg38GRCh38
GRCh375612,455 - 668,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365665,405 - 706,668 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5708,943 - 749,747 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5597,055 - 637,245 (+)NCBIHuRef
CHM1_15609,681 - 649,065 (+)NCBICHM1_1
T2T-CHM13v2.05610,390 - 666,525 (+)NCBIT2T-CHM13v2.0
Cep72
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,184,351 - 74,210,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,184,619 - 74,210,418 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381374,036,495 - 74,062,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,036,500 - 74,062,299 (-)Ensemblmm10GRCm38
MGSCv371374,173,943 - 74,199,733 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361374,503,837 - 74,528,276 (-)NCBIMGSCv36mm8
Celera1376,366,283 - 76,391,972 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.15NCBI
Cep72
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504305,161 - 335,477 (+)Ensembl
ChiLan1.0NW_004955504305,181 - 335,791 (+)NCBIChiLan1.0ChiLan1.0
CEP72
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24832,069 - 885,119 (+)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl5733,647 - 772,323 (+)EnsemblpanPan2panpan1.1
CEP72
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,639,794 - 11,684,041 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,649,221 - 11,685,767 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3416,141,869 - 16,195,347 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03411,532,589 - 11,586,247 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,540,282 - 11,586,229 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,583,276 - 11,636,989 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,563,186 - 11,617,544 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,773,889 - 11,827,585 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cep72
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,725,348 - 244,783,725 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815888,701 - 912,384 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936815886,633 - 918,445 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP72
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,559,046 - 79,591,249 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11679,559,046 - 79,591,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CEP72
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14490,307 - 525,435 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl4490,387 - 528,276 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606427,621,644 - 27,657,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep72
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624751332,428 - 352,664 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cep72
125 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:93
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000020780
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
RH144236  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,255,328 - 29,255,512 (+)MAPPERmRatBN7.2
Rnor_6.0131,864,973 - 31,865,156NCBIRnor6.0
Rnor_5.0133,289,535 - 33,289,718UniSTSRnor5.0
RGSC_v3.4130,061,760 - 30,061,943UniSTSRGSC3.4
Celera127,906,540 - 27,906,723UniSTS
RH 3.4 Map1341.9UniSTS
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 161 91 90 59 91 59 6 352 190 11 140 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020780   ⟹   ENSRNOP00000020780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl131,053,914 - 31,083,863 (+)Ensembl
mRatBN7.2 Ensembl129,225,361 - 29,255,271 (+)Ensembl
Rnor_6.0 Ensembl131,835,000 - 31,864,628 (+)Ensembl
RefSeq Acc Id: NM_001400076   ⟹   NP_001387005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,053,914 - 31,083,863 (+)NCBI
mRatBN7.2129,225,343 - 29,255,294 (+)NCBI
RefSeq Acc Id: XM_006227800   ⟹   XP_006227862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,053,884 - 31,083,863 (+)NCBI
mRatBN7.2129,225,312 - 29,255,294 (+)NCBI
Rnor_6.0131,834,979 - 31,864,938 (+)NCBI
Rnor_5.0133,259,539 - 33,289,662 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227801   ⟹   XP_006227863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,053,884 - 31,083,863 (+)NCBI
mRatBN7.2129,225,312 - 29,255,294 (+)NCBI
Rnor_6.0131,834,979 - 31,864,938 (+)NCBI
Rnor_5.0133,259,539 - 33,289,662 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099342   ⟹   XP_038955270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,061,341 - 31,083,863 (+)NCBI
mRatBN7.2129,241,156 - 29,255,294 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387005 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227862 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227863 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955270 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020780
  ENSRNOP00000020780.5
RefSeq Acc Id: XP_006227862   ⟸   XM_006227800
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006227863   ⟸   XM_006227801
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000020780   ⟸   ENSRNOT00000020780
RefSeq Acc Id: XP_038955270   ⟸   XM_039099342
- Peptide Label: isoform X3
- UniProtKB: A6JUV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001387005   ⟸   NM_001400076
- UniProtKB: D3ZVQ1 (UniProtKB/TrEMBL)
Protein Domains
U2A'/phosphoprotein 32 family A C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVQ1-F1-model_v2 AlphaFold D3ZVQ1 1-646 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689570
Promoter ID:EPDNEW_R84
Type:initiation region
Name:Cep72_1
Description:centrosomal protein 72
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0131,835,016 - 31,835,076EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566336 AgrOrtholog
BioCyc Gene G2FUF-61938 BioCyc
Ensembl Genes ENSRNOG00000015465 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020780 ENTREZGENE
  ENSRNOT00000020780.9 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro CEP72-like UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  U2A'_phosphoprotein32A_C UniProtKB/TrEMBL
NCBI Gene 308064 ENTREZGENE
PANTHER HEAT SHOCK REGULATED 2 UniProtKB/TrEMBL
  PTHR23311:SF7 UniProtKB/TrEMBL
Pfam LRR_9 UniProtKB/TrEMBL
PhenoGen Cep72 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015465 RatGTEx
SMART LRR_TYP UniProtKB/TrEMBL
  LRRcap UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A6JUV4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVQ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-27 Cep72  centrosomal protein 72  Cep72  centrosomal protein 72kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cep72  centrosomal protein 72kDa  Cep72  centrosomal protein 72  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Cep72  centrosomal protein 72  RGD1566336_predicted  similar to RIKEN cDNA 4933440J22 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566336_predicted  similar to RIKEN cDNA 4933440J22 (predicted)  LOC308064  similar to RIKEN cDNA 4933440J22  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC308064  similar to RIKEN cDNA 4933440J22      Symbol and Name status set to provisional 70820 PROVISIONAL