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Gene: Lurap1 (leucine rich adaptor protein 1) Rattus norvegicus

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Symbol:

Lurap1

Name:

leucine rich adaptor protein 1

RGD ID:

1566001

Description:

Involved in actomyosin structure organization and cell migration. Located in actomyosin. Orthologous to human LURAP1 (leucine rich adaptor protein 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adaptor protein LRAP35a; hypothetical protein LOC500527; leucine repeat adapter protein 35A; LOC500527; LRAP35a; Lrp35a; NF-kappa-B activator C1orf190 homolog; RGD1566001; similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LURAP1 (leucine rich adaptor protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Lurap1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lurap1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LURAP1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LURAP1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lurap1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LURAP1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LURAP1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lurap1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lurap1 (leucine rich adaptor protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LURAP1 (leucine rich adaptor protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lurap1 (leucine rich adaptor protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lurap1 (leucine rich adaptor protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lurap1 (leucine rich adaptor protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lurap1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lurap1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	134,855,643 - 134,865,366 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	134,855,224 - 134,865,459 (-)	Ensembl				GRCr8
mRatBN7.2	5	129,618,926 - 129,628,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	129,614,137 - 129,628,766 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	132,235,108 - 132,244,946 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	133,989,695 - 133,999,533 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	134,012,131 - 134,021,969 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	5	134,518,781 - 134,528,619 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	5	136,496,344 - 136,506,182 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	5	135,683,534 - 135,693,372 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	5	129,243,835 - 129,253,554 (-)	NCBI		F344_StmMcwi
Rnor_6.0	5	134,991,997 - 135,001,720 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	134,991,997 - 135,001,720 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	138,775,907 - 138,785,616 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	136,414,033 - 136,423,756 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	128,147,570 - 128,157,166 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,4'-trichlorobiphenyl (ISO)

acrylamide (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

doxorubicin (ISO)

furan (EXP)

gentamycin (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

melphalan (ISO)

methamphetamine (EXP)

nitrofen (EXP)

okadaic acid (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP)

PCB138 (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

SCH 23390 (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

thiram (ISO)

titanium dioxide (ISO)

triclosan (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actomyosin structure organization (IMP)

cell migration (IMP)

positive regulation of canonical NF-kappaB signal transduction (IBA,IEA,ISO)

positive regulation of cytokine production (IBA,ISO)

Cellular Component

actomyosin (IDA)

cytoplasm (IEA,ISO)

cytosol (ISO)

Molecular Function

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.	Tan I, etal., Cell. 2008 Oct 3;135(1):123-36. doi: 10.1016/j.cell.2008.09.018.

Additional References at PubMed

PMID:21048106

Genomics

Comparative Map Data

Lurap1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	134,855,643 - 134,865,366 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	134,855,224 - 134,865,459 (-)	Ensembl				GRCr8
mRatBN7.2	5	129,618,926 - 129,628,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	129,614,137 - 129,628,766 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	132,235,108 - 132,244,946 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	133,989,695 - 133,999,533 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	134,012,131 - 134,021,969 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	5	134,518,781 - 134,528,619 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	5	136,496,344 - 136,506,182 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	5	135,683,534 - 135,693,372 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	5	129,243,835 - 129,253,554 (-)	NCBI		F344_StmMcwi
Rnor_6.0	5	134,991,997 - 135,001,720 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	134,991,997 - 135,001,720 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	138,775,907 - 138,785,616 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	136,414,033 - 136,423,756 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	128,147,570 - 128,157,166 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

LURAP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	46,203,334 - 46,221,256 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	46,203,334 - 46,221,256 (+)	Ensembl			hg38	GRCh38
GRCh37	1	46,669,006 - 46,686,928 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	46,441,593 - 46,459,746 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	44,956,745 - 44,974,672 (+)	NCBI		Celera
Cytogenetic Map	1	p34.1	NCBI
HuRef	1	44,783,996 - 44,802,228 (+)	NCBI		HuRef
CHM1_1	1	46,786,144 - 46,804,069 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	46,075,666 - 46,098,473 (+)	NCBI		T2T-CHM13v2.0

Lurap1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	115,993,925 - 116,001,813 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	115,989,603 - 116,008,535 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	116,136,728 - 116,144,616 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	116,132,406 - 116,151,338 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	115,809,333 - 115,817,221 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	115,634,623 - 115,642,548 (-)	NCBI		MGSCv36	mm8
Celera	4	114,874,876 - 114,882,764 (-)	NCBI		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	53.1	NCBI

Lurap1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	12,056,588 - 12,072,266 (-)	Ensembl
ChiLan1.0	NW_004955464	12,056,588 - 12,072,266 (-)	NCBI	ChiLan1.0	ChiLan1.0

LURAP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	180,577,178 - 180,602,346 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	179,718,777 - 179,743,933 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	45,508,798 - 45,527,340 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	46,864,060 - 46,881,670 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	46,864,060 - 46,881,670 (+)	Ensembl			panPan2	panpan1.1

LURAP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	14,156,338 - 14,178,882 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	14,162,087 - 14,173,488 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	14,279,120 - 14,300,752 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	14,309,418 - 14,331,200 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	14,312,749 - 14,325,887 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	14,110,679 - 14,132,274 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	14,179,166 - 14,200,756 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	14,248,643 - 14,270,390 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lurap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	61,417,344 - 61,432,579 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	27,242,077 - 27,252,695 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	27,241,666 - 27,254,405 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LURAP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	165,188,925 - 165,207,730 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	165,187,707 - 165,208,191 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	152,674,047 - 152,687,490 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LURAP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	86,566,427 - 86,583,741 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	86,566,551 - 86,583,175 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	30,403,324 - 30,421,671 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lurap1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624906	2,133,747 - 2,150,860 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lurap1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	39,819,743 - 39,828,867 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lurap1
152 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	198
Count of miRNA genes:	132
Interacting mature miRNAs:	149
Transcripts:	ENSRNOT00000035348
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	130678987	145274255	Rat
7365049	Bp359	Blood pressure QTL 359			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133308734	140009902	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

36.MMHAP9FRD12.seq

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	129,625,990 - 129,626,164 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	134,999,060 - 134,999,233	NCBI	Rnor6.0
Rnor_5.0	5	138,782,956 - 138,783,129	UniSTS	Rnor5.0
RGSC_v3.4	5	136,421,096 - 136,421,269	UniSTS	RGSC3.4
Celera	5	128,154,506 - 128,154,679	UniSTS
Cytogenetic Map	5	q36	UniSTS

BE107967

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	129,619,479 - 129,619,652 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	134,992,551 - 134,992,723	NCBI	Rnor6.0
Rnor_5.0	5	138,776,461 - 138,776,633	UniSTS	Rnor5.0
RGSC_v3.4	5	136,414,587 - 136,414,759	UniSTS	RGSC3.4
Celera	5	128,148,124 - 128,148,296	UniSTS
RH 3.4 Map	5	834.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	32	59	6	293	132	11	139	78	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000035348 ⟹ ENSRNOP00000030673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	134,991,997 - 135,001,720 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102751 ⟹ ENSRNOP00000077115

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	129,614,137 - 129,625,330 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119550 ⟹ ENSRNOP00000088699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	129,614,137 - 129,628,766 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000153961 ⟹ ENSRNOP00000100156

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	134,855,224 - 134,865,386 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000162896 ⟹ ENSRNOP00000099496

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	134,855,224 - 134,865,459 (-)	Ensembl

RefSeq Acc Id:

NM_001109263 ⟹ NP_001102733

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	134,855,643 - 134,865,366 (-)	NCBI
mRatBN7.2	5	129,618,926 - 129,628,651 (-)	NCBI
Dahl_SR_JrHsd	5	134,518,781 - 134,528,619 (-)	NCBI
Lyon_Normotensive	5	136,496,344 - 136,506,182 (-)	NCBI
Lyon_Hypertensive	5	135,683,534 - 135,693,372 (-)	NCBI
F344_StmMcwi	5	129,243,835 - 129,253,554 (-)	NCBI
Rnor_6.0	5	134,991,997 - 135,001,720 (-)	NCBI
Rnor_5.0	5	138,775,907 - 138,785,616 (-)	NCBI
RGSC_v3.4	5	136,414,033 - 136,423,756 (-)	RGD
Celera	5	128,147,570 - 128,157,166 (-)	RGD

Sequence:

show sequence

GGGGCGGGCGGGGATCCACGGGTTTCGCTCGGCGTTCGTAGCAGAGAAGAGAGGACCCTTGGGA
ACCCGACCCTGGTCGCCCAGTTCTGTTCTGGCTTGGGCCCACATGGAGGGGACCGCGGAGTCCC
AGACGCCTGACTTACGAGACGTGGAGGGCAAGGTGGGCAGGAAGACCCCCGAAGGACTGCTCCG
CGGGCTCCGAGGCGAGTGCGATCTGGGAACCTCTGGGGATGTGCTGCTCCCGGGGGCTTCCAGC
ACTGGCCACGGCCTAGGGGACAAGATCATGGCGCTGAGGATGGAGCTGGCTTACCTGCGAGCCA
TCGATGTGAAGATTCTGCAGCAGCTGGTGACCTTGAATGAGGGAATTGAGGCAGTGCGCTGGCT
GCTGGAGGAGCGGGGGACACTGACCAGCCATTGCAGCAGTCTCACCAGCAGTCAGTATAGTCTG
ACAGGGGGAAGCCCAGAACGCTCAAGGCGGGGCAGTTGGGACAGCCTGCCAGATACCAGTTCAA
CTGACCGGCTGGACAGTGTCTCTATTGGCAGCTTCTTGGACACGGTGGCCCCCAGAGAGCTGGA
TGAACAAGGACACCCTGGGCCTTCCTGTCCTGAGATTGACTGGGCAAAGGTTATACCCAGTGAG
GACAGGGCCAGGACTGAGGTGGACATGACATCCACCAAGCTAGGGAGCCTAACAGCTACATGGA
AACTTCCAGGGGACGGGCTCCAATGTGGACCACCTGAGCCATCAGAAGATGACAGTGCTAAGCA
GGGCTTTGAGGCTCATTGGTACTGGGGACAGTGCCAGGATGATGTGACCTTCTTGTAAAAACTT
TCCTACCCATTTGCACTTTGTGGCTCTTTCAAATTTTGGCCCAAGTCTCCCTCAATTTTCTCTC
CACCTCCAACTAGACGGGGGCTGGAGGCTGTACTACAATCAGTTACCATGGAAGCCTGGCTTAT
CTCTCTGGTTCCTGGGGAGCCTCTGCATTTATCCCTCAATTATTAGGTCCCTAAGGCTATCTCC
ATAGAGATATTGACTCTAGAGGCCTAGCCTGTGGCTCCTGATGTAAGGCTATCTCCATTCCCCT
CCCCAGTGAGGTGAGTTTTATGGAATGTAGGGCCTCTAGGAGATCACTGAGGAAGAGATCTCAT
CAAAGCTTAGGAGCCAGGAATGCCTCTTACCAAAAAAATGGAGAATTGACCCTGTTTCAAAATG
CTCAAACCCCCAAGGATTGGTCCGCCTAGATACCTTTGGAGTTGGGAGACCAACCCTTTCATGC
CTGCTGGGTGATGTCGTTTCTTGTCATGATACATGAAGAGTGCTTCCTCTATACCAGTCCTGGT
GGGTTTGGCATTTAAAGTCCCTGCCACTGCCTCTTGTGAGAAGGAACATGTCGTTCTTCCTGGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102733	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D4A8G3	(Get FASTA)	NCBI Sequence Viewer
	EDL90291	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000100156

RefSeq Acc Id:

NP_001102733 ⟸ NM_001109263

- UniProtKB:

D4A8G3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEGTAESQTPDLRDVEGKVGRKTPEGLLRGLRGECDLGTSGDVLLPGASSTGHGLGDKIMALRM
ELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPERSRRGSWD
SLPDTSSTDRLDSVSIGSFLDTVAPRELDEQGHPGPSCPEIDWAKVIPSEDRARTEVDMTSTKL
GSLTATWKLPGDGLQCGPPEPSEDDSAKQGFEAHWYWGQCQDDVTFL

hide sequence

Ensembl Acc Id:

ENSRNOP00000030673 ⟸ ENSRNOT00000035348

Ensembl Acc Id:

ENSRNOP00000088699 ⟸ ENSRNOT00000119550

Ensembl Acc Id:

ENSRNOP00000077115 ⟸ ENSRNOT00000102751

Ensembl Acc Id:

ENSRNOP00000099496 ⟸ ENSRNOT00000162896

Ensembl Acc Id:

ENSRNOP00000100156 ⟸ ENSRNOT00000153961

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A8G3-F1-model_v2	AlphaFold	D4A8G3	1-239	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693929

Promoter ID:

EPDNEW_R4454

Type:

single initiation site

Name:

Lurap1_1

Description:

leucine rich adaptor protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	135,001,694 - 135,001,754	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566001	AgrOrtholog
BioCyc Gene	G2FUF-40264	BioCyc
Ensembl Genes	ENSRNOG00000023459	Ensembl
	ENSRNOG00000062943	Ensembl
	ENSRNOG00000085055	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000153961	ENTREZGENE
InterPro	LURA1/LRA25	UniProtKB/Swiss-Prot
	LURAP1	UniProtKB/Swiss-Prot
KEGG Report	rno:500527	UniProtKB/Swiss-Prot
NCBI Gene	500527	ENTREZGENE
PANTHER	LEUCINE RICH ADAPTOR PROTEIN 1	UniProtKB/Swiss-Prot
	PTHR33767	UniProtKB/Swiss-Prot
Pfam	LURAP	UniProtKB/Swiss-Prot
PhenoGen	Lurap1	PhenoGen
RatGTEx	ENSRNOG00000023459	RatGTEx
	ENSRNOG00000062943	RatGTEx
	ENSRNOG00000085055	RatGTEx
UniProt	A0ABK0KXM3_RAT	UniProtKB/TrEMBL
	A0ABK0KYN3_RAT	UniProtKB/TrEMBL
	D4A8G3	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-12	Lurap1	leucine rich adaptor protein 1	RGD1566001	similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1566001	similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed	RGD1566001_predicted	similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1566001_predicted	similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed (predicted)	LOC500527	similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500527	similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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