Bmx (BMX non-receptor tyrosine kinase) - Rat Genome Database

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Gene: Bmx (BMX non-receptor tyrosine kinase) Rattus norvegicus
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Symbol: Bmx
Name: BMX non-receptor tyrosine kinase
RGD ID: 1565643
Description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway and adaptive immune response. Predicted to be located in nucleoplasm and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human BMX (BMX non-receptor tyrosine kinase); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytoplasmic tyrosine-protein kinase BMX; LOC367786; RGD1565643; similar to protein tyrosine kinase Bmx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,859,128 - 33,921,876 (+)NCBIGRCr8
mRatBN7.2X30,227,251 - 30,290,015 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,227,251 - 30,289,993 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,259,834 - 31,322,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,697,126 - 34,759,876 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,884,657 - 30,947,292 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,976,231 - 32,046,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,984,612 - 32,045,448 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,349,437 - 32,417,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,982,940 - 51,047,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,571,855 - 30,633,715 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,ISO)
ruffle membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10688651   PMID:11331870   PMID:21929872   PMID:22723969   PMID:24785188  


Genomics

Comparative Map Data
Bmx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,859,128 - 33,921,876 (+)NCBIGRCr8
mRatBN7.2X30,227,251 - 30,290,015 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,227,251 - 30,289,993 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,259,834 - 31,322,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,697,126 - 34,759,876 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,884,657 - 30,947,292 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,976,231 - 32,046,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,984,612 - 32,045,448 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,349,437 - 32,417,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,982,940 - 51,047,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,571,855 - 30,633,715 (+)NCBICelera
Cytogenetic MapXq14NCBI
BMX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,500,807 - 15,556,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,464,246 - 15,556,529 (+)EnsemblGRCh38hg38GRCh38
GRCh37X15,518,930 - 15,574,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,428,821 - 15,484,573 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX19,634,383 - 19,690,144 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,280,437 - 13,329,298 (+)NCBIHuRef
CHM1_1X15,549,836 - 15,605,599 (+)NCBICHM1_1
T2T-CHM13v2.0X15,083,780 - 15,139,496 (+)NCBIT2T-CHM13v2.0
Bmx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,975,838 - 163,041,189 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,975,838 - 163,041,189 (-)EnsemblGRCm39 Ensembl
GRCm38X164,192,842 - 164,258,193 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,192,842 - 164,258,193 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X160,630,774 - 160,696,125 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,536,967 - 159,602,298 (-)NCBIMGSCv36mm8
CeleraX147,407,328 - 147,474,033 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
Bmx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,638,081 - 2,689,650 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,638,081 - 2,689,601 (-)NCBIChiLan1.0ChiLan1.0
BMX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,301,789 - 17,357,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,305,174 - 17,360,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,129,158 - 8,184,910 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,410,655 - 15,466,415 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,410,655 - 15,466,415 (+)Ensemblpanpan1.1panPan2
BMX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,742,805 - 11,795,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,738,365 - 11,795,436 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,649,493 - 11,702,008 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,704,650 - 11,756,150 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,710,976 - 11,756,149 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,767,214 - 11,819,905 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,761,559 - 11,813,987 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,786,755 - 11,839,476 (+)NCBIUU_Cfam_GSD_1.0
Bmx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,914,576 - 4,962,152 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,914,756 - 4,962,129 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,914,643 - 4,962,134 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,044,386 - 12,096,039 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,044,110 - 12,096,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,004,754 - 13,055,687 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X13,973,078 - 14,028,492 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX13,981,472 - 14,028,122 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,815,758 - 15,862,877 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829297,351 - 344,164 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829297,187 - 344,555 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmx
284 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:160
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000005181
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
px-24c3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,228,854 - 30,229,044 (+)MAPPERmRatBN7.2
Rnor_6.0X31,977,835 - 31,978,024NCBIRnor6.0
Rnor_5.0X32,351,041 - 32,351,230UniSTSRnor5.0
RGSC_v3.4X50,984,544 - 50,984,733UniSTSRGSC3.4
CeleraX30,573,459 - 30,573,648UniSTS
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 43 14 10 15 10 2 2 19 20 40 11 2
Below cutoff 43 31 4 31 6 9 55 15 1 6

Sequence


RefSeq Acc Id: ENSRNOT00000005181   ⟹   ENSRNOP00000005181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX30,227,251 - 30,289,993 (+)Ensembl
Rnor_6.0 EnsemblX31,984,612 - 32,045,448 (+)Ensembl
RefSeq Acc Id: NM_001109016   ⟹   NP_001102486
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,859,128 - 33,921,854 (+)NCBI
mRatBN7.2X30,227,251 - 30,289,993 (+)NCBI
Rnor_6.0X31,976,231 - 32,046,326 (+)NCBI
Rnor_5.0X32,349,437 - 32,417,878 (+)NCBI
RGSC_v3.4X50,982,940 - 51,047,351 (+)RGD
CeleraX30,571,855 - 30,633,715 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099943   ⟹   XP_038955871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,866,552 - 33,921,876 (+)NCBI
mRatBN7.2X30,234,677 - 30,290,015 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102486 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955871 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90515 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005181
  ENSRNOP00000005181.8
RefSeq Acc Id: NP_001102486   ⟸   NM_001109016
- UniProtKB: F1LVI0 (UniProtKB/TrEMBL),   A6K2L5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005181   ⟸   ENSRNOT00000005181
RefSeq Acc Id: XP_038955871   ⟸   XM_039099943
- Peptide Label: isoform X1
Protein Domains
PH   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVI0-F1-model_v2 AlphaFold F1LVI0 1-654 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565643 AgrOrtholog
BioCyc Gene G2FUF-2584 BioCyc
Ensembl Genes ENSRNOG00000003705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005181 ENTREZGENE
  ENSRNOT00000005181.8 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro BMX_SH2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/TrEMBL
KEGG Report rno:367786 UniProtKB/TrEMBL
NCBI Gene 367786 ENTREZGENE
PANTHER PTHR24418:SF91 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam BTK UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Bmx PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  ZF_BTK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003705 RatGTEx
SMART BTK UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A6K2L5 ENTREZGENE, UniProtKB/TrEMBL
  F1LVI0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Bmx  BMX non-receptor tyrosine kinase  RGD1565643_predicted  similar to protein tyrosine kinase Bmx (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565643_predicted  similar to protein tyrosine kinase Bmx (predicted)  LOC367786  similar to protein tyrosine kinase Bmx  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367786  similar to protein tyrosine kinase Bmx      Symbol and Name status set to provisional 70820 PROVISIONAL