Fignl2 (fidgetin-like 2) - Rat Genome Database

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Gene: Fignl2 (fidgetin-like 2) Rattus norvegicus
Analyze
Symbol: Fignl2
Name: fidgetin-like 2
RGD ID: 1566321
Description: Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Involved in negative regulation of axon regeneration. Predicted to be located in cell leading edge. Predicted to be active in cytoplasm and nucleus. Orthologous to human FIGNL2 (fidgetin like 2); INTERACTS WITH 6-propyl-2-thiouracil; methoxychlor; Monobutylphthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07058914.1; fidgetin-like protein 2; LOC102555469; LOC300238; putative fidgetin-like protein 2; putative fidgetin-like protein 2-like; RGD1566321; similar to fidgetin-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,038,734 - 134,066,626 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,038,672 - 134,067,893 (-)EnsemblGRCr8
mRatBN7.27132,160,006 - 132,187,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,162,390 - 132,164,336 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,961,636 - 133,989,506 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,191,152 - 136,219,022 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,101,893 - 136,129,789 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0155,127,315 - 5,133,550 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,694,759 - 142,696,347 (-)NCBIrn6Rnor6.0
Rnor_5.07140,494,661 - 140,501,240 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,805,382 - 139,807,381 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,628,426 - 128,651,176 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell cortex  (IEA)
cell leading edge  (IEA,ISO)
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration. Baker L, etal., JCI Insight. 2021 May 10;6(9):e138484. doi: 10.1172/jci.insight.138484.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fignl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,038,734 - 134,066,626 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,038,672 - 134,067,893 (-)EnsemblGRCr8
mRatBN7.27132,160,006 - 132,187,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,162,390 - 132,164,336 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,961,636 - 133,989,506 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,191,152 - 136,219,022 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,101,893 - 136,129,789 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0155,127,315 - 5,133,550 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,694,759 - 142,696,347 (-)NCBIrn6Rnor6.0
Rnor_5.07140,494,661 - 140,501,240 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,805,382 - 139,807,381 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,628,426 - 128,651,176 (-)NCBICelera
Cytogenetic Map7q36NCBI
FIGNL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,817,899 - 51,848,718 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,817,899 - 51,848,718 (-)Ensemblhg38GRCh38
GRCh371252,211,683 - 52,242,502 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,497,943 - 50,502,475 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1251,013,783 - 51,018,315 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,244,544 - 49,258,562 (-)NCBIHuRef
CHM1_11252,178,134 - 52,192,159 (-)NCBICHM1_1
T2T-CHM13v2.01251,781,425 - 51,812,316 (-)NCBIT2T-CHM13v2.0
Fignl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,948,075 - 100,976,465 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,948,075 - 100,976,448 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,050,192 - 101,078,584 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,050,194 - 101,078,567 (-)Ensemblmm10GRCm38
MGSCv3715100,882,896 - 100,884,830 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615100,879,984 - 100,882,439 (-)NCBIMGSCv36mm8
Celera15103,199,310 - 103,201,244 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.39NCBI
Fignl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555472,205,614 - 2,234,417 (-)NCBIChiLan1.0ChiLan1.0
FIGNL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,346,719 - 42,377,486 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,343,492 - 42,374,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,914,415 - 36,945,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,698,429 - 37,718,699 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,716,039 - 37,718,001 (+)EnsemblpanPan2panpan1.1
FIGNL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,138,800 - 3,168,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,091,187 - 43,117,719 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,135,508 - 3,162,038 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1273,152,136 - 3,178,852 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,138,359 - 3,164,826 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,489,583 - 43,516,095 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fignl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,870,170 - 63,877,428 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,289,926 - 9,291,931 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,287,391 - 9,293,741 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIGNL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,180,773 - 17,182,743 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1517,178,239 - 17,209,297 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,773,665 - 17,787,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FIGNL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,010,951 - 48,021,889 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037198,070,808 - 198,101,348 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fignl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816487,821 - 489,773 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624816464,601 - 493,218 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fignl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,018,073 - 262,044,629 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fignl2
164 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 42 17 88 45 11 41 36 32 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000044982   ⟹   ENSRNOP00000092082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,040,123 - 134,056,862 (-)Ensembl
mRatBN7.2 Ensembl7132,162,390 - 132,164,336 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124801   ⟹   ENSRNOP00000105682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,038,672 - 134,067,893 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140915   ⟹   ENSRNOP00000105512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,038,704 - 134,065,494 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169082   ⟹   ENSRNOP00000110043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,039,467 - 134,063,417 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173592   ⟹   ENSRNOP00000099701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,039,518 - 134,065,494 (-)Ensembl
RefSeq Acc Id: NM_001401883   ⟹   NP_001388812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,038,740 - 134,066,626 (-)NCBI
mRatBN7.27132,160,006 - 132,187,896 (-)NCBI
RefSeq Acc Id: XM_063262858   ⟹   XP_063118928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,038,734 - 134,066,366 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388812 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118928 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A8I6AGW3 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092082.1
  ENSRNOP00000105512
  ENSRNOP00000105682
Ensembl Acc Id: ENSRNOP00000092082   ⟸   ENSRNOT00000044982
RefSeq Acc Id: NP_001388812   ⟸   NM_001401883
- UniProtKB: A0A8I6AGW3 (UniProtKB/Swiss-Prot),   A6KCM6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118928   ⟸   XM_063262858
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGW3 (UniProtKB/Swiss-Prot),   A6KCM6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110043   ⟸   ENSRNOT00000169082
Ensembl Acc Id: ENSRNOP00000105682   ⟸   ENSRNOT00000124801
Ensembl Acc Id: ENSRNOP00000099701   ⟸   ENSRNOT00000173592
Ensembl Acc Id: ENSRNOP00000105512   ⟸   ENSRNOT00000140915
Protein Domains
AAA+ ATPase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566321 AgrOrtholog
Ensembl Genes ENSRNOG00000032026 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044982.5 UniProtKB/Swiss-Prot
  ENSRNOT00000124801 ENTREZGENE
  ENSRNOT00000140915 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  MT-severing_AAA_ATPase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
NCBI Gene Fignl2 ENTREZGENE
PANTHER AAA DOMAIN-CONTAINING UniProtKB/Swiss-Prot
  FIDGETIN-LIKE PROTEIN 2 UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
PhenoGen Fignl2 PhenoGen
RatGTEx ENSRNOG00000032026 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/Swiss-Prot
UniProt A0A8I6AGW3 ENTREZGENE
  A6KCM6 ENTREZGENE, UniProtKB/TrEMBL
  FIGL2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Fignl2  fidgetin-like 2  AABR07058914.1    Data merged from RGD:15003924 737654 PROVISIONAL
2021-03-09 Fignl2  fidgetin-like 2  LOC102555469  putative fidgetin-like protein 2-like  Data merged from RGD:7552859 737654 PROVISIONAL
2019-11-08 AABR07058914.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-12-17 LOC102555469  putative fidgetin-like protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Fignl2  fidgetin-like 2  RGD1566321  similar to fidgetin-like 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566321  similar to fidgetin-like 1   RGD1566321_predicted  similar to fidgetin-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566321_predicted  similar to fidgetin-like 1 (predicted)  LOC300238  similar to fidgetin-like 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300238  similar to fidgetin-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL