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Gene: Adgrf4 (adhesion G protein-coupled receptor F4) Rattus norvegicus

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Symbol:

Adgrf4

Name:

adhesion G protein-coupled receptor F4

RGD ID:

1565216

Description:

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G protein-coupled receptor 115; Gpr115; LOC501106; RGD1565216; similar to G-protein coupled receptor 115

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	25,769,265 - 25,800,438 (+)	NCBI		GRCr8
mRatBN7.2	9	18,272,050 - 18,303,219 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	18,272,050 - 18,303,217 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	26,859,932 - 26,890,907 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	31,934,474 - 31,965,449 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	30,220,316 - 30,251,291 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	20,951,249 - 20,982,493 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	20,951,260 - 20,982,487 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	19,813,518 - 19,843,615 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	14,006,763 - 14,122,217 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	15,974,864 - 16,005,898 (+)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adgrf4	Rat	schizophrenia		ISO	RGD:1315496	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:21822266

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adgrf4	Rat	(-)-demecolcine	increases expression	ISO	RGD:1315496	6480464	Demecolcine results in increased expression of ADGRF4 mRNA	CTD	PMID:23649840
Adgrf4	Rat	17beta-estradiol	multiple interactions	ISO	RGD:1315496	6480464	[Estradiol co-treated with TGFB1 protein] results in increased expression of ADGRF4 mRNA	CTD	PMID:30165855
Adgrf4	Rat	2,2',4,4'-Tetrabromodiphenyl ether	increases expression	EXP		6480464	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADGRF4 mRNA	CTD	PMID:27291303
Adgrf4	Rat	2,4-D	multiple interactions	ISO	RGD:1315497	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ...	CTD	PMID:37567420
Adgrf4	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of ADGRF4 mRNA	CTD	PMID:24780913
Adgrf4	Rat	aflatoxin B1	increases expression	ISO	RGD:1315496	6480464	Aflatoxin B1 results in increased expression of ADGRF4 mRNA	CTD	PMID:22100608\|PMID:32234424
Adgrf4	Rat	aldehydo-D-glucose	multiple interactions	ISO	RGD:1315497	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ...	CTD	PMID:37567420
Adgrf4	Rat	alpha-Zearalanol	multiple interactions	EXP		6480464	[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ADGRF4 mRNA	CTD	PMID:35163327
Adgrf4	Rat	aristolochic acid A	increases expression	ISO	RGD:1315496	6480464	aristolochic acid I results in increased expression of ADGRF4 mRNA	CTD	PMID:33212167
Adgrf4	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1315496	6480464	Benzo(a)pyrene results in decreased methylation of ADGRF4 5' UTR	CTD	PMID:27901495
Adgrf4	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1315496	6480464	Benzo(a)pyrene results in increased expression of ADGRF4 mRNA	CTD	PMID:32234424
Adgrf4	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1315496	6480464	Benzo(a)pyrene affects the methylation of ADGRF4 promoter	CTD	PMID:27901495
Adgrf4	Rat	Benzo[k]fluoranthene	decreases expression	ISO	RGD:1315497	6480464	benzo(k)fluoranthene results in decreased expression of ADGRF4 mRNA	CTD	PMID:26377693
Adgrf4	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of ADGRF4 mRNA	CTD	PMID:25181051
Adgrf4	Rat	bisphenol A	increases expression	ISO	RGD:1315497	6480464	bisphenol A results in increased expression of ADGRF4 mRNA	CTD	PMID:32156529
Adgrf4	Rat	calcitriol	increases expression	ISO	RGD:1315496	6480464	Calcitriol results in increased expression of ADGRF4 mRNA	CTD	PMID:16002434
Adgrf4	Rat	carbamazepine	affects expression	ISO	RGD:1315496	6480464	Carbamazepine affects the expression of ADGRF4 mRNA	CTD	PMID:25979313
Adgrf4	Rat	CGP 52608	multiple interactions	ISO	RGD:1315496	6480464	CGP 52608 promotes the reaction [RORA protein binds to ADGRF4 gene]	CTD	PMID:28238834
Adgrf4	Rat	copper atom	multiple interactions	ISO	RGD:1315496	6480464	[NSC 689534 binds to Copper] which results in increased expression of ADGRF4 mRNA	CTD	PMID:20971185
Adgrf4	Rat	copper(0)	multiple interactions	ISO	RGD:1315496	6480464	[NSC 689534 binds to Copper] which results in increased expression of ADGRF4 mRNA	CTD	PMID:20971185
Adgrf4	Rat	cyclosporin A	increases expression	ISO	RGD:1315496	6480464	Cyclosporine results in increased expression of ADGRF4 mRNA	CTD	PMID:20106945
Adgrf4	Rat	D-glucose	multiple interactions	ISO	RGD:1315497	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ...	CTD	PMID:37567420
Adgrf4	Rat	diuron	increases expression	EXP		6480464	Diuron results in increased expression of ADGRF4 mRNA	CTD	PMID:25152437
Adgrf4	Rat	formaldehyde	increases expression	ISO	RGD:1315496	6480464	Formaldehyde results in increased expression of ADGRF4 mRNA	CTD	PMID:23649840
Adgrf4	Rat	fructose	multiple interactions	ISO	RGD:1315497	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ...	CTD	PMID:37567420
Adgrf4	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of ADGRF4 mRNA	CTD	PMID:22061828
Adgrf4	Rat	glucose	multiple interactions	ISO	RGD:1315497	6480464	[lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ...	CTD	PMID:37567420
Adgrf4	Rat	GW 4064	decreases expression	ISO	RGD:1315497	6480464	GW 4064 results in decreased expression of ADGRF4 mRNA	CTD	PMID:26655953
Adgrf4	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1315496	6480464	Methyl Methanesulfonate results in increased expression of ADGRF4 mRNA	CTD	PMID:23649840
Adgrf4	Rat	N-ethyl-N-nitrosourea	increases mutagenesis	EXP		6480464	Ethylnitrosourea results in increased mutagenesis of ADGRF4 gene	CTD	PMID:16495775
Adgrf4	Rat	N-Nitrosopyrrolidine	increases expression	ISO	RGD:1315496	6480464	N-Nitrosopyrrolidine results in increased expression of ADGRF4 mRNA	CTD	PMID:32234424
Adgrf4	Rat	nickel atom	decreases expression	ISO	RGD:1315496	6480464	Nickel results in decreased expression of ADGRF4 mRNA	CTD	PMID:24768652
Adgrf4	Rat	O-methyleugenol	increases expression	ISO	RGD:1315496	6480464	methyleugenol results in increased expression of ADGRF4 mRNA	CTD	PMID:32234424
Adgrf4	Rat	okadaic acid	increases expression	ISO	RGD:1315496	6480464	Okadaic Acid results in increased expression of ADGRF4 mRNA	CTD	PMID:38832940
Adgrf4	Rat	perfluorohexanesulfonic acid	increases expression	ISO	RGD:1315497	6480464	perfluorohexanesulfonic acid results in increased expression of ADGRF4 mRNA	CTD	PMID:37995155
Adgrf4	Rat	perfluorooctanoic acid	multiple interactions	EXP		6480464	[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ADGRF4 mRNA	CTD	PMID:35163327
Adgrf4	Rat	propanal	increases expression	ISO	RGD:1315496	6480464	propionaldehyde results in increased expression of ADGRF4 mRNA	CTD	PMID:26079696
Adgrf4	Rat	silicon dioxide	increases expression	ISO	RGD:1315496	6480464	Silicon Dioxide analog results in increased expression of ADGRF4 mRNA	CTD	PMID:25895662
Adgrf4	Rat	sodium arsenite	increases expression	ISO	RGD:1315496	6480464	sodium arsenite results in increased expression of ADGRF4 mRNA	CTD	PMID:38568856
Adgrf4	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of ADGRF4 mRNA	CTD	PMID:33387578
Adgrf4	Rat	triptonide	increases expression	ISO	RGD:1315497	6480464	triptonide results in increased expression of ADGRF4 mRNA	CTD	PMID:33045310
Adgrf4	Rat	vincristine	increases expression	ISO	RGD:1315496	6480464	Vincristine results in increased expression of ADGRF4 mRNA	CTD	PMID:23649840

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adgrf4	Rat	adenylate cyclase-activating G protein-coupled receptor signaling pathway	involved_in	IBA	MGI:1924846\|PANTHER:PTN005252242	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adgrf4	Rat	cell surface receptor signaling pathway	involved_in	IEA	InterPro:IPR017981	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adgrf4	Rat	erythrocyte development	acts_upstream_of_or_within	ISO	RGD:1315497	1624291	MGI:2182928 PMID:28806758	RGD	PMID:28806758
Adgrf4	Rat	G protein-coupled receptor signaling pathway	involved_in	IEA	InterPro:IPR000832\|InterPro:IPR008078	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adgrf4	Rat	glomerular filtration	acts_upstream_of_or_within	ISO	RGD:1315497	1624291	MGI:2182928 PMID:28806758	RGD	PMID:28806758
Adgrf4	Rat	pharyngeal arch artery morphogenesis	acts_upstream_of_or_within	ISO	RGD:1315497	1624291	MGI:2182928 PMID:28806758	RGD	PMID:28806758

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adgrf4	Rat	membrane	located_in	IEA	InterPro:IPR000832\|InterPro:IPR008078\|InterPro:IPR017981	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adgrf4	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adgrf4	Rat	membrane	located_in	IEA	UniProtKB-SubCell:SL-0162	1600115	GO_REF:0000044	UniProt	GO_REF:0000044

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adgrf4	Rat	G protein-coupled receptor activity	enables	IBA	MGI:1924846\|PANTHER:PTN005252242	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adgrf4	Rat	G protein-coupled receptor activity	enables	IEA	InterPro:IPR000832\|InterPro:IPR008078	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adgrf4	Rat	protein binding	enables	ISO	RGD:1315496	1624291	UniProtKB:Q6FHY5 PMID:32296183	RGD	PMID:32296183
Adgrf4	Rat	transmembrane signaling receptor activity	enables	IEA	InterPro:IPR017981	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:28806758

Adgrf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	25,769,265 - 25,800,438 (+)	NCBI		GRCr8
mRatBN7.2	9	18,272,050 - 18,303,219 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	18,272,050 - 18,303,217 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	26,859,932 - 26,890,907 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	31,934,474 - 31,965,449 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	30,220,316 - 30,251,291 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	20,951,249 - 20,982,493 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	20,951,260 - 20,982,487 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	19,813,518 - 19,843,615 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	14,006,763 - 14,122,217 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	15,974,864 - 16,005,898 (+)	NCBI		Celera
Cytogenetic Map	9	q13	NCBI

ADGRF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	47,698,580 - 47,722,014 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	47,685,864 - 47,722,021 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	47,666,316 - 47,689,750 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	47,774,248 - 47,797,716 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	47,761,558 - 47,794,135	NCBI
Celera	6	49,222,549 - 49,246,023 (+)	NCBI		Celera
Cytogenetic Map	6	p12.3	NCBI
HuRef	6	47,394,206 - 47,417,677 (+)	NCBI		HuRef
CHM1_1	6	47,669,245 - 47,692,709 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	47,540,367 - 47,563,797 (+)	NCBI		T2T-CHM13v2.0

Adgrf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	42,967,099 - 43,008,460 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	42,967,782 - 43,003,175 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	42,656,208 - 42,697,569 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	42,656,891 - 42,692,284 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	42,793,840 - 42,829,233 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	42,120,371 - 42,155,768 (-)	NCBI		MGSCv36	mm8
Celera	17	46,077,195 - 46,113,100 (-)	NCBI		Celera
Cytogenetic Map	17	B3	NCBI
cM Map	17	19.65	NCBI

Adgrf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	12,127,361 - 12,147,346 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	12,127,365 - 12,147,227 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADGRF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	62,190,704 - 62,217,878 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	58,069,199 - 58,083,631 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	47,279,791 - 47,305,196 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	48,545,376 - 48,568,891 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	48,532,763 - 48,565,317 (+)	Ensembl	panpan1.1		panPan2

ADGRF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	15,740,427 - 15,771,939 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	15,741,534 - 15,771,948 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	15,771,250 - 15,779,068 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	16,242,995 - 16,274,295 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	16,243,119 - 16,274,289 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	15,752,448 - 15,783,737 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	15,844,924 - 15,876,192 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	15,992,597 - 16,023,878 (+)	NCBI		UU_Cfam_GSD_1.0

Adgrf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	51,123,890 - 51,147,260 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	12,814,919 - 12,847,180 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	12,814,919 - 12,827,974 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADGRF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	42,404,491 - 42,426,340 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	42,404,522 - 42,430,271 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	92,062,828 - 92,088,464 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADGRF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	24,546,272 - 24,594,430 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	24,570,790 - 24,582,638 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	47,703,864 - 47,757,035 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adgrf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	13,363,968 - 13,382,630 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Adgrf4
320 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	72
Count of miRNA genes:	63
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000016906
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
7411609	Foco16	Food consumption QTL 16	25.6	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	8952560	53952560	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	7954720	22071169	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
724543	Cm20	Cardiac mass QTL 20	3.9		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	16961398	40594091	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	13533770	42791750	Rat
11353947	Bp392	Blood pressure QTL 392			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	7283252	52283252	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
9589133	Insul26	Insulin level QTL 26	17.96	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	9	8952560	53952560	Rat

D9Rat34

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	18,363,301 - 18,363,454 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	21,040,359 - 21,040,511	NCBI	Rnor6.0
Rnor_5.0	9	19,901,192 - 19,901,344	UniSTS	Rnor5.0
RGSC_v3.4	9	14,119,478 - 14,119,630	UniSTS	RGSC3.4
RGSC_v3.4	9	14,119,477 - 14,119,630	RGD	RGSC3.4
RGSC_v3.1	9	14,116,800 - 14,116,952	RGD
Celera	9	16,065,744 - 16,065,896	UniSTS
RH 3.4 Map	9	145.0	RGD
RH 3.4 Map	9	145.0	UniSTS
RH 2.0 Map	9	111.0	RGD
SHRSP x BN Map	9	15.0998	RGD
FHH x ACI Map	9	11.19	RGD
Cytogenetic Map	9	q12	UniSTS

RH128548

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	18,302,902 - 18,303,103 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	20,982,173 - 20,982,373	NCBI	Rnor6.0
Rnor_5.0	9	19,843,299 - 19,843,499	UniSTS	Rnor5.0
RGSC_v3.4	9	14,052,242 - 14,052,442	UniSTS	RGSC3.4
Celera	9	16,005,578 - 16,005,778	UniSTS
Cytogenetic Map	9	q12	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

appendage	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
1	23	19	19	2	7	2	6	23	14	11	6	24	17


RefSeq Transcripts	NM_001399351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008757976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	FQ222190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016906 ⟹ ENSRNOP00000016906

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	18,272,050 - 18,303,217 (+)	Ensembl
Rnor_6.0 Ensembl	9	20,951,260 - 20,982,487 (+)	Ensembl

RefSeq Acc Id:

NM_001399351 ⟹ NP_001386280

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	25,769,265 - 25,800,438 (+)	NCBI
mRatBN7.2	9	18,272,050 - 18,303,219 (+)	NCBI


Protein RefSeqs	NP_001386280	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016906
	ENSRNOP00000016906.3

Ensembl Acc Id:

ENSRNOP00000016906 ⟸ ENSRNOT00000016906

RefSeq Acc Id:	NP_001386280 ⟸ NM_001399351
- Peptide Label:	precursor
- UniProtKB:	D3ZTY4 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 2 profile

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTY4-F1-model_v2	AlphaFold	D3ZTY4	1-698	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-28094	BioCyc
Ensembl Genes	ENSRNOG00000012535	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016906	ENTREZGENE
	ENSRNOT00000016906.6	UniProtKB/TrEMBL
Gene3D-CATH	2.60.220.50	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Adhesion_GPCR	UniProtKB/TrEMBL
	GAIN_dom_sf	UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/TrEMBL
	GPCR_2_Ig-hepta_rcpt	UniProtKB/TrEMBL
	GPCR_2_secretin-like	UniProtKB/TrEMBL
	GPS_dom	UniProtKB/TrEMBL
NCBI Gene	501106	ENTREZGENE
PANTHER	ADHESION G PROTEIN-COUPLED RECEPTOR F4	UniProtKB/TrEMBL
	PTHR45813	UniProtKB/TrEMBL
Pfam	7tm_2	UniProtKB/TrEMBL
PhenoGen	Adgrf4	PhenoGen
PRINTS	GPCRSECRETIN	UniProtKB/TrEMBL
	IGHEPTARCPTR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/TrEMBL
	GPS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012535	RatGTEx
SMART	GPS	UniProtKB/TrEMBL
UniProt	D3ZTY4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-03-16	Adgrf4	adhesion G protein-coupled receptor F4	Gpr115	G protein-coupled receptor 115	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Gpr115	G protein-coupled receptor 115	RGD1565216_predicted	similar to G-protein coupled receptor 115 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565216_predicted	similar to G-protein coupled receptor 115 (predicted)	LOC501106	similar to G-protein coupled receptor 115	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501106	similar to G-protein coupled receptor 115			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - CTD