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Gene: Alkbh6 (alkB homolog 6) Rattus norvegicus

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Symbol:

Alkbh6

Name:

alkB homolog 6

RGD ID:

1566318

Description:

Predicted to enable 2-oxoglutarate-dependent dioxygenase activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human ALKBH6 (alkB homolog 6); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alkB, alkylation repair homolog 6; alkB, alkylation repair homolog 6 (E. coli); alkylated DNA repair protein alkB homolog 6; alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; LOC108348106; LOC292780; MGC112693; probable alpha-ketoglutarate-dependent dioxygenase ABH6; similar to hypothetical protein MGC15677

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ALKBH6 (alkB homolog 6)	HGNC	Ensembl, Inparanoid, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Alkbh6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Alkbh6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ALKBH6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ALKBH6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Alkbh6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ALKBH6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ALKBH6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Alkbh6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Alkbh6 (alkB homolog 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ALKBH6 (alkB homolog 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Alkbh6 (alkB homolog 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	alkbh6 (alkB homolog 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	B0564.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6144	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	alkbh6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	94,690,979 - 94,696,429 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	94,691,822 - 94,696,427 (+)	Ensembl				GRCr8
mRatBN7.2	1	85,563,511 - 85,568,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,563,592 - 85,568,973 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	90,979,724 - 90,985,119 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,447,940 - 99,453,284 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	92,737,985 - 92,743,380 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	88,766,872 - 88,772,243 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	90,957,133 - 90,962,466 (-)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	1	88,766,872 - 88,772,242 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	92,094,314 - 92,099,684 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,255,190 - 85,260,560 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	79,937,451 - 79,942,812 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,3-dinitrobenzene (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (EXP)

disodium selenite (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

GSK-J4 (ISO)

hydrogen peroxide (ISO)

methyl methanesulfonate (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (EXP)

Soman (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

triadimefon (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

2-oxoglutarate-dependent dioxygenase activity (IEA,ISO)

dioxygenase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16174769

Genomics

Comparative Map Data

Alkbh6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	94,690,979 - 94,696,429 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	94,691,822 - 94,696,427 (+)	Ensembl				GRCr8
mRatBN7.2	1	85,563,511 - 85,568,977 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,563,592 - 85,568,973 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	90,979,724 - 90,985,119 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,447,940 - 99,453,284 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	92,737,985 - 92,743,380 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	88,766,872 - 88,772,243 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	90,957,133 - 90,962,466 (-)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	1	88,766,872 - 88,772,242 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	92,094,314 - 92,099,684 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,255,190 - 85,260,560 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	79,937,451 - 79,942,812 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

ALKBH6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	36,009,120 - 36,014,239 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	36,009,120 - 36,014,297 (-)	Ensembl			hg38	GRCh38
GRCh37	19	36,500,022 - 36,505,141 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	41,191,862 - 41,196,981 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	19	33,214,202 - 33,219,321 (-)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	33,005,571 - 33,010,690 (-)	NCBI		HuRef
CHM1_1	19	36,501,371 - 36,506,490 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	38,554,919 - 38,560,038 (-)	NCBI		T2T-CHM13v2.0

Alkbh6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,008,178 - 30,013,728 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,008,142 - 30,013,729 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	30,308,753 - 30,314,303 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,308,717 - 30,314,304 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	31,093,772 - 31,099,322 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,017,513 - 30,023,063 (+)	NCBI		MGSCv36	mm8
Celera	7	24,904,872 - 24,910,436 (+)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	17.38	NCBI

Alkbh6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	2,575,568 - 2,582,032 (+)	Ensembl
ChiLan1.0	NW_004955468	2,575,469 - 2,580,632 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALKBH6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	42,010,025 - 42,015,162 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,993,666 - 43,998,802 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,927,382 - 32,932,519 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,675,899 - 41,681,015 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,675,899 - 41,681,015 (-)	Ensembl			panPan2	panpan1.1

ALKBH6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	116,671,147 - 116,676,784 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	116,670,841 - 116,680,515 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,076,834 - 116,082,479 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,274,284 - 117,279,932 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,274,286 - 117,279,361 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	116,838,319 - 116,843,973 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	116,461,885 - 116,467,539 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	117,517,091 - 117,522,745 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Alkbh6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	11,274,066 - 11,279,691 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936922	44,807 - 49,834 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936922	44,201 - 49,792 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALKBH6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	45,384,957 - 45,390,244 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	45,384,955 - 45,390,247 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,787,631 - 40,792,954 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALKBH6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,920,192 - 30,925,659 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,920,185 - 30,925,362 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	8,715,150 - 8,720,323 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alkbh6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	10,271,116 - 10,274,845 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	10,275,555 - 10,280,725 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	10,271,107 - 10,281,055 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Alkbh6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	165,692,976 - 165,698,221 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Alkbh6
57 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	180
Count of miRNA genes:	84
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000051259, ENSRNOT00000071180
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat

Markers in Region

AI844915

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	85,563,010 - 85,563,149 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	85,563,010 - 85,563,149 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	88,766,277 - 88,766,415	NCBI	Rnor6.0
Rnor_6.0	1	90,962,959 - 90,963,097	NCBI	Rnor6.0
Rnor_5.0	1	92,100,141 - 92,100,279	UniSTS	Rnor5.0
Rnor_5.0	1	89,922,295 - 89,922,433	UniSTS	Rnor5.0
RGSC_v3.4	1	85,254,595 - 85,254,733	UniSTS	RGSC3.4
Celera	1	79,936,856 - 79,936,994	UniSTS
Cytogenetic Map	1	q21	UniSTS

AI044262

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	85,562,964 - 85,563,151 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	85,562,964 - 85,563,151 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	90,962,957 - 90,963,143	NCBI	Rnor6.0
Rnor_6.0	1	88,766,231 - 88,766,417	NCBI	Rnor6.0
Rnor_5.0	1	89,922,249 - 89,922,435	UniSTS	Rnor5.0
Rnor_5.0	1	92,100,139 - 92,100,325	UniSTS	Rnor5.0
RGSC_v3.4	1	85,254,549 - 85,254,735	UniSTS	RGSC3.4
Celera	1	79,936,810 - 79,936,996	UniSTS
RH 3.4 Map	1	882.29	UniSTS
Cytogenetic Map	1	q21	UniSTS

UniSTS:235641

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	85,562,890 - 85,563,026 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	85,562,890 - 85,563,026 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	88,766,157 - 88,766,292	NCBI	Rnor6.0
Rnor_6.0	1	90,963,082 - 90,963,217	NCBI	Rnor6.0
Rnor_5.0	1	92,100,264 - 92,100,399	UniSTS	Rnor5.0
Rnor_5.0	1	89,922,175 - 89,922,310	UniSTS	Rnor5.0
RGSC_v3.4	1	85,254,475 - 85,254,610	UniSTS	RGSC3.4
Celera	1	79,936,736 - 79,936,871	UniSTS
Cytogenetic Map	1	q21	UniSTS

CLIPR-59__4586

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	85,562,383 - 85,563,184 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	85,562,383 - 85,563,184 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	88,765,650 - 88,766,450	NCBI	Rnor6.0
Rnor_6.0	1	90,962,924 - 90,963,724	NCBI	Rnor6.0
Rnor_5.0	1	92,100,106 - 92,100,906	UniSTS	Rnor5.0
Rnor_5.0	1	89,921,668 - 89,922,468	UniSTS	Rnor5.0
RGSC_v3.4	1	85,253,968 - 85,254,768	UniSTS	RGSC3.4
Celera	1	79,936,229 - 79,937,029	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	20	102	204	99	104	67	105	67	437	239	11	187	105	111	37	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005501802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB581428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000051259 ⟹ ENSRNOP00000043754

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	94,691,822 - 94,696,427 (+)	Ensembl
mRatBN7.2 Ensembl	1	85,563,592 - 85,568,973 (+)	Ensembl
Rnor_6.0 Ensembl	1	88,766,872 - 88,772,242 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000071180 ⟹ ENSRNOP00000064657

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	90,957,261 - 90,961,717 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080613 ⟹ ENSRNOP00000072260

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	85,563,592 - 85,568,973 (+)	Ensembl
Rnor_6.0 Ensembl	1	90,957,133 - 90,962,466 (-)	Ensembl

RefSeq Acc Id:

NM_001127450 ⟹ NP_001120922

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	94,691,062 - 94,696,429 (+)	NCBI
mRatBN7.2	1	85,563,606 - 85,568,973 (+)	NCBI
Rnor_6.0	1	88,766,872 - 88,772,243 (+)	NCBI
Rnor_5.0	1	92,094,314 - 92,099,684 (-)	NCBI
RGSC_v3.4	1	85,255,190 - 85,260,560 (+)	RGD
Celera	1	79,937,451 - 79,942,812 (+)	RGD

Sequence:

show sequence

CTGGGGGGGCGTGCGACCATGAGCATGTTGAGTCTGGAAATTGGAGAAGACGTTGTGGACGGAC
GGCACACAAGGAGTTGATATCCATGGAGGAGCAGGACGCCAGGATCCCAGCACTGGAACCATTC
AGGGTGGAACAGGCGCCACCTCTAATCTACTATGTCCCTGACTTCATCTCCAAGGAAGAGGAGG
AGTATTTGCTTCGACAGGTTTTCAATGCCCCAAAGCCAAAGTGGACCCAGCTGTCCGGGAGGAA
GCTTCAGAACTGGGGTGGGCTCCCCCACCCCCGGGGGATGGTCCCTGAGCGACTCCCTCCATGG
CTTCAACGCTACGTGGACAAAGTGTCTGACCTCAGCCTTTTTGGGGGTCTCCCAGCTAACCATG
TCCTTGTGAACCAGTACCTGCCTGGGGAGGGCATCATGCCTCATGAAGATGGACCATTGTACTA
CCCAACAGTCAGCACCATTAGCCTGGGCTCCCATACTGTCCTTGACTTCTATGAACCTCGGCAG
CCAGACGATGACGTCCCTCCAGAACAGCCCAGGCCTCCTCAGCAGCCCATCACCTCGCTGCTGG
TGGAACCACGGAGCCTGCTGGTGCTCCGGGGCACGGCTTACACACGTCTGCTCCACGGCATCAC
AGCCACCCGCGTAGATGAGCTGGACTCCACCTCGCTGCCGCCCAATGCCGCTGCCTGCCAGTCG
GCGTTGCCCGGAGCCCGCCTGGTGCGTGGCACCCGTGTCTCGCTGACCATTCGACGTGTACCCC
GCGTGCTGCGCGCCAGCCTCCTGCTGAGCAAGTGACCACCAGGCTCCAAAACTCCTGACCTTGG
AACCTTAGGGCAGAGGTAGCTGCCCAGGGTTATTTATTTTCCCAGTAACTGTGGAAACCACGGA
GAAGTCACCATTCCAAATAAACAGAAAATACCTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039104487 ⟹ XP_038960415

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	94,690,979 - 94,696,429 (+)	NCBI
mRatBN7.2	1	85,563,511 - 85,568,977 (+)	NCBI

RefSeq Acc Id:

XM_063283620 ⟹ XP_063139690

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	94,692,417 - 94,696,429 (+)	NCBI

RefSeq Acc Id:

XR_005501802

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	94,690,984 - 94,696,175 (+)	NCBI
mRatBN7.2	1	85,563,512 - 85,568,977 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001120922	(Get FASTA)	NCBI Sequence Viewer
	XP_038960415	(Get FASTA)	NCBI Sequence Viewer
	XP_063139690	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82048	(Get FASTA)	NCBI Sequence Viewer
	AAH98707	(Get FASTA)	NCBI Sequence Viewer
	EDM07772	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000043754
	ENSRNOP00000043754.3

RefSeq Acc Id:

NP_001120922 ⟸ NM_001127450

- UniProtKB:

G3V9E2 (UniProtKB/TrEMBL), A6J9W2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEEQDARIPALEPFRVEQAPPLIYYVPDFISKEEEEYLLRQVFNAPKPKWTQLSGRKLQNWGGL
PHPRGMVPERLPPWLQRYVDKVSDLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPTVSTIS
LGSHTVLDFYEPRQPDDDVPPEQPRPPQQPITSLLVEPRSLLVLRGTAYTRLLHGITATRVDEL
DSTSLPPNAAACQSALPGARLVRGTRVSLTIRRVPRVLRASLLLSK

hide sequence

Ensembl Acc Id:

ENSRNOP00000072260 ⟸ ENSRNOT00000080613

Ensembl Acc Id:

ENSRNOP00000064657 ⟸ ENSRNOT00000071180

RefSeq Acc Id:	XP_038960415 ⟸ XM_039104487
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000043754 ⟸ ENSRNOT00000051259

RefSeq Acc Id:	XP_063139690 ⟸ XM_063283620
- Peptide Label:	isoform X1

Protein Domains

Fe2OG dioxygenase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V9E2-F1-model_v2	AlphaFold	G3V9E2	1-238	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689910

Promoter ID:

EPDNEW_R435

Type:

initiation region

Name:

Alkbh6_1

Description:

alkB homolog 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	88,766,896 - 88,766,956	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566318	AgrOrtholog
BioCyc Gene	G2FUF-60125	BioCyc
Ensembl Genes	ENSRNOG00000025216	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000047943	Ensembl
Ensembl Transcript	ENSRNOT00000051259	ENTREZGENE
	ENSRNOT00000051259.5	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.590	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131752	IMAGE-MGC_LOAD
InterPro	AlkB-like	UniProtKB/TrEMBL
	AlkB-like_sf	UniProtKB/TrEMBL
	ALKBH6	UniProtKB/TrEMBL
	Oxoglu/Fe-dep_dioxygenase	UniProtKB/TrEMBL
KEGG Report	rno:292780	UniProtKB/TrEMBL
MGC_CLONE	MGC:95194	IMAGE-MGC_LOAD
NCBI Gene	292780	ENTREZGENE
PANTHER	ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6	UniProtKB/TrEMBL
	PTHR46030	UniProtKB/TrEMBL
Pfam	2OG-FeII_Oxy_2	UniProtKB/TrEMBL
PhenoGen	Alkbh6	PhenoGen
PROSITE	FE2OG_OXY	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025216	RatGTEx
	ENSRNOG00000047943	RatGTEx
Superfamily-SCOP	Clavaminate synthase-like	UniProtKB/TrEMBL
UniProt	A6J9W2	ENTREZGENE, UniProtKB/TrEMBL
	G3V9E2	ENTREZGENE, UniProtKB/TrEMBL
	Q4KM81_RAT	UniProtKB/TrEMBL
	Q66H36_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Alkbh6	alkB homolog 6	LOC108348106	alpha-ketoglutarate-dependent dioxygenase alkB homolog 6	Data merged from RGD:11413490	737654	PROVISIONAL
2016-08-02	LOC108348106	alpha-ketoglutarate-dependent dioxygenase alkB homolog 6			Symbol and Name status set to provisional	70820	PROVISIONAL
2015-07-02	Alkbh6	alkB homolog 6	Alkbh6	alkB, alkylation repair homolog 6 (E. coli)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Alkbh6	alkB, alkylation repair homolog 6 (E. coli)	LOC292780	similar to hypothetical protein MGC15677	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC292780	similar to hypothetical protein MGC15677			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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