Gsta6 (glutathione S-transferase alpha 6) - Rat Genome Database

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Gene: Gsta6 (glutathione S-transferase alpha 6) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gsta6
Name: glutathione S-transferase alpha 6
RGD ID: 1565402
Description: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to human GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase A6; GST class-alpha member 6; LOC501110; similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,239,670 - 31,297,809 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl931,240,696 - 31,264,064 (-)EnsemblGRCr8
mRatBN7.2923,743,262 - 23,806,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,744,288 - 23,801,131 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx932,236,483 - 32,272,189 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0937,357,167 - 37,392,873 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,672,408 - 35,708,114 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd935,037,013 - 35,072,745 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive930,828,278 - 30,864,007 (-)NCBILyon_Normotensive
Lyon_Hypertensive930,904,728 - 30,940,459 (-)NCBILyon_Hypertensive
F344_StmMcwi932,870,561 - 32,906,296 (-)NCBIF344_StmMcwi
Rnor_6.0927,475,273 - 27,533,939 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,475,273 - 27,511,176 (-)Ensemblrn6Rnor6.0
Rnor_5.0926,322,566 - 26,381,233 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4920,091,284 - 20,126,965 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera921,318,408 - 21,353,799 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17086191   PMID:21492153   PMID:23012479   PMID:23533145   PMID:25931508  


Genomics

Variants

.
Variants in Gsta6
693 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:443
Count of miRNA genes:226
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000036813
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
D9Rat130  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8931,250,432 - 31,250,552 (+)Marker Load Pipeline
mRatBN7.2923,754,024 - 23,754,144 (+)MAPPERmRatBN7.2
Rnor_6.0927,486,036 - 27,486,155NCBIRnor6.0
Rnor_5.0926,333,329 - 26,333,448UniSTSRnor5.0
RGSC_v3.4920,102,034 - 20,102,447RGDRGSC3.4
RGSC_v3.4920,102,047 - 20,102,166UniSTSRGSC3.4
Celera921,328,905 - 21,329,024UniSTS
RGSC_v3.1920,099,890 - 20,100,009RGD
RH 3.4 Map9230.2UniSTS
RH 3.4 Map9230.2RGD
RH 2.0 Map9202.5RGD
SHRSP x BN Map920.1498RGD
Cytogenetic Map9q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 154 91 90 59 92 59 6 356 192 11 133 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000036813   ⟹   ENSRNOP00000031201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl931,240,696 - 31,264,064 (-)Ensembl
mRatBN7.2 Ensembl923,744,288 - 23,801,131 (-)Ensembl
Rnor_6.0 Ensembl927,475,273 - 27,511,176 (-)Ensembl
RefSeq Acc Id: NM_001024361   ⟹   NP_001019532
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,239,670 - 31,275,351 (-)NCBI
mRatBN7.2923,743,262 - 23,778,944 (-)NCBI
Dahl_SR_JrHsd935,037,013 - 35,072,745 (-)NCBI
Lyon_Normotensive930,828,278 - 30,864,007 (-)NCBI
Lyon_Hypertensive930,904,728 - 30,940,459 (-)NCBI
F344_StmMcwi932,870,561 - 32,906,296 (-)NCBI
Rnor_6.0927,475,273 - 27,511,176 (-)NCBI
Rnor_5.0926,322,566 - 26,381,233 (-)NCBI
RGSC_v3.4920,091,284 - 20,126,965 (-)RGD
Celera921,318,408 - 21,353,799 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244656   ⟹   XP_006244718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,297,809 (-)NCBI
mRatBN7.2923,743,265 - 23,806,242 (-)NCBI
Rnor_6.0927,475,276 - 27,533,939 (-)NCBI
Rnor_5.0926,322,566 - 26,381,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244657   ⟹   XP_006244719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,279,479 (-)NCBI
mRatBN7.2923,744,099 - 23,782,810 (-)NCBI
Rnor_6.0927,475,276 - 27,515,446 (-)NCBI
Rnor_5.0926,322,566 - 26,381,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084065   ⟹   XP_038939993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,297,597 (-)NCBI
mRatBN7.2923,744,099 - 23,795,978 (-)NCBI
RefSeq Acc Id: XM_039084066   ⟹   XP_038939994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,279,479 (-)NCBI
mRatBN7.2923,744,099 - 23,780,588 (-)NCBI
RefSeq Acc Id: XM_063267581   ⟹   XP_063123651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,264,042 (-)NCBI
RefSeq Acc Id: NP_001019532   ⟸   NM_001024361
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244718   ⟸   XM_006244656
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244719   ⟸   XM_006244657
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031201   ⟸   ENSRNOT00000036813
RefSeq Acc Id: XP_038939993   ⟸   XM_039084065
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038939994   ⟸   XM_039084066
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123651   ⟸   XM_063267581
- Peptide Label: isoform X2
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXY0-F1-model_v2 AlphaFold Q6AXY0 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565402 AgrOrtholog
BioCyc Gene G2FUF-28000 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000033402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036813 ENTREZGENE
  ENSRNOT00000036813.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133989 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:501110 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94389 IMAGE-MGC_LOAD
NCBI Gene 501110 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE A2 UniProtKB/Swiss-Prot
Pfam GST_C_3 UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PhenoGen Gsta6 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033402 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt GSTA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Gsta6  glutathione S-transferase alpha 6  LOC501110  similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha)  Name and Symbol changed 629549 APPROVED
2006-02-09 LOC501110  similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha)      Symbol and Name status set to provisional 70820 PROVISIONAL