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Gene: Actr3b (actin related protein 3B) Rattus norvegicus

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Symbol:

Actr3b

Name:

actin related protein 3B

RGD ID:

1565759

Description:

Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Predicted to be located in cytoplasm; cytoskeleton; and lamellipodium. Orthologous to several human genes including ACTR3B (actin related protein 3B); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

actin-related protein 3B; actin-related protein 3B-like; ARP3 actin related protein 3 homolog B; ARP3 actin-related protein 3 homolog B; ARP3 actin-related protein 3 homolog B (yeast); LOC100910079; LOC362298; RGD1565759; similar to actin-related protein 3-beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACTR3B (actin related protein 3B)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Actr3b (ARP3 actin-related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Actr3b (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACTR3B (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACTR3B (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Actr3b (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACTR3B (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACTR3B (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Actr3b (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Actr3b (actin related protein 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ACTR3C (actin related protein 3C)	HGNC	Ensembl, Treefam
Homo sapiens (human):	ACTR3 (actin related protein 3)	HGNC	EggNOG
Alliance orthologs ³
Mus musculus (house mouse):	Actr3b (ARP3 actin-related protein 3B)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Actr3b (ARP3 actin-related protein 3B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACTR3B (actin related protein 3B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA\|OrthoFinder\|PANTHER)
Homo sapiens (human):	ACTR3B (actin related protein 3B)	Alliance	DIOPT (HGNC\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACTR3C (actin related protein 3C)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	actr3b (actin related protein 3B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	actr3b (actin related protein 3B)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ARP3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Arp3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Arp3	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	arx-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	arx-1	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	9,995,553 - 10,089,422 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	9,996,155 - 10,089,553 (-)	Ensembl				GRCr8
mRatBN7.2	4	9,261,631 - 9,355,496 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	9,262,233 - 9,355,441 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	14,258,894 - 14,353,572 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	10,073,170 - 10,167,844 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	8,429,951 - 8,518,857 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	5,644,287 - 5,672,708 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	5,644,260 - 5,672,708 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	4	5,721,261 - 5,773,301 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	5,668,162 - 5,696,597 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	4,654,603 - 4,747,545 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	963,948 - 1,056,011 (+)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (EXP)

aflatoxin B1 (ISO)

amiodarone (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

bleomycin A2 (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

CU-O LINKAGE (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

diuron (EXP)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

fulvestrant (ISO)

glyphosate (EXP)

lithium atom (ISO)

lithium hydride (ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

paracetamol (EXP)

PCB138 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cell projection (IEA)

cytoskeleton (IEA)

lamellipodium (IEA)

Molecular Function

actin binding (IEA)

ATP binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:22082260	PMID:23533145	PMID:28131823

Genomics

Comparative Map Data

Actr3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	9,995,553 - 10,089,422 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	9,996,155 - 10,089,553 (-)	Ensembl				GRCr8
mRatBN7.2	4	9,261,631 - 9,355,496 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	9,262,233 - 9,355,441 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	14,258,894 - 14,353,572 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	10,073,170 - 10,167,844 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	8,429,951 - 8,518,857 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	5,644,287 - 5,672,708 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	5,644,260 - 5,672,708 (+)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	4	5,721,261 - 5,773,301 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	5,668,162 - 5,696,597 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	4,654,603 - 4,747,545 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	963,948 - 1,056,011 (+)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

ACTR3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	152,759,752 - 152,855,378 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	152,759,749 - 152,855,378 (+)	Ensembl			hg38	GRCh38
GRCh37	7	152,456,837 - 152,552,463 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	152,087,784 - 152,183,396 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	148,258,695 - 148,259,790 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1-q36.2	NCBI
HuRef	7	146,267,013 - 146,310,451 (+)	NCBI		HuRef
HuRef	7	146,326,572 - 146,359,033 (+)	NCBI		HuRef
CHM1_1	7	152,465,204 - 152,560,884 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	153,933,015 - 154,028,620 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	151,783,914 - 151,879,544 (+)	NCBI

Actr3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	25,964,960 - 26,055,686 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	25,964,995 - 26,055,686 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	25,759,941 - 25,850,691 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	25,759,997 - 25,850,688 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	25,265,844 - 25,356,160 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	25,270,091 - 25,360,407 (+)	NCBI		MGSCv36	mm8
Celera	5	22,699,772 - 22,788,698 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	12.35	NCBI

Actr3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	6,686,420 - 6,742,099 (+)	Ensembl
ChiLan1.0	NW_004955491	6,690,246 - 6,741,900 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACTR3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	189,175,351 - 190,156,098 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	41,185,617 - 41,281,574 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	144,340,531 - 144,436,456 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ACTR3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	16,470,965 - 16,555,777 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	16,470,853 - 16,555,259 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	17,087,180 - 17,171,836 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	18,202,406 - 18,287,120 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	18,202,376 - 18,287,112 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	16,575,306 - 16,660,017 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	17,156,385 - 17,241,264 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	17,207,225 - 17,292,092 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Actr3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	4,972,871 - 5,029,644 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	7,873,600 - 7,930,956 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	7,873,874 - 7,930,341 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACTR3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	4,643,255 - 4,748,182 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	18	4,637,408 - 4,748,233 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	4,955,097 - 4,999,916 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACTR3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	120,901,960 - 120,997,307 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	120,902,030 - 120,998,759 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666072	16,941,124 - 17,036,500 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Actr3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	4,256,748 - 4,322,758 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624800	4,257,418 - 4,373,677 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Actr3b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	154,947,465 - 155,041,685 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Actr3b
518 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	162
Count of miRNA genes:	129
Interacting mature miRNAs:	138
Transcripts:	ENSRNOT00000041876
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	28392287	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	1	45429897	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	32668025	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	32668025	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	28392287	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	32668025	Rat
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	28392287	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	40471598	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	8428551	30449094	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	34142783	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	34142783	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	33538816	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	31106810	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	32668025	Rat

Markers in Region

D4Got9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	9,341,938 - 9,342,116 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	5,759,801 - 5,759,978	NCBI	Rnor6.0
Rnor_5.0	4	5,783,927 - 5,784,104	UniSTS	Rnor5.0
RGSC_v3.4	4	4,734,045 - 4,734,223	RGD	RGSC3.4
RGSC_v3.4	4	4,734,046 - 4,734,223	UniSTS	RGSC3.4
Celera	4	977,247 - 977,424	UniSTS
RGSC_v3.1	4	4,734,045 - 4,734,223	RGD
RH 2.0 Map	4	0.0	RGD
Cytogenetic Map	4	q11	UniSTS

RH138413

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	9,262,054 - 9,262,188 (-)	MAPPER	mRatBN7.2
Rnor_6.0	4	5,672,753 - 5,672,886	NCBI	Rnor6.0
Rnor_5.0	4	5,696,642 - 5,696,775	UniSTS	Rnor5.0
RGSC_v3.4	4	4,654,425 - 4,654,558	UniSTS	RGSC3.4
Celera	4	1,056,056 - 1,056,189	UniSTS
Cytogenetic Map	4	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	90	59	6	349	190	11	141	76	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000041876 ⟹ ENSRNOP00000041576

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	9,996,155 - 10,051,515 (-)	Ensembl
mRatBN7.2 Ensembl	4	9,262,233 - 9,317,599 (-)	Ensembl
Rnor_6.0 Ensembl	4	5,644,260 - 5,672,708 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	5,721,261 - 5,773,301 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085713

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	5,721,261 - 5,773,301 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108546 ⟹ ENSRNOP00000095302

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	9,996,155 - 10,089,362 (-)	Ensembl
mRatBN7.2 Ensembl	4	9,262,233 - 9,355,441 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112959 ⟹ ENSRNOP00000087094

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	9,996,155 - 10,054,795 (-)	Ensembl
mRatBN7.2 Ensembl	4	9,262,233 - 9,321,057 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133631 ⟹ ENSRNOP00000100073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	9,996,155 - 10,089,553 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135504 ⟹ ENSRNOP00000101285

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	9,996,155 - 10,053,896 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000160106 ⟹ ENSRNOP00000110978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	9,996,155 - 10,054,256 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165559 ⟹ ENSRNOP00000101551

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	9,996,155 - 10,089,553 (-)	Ensembl

RefSeq Acc Id:

NM_001191860 ⟹ NP_001178789

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	9,996,155 - 10,089,362 (-)	NCBI
mRatBN7.2	4	9,262,233 - 9,355,441 (-)	NCBI
Rnor_6.0	4	5,644,287 - 5,672,708 (+)	NCBI
Rnor_5.0	4	5,668,162 - 5,696,597 (+)	NCBI
Celera	4	963,948 - 1,056,011 (+)	NCBI

Sequence:

show sequence

GCTAGGCTCTGGGTCCCCGGTGCACGCTGGGGCTGGTGGGGACCGAGCGCCTCGTGGACGAGCA
TGGCGGGCTCGCTGCCTCCCTGCGTGGTTGACTGCGGCACCGGGTACACCAAGCTCGGCTACGC
AGGCAACACTGAGCCACAGTTCATTATTCCGTCATGTATTGCCATCCGAGAGTCGGCAAAGGTA
GTTGACCAAGCCCAGAGGAGGGTGTTGAGAGGAGTTGATGACCTTGACTTCTTCATAGGGGATG
AAGCCATTGATAAACCTACCTACGCTACCAAGTGGCCTATACGACATGGCATCGTTGAAGACTG
GGATCTTATGGAAAGGTTCATGGAACAGGTGGTCTTTAAGTATCTCCGTGCCGAACCTGAGGAC
CATTATTTTTTAATGACAGAACCTCCACTGAACACACCAGAGAACAGAGAGTACCTTGCAGAAA
TCATGTTTGAATCATTTAATGTACCAGGGCTCTACATTGCAGTACAGGCAGTGCTGGCCCTGGC
GGCCTCTTGGACATCCCGGCAAGTTGGTGAACGCACCCTGACGGGGATAGTCATAGACAGTGGA
GATGGCGTCACCCATGTTATCCCGGTGGCAGAAGGTTATGTAATTGGAAGCTGCATCAAACACA
TCCCAATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGG
AATCCCTCCTGAGCAGTCACTGGAGACCGCAAAAGCCATTAAGGAGAAGTACTGTTACATATGC
CCTGATATTGTCAAGGAATTTGCTAAATATGACGTGGATCCCCGGAAGTGGATCAAACAGTATA
CAGGGATCAATGCAATCAACCAGAGGAAGTTCATTATAGATGTTGGTTATGAGAGGTTCCTGGG
ACCAGAAATATTCTTTCACCCTGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCGGATGTC
GTTGATGAAGTCATACAGAACTGTCCCATAGACGTGCGCCGACCGCTGTATAAGAACATCGTTC
TCTCTGGAGGCTCCACAATGTTCAGAGATTTTGGACGCCGTCTGCAGAGAGATTTGAAGAGAGT
GGTGGACGCCAGGTTAAAGCTGAGCCAAGAGCTCAGCGGGGGCAGGATAAAGCCTAAGCCTGTG
GAGGTGCAGGTGATCACACACCACATGCAGCGCTACGCCGTCTGGTTTGGAGGCTCTATGCTCG
CCTCGACTCCGGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTATGAGGAATACGGCCCCAG
CATCTGCCGCCACAACCCCGTCTTCGGAGTCATGTCCTAGTGTCTGCCTCAGAGCCATTGTCTT
GACAGTGTCCTGTTGGGGAATAAGTGTCCTTCAGAACCCAGAGCAGCCTTGGCTCCTGTACATA
GCAGTGTGGAATCAGTGTGTGAGCAGCGTGATTTCATGGCCGGTGCTCGGGGCCGGGCACAGTC
TTCCCAGTAAAGCCATTTATCCGGTG

hide sequence

RefSeq Acc Id:

XM_039107743 ⟹ XP_038963671

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	9,995,553 - 10,089,404 (-)	NCBI
mRatBN7.2	4	9,261,631 - 9,355,403 (-)	NCBI

RefSeq Acc Id:

XM_039107744 ⟹ XP_038963672

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	9,995,553 - 10,089,367 (-)	NCBI
mRatBN7.2	4	9,261,631 - 9,355,467 (-)	NCBI

RefSeq Acc Id:

XM_039107745 ⟹ XP_038963673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	9,995,553 - 10,089,417 (-)	NCBI
mRatBN7.2	4	9,261,631 - 9,355,496 (-)	NCBI

RefSeq Acc Id:

XM_039107746 ⟹ XP_038963674

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	9,995,553 - 10,089,422 (-)	NCBI
mRatBN7.2	4	9,261,631 - 9,355,496 (-)	NCBI

RefSeq Acc Id:

XM_039107747 ⟹ XP_038963675

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	10,016,825 - 10,089,417 (-)	NCBI
mRatBN7.2	4	9,282,905 - 9,355,496 (-)	NCBI

RefSeq Acc Id:

XM_063286224 ⟹ XP_063142294

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	9,995,553 - 10,050,891 (-)	NCBI

RefSeq Acc Id:

XM_063286225 ⟹ XP_063142295

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	9,995,553 - 10,061,892 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178789	(Get FASTA)	NCBI Sequence Viewer
	XP_038963671	(Get FASTA)	NCBI Sequence Viewer
	XP_038963672	(Get FASTA)	NCBI Sequence Viewer
	XP_038963673	(Get FASTA)	NCBI Sequence Viewer
	XP_038963674	(Get FASTA)	NCBI Sequence Viewer
	XP_038963675	(Get FASTA)	NCBI Sequence Viewer
	XP_063142294	(Get FASTA)	NCBI Sequence Viewer
	XP_063142295	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL86398	(Get FASTA)	NCBI Sequence Viewer
	EDL86399	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000041576.4
	ENSRNOP00000087094.1
	ENSRNOP00000095302
	ENSRNOP00000095302.1
	ENSRNOP00000100073.1
	ENSRNOP00000101285.1
	ENSRNOP00000101551.1
	ENSRNOP00000110978
	ENSRNOP00000110978.1

RefSeq Acc Id:

NP_001178789 ⟸ NM_001191860

- UniProtKB:

A0A8I6GL35 (UniProtKB/TrEMBL), A0A8I6A7C9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVVDQAQRRVLRGVDDLDFFIGD
EAIDKPTYATKWPIRHGIVEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAE
IMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKH
IPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQY
TGINAINQRKFIIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNIV
LSGGSTMFRDFGRRLQRDLKRVVDARLKLSQELSGGRIKPKPVEVQVITHHMQRYAVWFGGSML
ASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS

hide sequence

Ensembl Acc Id:

ENSRNOP00000041576 ⟸ ENSRNOT00000041876

RefSeq Acc Id:	XP_038963674 ⟸ XM_039107746
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A7C9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963673 ⟸ XM_039107745
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038963672 ⟸ XM_039107744
- Peptide Label:	isoform X3
- UniProtKB:	A6KJJ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963671 ⟸ XM_039107743
- Peptide Label:	isoform X3
- UniProtKB:	A6KJJ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963675 ⟸ XM_039107747
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000095302 ⟸ ENSRNOT00000108546

Ensembl Acc Id:

ENSRNOP00000087094 ⟸ ENSRNOT00000112959

RefSeq Acc Id:	XP_063142295 ⟸ XM_063286225
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A7C9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142294 ⟸ XM_063286224
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A7C9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000100073 ⟸ ENSRNOT00000133631

Ensembl Acc Id:

ENSRNOP00000110978 ⟸ ENSRNOT00000160106

Ensembl Acc Id:

ENSRNOP00000101551 ⟸ ENSRNOT00000165559

Ensembl Acc Id:

ENSRNOP00000101285 ⟸ ENSRNOT00000135504

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LY09-F1-model_v2	AlphaFold	F1LY09	1-315	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565759	AgrOrtholog
BioCyc Gene	G2FUF-46097	BioCyc
Ensembl Genes	ENSRNOG00000031855	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000061925	Ensembl
Ensembl Transcript	ENSRNOT00000041876.5	UniProtKB/TrEMBL
	ENSRNOT00000108546	ENTREZGENE
	ENSRNOT00000108546.2	UniProtKB/TrEMBL
	ENSRNOT00000112959.2	UniProtKB/TrEMBL
	ENSRNOT00000133631.1	UniProtKB/TrEMBL
	ENSRNOT00000135504.1	UniProtKB/TrEMBL
	ENSRNOT00000160106	ENTREZGENE
	ENSRNOT00000160106.1	UniProtKB/TrEMBL
	ENSRNOT00000165559.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.420.40	UniProtKB/TrEMBL
	Actin, Chain A, domain 2	UniProtKB/TrEMBL
	Actin, Chain A, domain 4	UniProtKB/TrEMBL
InterPro	Actin-like	UniProtKB/TrEMBL
	Actin/actin-like_CS	UniProtKB/TrEMBL
	ATPase_NBD	UniProtKB/TrEMBL
KEGG Report	rno:362298	UniProtKB/TrEMBL
NCBI Gene	362298	ENTREZGENE
PANTHER	Actin_like	UniProtKB/TrEMBL
Pfam	Actin	UniProtKB/TrEMBL
PhenoGen	Actr3b	PhenoGen
PROSITE	ACTINS_ACT_LIKE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000031855	RatGTEx
	ENSRNOG00000061925	RatGTEx
SMART	ACTIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53067	UniProtKB/TrEMBL
UniProt	A0A8I6A7C9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GL35	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L065_RAT	UniProtKB/TrEMBL
	A0ABK0LAT5_RAT	UniProtKB/TrEMBL
	A0ABK0LJX9_RAT	UniProtKB/TrEMBL
	A0ABK0M016_RAT	UniProtKB/TrEMBL
	A6KJJ7	ENTREZGENE, UniProtKB/TrEMBL
	F1LY09_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Actr3b	actin related protein 3B	LOC100910079	actin-related protein 3B-like	Data merged from RGD:6500542	737654	PROVISIONAL
2019-03-25	Actr3b	actin related protein 3B	Actr3b	ARP3 actin related protein 3 homolog B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-07-21	Actr3b	ARP3 actin related protein 3 homolog B	Actr3b	ARP3 actin-related protein 3 homolog B (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	LOC100910079	actin-related protein 3B-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-07	Actr3b	ARP3 actin-related protein 3 homolog B (yeast)	RGD1565759_predicted	similar to actin-related protein 3-beta (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565759_predicted	similar to actin-related protein 3-beta (predicted)	LOC362298	similar to actin-related protein 3-beta	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC362298	similar to actin-related protein 3-beta			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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