Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Nicotine results in increased expression of PRRC2C mRNA | CTD | PMID:16949557 | 1,2-dimethylhydrazine | affects expression | ISO | Prrc2c (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of PRRC2C mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PRRC2C mRNA | CTD | PMID:19167446 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PRRC2C mRNA | CTD | PMID:32145629 | 17beta-estradiol | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Estradiol results in increased expression of PRRC2C mRNA | CTD | PMID:23019147 and PMID:31614463 | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of PRRC2C mRNA | CTD | PMID:28522335 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRRC2C mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2C mRNA | CTD | PMID:28628672 | acrolein | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PRRC2C mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | aflatoxin B1 | decreases methylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PRRC2C gene | CTD | PMID:27153756 | aflatoxin B1 | increases methylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PRRC2C intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | PRRC2C (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of PRRC2C intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PRRC2C mRNA | CTD | PMID:15498508 and PMID:21934132 | alpha-pinene | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PRRC2C mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PRRC2C mRNA | CTD | PMID:32699268 | aristolochic acid A | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PRRC2C mRNA and aristolochic acid I results in decreased expression of PRRC2C protein | CTD | PMID:33212167 | arsenous acid | increases response to substance | ISO | PRRC2C (Homo sapiens) | 6480464 | PRRC2C protein results in increased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | atrazine | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Atrazine results in increased expression of PRRC2C mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PRRC2C mRNA | CTD | PMID:19770486 | benzo[a]pyrene | affects methylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PRRC2C intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PRRC2C 5' UTR and Benzo(a)pyrene results in decreased methylation of PRRC2C promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Prrc2c (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of PRRC2C mRNA | CTD | PMID:26271895 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bis(2-chloroethyl) sulfide | increases phosphorylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Mustard Gas results in increased phosphorylation of PRRC2C protein | CTD | PMID:19845377 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PRRC2C mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | affects splicing | ISO | Prrc2c (Mus musculus) | 6480464 | bisphenol A affects the splicing of PRRC2C mRNA | CTD | PMID:37894381 | bisphenol A | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PRRC2C protein | CTD | PMID:34186270 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PRRC2C mRNA | CTD | PMID:34947998 | bisphenol A | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PRRC2C mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PRRC2C protein | CTD | PMID:37567409 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PRRC2C mRNA | CTD | PMID:30816183 | bisphenol A | increases methylation | ISO | Prrc2c (Mus musculus) | 6480464 | bisphenol A results in increased methylation of PRRC2C promoter | CTD | PMID:27312807 | bisphenol A | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRRC2C mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2C mRNA | CTD | PMID:28628672 | cadmium atom | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PRRC2C mRNA | CTD | PMID:35301059 | cadmium dichloride | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Cadmium Chloride results in decreased expression of PRRC2C mRNA | CTD | PMID:24982889 | cadmium dichloride | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PRRC2C mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PRRC2C protein | CTD | PMID:35688186 | chlorpyrifos | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of PRRC2C mRNA | CTD | PMID:37019170 | cisplatin | decreases phosphorylation | ISO | Prrc2c (Mus musculus) | 6480464 | Cisplatin results in decreased phosphorylation of PRRC2C protein | CTD | PMID:22006019 | cisplatin | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PRRC2C mRNA | CTD | PMID:27594783 | clobetasol | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Clobetasol results in decreased expression of PRRC2C mRNA | CTD | PMID:27462272 | copper(II) sulfate | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PRRC2C mRNA | CTD | PMID:19549813 | coumarin | affects phosphorylation | ISO | PRRC2C (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of PRRC2C protein | CTD | PMID:35688186 | coumestrol | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PRRC2C mRNA | CTD | PMID:19167446 | cyclosporin A | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PRRC2C mRNA | CTD | PMID:25562108 | cytarabine | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of PRRC2C mRNA | CTD | PMID:19194470 | dexamethasone | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRRC2C mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2C mRNA | CTD | PMID:28628672 | dextran sulfate | multiple interactions | ISO | Prrc2c (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of PRRC2C mRNA | CTD | PMID:26271895 | diarsenic trioxide | increases response to substance | ISO | PRRC2C (Homo sapiens) | 6480464 | PRRC2C protein results in increased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | dicrotophos | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | dicrotophos results in increased expression of PRRC2C mRNA | CTD | PMID:28302478 | dioxygen | increases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of PRRC2C mRNA | CTD | PMID:24205000 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PRRC2C mRNA | CTD | PMID:25152437 | diuron | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Diuron results in decreased expression of PRRC2C mRNA | CTD | PMID:35967413 | dorsomorphin | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PRRC2C mRNA | CTD | PMID:29803840 | elemental selenium | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of PRRC2C mRNA | CTD | PMID:19244175 | elemental selenium | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Selenium results in decreased expression of PRRC2C mRNA | CTD | PMID:19244175 | Enterolactone | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PRRC2C mRNA | CTD | PMID:19167446 | ethanol | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PRRC2C mRNA | CTD | PMID:29432896 | ethanol | affects splicing | ISO | Prrc2c (Mus musculus) | 6480464 | Ethanol affects the splicing of PRRC2C mRNA | CTD | PMID:30319688 | FR900359 | affects phosphorylation | ISO | PRRC2C (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PRRC2C protein | CTD | PMID:37730182 | fulvestrant | increases methylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of PRRC2C gene | CTD | PMID:31601247 | geldanamycin | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | geldanamycin results in increased expression of PRRC2C mRNA | CTD | PMID:26705709 | hydrogen peroxide | multiple interactions | ISO | Prrc2c (Mus musculus) | 6480464 | [Hydrogen Peroxide co-treated with N-(oxo-5 more ... | CTD | PMID:31494107 | indometacin | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PRRC2C mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PRRC2C mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PRRC2C protein | CTD | PMID:32959892 | kojic acid | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | kojic acid results in increased expression of PRRC2C mRNA | CTD | PMID:16595896 | methamphetamine | decreases methylation | ISO | Prrc2c (Mus musculus) | 6480464 | Methamphetamine results in decreased methylation of PRRC2C promoter | CTD | PMID:26307267 | methamphetamine | increases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Methamphetamine results in increased expression of PRRC2C mRNA | CTD | PMID:26307267 | methylmercury chloride | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PRRC2C mRNA | CTD | PMID:26272509 and PMID:28001369 | miconazole | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Miconazole results in decreased expression of PRRC2C mRNA | CTD | PMID:27462272 | mitomycin C | affects response to substance | ISO | PRRC2C (Homo sapiens) | 6480464 | PRRC2C protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | N-methyl-4-phenylpyridinium | increases expression | ISO | Prrc2c (Mus musculus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PRRC2C mRNA | CTD | PMID:17475336 | nicotine | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Nicotine results in increased expression of PRRC2C mRNA | CTD | PMID:16949557 | ozone | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PRRC2C mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | paracetamol | affects expression | ISO | Prrc2c (Mus musculus) | 6480464 | Acetaminophen affects the expression of PRRC2C mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PRRC2C mRNA | CTD | PMID:21420995 | phosphorus atom | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Phosphorus results in increased expression of PRRC2C mRNA | CTD | PMID:17715259 | phosphorus(.) | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Phosphorus results in increased expression of PRRC2C mRNA | CTD | PMID:17715259 | propiconazole | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | propiconazole results in decreased expression of PRRC2C mRNA | CTD | PMID:21278054 | quercetin | increases phosphorylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Quercetin results in increased phosphorylation of PRRC2C protein | CTD | PMID:35688186 | SB 431542 | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | selenium atom | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of PRRC2C mRNA | CTD | PMID:19244175 | selenium atom | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Selenium results in decreased expression of PRRC2C mRNA | CTD | PMID:19244175 | sodium arsenate | increases expression | ISO | Prrc2c (Mus musculus) | 6480464 | sodium arsenate results in increased expression of PRRC2C mRNA | CTD | PMID:30953684 | sodium arsenite | increases expression | ISO | Prrc2c (Mus musculus) | 6480464 | sodium arsenite results in increased expression of PRRC2C mRNA | CTD | PMID:32068019 and PMID:36209798 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of PRRC2C mRNA | CTD | PMID:19281266 | tamibarotene | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | tamibarotene results in decreased expression of PRRC2C mRNA | CTD | PMID:15498508 | testosterone enanthate | affects expression | ISO | PRRC2C (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of PRRC2C mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PRRC2C mRNA | CTD | PMID:31919559 | thimerosal | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of PRRC2C mRNA | CTD | PMID:27188386 | titanium dioxide | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PRRC2C mRNA | CTD | PMID:23557971 and PMID:29264374 | torcetrapib | increases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | torcetrapib results in increased expression of PRRC2C mRNA | CTD | PMID:23228038 | trichostatin A | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PRRC2C mRNA | CTD | PMID:26272509 | trichostatin A | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | troglitazone | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | troglitazone results in decreased expression of PRRC2C mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Prrc2c (Mus musculus) | 6480464 | Tungsten results in decreased expression of PRRC2C mRNA | CTD | PMID:30912803 | valproic acid | affects expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PRRC2C mRNA | CTD | PMID:25979313 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PRRC2C mRNA | CTD | PMID:29427782 | valproic acid | decreases methylation | ISO | PRRC2C (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PRRC2C gene | CTD | PMID:29154799 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PRRC2C mRNA | CTD | PMID:19015723 | vitamin E | multiple interactions | ISO | PRRC2C (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of PRRC2C mRNA | CTD | PMID:19244175 | vitamin E | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of PRRC2C mRNA | CTD | PMID:19244175 | vorinostat | decreases expression | ISO | PRRC2C (Homo sapiens) | 6480464 | vorinostat results in decreased expression of PRRC2C mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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