Abcg3 (ATP-binding cassette, subfamily G (WHITE), member 3) - Rat Genome Database

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Gene: Abcg3 (ATP-binding cassette, subfamily G (WHITE), member 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Abcg3
Name: ATP-binding cassette, subfamily G (WHITE), member 3
RGD ID: 1565568
Description: Predicted to enable ATPase-coupled transmembrane transporter activity; efflux transmembrane transporter activity; and riboflavin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-binding cassette, sub-family G (WHITE), member 3; LOC498327; RGD1565568; similar to ATP-binding cassette, subfamily G, member 3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,068,275 - 5,143,762 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl145,086,356 - 5,143,945 (+)EnsemblGRCr8
mRatBN7.2144,763,552 - 4,839,061 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,730,453 - 4,839,244 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx144,717,733 - 4,782,974 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,017,918 - 6,083,164 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,728,497 - 4,784,991 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,971,984 - 6,053,039 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0145,953,815 - 6,032,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4145,888,471 - 5,945,387 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera144,918,864 - 4,978,899 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Abcg3
1570 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1439578789393298Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
RH143125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,632,960 - 4,633,115 (+)MAPPERmRatBN7.2
mRatBN7.2144,797,667 - 4,797,821 (+)MAPPERmRatBN7.2
Rnor_6.0146,016,711 - 6,016,864NCBIRnor6.0
Rnor_6.0145,803,378 - 5,803,532NCBIRnor6.0
Rnor_5.0145,996,753 - 5,996,906UniSTSRnor5.0
Rnor_5.0145,786,567 - 5,786,721UniSTSRnor5.0
RGSC_v3.4145,736,927 - 5,737,081UniSTSRGSC3.4
RGSC_v3.4145,904,466 - 5,904,619UniSTSRGSC3.4
Celera144,934,743 - 4,934,896UniSTS
Celera144,783,894 - 4,784,048UniSTS
RH 3.4 Map14127.0UniSTS
Cytogenetic Map14p22UniSTS
RH134900  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera144,748,515 - 4,748,960UniSTS
Celera144,978,678 - 4,979,126UniSTS
RH 3.4 Map1483.0UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 48 67 137 95 11 47 35 32 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000061267   ⟹   ENSRNOP00000057979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,086,356 - 5,143,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109379   ⟹   ENSRNOP00000086939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,086,356 - 5,143,754 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115444   ⟹   ENSRNOP00000084939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,730,453 - 4,839,244 (+)Ensembl
RefSeq Acc Id: NM_001128311   ⟹   NP_001121783
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,550 - 5,143,762 (+)NCBI
mRatBN7.2144,764,845 - 4,839,061 (+)NCBI
Rnor_6.0145,971,984 - 6,053,039 (+)NCBI
Rnor_5.0145,953,815 - 6,032,441 (+)NCBI
RGSC_v3.4145,888,471 - 5,945,387 (+)RGD
Celera144,918,864 - 4,978,899 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092263   ⟹   XP_038948191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,467 - 5,143,762 (+)NCBI
mRatBN7.2144,764,757 - 4,839,061 (+)NCBI
RefSeq Acc Id: XM_039092264   ⟹   XP_038948192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,068,275 - 5,143,762 (+)NCBI
mRatBN7.2144,763,552 - 4,839,061 (+)NCBI
RefSeq Acc Id: XM_039092267   ⟹   XP_038948195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,468 - 5,143,762 (+)NCBI
mRatBN7.2144,764,758 - 4,839,061 (+)NCBI
RefSeq Acc Id: XM_039092268   ⟹   XP_038948196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,074,231 - 5,143,762 (+)NCBI
mRatBN7.2144,769,526 - 4,839,061 (+)NCBI
RefSeq Acc Id: XM_039092269   ⟹   XP_038948197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,467 - 5,143,762 (+)NCBI
mRatBN7.2144,764,757 - 4,839,061 (+)NCBI
RefSeq Acc Id: XM_039092270   ⟹   XP_038948198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,468 - 5,140,643 (+)NCBI
mRatBN7.2144,764,756 - 4,835,964 (+)NCBI
RefSeq Acc Id: XM_039092271   ⟹   XP_038948199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,468 - 5,133,486 (+)NCBI
mRatBN7.2144,764,756 - 4,830,124 (+)NCBI
RefSeq Acc Id: XM_039092272   ⟹   XP_038948200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,470 - 5,131,238 (+)NCBI
mRatBN7.2144,764,760 - 4,826,534 (+)NCBI
RefSeq Acc Id: XM_039092273   ⟹   XP_038948201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,086,525 - 5,143,762 (+)NCBI
mRatBN7.2144,781,821 - 4,839,061 (+)NCBI
RefSeq Acc Id: XM_063273449   ⟹   XP_063129519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,466 - 5,143,022 (+)NCBI
RefSeq Acc Id: XM_063273450   ⟹   XP_063129520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,467 - 5,141,172 (+)NCBI
RefSeq Acc Id: XM_063273451   ⟹   XP_063129521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,069,468 - 5,141,172 (+)NCBI
RefSeq Acc Id: NP_001121783   ⟸   NM_001128311
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038948192   ⟸   XM_039092264
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948198   ⟸   XM_039092270
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948199   ⟸   XM_039092271
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948191   ⟸   XM_039092263
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948197   ⟸   XM_039092269
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948195   ⟸   XM_039092267
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948200   ⟸   XM_039092272
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038948196   ⟸   XM_039092268
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948201   ⟸   XM_039092273
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000084939   ⟸   ENSRNOT00000115444
RefSeq Acc Id: XP_063129519   ⟸   XM_063273449
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129520   ⟸   XM_063273450
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129521   ⟸   XM_063273451
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A0D0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086939   ⟸   ENSRNOT00000109379
Ensembl Acc Id: ENSRNOP00000057979   ⟸   ENSRNOT00000061267

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565568 AgrOrtholog
BioCyc Gene G2FUF-16534 BioCyc
Ensembl Genes ENSRNOG00000068418 UniProtKB/TrEMBL
  ENSRNOG00000070774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061267.5 UniProtKB/TrEMBL
  ENSRNOT00000109379 ENTREZGENE
  ENSRNOT00000109379.2 UniProtKB/TrEMBL
  ENSRNOT00000115444.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Guanylate-binding protein, C-terminal domain UniProtKB/TrEMBL
InterPro ABC_2_trans UniProtKB/TrEMBL
  ABC_transporter-like_ATP-bd UniProtKB/TrEMBL
  ABCG_transporters UniProtKB/TrEMBL
  G_GB1_RHD3_dom UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
  Guanylate-bd/ATL_C UniProtKB/TrEMBL
  Guanylate-bd_C_sf UniProtKB/TrEMBL
  Guanylate-bd_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 498327 ENTREZGENE
PANTHER ABC TRANSPORTER G FAMILY MEMBER 28 UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 3 UniProtKB/TrEMBL
  GUANYLATE BINDING PROTEIN UniProtKB/TrEMBL
Pfam ABC2_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
  GBP UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
PhenoGen Abcg3 PhenoGen
PROSITE ABC_TRANSPORTER_2 UniProtKB/TrEMBL
  G_GB1_RHD3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000068418 RatGTEx
  ENSRNOG00000070774 RatGTEx
Superfamily-SCOP Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6A0D0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6V0_RAT UniProtKB/TrEMBL
  D4A896_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-16 Abcg3  ATP-binding cassette, subfamily G (WHITE), member 3  Abcg3  ATP-binding cassette, sub-family G (WHITE), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Abcg3  ATP-binding cassette, sub-family G (WHITE), member 3  RGD1565568_predicted  similar to ATP-binding cassette, subfamily G, member 3 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565568_predicted  similar to ATP-binding cassette, subfamily G, member 3 (predicted)  LOC498327  similar to ATP-binding cassette, subfamily G, member 3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498327  similar to ATP-binding cassette, subfamily G, member 3      Symbol and Name status set to provisional 70820 PROVISIONAL