Gsta6 (glutathione S-transferase alpha 6) - Rat Genome Database

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Gene: Gsta6 (glutathione S-transferase alpha 6) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gsta6
Name: glutathione S-transferase alpha 6
RGD ID: 1565402
Description: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to human GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase A6; GST class-alpha member 6; LOC501110; similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,239,670 - 31,297,809 (-)NCBIGRCr8
mRatBN7.2923,743,262 - 23,806,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,744,288 - 23,801,131 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx932,236,483 - 32,272,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0937,357,167 - 37,392,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,672,408 - 35,708,114 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0927,475,273 - 27,533,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,475,273 - 27,511,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,322,566 - 26,381,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,091,284 - 20,126,965 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera921,318,408 - 21,353,799 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17086191   PMID:21492153   PMID:23012479   PMID:23533145   PMID:25931508  


Genomics

Variants

.
Variants in Gsta6
180 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:443
Count of miRNA genes:226
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000036813
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat

Markers in Region
D9Rat130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2923,754,024 - 23,754,144 (+)MAPPERmRatBN7.2
Rnor_6.0927,486,036 - 27,486,155NCBIRnor6.0
Rnor_5.0926,333,329 - 26,333,448UniSTSRnor5.0
RGSC_v3.4920,102,047 - 20,102,166UniSTSRGSC3.4
RGSC_v3.4920,102,034 - 20,102,447RGDRGSC3.4
RGSC_v3.1920,099,890 - 20,100,009RGD
Celera921,328,905 - 21,329,024UniSTS
RH 3.4 Map9230.2RGD
RH 3.4 Map9230.2UniSTS
RH 2.0 Map9202.5RGD
SHRSP x BN Map920.1498RGD
Cytogenetic Map9q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 23 7 19 7 5 16 29 11
Low 1 41 34 34 34 8 11 69 19 12 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036813   ⟹   ENSRNOP00000031201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,744,288 - 23,801,131 (-)Ensembl
Rnor_6.0 Ensembl927,475,273 - 27,511,176 (-)Ensembl
RefSeq Acc Id: NM_001024361   ⟹   NP_001019532
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,239,670 - 31,275,351 (-)NCBI
mRatBN7.2923,743,262 - 23,778,944 (-)NCBI
Rnor_6.0927,475,273 - 27,511,176 (-)NCBI
Rnor_5.0926,322,566 - 26,381,233 (-)NCBI
RGSC_v3.4920,091,284 - 20,126,965 (-)RGD
Celera921,318,408 - 21,353,799 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244656   ⟹   XP_006244718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,297,809 (-)NCBI
mRatBN7.2923,743,265 - 23,806,242 (-)NCBI
Rnor_6.0927,475,276 - 27,533,939 (-)NCBI
Rnor_5.0926,322,566 - 26,381,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244657   ⟹   XP_006244719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,279,479 (-)NCBI
mRatBN7.2923,744,099 - 23,782,810 (-)NCBI
Rnor_6.0927,475,276 - 27,515,446 (-)NCBI
Rnor_5.0926,322,566 - 26,381,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084065   ⟹   XP_038939993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,297,597 (-)NCBI
mRatBN7.2923,744,099 - 23,795,978 (-)NCBI
RefSeq Acc Id: XM_039084066   ⟹   XP_038939994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,279,479 (-)NCBI
mRatBN7.2923,744,099 - 23,780,588 (-)NCBI
RefSeq Acc Id: XM_063267581   ⟹   XP_063123651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,240,524 - 31,264,042 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001019532   ⟸   NM_001024361
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244718   ⟸   XM_006244656
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244719   ⟸   XM_006244657
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031201   ⟸   ENSRNOT00000036813
RefSeq Acc Id: XP_038939993   ⟸   XM_039084065
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038939994   ⟸   XM_039084066
- Peptide Label: isoform X1
- UniProtKB: Q6AXY0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123651   ⟸   XM_063267581
- Peptide Label: isoform X2
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXY0-F1-model_v2 AlphaFold Q6AXY0 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565402 AgrOrtholog
BioCyc Gene G2FUF-28000 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000033402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055019883 UniProtKB/Swiss-Prot
  ENSRNOG00060015492 UniProtKB/Swiss-Prot
  ENSRNOG00065018669 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036813.3 UniProtKB/Swiss-Prot
  ENSRNOT00055033965 UniProtKB/Swiss-Prot
  ENSRNOT00060026532 UniProtKB/Swiss-Prot
  ENSRNOT00065031345 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133989 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:501110 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94389 IMAGE-MGC_LOAD
NCBI Gene 501110 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE A2 UniProtKB/Swiss-Prot
Pfam GST_C_3 UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PhenoGen Gsta6 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033402 RatGTEx
  ENSRNOG00055019883 RatGTEx
  ENSRNOG00060015492 RatGTEx
  ENSRNOG00065018669 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt GSTA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Gsta6  glutathione S-transferase alpha 6  LOC501110  similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha)  Name and Symbol changed 629549 APPROVED
2006-02-09 LOC501110  similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha)      Symbol and Name status set to provisional 70820 PROVISIONAL