Triml2 (tripartite motif family-like 2) - Rat Genome Database

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Gene: Triml2 (tripartite motif family-like 2) Rattus norvegicus
Analyze
Symbol: Triml2
Name: tripartite motif family-like 2
RGD ID: 1565382
Description: Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within response to retinoic acid. Predicted to be active in cytoplasm. Orthologous to human TRIML2 (tripartite motif family like 2); INTERACTS WITH acrylamide; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290766; probable E3 ubiquitin-protein ligase TRIML2; RGD1565382; similar to hypothetical protein FLJ25801; similar to tripartite motif protein 39; tripartite motif family-like protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81655,677,142 - 55,693,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1655,677,142 - 55,693,379 (-)EnsemblGRCr8
mRatBN7.21648,944,712 - 48,960,949 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1648,944,838 - 48,955,453 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1654,331,090 - 54,341,742 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01657,711,357 - 57,722,031 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01652,969,092 - 52,979,744 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01652,116,975 - 52,127,591 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1652,116,975 - 52,127,591 (-)Ensemblrn6Rnor6.0
Rnor_5.01651,843,224 - 51,853,840 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41652,276,466 - 52,287,082 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1646,915,867 - 46,926,407 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18400104  


Genomics

Comparative Map Data
Triml2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81655,677,142 - 55,693,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1655,677,142 - 55,693,379 (-)EnsemblGRCr8
mRatBN7.21648,944,712 - 48,960,949 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1648,944,838 - 48,955,453 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1654,331,090 - 54,341,742 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01657,711,357 - 57,722,031 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01652,969,092 - 52,979,744 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01652,116,975 - 52,127,591 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1652,116,975 - 52,127,591 (-)Ensemblrn6Rnor6.0
Rnor_5.01651,843,224 - 51,853,840 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41652,276,466 - 52,287,082 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1646,915,867 - 46,926,407 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
TRIML2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384188,091,272 - 188,109,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4188,091,247 - 188,109,611 (-)Ensemblhg38GRCh38
GRCh374189,012,426 - 189,030,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364189,249,421 - 189,263,402 (-)NCBIBuild 36Build 36hg18NCBI36
Celera4186,321,751 - 186,335,768 (-)NCBICelera
Cytogenetic Map4q35.2NCBI
HuRef4184,748,981 - 184,762,959 (-)NCBIHuRef
CHM1_14188,988,780 - 189,002,847 (-)NCBICHM1_1
T2T-CHM13v2.04191,438,954 - 191,457,289 (-)NCBIT2T-CHM13v2.0
Triml2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39843,633,500 - 43,646,921 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl843,633,578 - 43,646,918 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38843,180,463 - 43,193,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl843,180,541 - 43,193,881 (+)Ensemblmm10GRCm38
MGSCv37844,268,476 - 44,279,238 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36844,679,313 - 44,692,701 (+)NCBIMGSCv36mm8
Celera845,859,264 - 45,869,971 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Triml2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540321,089,194 - 21,104,840 (+)NCBIChiLan1.0ChiLan1.0
TRIML2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23185,813,784 - 185,832,436 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14186,168,374 - 186,187,014 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04180,245,925 - 180,264,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14192,434,925 - 192,453,460 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4192,430,524 - 192,453,689 (-)EnsemblpanPan2panpan1.1
TRIML2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11642,984,204 - 43,000,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1642,984,303 - 43,000,051 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1643,472,754 - 43,488,609 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01645,204,136 - 45,219,987 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1645,204,233 - 45,219,986 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11643,164,393 - 43,180,208 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01643,744,659 - 43,760,558 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01643,874,241 - 43,890,223 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Triml2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494336,422,029 - 36,433,548 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365541,676,443 - 1,687,758 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365541,676,443 - 1,687,779 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIML2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,311,007 - 7,326,119 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1177,310,656 - 7,326,072 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2178,174,053 - 8,203,644 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIML2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17133,960,748 - 133,978,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7133,960,679 - 133,974,573 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037114,382,691 - 114,400,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Triml2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476919,032,190 - 19,050,326 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476919,032,145 - 19,050,539 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Triml2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11344,597,328 - 44,607,949 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Triml2
137 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000033652
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164975766656898388Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
D16Rat116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21648,972,512 - 48,972,724 (+)MAPPERmRatBN7.2
Rnor_6.01652,144,708 - 52,144,919NCBIRnor6.0
Rnor_5.01651,870,957 - 51,871,168UniSTSRnor5.0
RGSC_v3.41652,304,139 - 52,304,351RGDRGSC3.4
RGSC_v3.41652,304,140 - 52,304,351UniSTSRGSC3.4
Celera1646,943,426 - 46,943,637UniSTS
RGSC_v3.11652,304,214 - 52,304,426RGD
SHRSP x BN Map1618.11RGD
SHRSP x BN Map1618.11UniSTS
Cytogenetic Map16q12.1UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
integumental system
mesenchyme
nervous system
renal system
reproductive system
11 3 3 3 3 2 4 9 1 53

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000033652   ⟹   ENSRNOP00000035076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1655,677,142 - 55,693,379 (-)Ensembl
mRatBN7.2 Ensembl1648,944,838 - 48,955,453 (-)Ensembl
Rnor_6.0 Ensembl1652,116,975 - 52,127,591 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116620   ⟹   ENSRNOP00000095792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1655,677,142 - 55,693,379 (-)Ensembl
mRatBN7.2 Ensembl1648,944,838 - 48,955,453 (-)Ensembl
RefSeq Acc Id: NM_001191690   ⟹   NP_001178619
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,677,142 - 55,693,379 (-)NCBI
mRatBN7.21648,944,712 - 48,960,949 (-)NCBI
Rnor_6.01652,116,975 - 52,127,591 (-)NCBI
Rnor_5.01651,843,224 - 51,853,840 (-)NCBI
Celera1646,915,867 - 46,926,407 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178619 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035076
  ENSRNOP00000035076.5
  ENSRNOP00000095792.1
RefSeq Acc Id: NP_001178619   ⟸   NM_001191690
- UniProtKB: F1M5Y6 (UniProtKB/TrEMBL),   A0A8I6GLB5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035076   ⟸   ENSRNOT00000033652
Ensembl Acc Id: ENSRNOP00000095792   ⟸   ENSRNOT00000116620
Protein Domains
B30.2/SPRY

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M5Y6-F1-model_v2 AlphaFold F1M5Y6 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565382 AgrOrtholog
BioCyc Gene G2FUF-11287 BioCyc
Ensembl Genes ENSRNOG00000028299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033652 ENTREZGENE
  ENSRNOT00000033652.7 UniProtKB/TrEMBL
  ENSRNOT00000116620.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  Butyrophylin UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
  TRIM/RBCC UniProtKB/TrEMBL
KEGG Report rno:290766 UniProtKB/TrEMBL
NCBI Gene 290766 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/TrEMBL
Pfam PRY UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
PhenoGen Triml2 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028299 RatGTEx
SMART PRY UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/TrEMBL
  ConA_like_lec_gl UniProtKB/TrEMBL
UniProt A0A8I6GLB5 ENTREZGENE, UniProtKB/TrEMBL
  F1M5Y6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Triml2  tripartite motif family-like 2  LOC682851  similar to tripartite motif protein 39  Data merged from RGD:1593997 1643240 APPROVED
2008-03-07 Triml2  tripartite motif family-like 2  RGD1565382_predicted  similar to hypothetical protein FLJ25801 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC682851  similar to tripartite motif protein 39      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1565382_predicted  similar to hypothetical protein FLJ25801 (predicted)  LOC290766  similar to hypothetical protein FLJ25801  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290766  similar to hypothetical protein FLJ25801      Symbol and Name status set to provisional 70820 PROVISIONAL