Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pinx1 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PINX1 mRNA] | CTD | PMID:31150632 | Pinx1 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Pinx1 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of PINX1 mRNA | CTD | PMID:22206623 | Pinx1 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PINX1 mRNA | CTD | PMID:32145629 | Pinx1 | Rat | 17beta-estradiol | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of PINX1 mRNA | CTD | PMID:31614463 | Pinx1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PINX1 mRNA] | CTD | PMID:15034205 | Pinx1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PINX1 mRNA | CTD | PMID:33387578 | Pinx1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pinx1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PINX1 mRNA | CTD | PMID:15034205 | Pinx1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Pinx1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PINX1 mRNA | CTD | PMID:39298647 | Pinx1 | Rat | arsenous acid | decreases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PINX1 mRNA | CTD | PMID:22944098 | Pinx1 | Rat | atrazine | decreases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PINX1 mRNA | CTD | PMID:22378314 | Pinx1 | Rat | benzo[a]pyrene | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ... | CTD | PMID:15034205|PMID:27858113 | Pinx1 | Rat | benzo[a]pyrene | affects methylation | ISO | PINX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PINX1 intron | CTD | PMID:30157460 | Pinx1 | Rat | benzo[a]pyrene | increases expression | ISO | Pinx1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PINX1 mRNA | CTD | PMID:15034205 | Pinx1 | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ... | CTD | PMID:27858113 | Pinx1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PINX1 mRNA | CTD | PMID:25181051 | Pinx1 | Rat | bisphenol A | multiple interactions | ISO | PINX1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PINX1 gene | CTD | PMID:31601247 | Pinx1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PINX1 mRNA | CTD | PMID:32145629|PMID:34947998 | Pinx1 | Rat | bisphenol F | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of PINX1 mRNA | CTD | PMID:38685157 | Pinx1 | Rat | butanal | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of PINX1 mRNA | CTD | PMID:26079696 | Pinx1 | Rat | cadmium dichloride | decreases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of PINX1 mRNA | CTD | PMID:38382870 | Pinx1 | Rat | cadmium dichloride | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of PINX1 mRNA | CTD | PMID:38568856 | Pinx1 | Rat | caffeine | decreases phosphorylation | ISO | PINX1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PINX1 protein | CTD | PMID:35688186 | Pinx1 | Rat | carbon nanotube | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of PINX1 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Pinx1 | Rat | CGP 52608 | multiple interactions | ISO | PINX1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PINX1 gene] | CTD | PMID:28238834 | Pinx1 | Rat | chrysene | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ... | CTD | PMID:27858113 | Pinx1 | Rat | cobalt dichloride | decreases expression | ISO | PINX1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PINX1 mRNA | CTD | PMID:19320972 | Pinx1 | Rat | cocaine | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | [Cocaine co-treated with FOS protein mutant form] results in decreased expression of PINX1 mRNA | CTD | PMID:18355967 | Pinx1 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of PINX1 mRNA | CTD | PMID:26577399 | Pinx1 | Rat | cypermethrin | increases expression | ISO | Pinx1 (Mus musculus) | 6480464 | cypermethrin results in increased expression of PINX1 mRNA | CTD | PMID:21142847 | Pinx1 | Rat | DDE | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of PINX1 mRNA | CTD | PMID:38568856 | Pinx1 | Rat | diarsenic trioxide | decreases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PINX1 mRNA | CTD | PMID:22944098 | Pinx1 | Rat | dibutyl phthalate | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PINX1 mRNA | CTD | PMID:17361019 | Pinx1 | Rat | dioxygen | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PINX1 mRNA | CTD | PMID:30529165 | Pinx1 | Rat | enzyme inhibitor | multiple interactions | ISO | PINX1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 | Pinx1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PINX1 mRNA | CTD | PMID:24136188 | Pinx1 | Rat | folic acid | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PINX1 mRNA | CTD | PMID:25629700 | Pinx1 | Rat | FR900359 | decreases phosphorylation | ISO | PINX1 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of PINX1 protein | CTD | PMID:37730182 | Pinx1 | Rat | fulvestrant | multiple interactions | ISO | PINX1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PINX1 gene | CTD | PMID:31601247 | Pinx1 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PINX1 mRNA | CTD | PMID:33387578 | Pinx1 | Rat | hydrogen peroxide | affects expression | ISO | PINX1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of PINX1 mRNA | CTD | PMID:20044591 | Pinx1 | Rat | methyl methanesulfonate | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PINX1 mRNA | CTD | PMID:23649840 | Pinx1 | Rat | N-methyl-N-nitrosourea | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | Methylnitrosourea results in decreased expression of PINX1 mRNA | CTD | PMID:25270620 | Pinx1 | Rat | ozone | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... | CTD | PMID:34911549 | Pinx1 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PINX1 mRNA | CTD | PMID:33387578 | Pinx1 | Rat | pentanal | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | pentanal results in increased expression of PINX1 mRNA | CTD | PMID:26079696 | Pinx1 | Rat | pirinixic acid | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PINX1 mRNA | CTD | PMID:23811191 | Pinx1 | Rat | resveratrol | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | resveratrol results in decreased expression of PINX1 protein | CTD | PMID:25505154 | Pinx1 | Rat | silicon dioxide | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of PINX1 mRNA | CTD | PMID:25895662 | Pinx1 | Rat | sodium arsenite | decreases expression | ISO | PINX1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PINX1 mRNA | CTD | PMID:38568856 | Pinx1 | Rat | sodium fluoride | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of PINX1 mRNA | CTD | PMID:27862939 | Pinx1 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PINX1 mRNA | CTD | PMID:31150632 | Pinx1 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PINX1 mRNA] | CTD | PMID:31150632 | Pinx1 | Rat | tetraphene | multiple interactions | ISO | Pinx1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of more ... | CTD | PMID:27858113 | Pinx1 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PINX1 mRNA | CTD | PMID:34492290 | Pinx1 | Rat | titanium dioxide | decreases expression | ISO | Pinx1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PINX1 mRNA | CTD | PMID:23557971 | Pinx1 | Rat | titanium dioxide | increases methylation | ISO | Pinx1 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of PINX1 promoter | CTD | PMID:35295148 | Pinx1 | Rat | valproic acid | increases expression | ISO | PINX1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PINX1 mRNA | CTD | PMID:23179753|PMID:28001369 | Pinx1 | Rat | valproic acid | decreases methylation | ISO | PINX1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PINX1 gene | CTD | PMID:29154799 | Pinx1 | Rat | valproic acid | affects expression | ISO | PINX1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PINX1 mRNA | CTD | PMID:25979313 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















