Creb5 (cAMP responsive element binding protein 5) - Rat Genome Database

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Gene: Creb5 (cAMP responsive element binding protein 5) Rattus norvegicus
Analyze
Symbol: Creb5
Name: cAMP responsive element binding protein 5
RGD ID: 1566107
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; and white fat cell differentiation. Predicted to act upstream of or within adipose tissue development; fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human CREB5 (cAMP responsive element binding protein 5); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclic AMP-responsive element-binding protein 5; hypothetical protein LOC500131; LOC500131; RGD1566107; similar to cAMP responsive element binding protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8483,723,587 - 84,124,786 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl483,723,194 - 84,120,793 (+)EnsemblGRCr8
mRatBN7.2482,393,091 - 82,794,320 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl482,393,730 - 82,790,325 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx487,614,417 - 88,011,491 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0483,389,804 - 83,786,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0481,815,473 - 82,211,705 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0483,390,782 - 83,840,356 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl483,391,283 - 83,836,351 (+)Ensemblrn6Rnor6.0
Rnor_5.04148,055,895 - 148,503,535 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4481,719,509 - 82,033,894 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera477,275,487 - 77,671,208 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. Deng B, etal., Cell Biosci. 2014 Jul 9;4:35. doi: 10.1186/2045-3701-4-35. eCollection 2014.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8378084   PMID:19056867   PMID:19948881  


Genomics

Comparative Map Data
Creb5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8483,723,587 - 84,124,786 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl483,723,194 - 84,120,793 (+)EnsemblGRCr8
mRatBN7.2482,393,091 - 82,794,320 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl482,393,730 - 82,790,325 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx487,614,417 - 88,011,491 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0483,389,804 - 83,786,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0481,815,473 - 82,211,705 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0483,390,782 - 83,840,356 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl483,391,283 - 83,836,351 (+)Ensemblrn6Rnor6.0
Rnor_5.04148,055,895 - 148,503,535 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4481,719,509 - 82,033,894 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera477,275,487 - 77,671,208 (+)NCBICelera
Cytogenetic Map4q24NCBI
CREB5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38728,299,321 - 28,825,894 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl728,299,321 - 28,825,894 (+)Ensemblhg38GRCh38
GRCh37728,338,940 - 28,865,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36728,305,465 - 28,832,036 (+)NCBIBuild 36Build 36hg18NCBI36
Celera728,328,521 - 28,855,112 (+)NCBICelera
Cytogenetic Map7p15.1-p14.3NCBI
HuRef728,220,807 - 28,747,364 (+)NCBIHuRef
CHM1_1728,339,070 - 28,865,750 (+)NCBICHM1_1
T2T-CHM13v2.0728,436,682 - 28,963,385 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2728,389,121 - 28,915,762 (+)NCBI
Creb5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39653,264,154 - 53,677,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl653,264,255 - 53,677,361 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38653,287,226 - 53,700,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl653,287,270 - 53,700,376 (+)Ensemblmm10GRCm38
MGSCv37653,523,368 - 53,645,826 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36653,502,952 - 53,625,410 (+)NCBIMGSCv36mm8
Celera654,100,301 - 54,222,576 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map625.9NCBI
Creb5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541029,986,492 - 30,371,861 (+)Ensembl
ChiLan1.0NW_00495541029,982,965 - 30,371,861 (+)NCBIChiLan1.0ChiLan1.0
CREB5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2633,241,886 - 33,658,163 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1781,566,613 - 81,982,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0729,054,505 - 29,470,528 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1728,648,993 - 29,064,583 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl728,727,385 - 29,057,973 (+)EnsemblpanPan2panpan1.1
CREB5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11441,397,016 - 41,891,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1441,488,548 - 41,885,094 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1440,826,749 - 41,326,577 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01441,338,636 - 41,832,870 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1441,426,639 - 41,828,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11441,449,004 - 41,949,895 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01441,134,829 - 41,628,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01441,493,325 - 41,987,586 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Creb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511885,972,431 - 86,112,736 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364784,924,489 - 5,319,844 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364785,184,157 - 5,319,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREB5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1843,844,942 - 44,261,031 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11843,840,553 - 44,264,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21848,245,185 - 48,682,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CREB5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12129,542,030 - 29,960,393 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2129,548,662 - 29,902,289 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604274,784,572 - 75,203,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Creb5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247391,782,598 - 2,198,283 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247391,781,424 - 2,201,931 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Creb5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1687,383,181 - 87,693,858 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Creb5
3010 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:363
Count of miRNA genes:200
Interacting mature miRNAs:263
Transcripts:ENSRNOT00000031365
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)48021363484338055Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
D4Rat138  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,443,355 - 82,443,549 (+)MAPPERmRatBN7.2
Rnor_6.0483,441,613 - 83,441,806NCBIRnor6.0
Rnor_5.04148,105,124 - 148,105,317UniSTSRnor5.0
Celera477,323,318 - 77,323,511UniSTS
RH 3.4 Map4516.1UniSTS
RH 3.4 Map4516.1RGD
RH 2.0 Map4556.9RGD
SHRSP x BN Map440.85RGD
FHH x ACI Map449.0699RGD
Cytogenetic Map4q24UniSTS
D4Rat215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,576,018 - 82,576,250 (+)MAPPERmRatBN7.2
Rnor_6.0483,616,640 - 83,616,871NCBIRnor6.0
Rnor_5.04148,279,719 - 148,279,950UniSTSRnor5.0
RGSC_v3.4481,815,481 - 81,815,712UniSTSRGSC3.4
Celera477,457,074 - 77,457,305UniSTS
RGSC_v3.1482,100,003 - 82,100,344RGD
FHH x ACI Map449.0699RGD
FHH x ACI Map449.0699UniSTS
Cytogenetic Map4q24UniSTS
D4Kini1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,490,359 - 82,490,515 (+)MAPPERmRatBN7.2
Rnor_6.0483,531,021 - 83,531,176NCBIRnor6.0
Rnor_5.04148,193,854 - 148,194,009UniSTSRnor5.0
RGSC_v3.4481,729,616 - 81,729,771UniSTSRGSC3.4
Celera477,371,064 - 77,371,233UniSTS
Cytogenetic Map4q24UniSTS
BF389546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,754,599 - 82,754,800 (+)MAPPERmRatBN7.2
Rnor_6.0483,800,618 - 83,800,818NCBIRnor6.0
Rnor_5.04148,463,797 - 148,463,997UniSTSRnor5.0
RGSC_v3.4481,998,161 - 81,998,361UniSTSRGSC3.4
Celera477,635,499 - 77,635,699UniSTS
RH 3.4 Map4516.1UniSTS
Cytogenetic Map4q24UniSTS
RH130938  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,394,457 - 82,394,657 (+)MAPPERmRatBN7.2
Rnor_6.0483,467,223 - 83,467,422NCBIRnor6.0
Rnor_6.0483,392,011 - 83,392,210NCBIRnor6.0
Rnor_5.04148,130,734 - 148,130,933UniSTSRnor5.0
Rnor_5.04148,057,052 - 148,057,251UniSTSRnor5.0
RGSC_v3.4481,617,187 - 81,617,386UniSTSRGSC3.4
Celera477,276,215 - 77,276,414UniSTS
RH 3.4 Map4516.1UniSTS
Cytogenetic Map4q24UniSTS
RH143800  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,789,738 - 82,789,893 (+)MAPPERmRatBN7.2
Rnor_6.0483,835,765 - 83,835,919NCBIRnor6.0
Rnor_5.04148,498,944 - 148,499,098UniSTSRnor5.0
RGSC_v3.4482,033,308 - 82,033,462UniSTSRGSC3.4
Celera477,670,622 - 77,670,776UniSTS
RH 3.4 Map4516.2UniSTS
Cytogenetic Map4q24UniSTS
RH143924  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,394,184 - 82,394,448 (+)MAPPERmRatBN7.2
Rnor_6.0483,466,950 - 83,467,213NCBIRnor6.0
Rnor_6.0483,391,738 - 83,392,001NCBIRnor6.0
Rnor_5.04148,130,461 - 148,130,724UniSTSRnor5.0
Rnor_5.04148,056,779 - 148,057,042UniSTSRnor5.0
RGSC_v3.4481,616,914 - 81,617,177UniSTSRGSC3.4
Celera477,275,942 - 77,276,205UniSTS
RH 3.4 Map4515.7UniSTS
Cytogenetic Map4q24UniSTS
BF394265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2482,776,157 - 82,776,381 (+)MAPPERmRatBN7.2
Rnor_6.0483,822,186 - 83,822,409NCBIRnor6.0
Rnor_5.04148,485,365 - 148,485,588UniSTSRnor5.0
RGSC_v3.4482,019,729 - 82,019,952UniSTSRGSC3.4
Celera477,657,052 - 77,657,275UniSTS
RH 3.4 Map4516.5UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 87 86 55 59 55 6 319 159 11 144 81 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031365   ⟹   ENSRNOP00000036595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl483,724,225 - 84,120,793 (+)Ensembl
mRatBN7.2 Ensembl482,393,730 - 82,790,325 (+)Ensembl
Rnor_6.0 Ensembl483,391,283 - 83,836,351 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086473   ⟹   ENSRNOP00000073400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl483,999,040 - 84,120,366 (+)Ensembl
mRatBN7.2 Ensembl482,668,578 - 82,790,325 (+)Ensembl
Rnor_6.0 Ensembl483,713,666 - 83,834,178 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115589   ⟹   ENSRNOP00000079273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl483,723,798 - 84,120,793 (+)Ensembl
mRatBN7.2 Ensembl482,396,931 - 82,790,325 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153821   ⟹   ENSRNOP00000110626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl483,724,977 - 84,120,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164557   ⟹   ENSRNOP00000105065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl483,723,194 - 84,120,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173005   ⟹   ENSRNOP00000105860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl483,727,227 - 84,120,793 (+)Ensembl
RefSeq Acc Id: NM_001134621   ⟹   NP_001128093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8483,724,225 - 84,120,793 (+)NCBI
mRatBN7.2482,393,730 - 82,790,325 (+)NCBI
Rnor_6.0483,466,495 - 83,836,351 (+)NCBI
Rnor_5.04148,055,895 - 148,503,535 (+)NCBI
RGSC_v3.4481,719,509 - 82,033,894 (+)RGD
Celera477,275,487 - 77,671,208 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762908   ⟹   XP_008761130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8483,997,398 - 84,124,786 (+)NCBI
mRatBN7.2482,668,164 - 82,794,320 (+)NCBI
Rnor_6.0483,713,555 - 83,840,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592796   ⟹   XP_017448285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8483,723,623 - 84,124,786 (+)NCBI
mRatBN7.2482,393,123 - 82,794,320 (+)NCBI
Rnor_6.0483,390,782 - 83,840,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108134   ⟹   XP_038964062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8483,723,623 - 84,124,786 (+)NCBI
mRatBN7.2482,393,123 - 82,794,320 (+)NCBI
RefSeq Acc Id: XM_039108135   ⟹   XP_038964063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8483,723,623 - 84,124,786 (+)NCBI
mRatBN7.2482,393,123 - 82,794,320 (+)NCBI
RefSeq Acc Id: XM_039108136   ⟹   XP_038964064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8483,999,117 - 84,124,786 (+)NCBI
mRatBN7.2482,689,004 - 82,794,320 (+)NCBI
RefSeq Acc Id: XM_039108137   ⟹   XP_038964065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8483,723,587 - 84,082,825 (+)NCBI
mRatBN7.2482,393,091 - 82,718,680 (+)NCBI
RefSeq Acc Id: NP_001128093   ⟸   NM_001134621
- UniProtKB: D3ZBH0 (UniProtKB/TrEMBL),   A6K0T7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761130   ⟸   XM_008762908
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K5F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448285   ⟸   XM_017592796
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000036595   ⟸   ENSRNOT00000031365
Ensembl Acc Id: ENSRNOP00000073400   ⟸   ENSRNOT00000086473
RefSeq Acc Id: XP_038964065   ⟸   XM_039108137
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038964063   ⟸   XM_039108135
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964062   ⟸   XM_039108134
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038964064   ⟸   XM_039108136
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000079273   ⟸   ENSRNOT00000115589
Ensembl Acc Id: ENSRNOP00000105860   ⟸   ENSRNOT00000173005
Ensembl Acc Id: ENSRNOP00000105065   ⟸   ENSRNOT00000164557
Ensembl Acc Id: ENSRNOP00000110626   ⟸   ENSRNOT00000153821
Protein Domains
bZIP   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBH0-F1-model_v2 AlphaFold D3ZBH0 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566107 AgrOrtholog
BioCyc Gene G2FUF-44782 BioCyc
Ensembl Genes ENSRNOG00000008622 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031365 ENTREZGENE
  ENSRNOT00000031365.7 UniProtKB/TrEMBL
  ENSRNOT00000086473 ENTREZGENE
  ENSRNOT00000086473.3 UniProtKB/TrEMBL
  ENSRNOT00000115589.2 UniProtKB/TrEMBL
  ENSRNOT00000153821.1 UniProtKB/TrEMBL
  ENSRNOT00000164557 ENTREZGENE
  ENSRNOT00000164557.1 UniProtKB/TrEMBL
  ENSRNOT00000173005 ENTREZGENE
  ENSRNOT00000173005.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
  bZIP_transcription_factors UniProtKB/TrEMBL
  TF_cAMP-dep UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:500131 UniProtKB/TrEMBL
NCBI Gene 500131 ENTREZGENE
PANTHER CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
PhenoGen Creb5 PhenoGen
PIRSF ATF2_CRE-BP1 UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008622 RatGTEx
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
  SSF57959 UniProtKB/TrEMBL
UniProt A0A0G2K5F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQI5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LHB0_RAT UniProtKB/TrEMBL
  A0ABK0LPZ0_RAT UniProtKB/TrEMBL
  A0ABK0M602_RAT UniProtKB/TrEMBL
  A6K0T7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBH0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-27 Creb5  cAMP responsive element binding protein 5  RGD1566107  similar to cAMP responsive element binding protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566107  similar to cAMP responsive element binding protein 5   RGD1566107_predicted  similar to cAMP responsive element binding protein 5 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566107_predicted  similar to cAMP responsive element binding protein 5 (predicted)  LOC500131  similar to cAMP responsive element binding protein 5  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500131  similar to cAMP responsive element binding protein 5      Symbol and Name status set to provisional 70820 PROVISIONAL