Rhoxf4g (Rhox homeobox family member 4G) - Rat Genome Database

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Gene: Rhoxf4g (Rhox homeobox family member 4G) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rhoxf4g (Ensembl: Rhox4g)
Name: Rhox homeobox family member 4G (Ensembl:reproductive homeobox 4G)
RGD ID: 1565307
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein Rhox5-like; LOC103689929; LOC313451; reproductive homeobox 4G; reproductive homeobox on X chromosome 4; rhox homeobox family member 2-like; Rhox4g
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,337,766 - 121,343,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX121,337,766 - 121,343,527 (-)EnsemblGRCr8
mRatBN7.2X116,472,094 - 116,477,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,472,094 - 116,477,855 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX118,575,427 - 118,581,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,144,583 - 122,150,349 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,690,604 - 119,696,370 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,851,846 - 123,857,609 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,851,845 - 123,857,609 (-)Ensemblrn6Rnor6.0
Rnor_6.0 EnsemblX124,561,437 - 124,566,977 (-)Ensemblrn6Rnor6.0
Rnor_5.0X124,646,979 - 124,652,742 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X7,676,033 - 7,681,796 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX115,699,507 - 115,705,260 (-)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Rhoxf4g
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000034056
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
BI278869  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map190.0UniSTS
Cytogenetic MapXq11UniSTS


Expression

RNA-SEQ Expression

circulatory system
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
renal system
reproductive system
respiratory system
3 1 1 1 5 4 1 7 1

Sequence


Ensembl Acc Id: ENSRNOT00000034056   ⟹   ENSRNOP00000031307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX124,561,437 - 124,566,977 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086076   ⟹   ENSRNOP00000074443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX121,337,766 - 121,343,527 (-)Ensembl
mRatBN7.2 EnsemblX116,472,094 - 116,477,855 (-)Ensembl
Rnor_6.0 EnsemblX123,851,845 - 123,857,609 (-)Ensembl
RefSeq Acc Id: NM_001024889   ⟹   NP_001020060
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,337,766 - 121,343,527 (-)NCBI
mRatBN7.2X116,472,094 - 116,477,855 (-)NCBI
Rnor_6.0X123,851,846 - 123,857,609 (-)NCBI
Rnor_5.0X124,646,979 - 124,652,742 (-)NCBI
RGSC_v3.4X7,676,033 - 7,681,796 (+)RGD
CeleraX115,699,507 - 115,705,260 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020060 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAY58263 (Get FASTA)   NCBI Sequence Viewer  
  EDM10844 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074443
  ENSRNOP00000074443.1
RefSeq Acc Id: NP_001020060   ⟸   NM_001024889
- UniProtKB: Q4TU78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074443   ⟸   ENSRNOT00000086076
Ensembl Acc Id: ENSRNOP00000031307   ⟸   ENSRNOT00000034056
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4TU78-F1-model_v2 AlphaFold Q4TU78 1-201 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565307 AgrOrtholog
BioCyc Gene G2FUF-1290 BioCyc
Ensembl Genes ENSRNOG00000027994 Ensembl
  ENSRNOG00000058333 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086076 ENTREZGENE
  ENSRNOT00000086076.4 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:313451 UniProtKB/TrEMBL
NCBI Gene 313451 ENTREZGENE
PANTHER HOMEOBOX PROTEIN EHOX-RELATED UniProtKB/TrEMBL
  MCG113260-RELATED-RELATED UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Rhoxf4g PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027994 RatGTEx
  ENSRNOG00000058333 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt Q4TU78 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-07-21 Rhoxf4g  Rhox homeobox family member 4G  Rhox4g  reproductive homeobox 4G  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Rhox4g  reproductive homeobox 4G  LOC103689929  homeobox protein Rhox5-like  Data merged from RGD:9418829 737654 PROVISIONAL
2014-08-25 LOC103689929  homeobox protein Rhox5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Rhox4g  reproductive homeobox 4G  LOC313451  reproductive homeobox on X chromosome 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC313451  reproductive homeobox on X chromosome 4      Symbol and Name status set to provisional 70820 PROVISIONAL