Fam222a (family with sequence similarity 222, member A) - Rat Genome Database

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Pathways
Gene: Fam222a (family with sequence similarity 222, member A) Rattus norvegicus
Analyze
Symbol: Fam222a
Name: family with sequence similarity 222, member A
RGD ID: 1565883
Description: Orthologous to human FAM222A (family with sequence similarity 222 member A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC498193; LOC498193; RGD1565883; similar to hypothetical protein FLJ14721; uncharacterized protein LOC498193
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,647,221 - 47,693,703 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1247,647,405 - 47,693,703 (-)EnsemblGRCr8
mRatBN7.21241,982,064 - 42,033,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,986,780 - 42,033,682 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,155,111 - 43,200,387 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,768,690 - 43,813,963 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,829,191 - 42,874,470 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,742,449 - 47,793,534 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,748,165 - 47,793,534 (-)Ensemblrn6Rnor6.0
Rnor_5.01249,534,079 - 49,585,147 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41243,276,320 - 43,295,293 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1243,600,279 - 43,645,537 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fam222a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,647,221 - 47,693,703 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1247,647,405 - 47,693,703 (-)EnsemblGRCr8
mRatBN7.21241,982,064 - 42,033,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,986,780 - 42,033,682 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,155,111 - 43,200,387 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,768,690 - 43,813,963 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,829,191 - 42,874,470 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,742,449 - 47,793,534 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,748,165 - 47,793,534 (-)Ensemblrn6Rnor6.0
Rnor_5.01249,534,079 - 49,585,147 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41243,276,320 - 43,295,293 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1243,600,279 - 43,645,537 (-)NCBICelera
Cytogenetic Map12q16NCBI
FAM222A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,713,825 - 109,770,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,713,825 - 109,770,495 (+)Ensemblhg38GRCh38
GRCh3712110,151,630 - 110,208,300 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,656,955 - 108,692,682 (+)NCBIBuild 36Build 36hg18NCBI36
Celera12109,776,479 - 109,832,599 (+)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,168,401 - 107,224,456 (+)NCBIHuRef
CHM1_112110,119,970 - 110,176,122 (+)NCBICHM1_1
T2T-CHM13v2.012109,689,278 - 109,745,953 (+)NCBIT2T-CHM13v2.0
Fam222a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,706,312 - 114,751,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,706,077 - 114,751,281 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385114,568,251 - 114,613,220 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,568,016 - 114,613,220 (+)Ensemblmm10GRCm38
MGSCv375115,018,260 - 115,063,227 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365114,829,250 - 114,874,217 (+)NCBIMGSCv36mm8
Celera5111,665,314 - 111,710,745 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Fam222a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,791,240 - 8,834,997 (-)Ensembl
ChiLan1.0NW_0049554558,789,064 - 8,844,080 (-)NCBIChiLan1.0ChiLan1.0
FAM222A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,780,720 - 117,837,382 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,777,122 - 117,833,786 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,289,765 - 107,346,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,685,500 - 110,741,651 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,685,500 - 110,741,651 (+)EnsemblpanPan2panpan1.1
FAM222A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,342,414 - 17,373,775 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,340,855 - 17,366,475 (-)EnsemblcanFam3CanFam3.1
CanFam3.1 Ensembl2617,340,855 - 17,366,475 (-)NCBIcanFam3CanFam3.1
Dog10K_Boxer_Tasha2618,407,238 - 18,462,863 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02617,682,797 - 17,738,158 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2617,684,110 - 17,715,390 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,616,387 - 18,671,948 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,673,679 - 17,730,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,690,986 - 17,746,637 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fam222a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,059,210 - 144,081,204 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367691,394,734 - 1,415,521 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367691,369,062 - 1,416,684 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM222A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,177,355 - 41,233,331 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11441,177,331 - 41,233,859 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,693,114 - 43,749,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM222A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111104,950,072 - 105,007,173 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11104,950,904 - 105,005,947 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037140,112,308 - 140,169,230 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam222a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,696,158 - 10,740,844 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474710,696,173 - 10,746,027 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fam222a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11639,339,384 - 39,384,342 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:88
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000001588
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 160 91 90 59 84 59 6 344 182 11 139 79 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000001588   ⟹   ENSRNOP00000001588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1247,647,405 - 47,693,703 (-)Ensembl
mRatBN7.2 Ensembl1241,986,780 - 42,033,085 (-)Ensembl
Rnor_6.0 Ensembl1247,748,165 - 47,793,534 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095969   ⟹   ENSRNOP00000089749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1247,647,405 - 47,672,381 (-)Ensembl
mRatBN7.2 Ensembl1241,986,780 - 42,033,682 (-)Ensembl
RefSeq Acc Id: NM_001109067   ⟹   NP_001102537
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,648,406 - 47,693,703 (-)NCBI
mRatBN7.21241,987,780 - 42,033,085 (-)NCBI
Rnor_6.01247,748,165 - 47,793,534 (-)NCBI
Rnor_5.01249,534,079 - 49,585,147 (-)NCBI
RGSC_v3.41243,276,320 - 43,295,293 (-)RGD
Celera1243,600,279 - 43,645,537 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769352   ⟹   XP_008767574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,647,221 - 47,672,994 (-)NCBI
mRatBN7.21241,982,064 - 42,012,378 (-)NCBI
Rnor_6.01247,742,449 - 47,772,798 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598444   ⟹   XP_017453933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,647,221 - 47,690,018 (-)NCBI
mRatBN7.21241,982,064 - 42,031,002 (-)NCBI
Rnor_6.01247,742,449 - 47,791,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089709   ⟹   XP_038945637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,647,221 - 47,672,336 (-)NCBI
mRatBN7.21241,982,064 - 42,006,758 (-)NCBI
RefSeq Acc Id: XM_063271598   ⟹   XP_063127668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,647,221 - 47,672,329 (-)NCBI
RefSeq Acc Id: XM_063271599   ⟹   XP_063127669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,647,221 - 47,691,492 (-)NCBI
RefSeq Acc Id: NP_001102537   ⟸   NM_001109067
- UniProtKB: D3ZY38 (UniProtKB/TrEMBL),   A6J1Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767574   ⟸   XM_008769352
- Peptide Label: isoform X3
- UniProtKB: D3ZY38 (UniProtKB/TrEMBL),   A6J1Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453933   ⟸   XM_017598444
- Peptide Label: isoform X3
- UniProtKB: D3ZY38 (UniProtKB/TrEMBL),   A6J1Z5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001588   ⟸   ENSRNOT00000001588
RefSeq Acc Id: XP_038945637   ⟸   XM_039089709
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALN9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089749   ⟸   ENSRNOT00000095969
RefSeq Acc Id: XP_063127669   ⟸   XM_063271599
- Peptide Label: isoform X3
- UniProtKB: A6J1Z5 (UniProtKB/TrEMBL),   D3ZY38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127668   ⟸   XM_063271598
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZY38-F1-model_v2 AlphaFold D3ZY38 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565883 AgrOrtholog
BioCyc Gene G2FUF-18951 BioCyc
Ensembl Genes ENSRNOG00000001198 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001588 ENTREZGENE
  ENSRNOT00000001588.6 UniProtKB/TrEMBL
  ENSRNOT00000095969 ENTREZGENE
  ENSRNOT00000095969.2 UniProtKB/TrEMBL
InterPro FAM222 UniProtKB/TrEMBL
KEGG Report rno:498193 UniProtKB/TrEMBL
NCBI Gene 498193 ENTREZGENE
PANTHER PROTEIN FAM222A UniProtKB/TrEMBL
  PTHR16070 UniProtKB/TrEMBL
Pfam FAM222A UniProtKB/TrEMBL
PhenoGen Fam222a PhenoGen
RatGTEx ENSRNOG00000001198 RatGTEx
UniProt A0A8I6ALN9 ENTREZGENE, UniProtKB/TrEMBL
  A6J1Z5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZY38 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-12 Fam222a  family with sequence similarity 222, member A  RGD1565883  similar to hypothetical protein FLJ14721  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565883  similar to hypothetical protein FLJ14721   RGD1565883_predicted  similar to hypothetical protein FLJ14721 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565883_predicted  similar to hypothetical protein FLJ14721 (predicted)  LOC498193  similar to hypothetical protein FLJ14721  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498193  similar to hypothetical protein FLJ14721      Symbol and Name status set to provisional 70820 PROVISIONAL