Tmem74 (transmembrane protein 74) - Rat Genome Database

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Gene: Tmem74 (transmembrane protein 74) Rattus norvegicus
Analyze
Symbol: Tmem74
Name: transmembrane protein 74
RGD ID: 1566279
Description: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in macroautophagy. Predicted to act upstream of or within general adaptation syndrome, behavioral process. Predicted to be located in plasma membrane. Orthologous to human TMEM74 (transmembrane protein 74); INTERACTS WITH 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC500864; RGD1566279; similar to RIKEN cDNA B230382K22 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8776,814,000 - 76,822,633 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl776,813,212 - 76,822,925 (-)EnsemblGRCr8
mRatBN7.2774,929,290 - 74,937,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl774,931,694 - 74,937,934 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx776,780,654 - 76,789,275 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0778,983,152 - 78,991,777 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0778,858,660 - 78,867,300 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0782,684,666 - 82,689,753 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl782,686,213 - 82,687,130 (-)Ensemblrn6Rnor6.0
Rnor_5.0782,694,142 - 82,699,197 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4779,611,445 - 79,612,413 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera771,927,405 - 71,932,481 (-)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18294959  


Genomics

Comparative Map Data
Tmem74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8776,814,000 - 76,822,633 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl776,813,212 - 76,822,925 (-)EnsemblGRCr8
mRatBN7.2774,929,290 - 74,937,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl774,931,694 - 74,937,934 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx776,780,654 - 76,789,275 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0778,983,152 - 78,991,777 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0778,858,660 - 78,867,300 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0782,684,666 - 82,689,753 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl782,686,213 - 82,687,130 (-)Ensemblrn6Rnor6.0
Rnor_5.0782,694,142 - 82,699,197 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4779,611,445 - 79,612,413 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera771,927,405 - 71,932,481 (-)NCBICelera
Cytogenetic Map7q31NCBI
TMEM74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388108,606,850 - 108,787,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8108,606,850 - 108,787,624 (-)Ensemblhg38GRCh38
GRCh378109,619,079 - 109,799,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368109,864,522 - 109,868,946 (-)NCBIBuild 36Build 36hg18NCBI36
Celera8105,982,575 - 105,986,999 (-)NCBICelera
Cytogenetic Map8q23.1NCBI
HuRef8105,116,317 - 105,120,741 (-)NCBIHuRef
CHM1_18109,835,258 - 109,839,682 (-)NCBICHM1_1
T2T-CHM13v2.08109,735,330 - 109,916,112 (-)NCBIT2T-CHM13v2.0
Tmem74
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391543,726,741 - 43,733,462 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1543,728,042 - 43,733,432 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381543,863,345 - 43,870,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1543,864,646 - 43,870,036 (-)Ensemblmm10GRCm38
MGSCv371543,698,241 - 43,701,575 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361543,696,769 - 43,700,103 (-)NCBIMGSCv36mm8
Celera1544,326,949 - 44,330,313 (-)NCBICelera
Cytogenetic Map15B3.2NCBI
cM Map1516.82NCBI
Tmem74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541731,328,352 - 31,334,228 (-)NCBIChiLan1.0ChiLan1.0
TMEM74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27126,156,559 - 126,165,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18101,679,893 - 101,688,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08105,432,869 - 105,441,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18107,583,909 - 107,587,990 (-)NCBIPanPan1.1PanPan1.1panPan2
TMEM74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1139,407,005 - 9,415,906 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl139,412,368 - 9,413,285 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha139,383,998 - 9,391,724 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0139,680,515 - 9,688,244 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl139,680,528 - 9,689,421 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1139,423,244 - 9,430,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0139,548,243 - 9,555,974 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0139,628,842 - 9,636,571 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530328,658,650 - 28,667,449 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647036,087,350 - 36,088,267 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647036,084,902 - 36,091,517 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl428,722,273 - 28,731,093 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1428,722,243 - 28,727,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2431,062,896 - 31,067,648 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18103,604,060 - 103,637,945 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8103,509,309 - 103,510,226 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl8103,509,309 - 103,510,226 (-)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603936,940,773 - 37,071,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476323,762,606 - 23,765,496 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476323,762,204 - 23,765,889 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem74
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11218,265,317 - 218,268,785 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem74
41 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000006791
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
BE119323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2774,934,427 - 74,934,602 (+)MAPPERmRatBN7.2
Rnor_6.0782,686,230 - 82,686,404NCBIRnor6.0
Rnor_5.0782,695,699 - 82,695,873UniSTSRnor5.0
RGSC_v3.4779,611,513 - 79,611,687UniSTSRGSC3.4
Celera771,928,969 - 71,929,143UniSTS
RH 3.4 Map7521.7UniSTS
Cytogenetic Map7q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 10 56 138 53 50 21 29 21 6 197 113 7 121 45 90 29 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000006791   ⟹   ENSRNOP00000006791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl782,686,213 - 82,687,130 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111466   ⟹   ENSRNOP00000083619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl776,817,093 - 76,822,365 (-)Ensembl
mRatBN7.2 Ensembl774,931,694 - 74,937,934 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131487   ⟹   ENSRNOP00000109234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl776,813,907 - 76,822,906 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162775   ⟹   ENSRNOP00000099351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl776,813,212 - 76,822,925 (-)Ensembl
RefSeq Acc Id: NM_001398901   ⟹   NP_001385830
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8776,814,000 - 76,822,633 (-)NCBI
mRatBN7.2774,929,290 - 74,937,929 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385830 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083619.1
  ENSRNOP00000099351.1
  ENSRNOP00000109234
  ENSRNOP00000109234.1
Ensembl Acc Id: ENSRNOP00000006791   ⟸   ENSRNOT00000006791
Ensembl Acc Id: ENSRNOP00000083619   ⟸   ENSRNOT00000111466
RefSeq Acc Id: NP_001385830   ⟸   NM_001398901
- UniProtKB: A0A8I5ZWY5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109234   ⟸   ENSRNOT00000131487
Ensembl Acc Id: ENSRNOP00000099351   ⟸   ENSRNOT00000162775

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZR33-F1-model_v2 AlphaFold D3ZR33 1-305 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566279 AgrOrtholog
BioCyc Gene G2FUF-33488 BioCyc
Ensembl Genes ENSRNOG00000005114 Ensembl
  ENSRNOG00000065300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000111466.2 UniProtKB/TrEMBL
  ENSRNOT00000131487 ENTREZGENE
  ENSRNOT00000131487.1 UniProtKB/TrEMBL
  ENSRNOT00000162775.1 UniProtKB/TrEMBL
InterPro TMEM74-like UniProtKB/TrEMBL
NCBI Gene 500864 ENTREZGENE
PANTHER PTHR16125 UniProtKB/TrEMBL
  PTHR16125:SF3 UniProtKB/TrEMBL
Pfam Neurensin UniProtKB/TrEMBL
PhenoGen Tmem74 PhenoGen
RatGTEx ENSRNOG00000005114 RatGTEx
  ENSRNOG00000065300 RatGTEx
UniProt A0A8I5ZWY5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Tmem74  transmembrane protein 74  Tmem74  transmembrane protein 74  Data merged from RGD:149736141 737654 PROVISIONAL
2021-08-09 Tmem74  transmembrane protein 74      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-03-07 Tmem74  transmembrane protein 74  RGD1566279_predicted  similar to RIKEN cDNA B230382K22 gene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566279_predicted  similar to RIKEN cDNA B230382K22 gene (predicted)  LOC500864  similar to RIKEN cDNA B230382K22 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500864  similar to RIKEN cDNA B230382K22 gene      Symbol and Name status set to provisional 70820 PROVISIONAL