Cyssl1 (cystatin S like 1) - Rat Genome Database

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Gene: Cyssl1 (cystatin S like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyssl1
Name: cystatin S like 1
RGD ID: 1565109
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in response to axon injury and salivary gland development. Predicted to be active in cytoplasm; extracellular space; and vesicle.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cystatin S-like; LOC296235; MGC124773; similar to Cystatin S precursor (LM protein)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83157,944,699 - 157,949,905 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3157,944,702 - 157,949,905 (-)EnsemblGRCr8
mRatBN7.23137,484,098 - 137,489,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3137,484,101 - 137,489,304 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3141,418,076 - 141,423,286 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03150,001,767 - 150,006,975 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03147,717,092 - 147,722,298 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03144,480,098 - 144,485,304 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3144,480,312 - 144,485,304 (-)Ensemblrn6Rnor6.0
Rnor_5.03150,854,173 - 150,859,379 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43138,878,146 - 138,883,352 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3136,170,705 - 136,175,911 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Cyssl1
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:83
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000055522
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
8 21 24 19 1 19 3 22 2 1 4 1 3 5

Sequence


Ensembl Acc Id: ENSRNOT00000055522   ⟹   ENSRNOP00000052385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3157,944,702 - 157,949,905 (-)Ensembl
mRatBN7.2 Ensembl3137,484,101 - 137,489,304 (-)Ensembl
Rnor_6.0 Ensembl3144,480,312 - 144,485,304 (-)Ensembl
RefSeq Acc Id: NM_001037350   ⟹   NP_001032427
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83157,944,699 - 157,949,905 (-)NCBI
mRatBN7.23137,484,098 - 137,489,304 (-)NCBI
Rnor_6.03144,480,098 - 144,485,304 (-)NCBI
Rnor_5.03150,854,173 - 150,859,379 (-)NCBI
RGSC_v3.43138,878,146 - 138,883,352 (-)RGD
Celera3136,170,705 - 136,175,911 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01873 (Get FASTA)   NCBI Sequence Viewer  
  EDL95064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052385
  ENSRNOP00000052385.2
RefSeq Acc Id: NP_001032427   ⟸   NM_001037350
- Peptide Label: precursor
- UniProtKB: Q3MIE8 (UniProtKB/TrEMBL),   A6K7F5 (UniProtKB/TrEMBL),   G3V9M0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052385   ⟸   ENSRNOT00000055522
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9M0-F1-model_v2 AlphaFold G3V9M0 1-144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692511
Promoter ID:EPDNEW_R3036
Type:multiple initiation site
Name:LOC296235_1
Description:similar to Cystatin S precursor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03144,485,340 - 144,485,400EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565109 AgrOrtholog
BioCyc Gene G2FUF-47464 BioCyc
Ensembl Genes ENSRNOG00000036952 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055522 ENTREZGENE
  ENSRNOT00000055522.6 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621810 IMAGE-MGC_LOAD
InterPro Cystatin_sf UniProtKB/TrEMBL
  Prot_inh_cystat UniProtKB/TrEMBL
KEGG Report rno:296235 UniProtKB/TrEMBL
MGC_CLONE MGC:124773 IMAGE-MGC_LOAD
NCBI Gene 296235 ENTREZGENE
PANTHER CYSTATIN UniProtKB/TrEMBL
  CYSTATIN-C UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PhenoGen Cyssl1 PhenoGen
RatGTEx ENSRNOG00000036952 RatGTEx
SMART SM00043 UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A6K7F5 ENTREZGENE, UniProtKB/TrEMBL
  G3V9M0 ENTREZGENE, UniProtKB/TrEMBL
  Q3MIE8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-28 Cyssl1  cystatin S like 1  LOC296235  similar to Cystatin S precursor (LM protein)  Name and Symbol changed 629549 APPROVED
2006-02-09 LOC296235  similar to Cystatin S precursor (LM protein)      Symbol and Name status set to provisional 70820 PROVISIONAL