Vsig1 (V-set and immunoglobulin domain containing 1) - Rat Genome Database

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Pathways
Gene: Vsig1 (V-set and immunoglobulin domain containing 1) Rattus norvegicus
Analyze
Symbol: Vsig1
Name: V-set and immunoglobulin domain containing 1
RGD ID: 1565570
Description: Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to act upstream of or within epithelial cell morphogenesis. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Orthologous to human VSIG1 (V-set and immunoglobulin domain containing 1); INTERACTS WITH 17beta-estradiol; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC315920; MGC114516; similar to RIKEN cDNA 4930405J24; V-set and immunoglobulin domain-containing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X109,395,406 - 109,428,612 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX109,395,035 - 109,428,624 (+)EnsemblGRCr8
mRatBN7.2X104,607,031 - 104,640,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,607,031 - 104,639,249 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX106,736,345 - 106,768,561 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X110,235,703 - 110,267,919 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X107,789,739 - 107,821,925 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X112,268,786 - 112,303,849 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX112,270,986 - 112,303,846 (+)Ensemblrn6Rnor6.0
Rnor_5.0352,297,900 - 52,330,568 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X128,750,376 - 128,782,154 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera343,302,084 - 43,334,283 (-)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:21991385  


Genomics

Comparative Map Data
Vsig1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X109,395,406 - 109,428,612 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX109,395,035 - 109,428,624 (+)EnsemblGRCr8
mRatBN7.2X104,607,031 - 104,640,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX104,607,031 - 104,639,249 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX106,736,345 - 106,768,561 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X110,235,703 - 110,267,919 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X107,789,739 - 107,821,925 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X112,268,786 - 112,303,849 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX112,270,986 - 112,303,846 (+)Ensemblrn6Rnor6.0
Rnor_5.0352,297,900 - 52,330,568 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X128,750,376 - 128,782,154 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera343,302,084 - 43,334,283 (-)NCBICelera
Cytogenetic MapXq33NCBI
VSIG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X108,018,879 - 108,079,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX108,044,970 - 108,079,184 (+)Ensemblhg38GRCh38
GRCh37X107,288,295 - 107,322,414 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X107,174,856 - 107,209,070 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X107,094,344 - 107,128,558NCBI
CeleraX107,759,672 - 107,793,886 (+)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX96,911,024 - 96,945,061 (+)NCBIHuRef
CHM1_1X107,199,027 - 107,233,291 (+)NCBICHM1_1
T2T-CHM13v2.0X106,456,465 - 106,516,780 (+)NCBIT2T-CHM13v2.0
Vsig1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X139,808,357 - 139,840,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX139,808,357 - 139,840,221 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X140,907,608 - 140,939,472 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX140,907,608 - 140,939,472 (+)Ensemblmm10GRCm38
MGSCv37X137,442,147 - 137,474,011 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X136,253,984 - 136,285,322 (+)NCBIMGSCv36mm8
CeleraX124,163,008 - 124,194,683 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.62NCBI
Vsig1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554907,837,397 - 7,871,588 (-)Ensembl
ChiLan1.0NW_0049554907,837,846 - 7,871,540 (-)NCBIChiLan1.0ChiLan1.0
VSIG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X107,526,291 - 107,560,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X107,529,895 - 107,563,826 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X97,030,289 - 97,177,080 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X107,513,181 - 107,547,170 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX107,513,181 - 107,547,170 (+)EnsemblpanPan2panpan1.1
VSIG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X81,574,202 - 81,618,242 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX81,574,025 - 81,616,879 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX67,694,985 - 67,739,070 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X83,223,396 - 83,267,781 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX83,223,363 - 83,266,418 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X80,682,761 - 80,726,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X82,395,332 - 82,439,388 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X82,187,480 - 82,231,918 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vsig1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X80,919,499 - 80,950,165 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364996,708,049 - 6,738,306 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364996,708,049 - 6,738,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VSIG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX88,500,715 - 88,534,961 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X88,468,498 - 88,534,958 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
VSIG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X95,871,312 - 95,926,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX95,904,516 - 95,924,884 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606520,963,711 - 21,025,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vsig1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248038,422,036 - 8,457,102 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248038,421,863 - 8,457,044 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vsig1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X93,323,824 - 93,357,690 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vsig1
246 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000020974
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 31 121 58 57 26 76 26 6 251 132 6 102 71 88 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000082652   ⟹   ENSRNOP00000075185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX109,395,035 - 109,428,616 (+)Ensembl
mRatBN7.2 EnsemblX104,607,031 - 104,639,249 (+)Ensembl
Rnor_6.0 EnsemblX112,270,993 - 112,303,846 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091441   ⟹   ENSRNOP00000073037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX109,395,613 - 109,428,624 (+)Ensembl
mRatBN7.2 EnsemblX104,607,031 - 104,639,249 (+)Ensembl
Rnor_6.0 EnsemblX112,270,986 - 112,303,570 (+)Ensembl
RefSeq Acc Id: NM_001037784   ⟹   NP_001032873
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X109,395,518 - 109,427,736 (+)NCBI
mRatBN7.2X104,607,031 - 104,639,252 (+)NCBI
Rnor_6.0X112,270,993 - 112,303,849 (+)NCBI
Rnor_5.0352,297,900 - 52,330,568 (-)NCBI
RGSC_v3.4X128,750,376 - 128,782,154 (+)RGD
Celera343,302,084 - 43,334,283 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234243   ⟹   XP_006234305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X109,395,406 - 109,428,612 (+)NCBI
mRatBN7.2X104,607,079 - 104,640,128 (+)NCBI
Rnor_6.0X112,268,786 - 112,303,554 (+)NCBI
Rnor_5.0352,297,900 - 52,330,568 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234245   ⟹   XP_006234307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X109,411,907 - 109,428,612 (+)NCBI
mRatBN7.2X104,623,439 - 104,640,128 (+)NCBI
Rnor_6.0X112,284,875 - 112,303,554 (+)NCBI
Rnor_5.0352,297,900 - 52,330,568 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234246   ⟹   XP_006234308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X109,414,807 - 109,428,612 (+)NCBI
mRatBN7.2X104,626,297 - 104,640,128 (+)NCBI
Rnor_6.0X112,289,435 - 112,303,554 (+)NCBI
Rnor_5.0352,297,900 - 52,330,568 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032873 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234305 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234307 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234308 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98943 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073037
  ENSRNOP00000075185
  ENSRNOP00000075185.1
GenBank Protein Q4KLY3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032873   ⟸   NM_001037784
- Peptide Label: precursor
- UniProtKB: Q4KLY3 (UniProtKB/Swiss-Prot),   A6HLR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234305   ⟸   XM_006234243
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234307   ⟸   XM_006234245
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006234308   ⟸   XM_006234246
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000075185   ⟸   ENSRNOT00000082652
Ensembl Acc Id: ENSRNOP00000073037   ⟸   ENSRNOT00000091441
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLY3-F1-model_v2 AlphaFold Q4KLY3 1-404 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565570 AgrOrtholog
BioCyc Gene G2FUF-1531 BioCyc
Ensembl Genes ENSRNOG00000054219 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082652 ENTREZGENE
  ENSRNOT00000082652.2 UniProtKB/Swiss-Prot
  ENSRNOT00000091441 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7456980 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Myelin_P0-rel UniProtKB/Swiss-Prot
  VSIG1 UniProtKB/Swiss-Prot
KEGG Report rno:315920 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114516 IMAGE-MGC_LOAD
NCBI Gene 315920 ENTREZGENE
PANTHER PTHR44974 UniProtKB/Swiss-Prot
  V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Ig_3 UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PhenoGen Vsig1 PhenoGen
PRINTS MYELINP0 UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054219 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A0G2K4G7 ENTREZGENE, UniProtKB/TrEMBL
  A6HLR1 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLY3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Vsig1  V-set and immunoglobulin domain containing 1  LOC315920  similar to RIKEN cDNA 4930405J24  Symbol and Name updated 1299863 APPROVED
2006-02-09 LOC315920  similar to RIKEN cDNA 4930405J24      Symbol and Name status set to provisional 70820 PROVISIONAL