Zfp280b (zinc finger protein 280B) - Rat Genome Database

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Gene: Zfp280b (zinc finger protein 280B) Rattus norvegicus
Analyze
Symbol: Zfp280b
Name: zinc finger protein 280B
RGD ID: 1565460
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF280B (zinc finger protein 280B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909461; LOC294343; RGD1565460; similar to suppressor of hairy wing homolog 2; zinc finger protein 280B-like; Znf280b
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,626,550 - 12,641,383 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,626,259 - 12,646,139 (-)EnsemblGRCr8
mRatBN7.22012,627,106 - 12,641,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,627,106 - 12,646,683 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,326,059 - 13,340,942 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,686,990 - 12,701,873 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,158,777 - 13,173,659 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,566,381 - 13,581,215 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,567,803 - 13,581,164 (-)Ensemblrn6Rnor6.0
Rnor_5.02015,635,322 - 15,650,135 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,025,644 - 13,040,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,118,484 - 14,133,290 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp280b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,626,550 - 12,641,383 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2012,626,259 - 12,646,139 (-)EnsemblGRCr8
mRatBN7.22012,627,106 - 12,641,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,627,106 - 12,646,683 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2013,326,059 - 13,340,942 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,686,990 - 12,701,873 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,158,777 - 13,173,659 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,566,381 - 13,581,215 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,567,803 - 13,581,164 (-)Ensemblrn6Rnor6.0
Rnor_5.02015,635,322 - 15,650,135 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42013,025,644 - 13,040,457 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2014,118,484 - 14,133,290 (-)NCBICelera
Cytogenetic Map20p12NCBI
ZNF280B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,484,421 - 22,509,154 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,484,421 - 22,508,742 (-)Ensemblhg38GRCh38
GRCh372222,838,767 - 22,863,060 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,168,767 - 21,193,505 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342221,163,322 - 21,188,059NCBI
Celera226,646,667 - 6,671,408 (-)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef225,797,402 - 5,822,126 (-)NCBIHuRef
CHM1_12222,838,891 - 22,863,657 (-)NCBICHM1_1
T2T-CHM13v2.02222,907,263 - 22,932,010 (-)NCBIT2T-CHM13v2.0
Zfp280b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,868,235 - 75,878,804 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,868,484 - 75,879,068 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381076,032,401 - 76,042,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,032,650 - 76,043,234 (+)Ensemblmm10GRCm38
MGSCv371075,495,357 - 75,505,714 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361075,476,430 - 75,486,679 (+)NCBIMGSCv36mm8
Celera1077,076,547 - 77,086,900 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.67NCBI
LOC100152690
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11448,862,818 - 48,877,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,308,531 - 52,322,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF280B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,468,032 - 3,491,475 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,484,232 - 3,485,863 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660853,609,262 - 3,631,133 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf280b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247478,819,889 - 8,821,529 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247478,816,707 - 8,835,136 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp280b
132 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:851
Count of miRNA genes:296
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000033298, ENSRNOT00000071184, ENSRNOT00000071486
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 61 133 57 60 41 86 41 298 168 11 124 71 73 19 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033298   ⟹   ENSRNOP00000034023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,628,469 - 12,641,246 (-)Ensembl
mRatBN7.2 Ensembl2012,628,911 - 12,646,683 (-)Ensembl
Rnor_6.0 Ensembl2013,567,803 - 13,581,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081733   ⟹   ENSRNOP00000073790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,626,836 - 12,640,261 (-)Ensembl
mRatBN7.2 Ensembl2012,627,114 - 12,641,931 (-)Ensembl
Rnor_6.0 Ensembl2013,569,416 - 13,571,364 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119186   ⟹   ENSRNOP00000093243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,626,501 - 12,646,139 (-)Ensembl
mRatBN7.2 Ensembl2012,627,106 - 12,641,943 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142998   ⟹   ENSRNOP00000112397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,626,259 - 12,641,700 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164658   ⟹   ENSRNOP00000103456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,627,752 - 12,641,493 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167393   ⟹   ENSRNOP00000105589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2012,626,259 - 12,643,193 (-)Ensembl
RefSeq Acc Id: NM_001419514   ⟹   NP_001406443
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,626,550 - 12,641,383 (-)NCBI
mRatBN7.22012,627,106 - 12,641,943 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001406443 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97162 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034023.2
  ENSRNOP00000073790.1
  ENSRNOP00000093243.1
  ENSRNOP00000103456.1
  ENSRNOP00000105589.1
  ENSRNOP00000112397
  ENSRNOP00000112397.1
Ensembl Acc Id: ENSRNOP00000034023   ⟸   ENSRNOT00000033298
Ensembl Acc Id: ENSRNOP00000073790   ⟸   ENSRNOT00000081733
Ensembl Acc Id: ENSRNOP00000093243   ⟸   ENSRNOT00000119186
RefSeq Acc Id: NP_001406443   ⟸   NM_001419514
- UniProtKB: D3ZNU4 (UniProtKB/TrEMBL),   A6JKE6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112397   ⟸   ENSRNOT00000142998
Ensembl Acc Id: ENSRNOP00000105589   ⟸   ENSRNOT00000167393
Ensembl Acc Id: ENSRNOP00000103456   ⟸   ENSRNOT00000164658
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNU4-F1-model_v2 AlphaFold D3ZNU4 1-532 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565460 AgrOrtholog
BioCyc Gene G2FUF-4175 BioCyc
Ensembl Genes ENSRNOG00000028441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033298.5 UniProtKB/TrEMBL
  ENSRNOT00000081733.3 UniProtKB/TrEMBL
  ENSRNOT00000119186.2 UniProtKB/TrEMBL
  ENSRNOT00000142998 ENTREZGENE
  ENSRNOT00000142998.1 UniProtKB/TrEMBL
  ENSRNOT00000164658.1 UniProtKB/TrEMBL
  ENSRNOT00000167393.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro DUF4195 UniProtKB/TrEMBL
  Snail/Krueppel_Znf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 294343 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 280B UniProtKB/TrEMBL
Pfam DUF4195 UniProtKB/TrEMBL
PhenoGen Zfp280b PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028441 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A6JKE6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZNU4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zfp280b  zinc finger protein 280B  LOC100909461  zinc finger protein 280B-like  Data merged from RGD:6503723 737654 PROVISIONAL
2012-07-05 LOC100909461  zinc finger protein 280B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-07-19 Zfp280b  zinc finger protein 280B  Znf280b  zinc finger protein 280B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-09 Znf280b  zinc finger protein 280B  Zfp280b  zinc finger protein 280b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Zfp280b  zinc finger protein 280b  RGD1565460_predicted  similar to suppressor of hairy wing homolog 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565460_predicted  similar to suppressor of hairy wing homolog 2 (predicted)  LOC294343  similar to suppressor of hairy wing homolog 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294343  similar to suppressor of hairy wing homolog 2      Symbol and Name status set to provisional 70820 PROVISIONAL