Rnase1l2 (ribonuclease, RNase A family, 1-like 2) - Rat Genome Database

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Gene: Rnase1l2 (ribonuclease, RNase A family, 1-like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rnase1l2
Name: ribonuclease, RNase A family, 1-like 2 (Ensembl:ribonuclease, RNase A family, 1-like 2 (pancreatic))
RGD ID: 1565230
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Orthologous to human RNASE1 (ribonuclease A family member 1, pancreatic); INTERACTS WITH 17beta-estradiol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC103694853; LOC305844; pancreatic ribonuclease gamma; RGD1565230; ribonuclease pancreatic gamma-type; ribonuclease, RNase A family, 1-like 2 (pancreatic); RNase 1 gamma
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,895,318 - 26,897,025 (+)NCBIGRCr8
mRatBN7.21524,421,825 - 24,423,513 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,421,859 - 24,423,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,193,950 - 27,194,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_WKY_Bbb_1.01526,402,513 - 26,402,971 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,127,147 - 28,128,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,128,078 - 28,128,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,956,319 - 31,959,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,184,639 - 27,185,097 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,739,144 - 24,742,074 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Pancreatic-type ribonuclease 1 gene duplications in rat species. Dubois JY, etal., J Mol Evol 2002 Nov;55(5):522-33.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Rnase1l2
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:108
Interacting mature miRNAs:111
Transcripts:ENSRNOT00000046615
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082938   ⟹   ENSRNOP00000072263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1528,128,078 - 28,128,536 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086427   ⟹   ENSRNOP00000068653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,421,859 - 24,423,611 (+)Ensembl
RefSeq Acc Id: NM_001025116   ⟹   NP_001020287
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,896,306 - 26,896,764 (+)NCBI
mRatBN7.21524,422,794 - 24,423,252 (+)NCBI
Rnor_6.01528,128,078 - 28,128,536 (+)NCBI
Rnor_5.01531,956,319 - 31,959,062 (+)NCBI
RGSC_v3.41527,184,639 - 27,185,097 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251875   ⟹   XP_006251937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,895,318 - 26,897,025 (+)NCBI
mRatBN7.21524,421,825 - 24,423,513 (+)NCBI
Rnor_6.01528,127,147 - 28,128,797 (+)NCBI
Rnor_5.01531,956,319 - 31,959,062 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001020287 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251937 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC86441 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068653
  ENSRNOP00000068653.2
  ENSRNOP00060039121
  ENSRNOP00065045950
GenBank Protein Q8VD89 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001020287   ⟸   NM_001025116
- Peptide Label: precursor
- UniProtKB: Q8VD89 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006251937   ⟸   XM_006251875
- Peptide Label: isoform X1
- UniProtKB: Q8VD89 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072263   ⟸   ENSRNOT00000082938
RefSeq Acc Id: ENSRNOP00000068653   ⟸   ENSRNOT00000086427

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VD89-F1-model_v2 AlphaFold Q8VD89 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699630
Promoter ID:EPDNEW_R10153
Type:single initiation site
Name:Rnase1l2_1
Description:ribonuclease, RNase A family, 1-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,128,041 - 28,128,101EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565230 AgrOrtholog
BioCyc Gene G2FUF-14018 BioCyc
Ensembl Genes ENSRNOG00000057064 Ensembl
  ENSRNOG00000069584 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00060027126 UniProtKB/Swiss-Prot
  ENSRNOG00065032418 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086427.2 UniProtKB/Swiss-Prot
  ENSRNOT00060047037 UniProtKB/Swiss-Prot
  ENSRNOT00065055785 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot
InterPro RNaseA UniProtKB/Swiss-Prot
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot
  RNaseA_AS UniProtKB/Swiss-Prot
  RNaseA_domain UniProtKB/Swiss-Prot
KEGG Report rno:305844 UniProtKB/Swiss-Prot
NCBI Gene 305844 ENTREZGENE
PANTHER PTHR11437 UniProtKB/Swiss-Prot
  RIBONUCLEASE PANCREATIC UniProtKB/Swiss-Prot
Pfam RnaseA UniProtKB/Swiss-Prot
PhenoGen Rnase1l2 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot
PROSITE RNASE_PANCREATIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057064 RatGTEx
  ENSRNOG00000069584 RatGTEx
  ENSRNOG00060027126 RatGTEx
  ENSRNOG00065032418 RatGTEx
SMART RNAse_Pc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot
UniProt Q8VD89 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-22 Rnase1l2  ribonuclease, RNase A family, 1-like 2  Rnase1l2  ribonuclease, RNase A family, 1-like 2 (pancreatic)  Name changed 629549 APPROVED
2021-03-09 Rnase1l2  ribonuclease, RNase A family, 1-like 2 (pancreatic)  LOC103694853  ribonuclease pancreatic gamma-type  Data merged from RGD:9320685 737654 PROVISIONAL
2014-08-25 LOC103694853  ribonuclease pancreatic gamma-type      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-05-15 Rnase1l2  ribonuclease, RNase A family, 1-like 2 (pancreatic)  RGD1565230  pancreatic ribonuclease gamma   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565230  pancreatic ribonuclease gamma   RGD1565230_predicted  pancreatic ribonuclease gamma (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565230_predicted  pancreatic ribonuclease gamma (predicted)  LOC305844  pancreatic ribonuclease gamma  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305844  pancreatic ribonuclease gamma      Symbol and Name status set to provisional 70820 PROVISIONAL