Asb11 (ankyrin repeat and SOCS box containing 11) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Asb11 (ankyrin repeat and SOCS box containing 11) Rattus norvegicus
Analyze
Symbol: Asb11
Name: ankyrin repeat and SOCS box containing 11
RGD ID: 1566298
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K11-linked ubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to several human genes including ASB9 (ankyrin repeat and SOCS box containing 9); INTERACTS WITH alpha-Zearalanol; bisphenol A; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase; ankyrin repeat and SOCS box protein 11; ankyrin repeat and SOCS box-containing 11; ankyrin repeat and SOCS box-containing protein 11; LOC302666; RGD1566298; similar to ankyrin repeat and SOCS box-containing protein 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,646,389 - 33,669,790 (-)NCBIGRCr8
mRatBN7.2X30,014,485 - 30,037,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,992,416 - 30,037,807 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,054,103 - 31,076,005 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,484,645 - 34,506,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,678,440 - 30,700,338 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,758,294 - 31,781,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,700,633 - 31,780,425 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,131,988 - 32,155,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,771,241 - 50,793,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,361,465 - 30,383,325 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24337577  


Genomics

Comparative Map Data
Asb11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,646,389 - 33,669,790 (-)NCBIGRCr8
mRatBN7.2X30,014,485 - 30,037,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,992,416 - 30,037,807 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,054,103 - 31,076,005 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,484,645 - 34,506,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,678,440 - 30,700,338 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,758,294 - 31,781,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,700,633 - 31,780,425 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,131,988 - 32,155,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,771,241 - 50,793,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,361,465 - 30,383,325 (-)NCBICelera
Cytogenetic MapXq14NCBI
ASB11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,281,697 - 15,315,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,281,697 - 15,315,640 (-)EnsemblGRCh38hg38GRCh38
GRCh37X15,299,819 - 15,333,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,211,548 - 15,243,648 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X15,061,283 - 15,093,384NCBI
CeleraX19,417,215 - 19,449,322 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,058,321 - 13,092,558 (-)NCBIHuRef
CHM1_1X15,330,773 - 15,364,700 (-)NCBICHM1_1
T2T-CHM13v2.0X14,864,580 - 14,898,525 (-)NCBIT2T-CHM13v2.0
Asb11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X163,219,976 - 163,242,166 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX163,219,990 - 163,242,166 (+)EnsemblGRCm39 Ensembl
GRCm38X164,436,953 - 164,459,170 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,436,994 - 164,459,170 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,876,033 - 160,897,032 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,782,206 - 159,803,205 (+)NCBIMGSCv36mm8
CeleraX147,653,204 - 147,674,239 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.53NCBI
Asb11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,875,212 - 2,896,191 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,875,287 - 2,896,122 (+)NCBIChiLan1.0ChiLan1.0
ASB11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,082,815 - 17,114,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,086,482 - 17,118,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X7,909,843 - 7,942,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,192,234 - 15,225,022 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,192,234 - 15,225,022 (-)Ensemblpanpan1.1panPan2
ASB11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,542,466 - 11,567,633 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,542,466 - 11,582,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,449,703 - 11,474,846 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,504,544 - 11,529,691 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,476,043 - 11,545,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,567,464 - 11,592,602 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,558,808 - 11,583,955 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,586,899 - 11,612,032 (-)NCBIUU_Cfam_GSD_1.0
Asb11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,692,233 - 4,728,528 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,701,681 - 4,728,555 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,701,670 - 4,728,527 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASB11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX11,842,855 - 11,868,793 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X11,842,855 - 11,871,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X12,803,421 - 12,829,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASB11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X13,752,138 - 13,784,368 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX13,749,385 - 13,783,846 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,589,300 - 15,620,474 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asb11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829103,969 - 123,033 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829104,065 - 122,955 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asb11
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:42
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000004693
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
RH130732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,015,102 - 30,015,287 (+)MAPPERmRatBN7.2
Rnor_6.0X31,758,912 - 31,759,096NCBIRnor6.0
Rnor_5.0X32,132,606 - 32,132,790UniSTSRnor5.0
RGSC_v3.4X50,771,588 - 50,771,772UniSTSRGSC3.4
CeleraX30,361,812 - 30,361,996UniSTS
Cytogenetic MapXq21UniSTS
RH134847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,014,640 - 30,014,827 (+)MAPPERmRatBN7.2
Rnor_6.0X31,758,450 - 31,758,636NCBIRnor6.0
Rnor_5.0X32,132,144 - 32,132,330UniSTSRnor5.0
RGSC_v3.4X50,771,126 - 50,771,312UniSTSRGSC3.4
CeleraX30,361,350 - 30,361,536UniSTS
RH 3.4 MapX403.5UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 11 39 63 73 76 48 16 48 6 178 74 47 43 54 28

Sequence


Ensembl Acc Id: ENSRNOT00000004693   ⟹   ENSRNOP00000004693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX30,014,754 - 30,036,677 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108098   ⟹   ENSRNOP00000081538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX29,992,416 - 30,037,807 (-)Ensembl
RefSeq Acc Id: NM_001106962   ⟹   NP_001100432
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,646,660 - 33,668,520 (-)NCBI
mRatBN7.2X30,014,756 - 30,036,618 (-)NCBI
Rnor_6.0X31,758,565 - 31,780,425 (-)NCBI
Rnor_5.0X32,131,988 - 32,155,334 (-)NCBI
RGSC_v3.4X50,771,241 - 50,793,101 (-)RGD
CeleraX30,361,465 - 30,383,325 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256858   ⟹   XP_006256920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,646,389 - 33,669,790 (-)NCBI
mRatBN7.2X30,014,485 - 30,037,808 (-)NCBI
Rnor_6.0X31,758,294 - 31,781,863 (-)NCBI
Rnor_5.0X32,131,988 - 32,155,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773166   ⟹   XP_008771388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,646,389 - 33,664,497 (-)NCBI
mRatBN7.2X30,014,485 - 30,032,540 (-)NCBI
Rnor_6.0X31,758,294 - 31,776,489 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001100432   ⟸   NM_001106962
- UniProtKB: D3ZSF1 (UniProtKB/TrEMBL),   A6K2K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256920   ⟸   XM_006256858
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771388   ⟸   XM_008773166
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000081538   ⟸   ENSRNOT00000108098
Ensembl Acc Id: ENSRNOP00000004693   ⟸   ENSRNOT00000004693
Protein Domains
SOCS box

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701794
Promoter ID:EPDNEW_R12318
Type:single initiation site
Name:Asb9_1
Description:ankyrin repeat and SOCS box-containing 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X31,780,489 - 31,780,549EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566298 AgrOrtholog
BioCyc Gene G2FUF-2595 BioCyc
Ensembl Genes ENSRNOG00000003452 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004693.6 UniProtKB/TrEMBL
  ENSRNOT00000108098.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro Ankyrin-SOCS_box_domain UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  SOCS_box_dom_like UniProtKB/TrEMBL
  SOCS_C UniProtKB/TrEMBL
KEGG Report rno:302666 UniProtKB/TrEMBL
NCBI Gene 302666 ENTREZGENE
PANTHER ANKYRIN REPEAT AND SOCS BOX PROTEIN 11 UniProtKB/TrEMBL
  SOWAH (DROSOPHILA) HOMOLOG UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PhenoGen Asb11 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003452 RatGTEx
SMART ANK UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SSF158235 UniProtKB/TrEMBL
UniProt A0A8I5ZSR2 ENTREZGENE, UniProtKB/TrEMBL
  A6K2K4 ENTREZGENE, UniProtKB/TrEMBL
  A6K2K5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSF1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Asb11  ankyrin repeat and SOCS box containing 11  Asb11  ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-25 Asb11  ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase  Asb11  ankyrin repeat and SOCS box-containing 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Asb11  ankyrin repeat and SOCS box-containing 11  Asb11  ankyrin repeat and SOCS box-containing protein 11   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Asb11  ankyrin repeat and SOCS box-containing protein 11   Asb11_predicted  ankyrin repeat and SOCS box-containing protein 11 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Asb11_predicted  ankyrin repeat and SOCS box-containing protein 11 (predicted)  RGD1566298_predicted  similar to ankyrin repeat and SOCS box-containing protein 11 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1566298_predicted  similar to ankyrin repeat and SOCS box-containing protein 11 (predicted)  LOC302666  similar to ankyrin repeat and SOCS box-containing protein 11  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302666  similar to ankyrin repeat and SOCS box-containing protein 11      Symbol and Name status set to provisional 70820 PROVISIONAL