Hyal5 (hyaluronoglucosaminidase 5) - Rat Genome Database

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Gene: Hyal5 (hyaluronoglucosaminidase 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hyal5
Name: hyaluronoglucosaminidase 5
RGD ID: 1566275
Description: Predicted to enable hyalurononglucosaminidase activity. Predicted to be involved in hyaluronan catabolic process. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in external side of plasma membrane. Predicted to be active in acrosomal vesicle. Orthologous to human SPAM1 (sperm adhesion molecule 1); PARTICIPATES IN glycosaminoglycan degradation pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hyaluronidase PH-20; MGC108951; similar to Hyal-5
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,306,643 - 54,378,272 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl454,306,697 - 54,336,329 (+)EnsemblGRCr8
mRatBN7.2453,341,105 - 53,412,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,343,475 - 53,370,785 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx458,327,976 - 58,357,624 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0454,241,515 - 54,271,153 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,663,453 - 52,692,998 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd456,056,502 - 56,086,050 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive453,463,694 - 53,493,240 (+)NCBILyon_Normotensive
Lyon_Hypertensive454,057,194 - 54,086,743 (+)NCBILyon_Hypertensive
F344_StmMcwi453,862,486 - 53,892,033 (+)NCBIF344_StmMcwi
Rnor_6.0452,232,565 - 52,319,777 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl452,235,811 - 52,275,936 (+)Ensemblrn6Rnor6.0
Rnor_5.0452,002,528 - 52,165,318 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4451,316,917 - 51,347,273 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera448,504,223 - 48,533,092 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:16330764   PMID:16925524  


Genomics

Variants

.
Variants in Hyal5
592 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:114
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000060478
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)45014392658080146Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)45014392658080146Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)45014392658080146Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 3 1 15 4 8 3 1 3 3 12 2 12 2 27 5

Sequence


Ensembl Acc Id: ENSRNOT00000060478   ⟹   ENSRNOP00000057222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,306,697 - 54,336,329 (+)Ensembl
mRatBN7.2 Ensembl453,343,475 - 53,370,785 (+)Ensembl
Rnor_6.0 Ensembl452,235,811 - 52,275,936 (+)Ensembl
RefSeq Acc Id: NM_001024321   ⟹   NP_001019492
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,306,691 - 54,336,335 (+)NCBI
mRatBN7.2453,341,149 - 53,370,793 (+)NCBI
Dahl_SR_JrHsd456,056,502 - 56,086,050 (+)NCBI
Lyon_Normotensive453,463,694 - 53,493,240 (+)NCBI
Lyon_Hypertensive454,057,194 - 54,086,743 (+)NCBI
F344_StmMcwi453,862,486 - 53,892,033 (+)NCBI
Rnor_6.0452,232,605 - 52,275,944 (+)NCBI
Rnor_5.0452,002,528 - 52,165,318 (+)NCBI
RGSC_v3.4451,316,917 - 51,347,273 (+)RGD
Celera448,504,223 - 48,533,092 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236166   ⟹   XP_006236228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,306,658 - 54,336,335 (+)NCBI
mRatBN7.2453,341,121 - 53,370,793 (+)NCBI
Rnor_6.0452,232,567 - 52,275,956 (+)NCBI
Rnor_5.0452,002,528 - 52,165,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592781   ⟹   XP_017448270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,306,643 - 54,378,272 (+)NCBI
mRatBN7.2453,341,105 - 53,412,280 (+)NCBI
Rnor_6.0452,232,565 - 52,318,424 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001019492 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236228 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448270 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91219 (Get FASTA)   NCBI Sequence Viewer  
  EDM15181 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057222
  ENSRNOP00000057222.2
RefSeq Acc Id: NP_001019492   ⟸   NM_001024321
- UniProtKB: Q5BK36 (UniProtKB/TrEMBL),   F7FB21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236228   ⟸   XM_006236166
- Peptide Label: isoform X1
- UniProtKB: Q5BK36 (UniProtKB/TrEMBL),   F7FB21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448270   ⟸   XM_017592781
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000057222   ⟸   ENSRNOT00000060478

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK36-F1-model_v2 AlphaFold Q5BK36 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566275 AgrOrtholog
BioCyc Gene G2FUF-45472 BioCyc
Ensembl Genes ENSRNOG00000039466 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060478 ENTREZGENE
  ENSRNOT00000060478.6 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112082 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Glyco_hydro_56_PH20 UniProtKB/TrEMBL
  Glyco_hydro_catalytic_core UniProtKB/TrEMBL
  Hyaluronidase UniProtKB/TrEMBL
KEGG Report rno:500052 UniProtKB/TrEMBL
MGC_CLONE MGC:108951 IMAGE-MGC_LOAD
NCBI Gene 500052 ENTREZGENE
PANTHER Glyco_hydro_56 UniProtKB/TrEMBL
  HYALURONIDASE PH-20 UniProtKB/TrEMBL
Pfam Glyco_hydro_56 UniProtKB/TrEMBL
PhenoGen Hyal5 PhenoGen
PIRSF Hyaluronidase UniProtKB/TrEMBL
  Hyaluronidase_PH20_Hyal5 UniProtKB/TrEMBL
PRINTS GLHYDRLASE56 UniProtKB/TrEMBL
  SPERMPH20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039466 RatGTEx
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
UniProt F7FB21 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK36 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Hyal5  hyaluronoglucosaminidase 5  MGC108951  similar to Hyal-5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC108951  similar to Hyal-5      Symbol and Name status set to provisional 70820 PROVISIONAL