Ifgga2l2 (interferon-gamma-inducible GTPase 2 like 2) - Rat Genome Database

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Gene: Ifgga2l2 (interferon-gamma-inducible GTPase 2 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ifgga2l2
Name: interferon-gamma-inducible GTPase 2 like 2
RGD ID: 1565797
Description: Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly; cellular response to interferon-beta; and innate immune response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498873; Ifgga5; interferon-gamma-inducible GTPase Ifgga5 protein; MGC105567; similar to cDNA sequence BC023105; uncharacterized protein LOC498873
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,141,281 - 56,160,578 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1856,141,275 - 56,160,722 (+)EnsemblGRCr8
mRatBN7.21853,870,838 - 53,890,135 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1853,870,795 - 53,892,024 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1855,959,400 - 55,978,251 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01856,674,003 - 56,692,854 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01854,494,773 - 54,514,070 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1855,590,155 - 55,609,452 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1855,830,628 - 55,849,925 (+)NCBILyon_Normotensive
Lyon_Hypertensive1856,015,219 - 56,034,516 (+)NCBILyon_Hypertensive
F344_StmMcwi1855,612,645 - 55,631,496 (+)NCBIF344_StmMcwi
Rnor_6.01855,685,613 - 55,704,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1855,685,613 - 55,704,904 (+)Ensemblrn6Rnor6.0
Rnor_5.01854,920,890 - 54,939,120 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41856,363,025 - 56,383,507 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1852,027,248 - 52,045,070 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Ifgga2l2
190 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:52
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000040116
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 62 158 91 90 59 91 59 6 349 186 11 137 80 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000040116   ⟹   ENSRNOP00000049730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1856,141,336 - 56,160,722 (+)Ensembl
mRatBN7.2 Ensembl1853,870,795 - 53,892,024 (+)Ensembl
Rnor_6.0 Ensembl1855,685,613 - 55,704,904 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159028   ⟹   ENSRNOP00000107907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1856,141,275 - 56,160,571 (+)Ensembl
RefSeq Acc Id: NM_001024284   ⟹   NP_001019455
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,141,281 - 56,160,578 (+)NCBI
mRatBN7.21853,870,838 - 53,890,135 (+)NCBI
Dahl_SR_JrHsd1855,590,155 - 55,609,452 (+)NCBI
Lyon_Normotensive1855,830,628 - 55,849,925 (+)NCBI
Lyon_Hypertensive1856,015,219 - 56,034,516 (+)NCBI
F344_StmMcwi1855,612,645 - 55,631,496 (+)NCBI
Rnor_6.01855,685,613 - 55,704,910 (+)NCBI
Rnor_5.01854,920,890 - 54,939,120 (+)NCBI
RGSC_v3.41856,363,025 - 56,383,507 (+)RGD
Celera1852,027,248 - 52,045,070 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001019455 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH93614 (Get FASTA)   NCBI Sequence Viewer  
  CBY66003 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049730
  ENSRNOP00000049730.3
  ENSRNOP00000107907.1
RefSeq Acc Id: NP_001019455   ⟸   NM_001024284
- UniProtKB: Q566C9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049730   ⟸   ENSRNOT00000040116
Ensembl Acc Id: ENSRNOP00000107907   ⟸   ENSRNOT00000159028
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q566C9-F1-model_v2 AlphaFold Q566C9 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700801
Promoter ID:EPDNEW_R11324
Type:initiation region
Name:MGC105567_1
Description:similar to cDNA sequence BC023105
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01855,685,596 - 55,685,656EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565797 AgrOrtholog
BioCyc Gene G2FUF-7367 BioCyc
Ensembl Genes ENSRNOG00000038955 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040116 ENTREZGENE
  ENSRNOT00000040116.7 UniProtKB/TrEMBL
  ENSRNOT00000159028.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7309663 IMAGE-MGC_LOAD
InterPro G_IRG_dom UniProtKB/TrEMBL
  Interferon-inducible_GTPase UniProtKB/TrEMBL
  IRG UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:498873 UniProtKB/TrEMBL
MGC_CLONE MGC:105567 IMAGE-MGC_LOAD
NCBI Gene 498873 ENTREZGENE
PANTHER INTERFERON-GAMMA-INDUCIBLE GTPASE IFGGA3 PROTEIN-RELATED UniProtKB/TrEMBL
  INTERFERON-INDUCIBLE GTPASE UniProtKB/TrEMBL
Pfam IIGP UniProtKB/TrEMBL
PhenoGen Ifgga2l2 PhenoGen
PROSITE G_IRG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038955 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt Q566C9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ifgga2l2  interferon-gamma-inducible GTPase 2 like 2  MGC105567  similar to cDNA sequence BC023105  Symbol and Name Changed 1299863 APPROVED
2006-02-09 MGC105567  similar to cDNA sequence BC023105      Symbol and Name status set to provisional 70820 PROVISIONAL