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Gene: Vwc2l (von Willebrand factor C domain containing 2 like) Rattus norvegicus

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Symbol:

Vwc2l

Name:

von Willebrand factor C domain containing 2 like

RGD ID:

1565501

Description:

Predicted to be involved in negative regulation of BMP signaling pathway. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be located in extracellular region and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space. Orthologous to human VWC2L (von Willebrand factor C domain containing 2 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC501160; RGD1565501; similar to PSST739 protein; von Willebrand factor C domain-containing protein 2-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	79,702,396 - 79,897,153 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	79,702,908 - 79,897,151 (+)	Ensembl				GRCr8
mRatBN7.2	9	72,252,793 - 72,448,543 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	72,253,387 - 72,444,839 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	80,732,844 - 80,918,500 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	85,861,726 - 86,047,398 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	84,247,796 - 84,433,401 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	77,833,534 - 78,024,670 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	77,834,091 - 78,021,846 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	77,608,923 - 77,801,954 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	69,738,883 - 69,944,712 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	69,691,655 - 69,876,576 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

glyphosate (ISO)

lead diacetate (EXP)

N,N-diethyl-m-toluamide (EXP)

PCB138 (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

permethrin (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of BMP signaling pathway (IBA,ISO)

positive regulation of neuron differentiation (ISO)

Cellular Component

AMPA glutamate receptor complex (IBA,IEA,ISO)

extracellular region (IEA)

extracellular space (IBA,IEA,ISO)

synapse (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19852960	PMID:22632720

Genomics

Comparative Map Data

Vwc2l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	79,702,396 - 79,897,153 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	79,702,908 - 79,897,151 (+)	Ensembl				GRCr8
mRatBN7.2	9	72,252,793 - 72,448,543 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	72,253,387 - 72,444,839 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	80,732,844 - 80,918,500 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	85,861,726 - 86,047,398 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	84,247,796 - 84,433,401 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	77,833,534 - 78,024,670 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	77,834,091 - 78,021,846 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	77,608,923 - 77,801,954 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	69,738,883 - 69,944,712 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	69,691,655 - 69,876,576 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

VWC2L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	214,411,054 - 214,578,976 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	214,411,054 - 214,578,976 (+)	Ensembl			hg38	GRCh38
GRCh37	2	215,275,778 - 215,443,700 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	214,984,537 - 215,149,052 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	2	209,044,703 - 209,208,866 (+)	NCBI		Celera
Cytogenetic Map	2	q34-q35	NCBI
HuRef	2	207,132,504 - 207,296,723 (+)	NCBI		HuRef
CHM1_1	2	215,282,976 - 215,447,073 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	214,895,548 - 215,063,486 (+)	NCBI		T2T-CHM13v2.0

Vwc2l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	70,764,471 - 70,928,097 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	70,764,874 - 70,924,556 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	70,725,439 - 70,888,938 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	70,725,715 - 70,885,397 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	70,772,289 - 70,931,971 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	70,658,923 - 70,818,605 (+)	NCBI		MGSCv36	mm8
Celera	1	71,281,471 - 71,441,088 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	35.46	NCBI

Vwc2l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	1,392,507 - 1,540,330 (-)	Ensembl
ChiLan1.0	NW_004955457	1,392,622 - 1,540,314 (-)	NCBI	ChiLan1.0	ChiLan1.0

VWC2L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	117,032,899 - 117,207,073 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	117,047,861 - 117,222,003 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	101,666,338 - 101,835,393 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	220,140,242 - 220,307,735 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	220,143,121 - 220,330,678 (+)	Ensembl			panPan2	panpan1.1

VWC2L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	21,690,649 - 21,845,435 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	21,694,137 - 21,842,599 (+)	Ensembl			canFam3	CanFam3.1
ROS_Cfam_1.0	37	21,698,911 - 21,853,823 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	21,699,485 - 21,892,697 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	21,588,932 - 21,743,455 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	21,539,455 - 21,694,457 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	21,556,126 - 21,710,949 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Vwc2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	170,086,975 - 170,238,442 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936586	2,387,138 - 2,538,669 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936586	2,387,526 - 2,538,871 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VWC2L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	116,761,633 - 116,915,365 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	116,764,621 - 116,916,993 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	129,318,312 - 129,459,264 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VWC2L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	100,215,973 - 100,393,347 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	98,978,939 - 99,151,571 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vwc2l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	1,566,397 - 1,718,919 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624765	1,566,841 - 1,718,819 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Vwc2l
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	144,092,110 - 144,262,126 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Vwc2l
1237 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	35
Interacting mature miRNAs:	41
Transcripts:	ENSRNOT00000033459
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	34960590	79960590	Rat

Markers in Region

D9Rat55

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	79,836,951 - 79,837,097 (+)	Marker Load Pipeline
Rnor_6.0	9	77,966,734 - 77,966,876	NCBI	Rnor6.0
Rnor_5.0	9	77,741,750 - 77,741,892	UniSTS	Rnor5.0
RGSC_v3.4	9	69,875,082 - 69,875,226	RGD	RGSC3.4
RGSC_v3.4	9	69,875,083 - 69,875,226	UniSTS	RGSC3.4
Celera	9	69,825,480 - 69,825,623	UniSTS
RGSC_v3.1	9	70,022,064 - 70,022,208	RGD
RH 3.4 Map	9	669.3	RGD
RH 3.4 Map	9	669.3	UniSTS
RH 2.0 Map	9	721.8	RGD
FHH x ACI Map	9	45.63	RGD
Cytogenetic Map	9	q32	UniSTS

D9Got79

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	72,438,872 - 72,439,157 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	78,015,882 - 78,016,166	NCBI	Rnor6.0
Rnor_5.0	9	77,793,166 - 77,793,450	UniSTS	Rnor5.0
RGSC_v3.4	9	69,938,747 - 69,939,032	RGD	RGSC3.4
RGSC_v3.4	9	69,938,748 - 69,939,032	UniSTS	RGSC3.4
Celera	9	69,870,613 - 69,870,897	UniSTS
RGSC_v3.1	9	70,085,730 - 70,086,014	RGD
RH 3.4 Map	9	670.0	UniSTS
RH 3.4 Map	9	670.0	RGD
RH 2.0 Map	9	725.6	RGD
Cytogenetic Map	9	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	1	12	124	24	25	9	9	9	6	84	33	1	111	33	34	16	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001413944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001413945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033459 ⟹ ENSRNOP00000038764

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	79,703,449 - 79,835,098 (+)	Ensembl
mRatBN7.2 Ensembl	9	72,253,387 - 72,444,839 (+)	Ensembl
Rnor_6.0 Ensembl	9	77,834,091 - 78,021,846 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095991 ⟹ ENSRNOP00000096961

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	79,702,928 - 79,897,151 (+)	Ensembl
mRatBN7.2 Ensembl	9	72,253,420 - 72,444,839 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000134443 ⟹ ENSRNOP00000105902

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	79,703,449 - 79,897,151 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000145592 ⟹ ENSRNOP00000099038

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	79,703,449 - 79,711,748 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000150145 ⟹ ENSRNOP00000107695

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	79,702,908 - 79,897,151 (+)	Ensembl

RefSeq Acc Id:

NM_001413944 ⟹ NP_001400873

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	79,702,954 - 79,897,150 (+)	NCBI
mRatBN7.2	9	72,253,461 - 72,447,663 (+)	NCBI

RefSeq Acc Id:

NM_001413945 ⟹ NP_001400874

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	79,702,954 - 79,897,150 (+)	NCBI
mRatBN7.2	9	72,253,461 - 72,447,663 (+)	NCBI

RefSeq Acc Id:

XM_017596605 ⟹ XP_017452094

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	79,702,396 - 79,897,153 (+)	NCBI
mRatBN7.2	9	72,252,793 - 72,448,543 (+)	NCBI
Rnor_6.0	9	77,833,534 - 78,024,670 (+)	NCBI

Sequence:

show sequence

TTTAGAGACAGGGCATCCTTGCTAGGAGGTTGGAAGAAACAGCTTTACAATGACGCCTAATGAC
AGACTAGATGAATTACAAGACATTGATTTTTAACGTTAGAGAACAAACTGCAGGAAAACGCGGC
TACTTTTTTTTTTAAATCAAATCCGAGCTGCAGAAGACCCAAAGTTGAATTATGTATAGCACAA
GGAAAATCTTTCTATAACCAGAGGGTCAAAGAGAGTCAGAAAGCATACATTTCCACAGATTCTT
TGACAATGAGTGTGCTTTATCTATTAGTAATAACCAACGACTGCAGATGGCTTAAATCTAAAGG
CAAGTCCCCCGGAACTTTCATCTCTGCAGCCCATGCAAGAATGCATTAGGTAAAATTACATCTT
TCTAATTTTTTTATTGTGATTTAAATGCAAATAAGTGTCTTGCATGCAGAACCTCCCGCTCCCC
CCACACACCCCCCAAGCTTGCTCGCATCAGCTGAATCAAGTGACTGCCTTAGACAACACTACAG
CCTGGTCCGCGGAAGCAGCTGGGGGGGTTTCGACCAAGCTGGGCTCAGAAGCCAGTTGTTGGCG
CTGTCCGTGGTGCTGAGGAATTCCCGGCTGCCGTCAGGATGAGCTCCGAATCAGCAGTCTGCAA
ACTGCTCCCAGCGATGCCAAACCCCAGTTAAAGTTGCGCCTTTGCTTCACATCCACAGTTAGAA
TCTTCCGGTGTGTGAGGAGGGATTCAGTCAACATACTGTGGACGATGCCGATGCTTCTGCTGGT
GGAGTGGGCTTTAAGCTTCAGTATGCTGTTTCTGTTTGTGATCCTCAGAGCCTAGCCAAGTCAC
CTCTACTGCCGTAGCAAACACTGTGTAAGTGAACTCATGTGTGGAGGAGGCGTAATCAGCCAGG
AAATTTCATAGAAGGATCTAAGAAAACGCTAAAAATAAGTTCAACATGATTCTGCTACCGGGGT
CCAGATTTCCACAGGACCAGCACTGCTTCTGGCTTTGAATTCTGAAGACAGGTCCAAAGCGTAT
TTCTTATGTGTGTCTGCTGTGTTCCTGTCTGGAAGGGTGGGAGACTGCTTCTTGGCTGTGTTTT
GAAATGGGGAATAGAGAGGACGGATTGCCTTTAATTCATGCCTGAAAATGCATTCTTTGGGTGA
CTAAAGAGGACCGGCTTACCTAAGAGATACCTGACCTTTAAGTTCAGATTGGTCTGTGACCCCC
AGCACCACCATTAACCTCAGAGTGACTAGCCCACCCCTCTTGCATTCCCATGGAAGGAGCTGAG
TGTGTTTAATATTAGGAGAACATCCAGAAGTCTGTGAGGAGGGGGATGGCTCTTCATATTCATG
AAGCTTGCATACTTCTATTGGTCATCCCTGGATTGGTCACCCCTGCTGCCATCAGTCACGAAGA
CTATCCTGCTGATGAAGATGGACCTGTCTGTGACCAGCCGGAATGCCCTAAAATTCATCCGAAA
TGTACAAAAGTGGAACACAATGGATGCTGTCCTGAATGTAAAGAAGTGAAAAACTTTTGTGAAT
ATCATGGGAAAAATTACAAAATCTTGGAGGAATTTAAGCCCTCTCCATGTGAATGGTGTCGCTG
TGAGCCCAGCAATGAAGTTCACTGTGTTGTAGCAGACTGCGCAGTTCCAGAGTGTGTCAACCCA
ATCTATGAACCAGAGCAATGTTGTCCTGTCTGCAAAAATGGTCCAAACTGCTTTGCAGGAACTA
CAATAATTCCAGCTGGCATTGAAGTTAAAGTGGACGACTGTAACATCTGTCACTGTCACAACGG
GGATTGGTGGAAACCCGCTCAGTGTTCAAAGCGCGAATGCCAAGGCAAGCAGACTGTCTAGGGC
AAATTCCCGACCGGTGACAAGTGCTAAGAGGGGATGCTATGGCTTCTACACTGCACACATATCG
CACTCAACAGAATAAGCAAGCAAACCCCTGCCAGCTACAACACGGTCACCAGCAAAATCTTCTG
GGGTTGACAAAAGTGAATATTTTACGAAGAGGAAATCTCTCTCTCTTTATCTTGCTATATAAAA
TACACATAGCATATAGCTATCTAAAGCACTTTTATAATTGTCAATGCTTGATGGTGACTAGACA
ACCAAGATTTCTTGGACAAGAAAGAAAGAACACAGCCTTGGACAGGCTCATTCCCAGGTGATGC
CTCTGACCTGCCAGCTCACGTCCCTTGATTGACTCCATCTTTACTCCGGTGTGCACCCTACATT
TTTCTCTTGTATGTTTTCTACCTTTGGAATCTAAAGGGGTTAGATTGGACTACACGGTAAAGTT
TTGTGTTTTCATGAGAATTGTTTGATAAAGAAACTTTGTGGGGGAAGTCTCCTTCCAGAGGGGA
AAGATTGAAGAGTGTACAAGCCTTGACTCTCTTGGGGGTAGTTATGTTTGTAGGCTAAGAAACA
GAGAGGTAAACTGGGTCCTCTGCAGATCAGGCGAGAAACAGGTATACATTGGGGCTCACTGTTG
ATTCTTACAGACCACACATTTCACACATAAAATTTTGAAACTGCCTATCAGAACCAAGTAGGCG
AGCGAGAACACCATGACTGAAGAACCCACAGAAACGGGTTTTCAAAAGTGTAGCATTTAATCAC
TGGACTTCTTCATGATGCCAGCTTTGAGCTTGGTTTATAATTAAACACACAGCAAAGCCCACCT
TGTCATCGGGCGATATAAATACCAGAACCAGGGTGAGTAGCCCCACTGTGAATCAATCTTTCTA
AACATTTCTGACTTTCAAGTTCCAATTGGCTGAAAGCCAGTCCTATACACAGCAGTTTTTATGG
TTCAGGACTGTGTTTGCCACGTTCCAGTAACAACCACTCAGCCCTAAATCTAAAATCCAGATTC
AGGACACTCTTTCCACCTTAAGTGCTGATGTAAATTAAAGATTAGGGTAGAGTGAGTCTTGCAC
AATACAATTTCATTAGTTTAACATTTTTTAATGTATATAATAGGTACTAAGCGATTAAAGAGAA
CCTTTGAAGAGTCTCAAGGTTGCCCTGGTAATGCTGCTAGTCTAATAATGGAAATTAATAATAA
TAAAAATAATAATAAAAGAAATACACAGGGTATCTGATGCCACCTCCAGTATAAAATTCACAGC
TCTGAGACCACATGGTCTAGTCACTTATCCCACTATCTGTCCTAAAAACCTTGGTGCAGATCTA
ATAGGGTCCTTAGGAAACTTCAAAGTATTCTTCATCTCCAGTTGTCTTTCTTTTTCTTGTTTTC
TGCTTCCACCCCTAATCTGCGTTTCATGTGGCTTCTGTGAAGGACCACGTTACATGGACGGATA
TGCTAAGCGACATTCTTGGATTTCTTCCACTAGGTATCAGGAGCACCTACCTAGTTATATCAAC
CAAATGTCCCCAGACTTAGCCAAAAGTCCTTGAGGGGTGTGGGTAGGGAACAAAGTGTTACCTG
GTTGGGAAGCTGTGTCATCCAGCTATATCATGTCTGTCATATAACAAGCTGGGAAGACTGCACA
CACATGACTTTGTTGAGCCCCTGAGCCCTTTGGATCATGCACAAACAGTAACCCCAAGGGTCAC
TCTCCTCCCTGTTAAGTGATGTTTCTAACACCCACTCTTCGGACACCAGTTTCTTTAGTCTCAT
AAATTAGTTTTCTCATTTAAAATTGTCAGCCTCTCCTCCCTGGAAGCACTGCCTGTCATCAAGA
AAGAGTTGTCATTTCCAAAATTAATGTGCTGACGAGCCAGACCTGACACTTTTACACACACTGT
GCTTGTGTTATGATACAAATAACCATCCTGGTGCCATCCGAGGAAGAACATCCAGCCGCCTTCC
CTTAGAACACCAATTTGCTGAGAGGTTGGTGCCTTTCAGTTGCCACTATGGATACATCATAGAG
ACAGCCATGAATCATTCATGAGCAATTCTGCATGATTTATGCCTACACTCAAAAGCAAAGGCAC
TCCATACTTCCCCCCATGTCTAGACAGAGTTGTACTGTACGGCTTTCTTTGCTCTAAGGTTGCC
TAACACCAGTTCCAAAAACCCACATTCTTGGAAAGACATAACAATCATTATCATTATTACAATA
AATGACAGGAATAAGGTCAAAAACTGAGAAAAATATACTGCTAATAGAGAGACCCATGTAGCCT
AGACCCTTATCTACTATTAAGGAGTTACTATGTTCTTAGGAACAGAATGGGCAACCTGGAAGCC
AAGGTACAGAAATTTTGTATCTGAGCCCACTGACATTCCCAGCACGGACTGGGTAGGCTAGAGT
GTAACTCGCTCAACATTCTTCAGAGAGCTTTGGGCTGGCAGCAGATCAATAGTGGCCTCTATGA
CAAACTTGAGCAGGAGATTTTTATCACTGTTTATGTCGGGTTTGGGCTTGGTTTCTTTTGTCTG
ATTGCTTTGTTCTTCTGACTGTGCTCGGCTTCACTACAGTATGTCCCTTAACGCTCCCAAGCAC
CAATGTTTTCCCACCTTAAGCGAGAGACAGAGCTATACTGTGGCAGGATTTCTCATAAATGGAT
AAACATTCAACAACTTCCTACTACCAGGTCACGGAGAAATTCTTTCCAAGATCAGAACATCAGA
GTTCTTCTGGTCTACCATTTTGTTATTTTTTTTAAGGTTTTGATTACAGCCACACGGTCGCCTC
TGTGTTACTATTTCTCTTCTGCCTTTGGCTCTAGACTTTAAATTCAGCTATGTTTAAATAAGGG
GTCAGTATCTGGTTTGTCAGCTGATGCCTGTTAAACTGATTCAGTTCCTAAAACCTTTGAAAAA
TGGTGTGCCTGAAAACTAGTGAGAGAGAGGGGGGGAAAAAACAAACCACTAAATACTAAACTGT
AAAAAAGGGATTCTAGCAACAATATTTGATGTGTAAAAGAATATATTATTAAAAAATTATTTTG
TTAAATATAAAGTGTGTTAACCAGT

hide sequence

RefSeq Acc Id:

XM_039084106 ⟹ XP_038940034

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	79,702,396 - 79,838,874 (+)	NCBI
mRatBN7.2	9	72,252,793 - 72,387,486 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001400873	(Get FASTA)	NCBI Sequence Viewer
	NP_001400874	(Get FASTA)	NCBI Sequence Viewer
	XP_017452094	(Get FASTA)	NCBI Sequence Viewer
	XP_038940034	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL75270	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038764.4
	ENSRNOP00000096961
	ENSRNOP00000096961.1
	ENSRNOP00000099038.1
	ENSRNOP00000105902
	ENSRNOP00000105902.1
	ENSRNOP00000107695
	ENSRNOP00000107695.1

RefSeq Acc Id:	XP_017452094 ⟸ XM_017596605
- Peptide Label:	isoform X2
- UniProtKB:	D4A0X1 (UniProtKB/TrEMBL), A6KFF7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALHIHEACILLLVIPGLVTPAAISHEDYPADEDGPVCDQPECPKIHPKCTKVEHNGCCPECKE VKNFCEYHGKNYKILEEFKPSPCEWCRCEPSNEVHCVVADCAVPECVNPIYEPEQCCPVCKNGP NCFAGTTIIPAGIEVKVDDCNICHCHNGDWWKPAQCSKRECQGKQTV hide sequence

Ensembl Acc Id:

ENSRNOP00000038764 ⟸ ENSRNOT00000033459

RefSeq Acc Id:	XP_038940034 ⟸ XM_039084106
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000096961 ⟸ ENSRNOT00000095991

RefSeq Acc Id:	NP_001400873 ⟸ NM_001413944
- Peptide Label:	isoform 1 precursor
- UniProtKB:	A0A8I6AU98 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001400874 ⟸ NM_001413945
- Peptide Label:	isoform 2 precursor

Ensembl Acc Id:

ENSRNOP00000099038 ⟸ ENSRNOT00000145592

Ensembl Acc Id:

ENSRNOP00000107695 ⟸ ENSRNOT00000150145

Ensembl Acc Id:

ENSRNOP00000105902 ⟸ ENSRNOT00000134443

Protein Domains

VWFC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A0X1-F1-model_v2	AlphaFold	D4A0X1	1-175	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696732

Promoter ID:

EPDNEW_R7256

Type:

single initiation site

Name:

Vwc2l_1

Description:

von Willebrand factor C domain-containing protein 2-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	77,834,048 - 77,834,108	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565501	AgrOrtholog
BioCyc Gene	G2FUF-27256	BioCyc
Ensembl Genes	ENSRNOG00000027400	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033459.5	UniProtKB/TrEMBL
	ENSRNOT00000095991	ENTREZGENE
	ENSRNOT00000095991.2	UniProtKB/TrEMBL
	ENSRNOT00000134443	ENTREZGENE
	ENSRNOT00000134443.1	UniProtKB/TrEMBL
	ENSRNOT00000145592.1	UniProtKB/TrEMBL
	ENSRNOT00000150145	ENTREZGENE
	ENSRNOT00000150145.1	UniProtKB/TrEMBL
Gene3D-CATH	6.20.200.20	UniProtKB/TrEMBL
InterPro	VWC2/VWC2L	UniProtKB/TrEMBL
	VWF_C	UniProtKB/TrEMBL
NCBI Gene	501160	ENTREZGENE
PANTHER	PTHR46252	UniProtKB/TrEMBL
	VON WILLEBRAND FACTOR C DOMAIN-CONTAINING PROTEIN 2-LIKE	UniProtKB/TrEMBL
Pfam	VWC2L_1st	UniProtKB/TrEMBL
	VWC2L_2nd	UniProtKB/TrEMBL
	VWC2L_C	UniProtKB/TrEMBL
PhenoGen	Vwc2l	PhenoGen
PROSITE	VWFC_1	UniProtKB/TrEMBL
	VWFC_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000027400	RatGTEx
SMART	VWC	UniProtKB/TrEMBL
Superfamily-SCOP	FnI-like domain	UniProtKB/TrEMBL
UniProt	A0A8I6AU98	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L462_RAT	UniProtKB/TrEMBL
	A0ABK0LAQ0_RAT	UniProtKB/TrEMBL
	A0ABK0LLT0_RAT	UniProtKB/TrEMBL
	A6KFF7	ENTREZGENE, UniProtKB/TrEMBL
	D4A0X1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-08-21	Vwc2l	von Willebrand factor C domain containing 2 like	Vwc2l	von Willebrand factor C domain-containing protein 2-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-02-12	Vwc2l	von Willebrand factor C domain-containing protein 2-like	RGD1565501	similar to PSST739 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1565501	similar to PSST739 protein	RGD1565501_predicted	similar to PSST739 protein (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1565501_predicted	similar to PSST739 protein (predicted)	LOC501160	similar to PSST739 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501160	similar to PSST739 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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