C1ql4 (complement C1q like 4) - Rat Genome Database

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Gene: C1ql4 (complement C1q like 4) Rattus norvegicus
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Symbol: C1ql4
Name: complement C1q like 4
RGD ID: 1565968
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. Orthologous to human C1QL4 (complement C1q like 4); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adik; adiponectin k; complement C1q-like protein 4; complement component 1, q subcomponent-like 4; LOC300220; RGD1565968; similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,122,537 - 132,125,609 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7132,122,537 - 132,125,609 (-)EnsemblGRCr8
mRatBN7.27130,243,606 - 130,246,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,243,606 - 130,246,678 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7132,053,810 - 132,056,883 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,279,384 - 134,282,457 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,191,891 - 134,194,964 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,766,517 - 140,771,415 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,767,737 - 140,770,647 (-)Ensemblrn6Rnor6.0
Rnor_5.0X115,271,464 - 115,276,272 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47137,861,471 - 137,864,381 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7126,728,345 - 126,731,417 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23449976  


Genomics

Comparative Map Data
C1ql4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,122,537 - 132,125,609 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7132,122,537 - 132,125,609 (-)EnsemblGRCr8
mRatBN7.27130,243,606 - 130,246,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,243,606 - 130,246,678 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7132,053,810 - 132,056,883 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,279,384 - 134,282,457 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,191,891 - 134,194,964 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,766,517 - 140,771,415 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,767,737 - 140,770,647 (-)Ensemblrn6Rnor6.0
Rnor_5.0X115,271,464 - 115,276,272 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47137,861,471 - 137,864,381 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7126,728,345 - 126,731,417 (-)NCBICelera
Cytogenetic Map7q36NCBI
C1QL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,332,409 - 49,337,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,332,409 - 49,337,188 (-)Ensemblhg38GRCh38
GRCh371249,726,192 - 49,730,971 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,012,467 - 48,017,238 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1248,519,505 - 48,524,276 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,756,631 - 46,761,375 (-)NCBIHuRef
CHM1_11249,691,897 - 49,696,668 (-)NCBICHM1_1
T2T-CHM13v2.01249,294,599 - 49,299,378 (-)NCBIT2T-CHM13v2.0
C1ql4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,981,967 - 98,988,555 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,981,967 - 98,985,698 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381599,084,086 - 99,090,674 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,084,086 - 99,087,817 (-)Ensemblmm10GRCm38
MGSCv371598,915,185 - 98,918,159 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361598,912,788 - 98,915,762 (-)NCBIMGSCv36mm8
Celera15101,239,028 - 101,242,002 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1555.84NCBI
C1QL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,848,114 - 44,852,902 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,844,875 - 44,849,663 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,414,635 - 39,419,422 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,301,076 - 40,304,503 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,301,076 - 40,304,503 (+)EnsemblpanPan2panpan1.1
C1QL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,278,347 - 5,281,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,278,360 - 5,281,841 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2740,974,923 - 40,978,405 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0275,329,710 - 5,333,186 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,329,725 - 5,333,200 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,295,089 - 5,298,570 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,284,610 - 5,288,086 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,368,031 - 41,371,513 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
C1ql4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,071,440 - 66,077,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,087,110 - 7,091,343 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,087,116 - 7,091,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1QL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,308,210 - 15,311,915 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1515,308,307 - 15,311,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,714,740 - 15,718,176 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C1QL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,560,805 - 45,569,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,561,448 - 45,564,888 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037200,562,838 - 200,567,730 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C1ql4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,849,484 - 2,853,069 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248162,848,774 - 2,853,070 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
C1ql4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11271,911,863 - 271,916,066 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C1ql4
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:52
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000003152
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 1 17 96 27 30 20 22 20 1 143 42 93 71 46 10 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000081784   ⟹   ENSRNOP00000069930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7132,122,537 - 132,125,609 (-)Ensembl
mRatBN7.2 Ensembl7130,243,606 - 130,246,678 (-)Ensembl
Rnor_6.0 Ensembl7140,767,737 - 140,770,647 (-)Ensembl
RefSeq Acc Id: NM_001271242   ⟹   NP_001258171
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,122,537 - 132,125,609 (-)NCBI
mRatBN7.27130,243,606 - 130,246,678 (-)NCBI
Rnor_6.07140,767,664 - 140,770,736 (-)NCBI
Rnor_5.0X115,271,464 - 115,276,272 (-)NCBI
Celera7126,728,345 - 126,731,417 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258171 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87002 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069930
  ENSRNOP00000069930.1
GenBank Protein SOR70295 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258171   ⟸   NM_001271242
- Peptide Label: precursor
- UniProtKB: D3ZMN4 (UniProtKB/TrEMBL),   A6KCE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069930   ⟸   ENSRNOT00000081784
Protein Domains
C1q

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMN4-F1-model_v2 AlphaFold D3ZMN4 1-238 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565968 AgrOrtholog
BioCyc Gene G2FUF-32086 BioCyc
Ensembl Genes ENSRNOG00000060020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081784 ENTREZGENE
  ENSRNOT00000081784.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro C1q UniProtKB/TrEMBL
  Cerebellin_Synaptic_Org UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
KEGG Report rno:300220 UniProtKB/TrEMBL
NCBI Gene 300220 ENTREZGENE
PANTHER CEREBELLIN-RELATED UniProtKB/TrEMBL
  COMPLEMENT C1Q-LIKE PROTEIN 4 UniProtKB/TrEMBL
Pfam C1q UniProtKB/TrEMBL
PhenoGen C1ql4 PhenoGen
PRINTS COMPLEMNTC1Q UniProtKB/TrEMBL
PROSITE C1Q UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060020 RatGTEx
SMART C1Q UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A6KCE0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMN4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 C1ql4  complement C1q like 4  C1ql4  complement component 1, q subcomponent-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 C1ql4  complement component 1, q subcomponent-like 4   C1ql4_predicted  complement component 1, q subcomponent-like 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 C1ql4_predicted  complement component 1, q subcomponent-like 4 (predicted)  RGD1565968_predicted  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1) (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-10 RGD1565968_predicted  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1) (predicted)      Name updated 1299863 APPROVED
2006-03-07 RGD1565968_predicted  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1) (predicted)  LOC300220  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300220  similar to C1q-related factor precursor (Complement component 1 Q subcomponent-like 1)      Symbol and Name status set to provisional 70820 PROVISIONAL