Acot5 (acyl-CoA thioesterase 5) - Rat Genome Database

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Gene: Acot5 (acyl-CoA thioesterase 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Acot5
Name: acyl-CoA thioesterase 5
RGD ID: 1565917
Description: Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Orthologous to human ACOT2 (acyl-CoA thioesterase 2); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyl-coenzyme A thioesterase 5; LOC503049; MGC156788; RGD1565917; similar to peroxisomal acyl-CoA thioesterase Ic
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Acot5-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,433,062 - 109,439,846 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6109,453,391 - 109,461,035 (-)EnsemblGRCr8
GRCr8 Ensembl6109,433,062 - 109,439,846 (+)EnsemblGRCr8
mRatBN7.26103,701,908 - 103,708,696 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6103,723,326 - 103,729,482 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl6103,701,908 - 103,708,696 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6103,863,706 - 103,870,504 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,162,924 - 104,169,722 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,532,373 - 103,539,171 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06107,550,904 - 107,557,688 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6107,550,904 - 107,557,688 (+)Ensemblrn6Rnor6.0
Rnor_5.06117,987,407 - 117,994,244 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46108,114,686 - 108,122,769 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6101,530,218 - 101,537,087 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Acot5
95 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:18
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000013760
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 4 7 111 81 76 59 9 59 4 179 34 2 94 69 60 17 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000013760   ⟹   ENSRNOP00000013760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6109,433,062 - 109,439,846 (+)Ensembl
mRatBN7.2 Ensembl6103,701,908 - 103,708,696 (+)Ensembl
Rnor_6.0 Ensembl6107,550,904 - 107,557,688 (+)Ensembl
RefSeq Acc Id: NM_001079709   ⟹   NP_001073177
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,433,062 - 109,439,846 (+)NCBI
mRatBN7.26103,701,908 - 103,708,696 (+)NCBI
Rnor_6.06107,550,904 - 107,557,688 (+)NCBI
Rnor_5.06117,987,407 - 117,994,244 (-)NCBI
RGSC_v3.46108,114,686 - 108,122,769 (+)RGD
Celera6101,530,218 - 101,537,087 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001073177 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI28771 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013760
  ENSRNOP00000013760.3
  ENSRNOP00000073103.3
RefSeq Acc Id: NP_001073177   ⟸   NM_001079709
- UniProtKB: A1A5R4 (UniProtKB/TrEMBL),   A0A0G2K4M8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013760   ⟸   ENSRNOT00000013760
Protein Domains
Acyl-CoA thioester hydrolase/bile acid-CoA amino   BAAT/Acyl-CoA thioester hydrolase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1A5R4-F1-model_v2 AlphaFold A1A5R4 1-421 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694718
Promoter ID:EPDNEW_R5242
Type:multiple initiation site
Name:Acot5_1
Description:acyl-CoA thioesterase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06107,551,272 - 107,551,332EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565917 AgrOrtholog
BioCyc Gene G2FUF-36842 BioCyc
BioCyc Pathway PWY-5148 [acyl-CoA hydrolysis] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-5996 [oleate biosynthesis II (animals and fungi)] BioCyc
  PWY-8042 [acylceramide biosynthesis] BioCyc
  PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)] BioCyc
BioCyc Pathway Image PWY-5148 BioCyc
  PWY-5972 BioCyc
  PWY-5996 BioCyc
  PWY-8042 BioCyc
  PWY3O-1801 BioCyc
Ensembl Genes ENSRNOG00000032508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000053460 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013760 ENTREZGENE
  ENSRNOT00000013760.6 UniProtKB/TrEMBL
  ENSRNOT00000077555.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2240 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127435 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/TrEMBL
  Acyl-CoA_thioEstase_long-chain UniProtKB/TrEMBL
  BAAT_C UniProtKB/TrEMBL
  Thio_Ohase/aa_AcTrfase UniProtKB/TrEMBL
  Thio_Ohase/BAAT_N UniProtKB/TrEMBL
KEGG Report rno:503049 UniProtKB/TrEMBL
MGC_CLONE MGC:156788 IMAGE-MGC_LOAD
NCBI Gene 503049 ENTREZGENE
PANTHER ACYL-COENZYME A THIOESTERASE 5 UniProtKB/TrEMBL
  ACYL-COENZYME A THIOESTERASE-RELATED UniProtKB/TrEMBL
Pfam BAAT_C UniProtKB/TrEMBL
  Bile_Hydr_Trans UniProtKB/TrEMBL
PhenoGen Acot5 PhenoGen
PIRSF Acyl-CoA_hydro UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032508 RatGTEx
  ENSRNOG00000053460 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A0G2K4M8 ENTREZGENE, UniProtKB/TrEMBL
  A1A5R4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Acot5  acyl-CoA thioesterase 5  RGD1565917_predicted  similar to peroxisomal acyl-CoA thioesterase Ic (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565917_predicted  similar to peroxisomal acyl-CoA thioesterase Ic (predicted)  LOC503049  similar to peroxisomal acyl-CoA thioesterase Ic  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503049  similar to peroxisomal acyl-CoA thioesterase Ic      Symbol and Name status set to provisional 70820 PROVISIONAL