Adgrf4 (adhesion G protein-coupled receptor F4) - Rat Genome Database

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Gene: Adgrf4 (adhesion G protein-coupled receptor F4) Rattus norvegicus
Analyze
Symbol: Adgrf4
Name: adhesion G protein-coupled receptor F4
RGD ID: 1565216
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 115; Gpr115; LOC501106; RGD1565216; similar to G-protein coupled receptor 115
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,769,265 - 25,800,438 (+)NCBIGRCr8
mRatBN7.2918,272,050 - 18,303,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,272,050 - 18,303,217 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,859,932 - 26,890,907 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,934,474 - 31,965,449 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0930,220,316 - 30,251,291 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0920,951,249 - 20,982,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,951,260 - 20,982,487 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,813,518 - 19,843,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4914,006,763 - 14,122,217 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera915,974,864 - 16,005,898 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28806758  


Genomics

Comparative Map Data
Adgrf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,769,265 - 25,800,438 (+)NCBIGRCr8
mRatBN7.2918,272,050 - 18,303,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,272,050 - 18,303,217 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,859,932 - 26,890,907 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0931,934,474 - 31,965,449 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0930,220,316 - 30,251,291 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0920,951,249 - 20,982,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,951,260 - 20,982,487 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,813,518 - 19,843,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4914,006,763 - 14,122,217 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera915,974,864 - 16,005,898 (+)NCBICelera
Cytogenetic Map9q13NCBI
ADGRF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38647,698,580 - 47,722,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl647,685,864 - 47,722,021 (+)EnsemblGRCh38hg38GRCh38
GRCh37647,666,316 - 47,689,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,774,248 - 47,797,716 (+)NCBINCBI36Build 36hg18NCBI36
Build 34647,761,558 - 47,794,135NCBI
Celera649,222,549 - 49,246,023 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef647,394,206 - 47,417,677 (+)NCBIHuRef
CHM1_1647,669,245 - 47,692,709 (+)NCBICHM1_1
T2T-CHM13v2.0647,540,367 - 47,563,797 (+)NCBIT2T-CHM13v2.0
Adgrf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391742,967,099 - 43,008,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1742,967,782 - 43,003,175 (-)EnsemblGRCm39 Ensembl
GRCm381742,656,208 - 42,697,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,656,891 - 42,692,284 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,793,840 - 42,829,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,120,371 - 42,155,768 (-)NCBIMGSCv36mm8
Celera1746,077,195 - 46,113,100 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.65NCBI
Adgrf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543712,127,361 - 12,147,346 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543712,127,365 - 12,147,227 (+)NCBIChiLan1.0ChiLan1.0
ADGRF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2562,190,704 - 62,217,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1658,069,199 - 58,083,631 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0647,279,791 - 47,305,196 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1648,545,376 - 48,568,891 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl648,532,763 - 48,565,317 (+)Ensemblpanpan1.1panPan2
ADGRF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,740,427 - 15,771,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,741,534 - 15,771,948 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1215,771,250 - 15,779,068 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01216,242,995 - 16,274,295 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1216,243,119 - 16,274,289 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,752,448 - 15,783,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,844,924 - 15,876,192 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,992,597 - 16,023,878 (+)NCBIUU_Cfam_GSD_1.0
Adgrf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494651,123,890 - 51,147,260 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647612,814,919 - 12,847,180 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647612,814,919 - 12,827,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl742,404,491 - 42,426,340 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1742,404,522 - 42,430,271 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,062,828 - 92,088,464 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11724,546,272 - 24,594,430 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1724,570,790 - 24,582,638 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604447,703,864 - 47,757,035 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475413,363,968 - 13,382,630 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrf4
320 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:63
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000016906
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat

Markers in Region
D9Rat34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2918,363,301 - 18,363,454 (+)MAPPERmRatBN7.2
Rnor_6.0921,040,359 - 21,040,511NCBIRnor6.0
Rnor_5.0919,901,192 - 19,901,344UniSTSRnor5.0
RGSC_v3.4914,119,478 - 14,119,630UniSTSRGSC3.4
RGSC_v3.4914,119,477 - 14,119,630RGDRGSC3.4
RGSC_v3.1914,116,800 - 14,116,952RGD
Celera916,065,744 - 16,065,896UniSTS
RH 3.4 Map9145.0RGD
RH 3.4 Map9145.0UniSTS
RH 2.0 Map9111.0RGD
SHRSP x BN Map915.0998RGD
FHH x ACI Map911.19RGD
Cytogenetic Map9q12UniSTS
RH128548  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2918,302,902 - 18,303,103 (+)MAPPERmRatBN7.2
Rnor_6.0920,982,173 - 20,982,373NCBIRnor6.0
Rnor_5.0919,843,299 - 19,843,499UniSTSRnor5.0
RGSC_v3.4914,052,242 - 14,052,442UniSTSRGSC3.4
Celera916,005,578 - 16,005,778UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 23 19 19 2 7 2 6 23 14 11 6 24 17

Sequence


Ensembl Acc Id: ENSRNOT00000016906   ⟹   ENSRNOP00000016906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl918,272,050 - 18,303,217 (+)Ensembl
Rnor_6.0 Ensembl920,951,260 - 20,982,487 (+)Ensembl
RefSeq Acc Id: NM_001399351   ⟹   NP_001386280
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,769,265 - 25,800,438 (+)NCBI
mRatBN7.2918,272,050 - 18,303,219 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016906.3
Ensembl Acc Id: ENSRNOP00000016906   ⟸   ENSRNOT00000016906
RefSeq Acc Id: NP_001386280   ⟸   NM_001399351
- Peptide Label: precursor
- UniProtKB: D3ZTY4 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTY4-F1-model_v2 AlphaFold D3ZTY4 1-698 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565216 AgrOrtholog
BioCyc Gene G2FUF-28094 BioCyc
Ensembl Genes ENSRNOG00000012535 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016906.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Adhesion_GPCR UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_Ig-hepta_rcpt UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPS_dom UniProtKB/TrEMBL
NCBI Gene 501106 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR F4 UniProtKB/TrEMBL
  PTHR45813 UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
PhenoGen Adgrf4 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/TrEMBL
  IGHEPTARCPTR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012535 RatGTEx
SMART GPS UniProtKB/TrEMBL
UniProt D3ZTY4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Adgrf4  adhesion G protein-coupled receptor F4  Gpr115  G protein-coupled receptor 115  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Gpr115  G protein-coupled receptor 115  RGD1565216_predicted  similar to G-protein coupled receptor 115 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565216_predicted  similar to G-protein coupled receptor 115 (predicted)  LOC501106  similar to G-protein coupled receptor 115  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501106  similar to G-protein coupled receptor 115      Symbol and Name status set to provisional 70820 PROVISIONAL