Krt90 (keratin 90) - Rat Genome Database

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Gene: Krt90 (keratin 90) Rattus norvegicus
Analyze
Symbol: Krt90
Name: keratin 90
RGD ID: 1565564
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Orthologous to human KRT90P (keratin 90, pseudogene); INTERACTS WITH acrylamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kb15; keratin, type II cytoskeletal cochleal; type II keratin Kb15
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,555,972 - 134,565,420 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,556,526 - 134,565,359 (-)EnsemblGRCr8
mRatBN7.27132,677,994 - 132,686,634 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,677,751 - 132,686,759 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,480,035 - 134,488,676 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,709,557 - 136,718,198 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,619,217 - 136,627,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,208,034 - 143,217,771 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,208,527 - 143,217,535 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,009,311 - 141,018,028 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,309,970 - 140,318,610 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,141,017 - 129,149,657 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Hepatomegaly  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10866680   PMID:15601842   PMID:19056892   PMID:23006328   PMID:23533145   PMID:23662636   PMID:25931508   PMID:35352799  


Genomics

Comparative Map Data
Krt90
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,555,972 - 134,565,420 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,556,526 - 134,565,359 (-)EnsemblGRCr8
mRatBN7.27132,677,994 - 132,686,634 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,677,751 - 132,686,759 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,480,035 - 134,488,676 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,709,557 - 136,718,198 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,619,217 - 136,627,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,208,034 - 143,217,771 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,208,527 - 143,217,535 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,009,311 - 141,018,028 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,309,970 - 140,318,610 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,141,017 - 129,149,657 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT90P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,413,861 - 52,419,240 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,411,742 - 52,421,867 (-)Ensemblhg38GRCh38
GRCh371252,807,645 - 52,813,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,093,912 - 51,099,291 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1252,453,802 - 52,459,181 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,851,539 - 49,856,917 (-)NCBIHuRef
CHM1_11252,774,506 - 52,779,884 (-)NCBICHM1_1
T2T-CHM13v2.01252,378,125 - 52,383,503 (-)NCBIT2T-CHM13v2.0
Krt90
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,460,791 - 101,471,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,460,791 - 101,471,385 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,552,356 - 101,562,950 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,552,356 - 101,562,950 (-)Ensemblmm10GRCm38
MGSCv3715101,382,787 - 101,393,381 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,380,390 - 101,390,984 (-)NCBIMGSCv36mm8
Celera15103,704,518 - 103,715,124 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.9NCBI

Variants

.
Variants in Krt90
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000038242
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
AI070206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,687,244 - 132,687,425 (+)MAPPERmRatBN7.2
Rnor_6.07143,218,021 - 143,218,201NCBIRnor6.0
Rnor_5.07141,018,562 - 141,018,742UniSTSRnor5.0
RGSC_v3.47140,319,221 - 140,319,401UniSTSRGSC3.4
Celera7129,150,268 - 129,150,448UniSTS
RH 3.4 Map71122.71UniSTS
Cytogenetic Map7q36UniSTS
RH135363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,688,256 - 132,688,468 (+)MAPPERmRatBN7.2
Rnor_6.07143,219,033 - 143,219,244NCBIRnor6.0
Rnor_5.07141,019,574 - 141,019,785UniSTSRnor5.0
RGSC_v3.47140,320,233 - 140,320,444UniSTSRGSC3.4
Celera7129,151,280 - 129,151,491UniSTS
RH 3.4 Map71061.5UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 1 3 48 24 24 3 15 3 6 42 24 37 2 46 21 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000088316   ⟹   ENSRNOP00000069411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,556,526 - 134,565,359 (-)Ensembl
mRatBN7.2 Ensembl7132,677,751 - 132,686,759 (-)Ensembl
Rnor_6.0 Ensembl7143,208,527 - 143,217,535 (-)Ensembl
RefSeq Acc Id: NM_001008825   ⟹   NP_001008825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,556,719 - 134,565,359 (-)NCBI
mRatBN7.27132,677,994 - 132,686,634 (-)NCBI
Rnor_6.07143,208,770 - 143,217,410 (-)NCBI
Rnor_5.07141,009,311 - 141,018,028 (-)NCBI
RGSC_v3.47140,309,970 - 140,318,610 (-)RGD
Celera7129,141,017 - 129,149,657 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264074   ⟹   XP_063120144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,555,972 - 134,565,420 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001008825 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426766 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120144 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA02236 (Get FASTA)   NCBI Sequence Viewer  
  EDL86886 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069411
  ENSRNOP00000069411.1
RefSeq Acc Id: NP_001008825   ⟸   NM_001008825
- UniProtKB: G3V908 (UniProtKB/TrEMBL),   Q6IFZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069411   ⟸   ENSRNOT00000088316
RefSeq Acc Id: XP_063120144   ⟸   XM_063264074
- Peptide Label: isoform X1
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVA8-F1-model_v2 AlphaFold A0A0G2JVA8 1-537 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565564 AgrOrtholog
BioCyc Gene G2FUF-31977 BioCyc
Ensembl Genes ENSRNOG00000009105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088316 ENTREZGENE
  ENSRNOT00000088316.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_rod_dom UniProtKB/TrEMBL
  Intermediate_filament_CS UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
  Keratin_II UniProtKB/TrEMBL
KEGG Report rno:366992 UniProtKB/TrEMBL
NCBI Gene 366992 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KERATIN 90 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
PhenoGen Krt90 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  PS00226 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009105 RatGTEx
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt A0A0G2JVA8 ENTREZGENE, UniProtKB/TrEMBL
  A6KCQ6 ENTREZGENE, UniProtKB/TrEMBL
  G3V908 ENTREZGENE, UniProtKB/TrEMBL
  Q6IFZ4 ENTREZGENE
UniProt Secondary Q6IFZ4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-21 Krt90  keratin 90  Kb15  type II keratin Kb15  Name and Symbol changed 629549 APPROVED
2006-02-09 Kb15  type II keratin Kb15      Symbol and Name status set to provisional 70820 PROVISIONAL