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Gene: Tuba3b (tubulin, alpha 3B) Rattus norvegicus

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Symbol:

Tuba3b

Name:

tubulin, alpha 3B

RGD ID:

1565155

Description:

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in keratoconus. Orthologous to several human genes including TUBA3D (tubulin alpha 3d); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH acetamide; ammonium chloride; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

alpha-tubulin 3; LOC500363; RGD1565155; similar to Tubulin alpha-3 chain (Alpha-tubulin 3); Tuba3a; tubulin alpha-3 chain

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TUBA3D (tubulin alpha 3d)	HGNC	EggNOG, Ensembl, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tuba3b (tubulin, alpha 3B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC608051 (tubulin alpha-3 chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100510930 (tubulin alpha-3 chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tuba3d (tubulin alpha 3d)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TUBA3E (tubulin alpha 3e)	HGNC	HomoloGene, PhylomeDB
Homo sapiens (human):	TUBA3C (tubulin alpha 3c)	HGNC	Ensembl, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Tuba3b (tubulin, alpha 3B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tuba3b (tubulin, alpha 3B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TUBA3C (tubulin alpha 3c)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TUBA3C (tubulin alpha 3c)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Homo sapiens (human):	TUBA3D (tubulin alpha 3d)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TUBA3D (tubulin alpha 3d)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tuba3a (tubulin, alpha 3A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tuba3a (tubulin, alpha 3A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tuba7l (tubulin, alpha 7 like)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	tuba7l (tubulin, alpha 7 like)	Alliance	DIOPT (PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	TUB1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TUB1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TUB3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TUB3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mec-12	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaTub84B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaTub84B	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaTub84D	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaTub84D	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaTub85E	Alliance	DIOPT (Hieranoid\|PANTHER\|SonicParanoid)

Related Pseudogenes:

Tuba1c-ps1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	180,319,600 - 180,325,149 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	180,319,600 - 180,325,147 (+)	Ensembl				GRCr8
mRatBN7.2	4	178,588,779 - 178,594,328 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	178,588,779 - 178,594,326 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	184,874,407 - 184,879,962 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	180,658,915 - 180,664,470 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	179,279,330 - 179,284,885 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	4	182,620,459 - 182,626,016 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	4	180,257,455 - 180,263,012 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	4	180,752,948 - 180,758,505 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	4	179,986,692 - 179,992,247 (+)	NCBI		F344_StmMcwi
Rnor_6.0	4	179,905,154 - 179,910,703 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	179,905,116 - 179,910,704 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	244,079,934 - 244,085,483 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	183,289,130 - 183,294,679 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	167,094,233 - 167,099,782 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Keratoconus 9 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

cocaine (ISO)

copper(II) chloride (ISO)

CU-O LINKAGE (ISO)

DDT (EXP)

diallyl trisulfide (EXP)

ethanol (EXP)

folic acid (ISO)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (EXP)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (ISO)

phenethyl isothiocyanate (ISO)

pirinixic acid (ISO)

sevoflurane (EXP)

sodium arsenite (ISO)

sulforaphane (ISO)

testosterone (ISO)

vincristine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

microtubule cytoskeleton organization (IBA)

microtubule-based process (IEA)

mitotic cell cycle (IBA)

Cellular Component

cilium (ISO)

cytoplasm (IBA)

cytoskeleton (IEA)

membrane raft (IEA)

microtubule (IBA,IEA)

microtubule cytoskeleton (ISO)

Molecular Function

GTP binding (IBA,IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

structural constituent of cytoskeleton (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

phagocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A revised nomenclature for the human and rodent alpha-tubulin gene family.	Khodiyar VK, etal., Genomics. 2007 May 31;.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:15632090	PMID:21630459

Genomics

Comparative Map Data

Tuba3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	180,319,600 - 180,325,149 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	180,319,600 - 180,325,147 (+)	Ensembl				GRCr8
mRatBN7.2	4	178,588,779 - 178,594,328 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	178,588,779 - 178,594,326 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	184,874,407 - 184,879,962 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	180,658,915 - 180,664,470 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	179,279,330 - 179,284,885 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	4	182,620,459 - 182,626,016 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	4	180,257,455 - 180,263,012 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	4	180,752,948 - 180,758,505 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	4	179,986,692 - 179,992,247 (+)	NCBI		F344_StmMcwi
Rnor_6.0	4	179,905,154 - 179,910,703 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	179,905,116 - 179,910,704 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	244,079,934 - 244,085,483 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	183,289,130 - 183,294,679 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	167,094,233 - 167,099,782 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

TUBA3D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	131,476,119 - 131,482,934 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	131,476,119 - 131,482,934 (+)	Ensembl			hg38	GRCh38
GRCh37	2	132,233,692 - 132,240,507 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	131,950,136 - 131,956,977 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Cytogenetic Map	2	q21.1	NCBI
HuRef	2	124,227,036 - 124,233,962 (+)	NCBI		HuRef
CHM1_1	2	132,237,201 - 132,244,128 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	131,910,887 - 131,917,702 (+)	NCBI		T2T-CHM13v2.0

Tuba3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	145,561,689 - 145,567,203 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	145,561,483 - 145,567,205 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	145,615,963 - 145,621,477 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	145,615,757 - 145,621,479 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	145,564,483 - 145,569,997 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	145,573,198 - 145,578,628 (+)	NCBI		MGSCv36	mm8
Celera	6	148,691,160 - 148,696,674 (+)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	77.62	NCBI

LOC608051
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	30,428,955 - 30,437,431 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	30,428,954 - 30,437,353 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	30,387,644 - 30,399,096 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	31,837,791 - 31,849,503 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	26	29,883,647 - 29,895,338 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	29,507,858 - 29,519,551 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	30,597,289 - 30,608,735 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC100510930
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	14	50,594,115 - 50,600,789 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	54,042,851 - 54,049,328 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tuba3d
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	8,700,766 - 8,702,088 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tuba3b
34 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	29
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000052352
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	160623982	184426481	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	176806581	181925369	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
15	12	34	101	105	106	64	43	64	11	236	102	78	46	117	42

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000052352 ⟹ ENSRNOP00000039152

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	180,319,600 - 180,325,147 (+)	Ensembl
mRatBN7.2 Ensembl	4	178,588,779 - 178,594,326 (+)	Ensembl
Rnor_6.0 Ensembl	4	179,905,116 - 179,910,704 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117473 ⟹ ENSRNOP00000087234

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	180,321,798 - 180,325,147 (+)	Ensembl
mRatBN7.2 Ensembl	4	178,590,977 - 178,594,326 (+)	Ensembl

RefSeq Acc Id:

NM_001024336 ⟹ NP_001019507

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	180,319,600 - 180,325,149 (+)	NCBI
mRatBN7.2	4	178,588,779 - 178,594,328 (+)	NCBI
Dahl_SR_JrHsd	4	182,620,459 - 182,626,016 (+)	NCBI
Lyon_Normotensive	4	180,257,455 - 180,263,012 (+)	NCBI
Lyon_Hypertensive	4	180,752,948 - 180,758,505 (+)	NCBI
F344_StmMcwi	4	179,986,692 - 179,992,247 (+)	NCBI
Rnor_6.0	4	179,905,154 - 179,910,703 (+)	NCBI
Rnor_5.0	4	244,079,934 - 244,085,483 (+)	NCBI
RGSC_v3.4	4	183,289,130 - 183,294,679 (+)	RGD
Celera	4	167,094,233 - 167,099,782 (+)	RGD

Sequence:

show sequence

GGAGCATCGCTGAGGATCGGCTGAGGTGCTCTGCTAGGAGCTCAGCATGCGTGAGTGCATCTCT
ATCCACGTGGGGCAGGCAGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTGTACTGCCTTGAAC
ATGGTATTCAGCCCGATGGTCAAATGCCAAGTGACAAAACCATTGGTGGTGGGGACGACTCATT
CAACACGTTCTTCAGTGAGACTGGCGCCGGCAAGCATGTGCCCAGAGCAGTGTTTGTGGATCTG
GAGCCCACTGTGGTTGATGAAGTGCGCACCGGAACCTACCGGCAGCTTTTCCACCCAGAGCAGC
TGATCACTGGGAAGGAAGATGCAGCCAACAATTATGCCAGAGGTCATTATACCATTGGCAAGGA
GATTGTTGACCTGGTCCTGGACCGGATCCGAAAACTGGCTGATCTGTGCACGGGGCTGCAGGGC
TTCCTCATCTTCCACAGCTTTGGAGGGGGCACAGGGTCTGGGTTCGCATCTCTGCTGATGGAGC
GGCTTTCCGTGGACTACGGCAAGAAGTCCAAGCTGGAGTTTGCCATCTACCCAGCCCCCCAGGT
CTCCACGGCTGTCGTGGAGCCCTACAACTCCATCCTGACCACGCACACGACGCTGGAGCACTCT
GACTGTGCTTTCATGGTGGACAATGAAGCCATCTACGACATCTGTCGGCGAAACCTGGACATTG
AACGTCCCACTTACACCAACCTCAATCGTCTGATTGGGCAGATTGTGTCGTCCATCACAGCTTC
TCTGAGGTTCGACGGGGCCCTGAATGTGGACTTAACAGAATTCCAGACCAACCTGGTGCCGTAC
CCTCGCATCCACTTCCCGCTGGCCACCTATGCCCCGGTCATCTCGGCCGAGAAGGCCTACCATG
AGCAGCTGTCAGTGGCAGAGATCACCAACGCTTGCTTTGAGCCAGCCAATCAGATGGTCAAGTG
TGACCCTCGCCATGGCAAATACATGGCCTGCTGCATGTTGTACAGGGGGGATGTGGTTCCAAAA
GATGTCAATGCGGCTATTGCTACCATCAAGACCAAGCGTACCATCCAGTTTGTGGATTGGTGCC
CAACTGGCTTTAAGGTGGGTATTAACTACCAGCCTCCCACCGTGGTCCCTGGGGGCGACCTGGC
CAAGGTGCAGCGGGCCGTGTGCATGCTGAGCAACACCACTGCCATCGCAGAGGCCTGGGCCCGC
CTGGACCACAAATTTGACCTCATGTACGCCAAGCGGGCCTTCGTGCATTGGTACGTGGGAGAGG
GCATGGAGGAAGGGGAGTTCTCAGAGGCCCGGGAGGACCTGGCAGCTCTGGAGAAGGATTATGA
AGAGGTGGGCGTGGATTCCGTGGAAGCAGAGGCAGAAGAAGGGGAGGAATACTGAGTACATGGA
TCTGGCTGGCAGCCATCCATTTCCGCCTTCCCCACCATTGTCACTAAAGGCTATGTTTACTTAT
TAAAGTTTTTAAATGGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001019507	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79242	(Get FASTA)	NCBI Sequence Viewer
	EDM01431	(Get FASTA)	NCBI Sequence Viewer
	EDM01432	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000039152
	ENSRNOP00000039152.2
	ENSRNOP00000049998.1
GenBank Protein	Q68FR8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019507 ⟸ NM_001024336

- UniProtKB:

Q68FR8 (UniProtKB/Swiss-Prot), A6ILT9 (UniProtKB/TrEMBL), A0A8I6ALV8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPR
AVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADL
CTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTH
TTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQ
TNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYR
GDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAI
AEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAEAEEGE
EY

hide sequence

Ensembl Acc Id:

ENSRNOP00000039152 ⟸ ENSRNOT00000052352

Ensembl Acc Id:

ENSRNOP00000087234 ⟸ ENSRNOT00000117473

Protein Domains

Tubulin/FtsZ 2-layer sandwich Tubulin/FtsZ GTPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FR8-F1-model_v2	AlphaFold	Q68FR8	1-450	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693501

Promoter ID:

EPDNEW_R4024

Type:

initiation region

Name:

Tuba3a_1

Description:

tubulin, alpha 3A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	179,905,130 - 179,905,190	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565155	AgrOrtholog
BioCyc Gene	G2FUF-42450	BioCyc
Ensembl Genes	ENSRNOG00000031707	UniProtKB/Swiss-Prot
	ENSRNOG00000032967	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000044425.3	UniProtKB/Swiss-Prot
	ENSRNOT00000052352	ENTREZGENE
	ENSRNOT00000052352.4	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.600	UniProtKB/Swiss-Prot
	3.30.1330.20	UniProtKB/Swiss-Prot
	3.40.50.1440	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7132665	IMAGE-MGC_LOAD
InterPro	Alpha_tubulin	UniProtKB/Swiss-Prot
	Tub_FtsZ_C	UniProtKB/Swiss-Prot
	Tubulin	UniProtKB/Swiss-Prot
	Tubulin/FtsZ_2-layer-sand-dom	UniProtKB/Swiss-Prot
	Tubulin/FtsZ_C_sf	UniProtKB/Swiss-Prot
	Tubulin/FtsZ_GTPase_sf	UniProtKB/Swiss-Prot
	Tubulin_C	UniProtKB/Swiss-Prot
	Tubulin_CS	UniProtKB/Swiss-Prot
	Tubulin_FtsZ_GTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:500319	UniProtKB/Swiss-Prot
	rno:500363	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94324	IMAGE-MGC_LOAD
NCBI Gene	500363	ENTREZGENE
PANTHER	PTHR11588	UniProtKB/Swiss-Prot
Pfam	Tubulin	UniProtKB/Swiss-Prot
	Tubulin_C	UniProtKB/Swiss-Prot
PhenoGen	Tuba3b	PhenoGen
PRINTS	ALPHATUBULIN	UniProtKB/Swiss-Prot
	TUBULIN	UniProtKB/Swiss-Prot
PROSITE	TUBULIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000031707	RatGTEx
	ENSRNOG00000032967	RatGTEx
SMART	Tubulin	UniProtKB/Swiss-Prot
	Tubulin_C	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52490	UniProtKB/Swiss-Prot
	SSF55307	UniProtKB/Swiss-Prot
UniProt	A0A8I6ALV8	ENTREZGENE
	A6ILT9	ENTREZGENE, UniProtKB/TrEMBL
	Q68FR8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-05-17	Tuba3b	tubulin, alpha 3B	RGD1565155_predicted	similar to Tubulin alpha-3 chain (Alpha-tubulin 3) (predicted)	Symbol and Name updated	1624988	APPROVED
2006-03-07	RGD1565155_predicted	similar to Tubulin alpha-3 chain (Alpha-tubulin 3) (predicted)	LOC500363	similar to Tubulin alpha-3 chain (Alpha-tubulin 3)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500363	similar to Tubulin alpha-3 chain (Alpha-tubulin 3)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)