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Gene: Dtx3l (deltex E3 ubiquitin ligase 3L) Rattus norvegicus

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Symbol:

Dtx3l

Name:

deltex E3 ubiquitin ligase 3L

RGD ID:

1565144

Description:

Predicted to enable several functions, including STAT family protein binding activity; histone H4K91 ubiquitin ligase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of protein localization; protein ubiquitination; and regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including cytosol; early endosome; and lysosome. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human DTX3L (deltex E3 ubiquitin ligase 3L); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

deltex 3 like, E3 ubiquitin ligase; deltex 3-like; deltex 3-like (Drosophila); E3 ubiquitin-protein ligase DTX3L; LOC498089; RGD1565144; similar to deltex 3-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DTX3L (deltex E3 ubiquitin ligase 3L)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dtx3l (deltex 3-like, E3 ubiquitin ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dtx3l (deltex E3 ubiquitin ligase 3L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DTX3L (deltex E3 ubiquitin ligase 3L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DTX3L (deltex E3 ubiquitin ligase 3L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dtx3l (deltex E3 ubiquitin ligase 3L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DTX3L (deltex E3 ubiquitin ligase 3L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DTX3L (deltex E3 ubiquitin ligase 3L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dtx3l (deltex E3 ubiquitin ligase 3L)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DTX3L (deltex E3 ubiquitin ligase 3L)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dtx3l (deltex 3-like, E3 ubiquitin ligase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-40c23.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dtex3l2.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	78,320,225 - 78,329,837 (+)	NCBI		GRCr8
mRatBN7.2	11	64,814,926 - 64,824,539 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	64,814,926 - 64,824,538 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	73,639,962 - 73,649,453 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	66,302,229 - 66,311,720 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	65,333,475 - 65,342,966 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	67,758,093 - 67,767,623 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	11	67,768,542 - 67,772,428 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	67,757,928 - 67,767,622 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	70,846,234 - 70,855,845 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	66,649,508 - 66,659,119 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	64,280,848 - 64,290,468 (+)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

familial hypocalciuric hypercalcemia (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

atrazine (EXP)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

diethyl maleate (EXP)

diethylstilbestrol (ISO)

dioxygen (EXP)

doxorubicin (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

fipronil (EXP)

formaldehyde (ISO)

FR900359 (ISO)

furan (EXP)

gentamycin (EXP)

hydroquinone (ISO)

inulin (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

methapyrilene (EXP)

methylparaben (ISO)

N-ethyl-N-nitrosourea (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP)

Soman (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

topotecan (EXP)

triclosan (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage checkpoint signaling (ISO)

DNA repair-dependent chromatin remodeling (ISO)

double-strand break repair (ISO)

endosome to lysosome transport (ISO)

negative regulation of ubiquitin-protein transferase activity (ISO)

Notch signaling pathway (IBA)

positive regulation of defense response to virus by host (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of protein localization to early endosome (ISO)

positive regulation of protein localization to nucleus (ISO)

positive regulation of receptor catabolic process (ISO)

protein autoubiquitination (ISO)

protein K48-linked ubiquitination (ISO)

protein ubiquitination (IBA)

ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

early endosome (ISO)

lysosome (ISO)

nucleoplasm (IBA,ISO)

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

enzyme binding (ISO)

enzyme inhibitor activity (ISO)

histone binding (ISO)

histone H4K91 ubiquitin ligase activity (ISO)

histone ubiquitin ligase activity (ISO)

protein ADP-ribosyltransferase-substrate adaptor activity (ISO)

protein binding (ISO)

STAT family protein binding (ISO)

ubiquitin protein ligase activity (IBA)

ubiquitin-like protein ligase binding (ISO)

ubiquitin-protein transferase activity (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Notch signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16809771	PMID:19028597	PMID:19818714	PMID:23230272	PMID:24790097	PMID:26479788	PMID:28525742	PMID:31505169

Genomics

Comparative Map Data

Dtx3l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	78,320,225 - 78,329,837 (+)	NCBI		GRCr8
mRatBN7.2	11	64,814,926 - 64,824,539 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	64,814,926 - 64,824,538 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	73,639,962 - 73,649,453 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	66,302,229 - 66,311,720 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	65,333,475 - 65,342,966 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	67,758,093 - 67,767,623 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	11	67,768,542 - 67,772,428 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	67,757,928 - 67,767,622 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	70,846,234 - 70,855,845 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	66,649,508 - 66,659,119 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	64,280,848 - 64,290,468 (+)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

DTX3L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	122,564,338 - 122,575,203 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	122,564,338 - 122,575,203 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	122,283,185 - 122,294,050 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	123,765,956 - 123,775,973 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	123,765,955 - 123,775,966	NCBI
Celera	3	120,692,995 - 120,703,860 (+)	NCBI		Celera
Cytogenetic Map	3	q21.1	NCBI
HuRef	3	119,656,463 - 119,667,327 (+)	NCBI		HuRef
CHM1_1	3	122,246,867 - 122,257,728 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	125,283,584 - 125,294,443 (+)	NCBI		T2T-CHM13v2.0

Dtx3l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	35,746,885 - 35,759,397 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	35,746,881 - 35,759,521 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	35,926,515 - 35,939,027 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	35,926,511 - 35,939,151 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	35,926,601 - 35,939,113 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	35,846,258 - 35,858,670 (-)	NCBI		MGSCv36	mm8
Celera	16	36,406,742 - 36,419,270 (-)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	25.43	NCBI

Dtx3l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	21,806,192 - 21,815,031 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955427	21,806,170 - 21,812,701 (+)	NCBI	ChiLan1.0	ChiLan1.0

DTX3L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	120,459,715 - 120,519,800 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	120,464,495 - 120,521,883 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	119,654,019 - 119,664,918 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	126,510,372 - 126,569,813 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	126,558,924 - 126,569,807 (+)	Ensembl	panpan1.1		panPan2

DTX3L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	25,676,686 - 25,684,270 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	25,677,076 - 25,684,175 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	25,700,998 - 25,708,596 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	25,911,755 - 25,919,417 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	25,912,140 - 25,919,608 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	25,708,920 - 25,716,524 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	25,752,223 - 25,759,866 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	26,309,779 - 26,317,453 (+)	NCBI		UU_Cfam_GSD_1.0

Dtx3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	128,668,583 - 128,677,233 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936536	8,844,575 - 8,851,146 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936536	8,844,778 - 8,853,442 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DTX3L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	137,950,272 - 137,961,343 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	137,950,266 - 137,961,381 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	147,572,591 - 147,581,251 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DTX3L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	58,287,331 - 58,298,519 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	58,290,764 - 58,298,376 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	108,048,854 - 108,059,822 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dtx3l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624912	871,584 - 880,626 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624912	871,024 - 880,299 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dtx3l
200 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	65
Count of miRNA genes:	58
Interacting mature miRNAs:	61
Transcripts:	ENSRNOT00000039215
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	45459323	75190161	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	19456205	76331918	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat

Markers in Region

RH133296

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	64,824,234 - 64,824,441 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	67,772,125 - 67,772,331	NCBI	Rnor6.0
Rnor_6.0	11	67,767,319 - 67,767,525	NCBI	Rnor6.0
Rnor_5.0	11	70,860,348 - 70,860,554	UniSTS	Rnor5.0
Rnor_5.0	11	70,855,542 - 70,855,748	UniSTS	Rnor5.0
RGSC_v3.4	11	66,658,816 - 66,659,022	UniSTS	RGSC3.4
Celera	11	64,290,165 - 64,290,371	UniSTS
RH 3.4 Map	11	487.5	UniSTS
Cytogenetic Map	11	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000039215 ⟹ ENSRNOP00000034974

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	64,814,926 - 64,824,538 (+)	Ensembl
Rnor_6.0 Ensembl	11	67,757,928 - 67,767,622 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115201 ⟹ ENSRNOP00000082308

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	64,814,954 - 64,824,538 (+)	Ensembl

RefSeq Acc Id:

NM_001109053 ⟹ NP_001102523

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	78,320,225 - 78,329,837 (+)	NCBI
mRatBN7.2	11	64,814,926 - 64,824,539 (+)	NCBI
Rnor_6.0	11	67,768,542 - 67,772,428 (+)	NCBI
Rnor_5.0	11	70,846,234 - 70,855,845 (+)	NCBI
RGSC_v3.4	11	66,649,508 - 66,659,119 (+)	RGD
Celera	11	64,280,848 - 64,290,468 (+)	RGD

Sequence:

show sequence

CCCGGGAAACGAAACTGAAACTTTGCCTCTCGGGTCTCTGGGGCAGGACGCGCCTTCTCTCTGT
CCTGGTTGTGCAGCACCCCTGAGCCCCAAGCGAGCCAGACGCAGCCAGCCATGGCCTCCAGTCC
GGACCCGCCGTCCCCACTACTCGTAAGGCTGCCGGAGTCCATCCCCCGAGCGCACATGAAGCTG
GAGATATATTTCCAGAGCCGGGCCTCCGGAGGCGGGGAGTGCTCTGTTCATCCCGTGGGGCCCG
GCGCCCCGGACACCTTCGAGGTGAAGTTCCTTGAAAAAGCAGATAAGGAGAATGTGTTGAAAAG
GGGAAAACACAAGCTGTTGGTTGATGACAAATCTGTGCCTATTGTCCTGGAAACTATTAAAAAG
CCAGAAGAGGACCTGAGACCCAGACCTCCATCACTGACACAGCCAGCTGAGACACCAAGCTCCC
GAACTCCGTCCTTGACAGAGTCCCTGGATGAAGCACTGGGTGATAAGATACATCCCAGTGATGG
GCCCGTTTTTAACTCTGTTGACTCAGTTGTCCAAAAGGTCTTTCTCGCTGTGACCGCTGAGCTG
AACTGTGAACTGCTCTCCAAAGAGCAGAGAGCACAGATTACTGCTGTCTGCCCTCATATCAAAA
GCATGGAGGGCAGTGACGGAATTAAGAAGGTGTGTGGCAACTTCAAAGATATTGAAAAGATACA
TCACTTCCTGAGTTCGCAGCTTTTGGAAAGTGAGCCGACACGAAAGTACGTCCCACAGAAATAC
ACACCTTCCGATGTGGAGAGGGAGCCCCCCAGTCAGAGAAGTTTTGAAGTTTCTGTGCTTTTCC
TTGAATATTTCAAACATATTTATCCGGGTAGAATAGAATCCATAGAGAAAAAATTTGGTGTAAA
CATCAAAATCCAAGATAGTTCTCCGTATATGGTCTCTATAGGCTTCACCTCCAGACAATCAGGC
AACTTAGAAGAAGCTTGTCAGTCTTTTGTCAGAGACTTTCAGAAATGCACGCAGTCTCTGAAGC
AAGATTGTATCTCTTTAGAGGACCAACAGAGAGCAAAGAAGGTCAGGCAGGAGCTGAGTCGCTG
CTTCCCAAAGCTCTTGATAAAGGAACAGGGAAGGATGCTAACTCTCCTGGGCTCTGCTGCTGAC
ATTGCAGCTGCCGCAGAAAAAGTCTCCCAAACTCTTGTCCCAGCACCTGTGAAAATAGTAGCCA
CACCTGTGAAAATAGCCACACCTGTGAAAATAGCCACGTCTGGGTACATGACAGGGATCGAGGT
CGATTCGACCCGCTTTAAGCTTCTAGAACCTGAGCTGCTCCAGGAAATCGCAGAGATCGAGCAG
AAGTTTAACACTTGTGGCAAAGTCCAGGAAAAAGGCCAGAAAACCTGCATTCTCTTTGTCCCCA
AGGATAAAGAGTTAGACCTGTCTGTGCAATCTTACACAAGTTTTACTGAGGCCTTCCAGCATGC
CACGTGCCAGTTGAGGACAGAAGTTCTGTCGCTGAAACAGCTGGGCAAGGAGAAAGCTCAATTG
CACAAGACCAAGTTTGCTGACGACTTTAAAATAAAACACCCAAACGTGCACTTCGTGATATCTC
AAGAGTCAGTGACCTTGACTGGTTTGCCCAATCACCTTGGGCAGGCAATGCAGTATGTTGCCAA
AAGGATAGGAATGCCCACGTTGTTGTCGTCTGGAGAGAAATTGGCTATGGATCATGAAACGCCC
ATGGAGGTCCACAGGAATGACTCAGATGTGGCGTTACTTTCTTTCGGAAGCTCTGCTAGCAGCC
CTACGGCCTCGAAGGGGAACAAGGACGAGGACAACTGCGTCATCTGCATGGACACCATCAGGAA
CAAGCAGGTGCTCCCTAAGTGCAAGCATGAATTCTGCTCCTCTTGTATCAGCAAAGCCATGTCA
TTCAAGCCTGTCTGTCCTGTGTGTCTGACTCCCTACGGTGTCCAGAAAGGGAACCAGCCAGAGG
GAACCATGGCTCACACCATTCAAAAAGACTCACTTCCGGGTTATGAAGGCTGCGGGACTATTGT
GATTCAGTACAGTTTTGGAGATGGCATACAAACAAAGGAGCACCCAAACCCAGGAAAAGCTTAC
TCTGGAACTTATCGGGTTGCATATTTGCCTGATAATGCGGAGGGGAGAAAGGTTTTGCATCTGC
TCCGAAAAGCCTTTGATCAGAAGCTGATTTTCACAGTAGGAGAATCTCGGGTATTAGGAATCTC
GAATGTCATTACATGGAATGATATTCATCACAAAACAGCCAAGTTTGGAGGACCATCAAATTTC
GGCTACCCTGATCCTGATTACCTGAAACGTGTCAAGGAGGAGCTGAAATCAAAAGGGATCGAGT
AAGGAAACTGCAGGGAAGATGTCTATCCACTCTCTAAAGAAGTGTGTTTAGGAGGCTGTATTAG
TACAACCAAAATCTTTTTCTAGAAAAACTTAATAACATTTCTCATGTGGCGTAGTCTGCTTGCC
AGTCATTTCCAGAGCGTCACTCTCTCGTGGAACGCAAACTCTAAAGGGCACAGGCTGGGGAAAT
GGCTCTGCCTACCAAGTGTGAAGAAATGAGCTCGGATCTGCATCCTCCATGGAAAAGCCTGGTG
TGATGGTGTGCACTTGTAATCTTAGCACTGTGGAGGCAGGAGGATTCCTGGAGCTTACTGGCCA
ACTGGTCTAGTCAAAACCATGAGCTCCAGGCTCACAGAGAGACCTTGTCTCAAGAAATAAGGTA
GATCGGAGCATGGCAGTGCATGCCTTTAATGCCAAAACTTGGAAGGCAGATACAGGCAATCTCC
GTGAGTCCAGACCCAGCCTTCTCTACAGAGCCCAAGTCCCAGGACAGCCAGCTATACCTAGTGA
GATCCTGTCTCAAAACAAATATTAGGTGGACAGAATTAAAGATATCTGACAACCTCCTCTGTCC
TGCGTACGCATCTCCCCCTCCCCACACTCACACATGGGGGGGTGGAAAAGAAAACTTTATCGTT
TTATAGGATTTCAGTTTTTGCTGAAGAAATCTGATGTCATTTTTGTGTTATGGTTGGGGTGTTA
GGTGAGTTAATGGAACCTTCCCTGGTTTGTGTTTGTTTGGGTTTTTTTGTCATTGCTTTTTTTG
TTTGTTTGTTTTGGTAGGTTTGGTTTGGTTTGGTTTGATTTGATTTGATTTGATTTGATTTGAT
TTTGCTGTTGGGACTTAAACCCCAGGCCGATGAGTTCCGCCCCATTATCCTTGTTTCGTGTCCA
TCTCTGTAGCAATACATTAGTCGTTTCTTAATCTCTGAACCTTTGTGCATATGGGCAAGCGAAA
CTCTTGTTCAAACGGGATATTTAAAAAGAGGTTTAGCTGAGAAAGACCCATTATTTCCTTCCCT
ACCCATAGCAAGCAAAGTTTCTAGATCAGGCAACTTTTGGTAATAAATAGAGTGAGAAGACTCA
TAGTTTTCAGAGCCTAGGAGATGGTGTGTGATAACTGCCTGACTCAAGCTGCTAGTAGCTCAAC
AGAGGGATAAATATATAAAAAGGTATGTCCCCCAAATCTTTGGGAAAGGGATGACTTGAGACCT
TAGCATTCATTTGGAAAATAGTTTCTTACCCCAACATGTACTTACTAGACTCTGACTAAGCCTT
GAACTGGGGCCCTACTTTCCCCTGATCCATGGAACCTGTCTTAGAGGGTACACTTGCCCTGCTA
TAGAAGTGTAACATGTTTGTTACATTTTCCCCCACTTTTTGAGTATATACTGTTTCAAGTTCTA
ACAGGTGAATAGCCTTGCCTTAGTTTAATATTTTATAATAATTGGTATCTGCAATGTAGTAGCT
TTTTGTTTTTCAATCCTTGAGTGAATCCCAGCAGTCTATGCTAGCCCTCATATATAGTCTTTCT
AATCCTTTCCCTGGACAGGAATAAAGGAGAAAGGTAAATCTACTGTACAATCTATATGGTATGT
CACAGTTCACTAAGGGCTTCTCCAAGTCAGAAGAAAATCACAGCAGACAGTGATCTGGTGACCT
GCATTCCAGCAACTCTCCAAAATGGTAGATGACACCTTGACCTTCTCCTTATGACACACATGTA
CATACATAAAAACCATTTTGGCTAGATATTGATAGCAAGGATTTATCAATTACTTACTCAGTAA
GTTCTATATGTTGATATGACCAGTACAATTAATAGCCCCATTCTTTGAACAGGAAAGTCATGCG
CAATAGTATGAGCATAGCTGTCAATCACCAAAGGTGACATCATCACTAAATAGAAGTGCTGACT
TTTACTTTCATCTCCATTTTGCTTTTTTGGGGGGGGATTGTTTGTTTATTTTTTGTTTTTTGTT
TTGTTTGGGTTTTTTGTTGTTTTGTTTTGTTCTGTTTTTTGTTTTTTTGAGACAAGGTCTCATG
TAACCTACACTGGTCTCTCCCTATGTCGCCAATGCTATTCTTGAACTCTGACCCTTCTGCCTCG
CCTCCTGCCCAAGTTCTTGCATGTATACTAGGAGGATCTCTCAGGCTCTGCTTTTGCAGACATC
CAAGTGCAAGGCATGCACCACCATGCCTGACTTCTGCATCCAGTATAGACCTTTTACTTTTGTC
GATTCACCAAGTGTTTATCATTAAGACTAACTGATCGTTTTCTGTCTTCTAATCTTGTAATTAA
ATTTACTCTAAAGAAGCAAAAAGTAAATGGTTCCTGTTAAGTTCTGGATCTTTCATACAGTGTG
CACATGCAAATTCTATGTGGTGTTGAGTGCTTCATGACATTTGGATTTCTTCTTTTGCAAGGCG
GAATTATCTGTATGAAATAAAGTTAGGTGCTTGCGAACTAC

hide sequence

RefSeq Acc Id:

XM_063270706 ⟹ XP_063126776

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	78,320,408 - 78,327,367 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102523	(Get FASTA)	NCBI Sequence Viewer
	XP_063126776	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM11302	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034974.4
	ENSRNOP00000082308.1

RefSeq Acc Id:

NP_001102523 ⟸ NM_001109053

- UniProtKB:

D3Z8X6 (UniProtKB/TrEMBL), A6IRE9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASSPDPPSPLLVRLPESIPRAHMKLEIYFQSRASGGGECSVHPVGPGAPDTFEVKFLEKADKE
NVLKRGKHKLLVDDKSVPIVLETIKKPEEDLRPRPPSLTQPAETPSSRTPSLTESLDEALGDKI
HPSDGPVFNSVDSVVQKVFLAVTAELNCELLSKEQRAQITAVCPHIKSMEGSDGIKKVCGNFKD
IEKIHHFLSSQLLESEPTRKYVPQKYTPSDVEREPPSQRSFEVSVLFLEYFKHIYPGRIESIEK
KFGVNIKIQDSSPYMVSIGFTSRQSGNLEEACQSFVRDFQKCTQSLKQDCISLEDQQRAKKVRQ
ELSRCFPKLLIKEQGRMLTLLGSAADIAAAAEKVSQTLVPAPVKIVATPVKIATPVKIATSGYM
TGIEVDSTRFKLLEPELLQEIAEIEQKFNTCGKVQEKGQKTCILFVPKDKELDLSVQSYTSFTE
AFQHATCQLRTEVLSLKQLGKEKAQLHKTKFADDFKIKHPNVHFVISQESVTLTGLPNHLGQAM
QYVAKRIGMPTLLSSGEKLAMDHETPMEVHRNDSDVALLSFGSSASSPTASKGNKDEDNCVICM
DTIRNKQVLPKCKHEFCSSCISKAMSFKPVCPVCLTPYGVQKGNQPEGTMAHTIQKDSLPGYEG
CGTIVIQYSFGDGIQTKEHPNPGKAYSGTYRVAYLPDNAEGRKVLHLLRKAFDQKLIFTVGESR
VLGISNVITWNDIHHKTAKFGGPSNFGYPDPDYLKRVKEELKSKGIE

hide sequence

Ensembl Acc Id:

ENSRNOP00000034974 ⟸ ENSRNOT00000039215

Ensembl Acc Id:

ENSRNOP00000082308 ⟸ ENSRNOT00000115201

RefSeq Acc Id:	XP_063126776 ⟸ XM_063270706
- Peptide Label:	isoform X1
- UniProtKB:	A6IRE9 (UniProtKB/TrEMBL)

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z8X6-F1-model_v2	AlphaFold	D3Z8X6	1-750	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698187

Promoter ID:

EPDNEW_R8711

Type:

initiation region

Name:

Dtx3l_1

Description:

deltex E3 ubiquitin ligase 3L

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	67,758,027 - 67,758,087	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565144	AgrOrtholog
BioCyc Gene	G2FUF-21206	BioCyc
Ensembl Genes	ENSRNOG00000023400	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039215.7	UniProtKB/TrEMBL
	ENSRNOT00000115201.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.390.130	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	3.30.70.330	UniProtKB/TrEMBL
InterPro	Deltex_C	UniProtKB/TrEMBL
	Deltex_C_sf	UniProtKB/TrEMBL
	Deltex_fam	UniProtKB/TrEMBL
	DTX3L_a/b_dom	UniProtKB/TrEMBL
	DTX3L_KH-like	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	rno:498089	UniProtKB/TrEMBL
NCBI Gene	498089	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE DTX3L	UniProtKB/TrEMBL
	PTHR12622	UniProtKB/TrEMBL
Pfam	DTC	UniProtKB/TrEMBL
	DTX3L_a-b	UniProtKB/TrEMBL
	DTX3L_KH-like	UniProtKB/TrEMBL
	zf-C3HC4_2	UniProtKB/TrEMBL
PhenoGen	Dtx3l	PhenoGen
PROSITE	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000023400	RatGTEx
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A8I6G788_RAT	UniProtKB/TrEMBL
	A6IRE9	ENTREZGENE, UniProtKB/TrEMBL
	D3Z8X6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-22	Dtx3l	deltex E3 ubiquitin ligase 3L	Dtx3l	deltex 3 like, E3 ubiquitin ligase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-02-06	Dtx3l	deltex 3 like, E3 ubiquitin ligase	Dtx3l	deltex 3-like (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Dtx3l	deltex 3-like (Drosophila)	RGD1565144_predicted	similar to deltex 3-like (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565144_predicted	similar to deltex 3-like (predicted)	LOC498089	similar to deltex 3-like	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498089	similar to deltex 3-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)