Gene: Lrrc34 (leucine rich repeat containing 34) Rattus norvegicus
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Symbol:
Lrrc34
Name:
leucine rich repeat containing 34
RGD ID:
1565052
Description:
Predicted to be involved in cell differentiation. Predicted to act upstream of or within gene expression and telomere maintenance. Predicted to be located in cytoplasm and nucleolus. Orthologous to human LRRC34 (leucine rich repeat containing 34); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
leucine-rich repeat-containing protein 34; LOC499589; MGC114480; RGD1565052; similar to hypothetical protein MGC27085
RGD Orthologs
Alliance Orthologs
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Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 2 114,680,787 - 114,702,961 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 2 114,680,094 - 114,702,961 (+) Ensembl GRCr8 mRatBN7.2 2 112,752,294 - 112,774,463 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 2 112,754,578 - 112,774,459 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 2 119,406,048 - 119,425,829 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 2 117,518,613 - 117,538,391 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 2 112,235,611 - 112,255,425 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 2 116,370,013 - 116,391,964 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 116,372,519 - 116,391,959 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 2 136,063,823 - 136,085,769 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 2 117,173,233 - 117,193,239 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 2 107,933,501 - 107,953,312 (+) NCBI Celera Cytogenetic Map 2 q24 NCBI
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Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Lrrc34 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Lrrc34 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Lrrc34 Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of LRRC34 mRNA CTD PMID:29097150 Lrrc34 Rat 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of LRRC34 mRNA CTD PMID:26496021 Lrrc34 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Lrrc34 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Lrrc34 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Lrrc34 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Lrrc34 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Lrrc34 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Lrrc34 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of LRRC34 mRNA CTD PMID:24780913 Lrrc34 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of LRRC34 mRNA CTD PMID:25825206|PMID:30047161 Lrrc34 Rat acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of LRRC34 mRNA CTD PMID:32151602 Lrrc34 Rat aldehydo-D-glucose increases expression ISO Lrrc34 (Mus musculus) 6480464 Glucose results in increased expression of LRRC34 mRNA CTD PMID:39922521 Lrrc34 Rat all-trans-retinoic acid decreases expression ISO LRRC34 (Homo sapiens) 6480464 Tretinoin results in decreased expression of LRRC34 mRNA CTD PMID:23724009|PMID:33167477 Lrrc34 Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of LRRC34 mRNA CTD PMID:30047161 Lrrc34 Rat benzo[a]pyrene decreases expression ISO Lrrc34 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of LRRC34 mRNA CTD PMID:22228805 Lrrc34 Rat benzo[a]pyrene affects methylation ISO LRRC34 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of LRRC34 promoter CTD PMID:27901495 Lrrc34 Rat bis(2-ethylhexyl) phthalate increases expression ISO Lrrc34 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of LRRC34 mRNA CTD PMID:34319233 Lrrc34 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of LRRC34 mRNA CTD PMID:26496021 Lrrc34 Rat bisphenol A increases expression ISO Lrrc34 (Mus musculus) 6480464 bisphenol A results in increased expression of LRRC34 mRNA CTD PMID:32156529 Lrrc34 Rat bisphenol A multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of LRRC34 gene CTD PMID:31601247 Lrrc34 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of LRRC34 gene CTD PMID:28505145 Lrrc34 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LRRC34 mRNA CTD PMID:25181051|PMID:29097150|PMID:30816183|PMID:32528016 Lrrc34 Rat cadmium atom decreases expression ISO LRRC34 (Homo sapiens) 6480464 Cadmium results in decreased expression of LRRC34 mRNA CTD PMID:24376830 Lrrc34 Rat calyculin A decreases expression ISO Lrrc34 (Mus musculus) 6480464 calyculin A results in decreased expression of LRRC34 mRNA CTD PMID:25270620 Lrrc34 Rat carbamazepine affects expression ISO LRRC34 (Homo sapiens) 6480464 Carbamazepine affects the expression of LRRC34 mRNA CTD PMID:25979313 Lrrc34 Rat carbon nanotube decreases expression ISO Lrrc34 (Mus musculus) 6480464 Nanotubes, Carbon analog results in decreased expression of LRRC34 mRNA; Nanotubes, Carbon results in decreased more ... CTD PMID:25554681 Lrrc34 Rat copper atom multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of LRRC34 mRNA CTD PMID:20971185 Lrrc34 Rat copper(0) multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of LRRC34 mRNA CTD PMID:20971185 Lrrc34 Rat D-glucose increases expression ISO Lrrc34 (Mus musculus) 6480464 Glucose results in increased expression of LRRC34 mRNA CTD PMID:39922521 Lrrc34 Rat dorsomorphin multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Lrrc34 Rat fulvestrant multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of LRRC34 gene CTD PMID:31601247 Lrrc34 Rat genistein increases expression ISO Lrrc34 (Mus musculus) 6480464 Genistein results in increased expression of LRRC34 mRNA CTD PMID:32186404 Lrrc34 Rat glucose increases expression ISO Lrrc34 (Mus musculus) 6480464 Glucose results in increased expression of LRRC34 mRNA CTD PMID:39922521 Lrrc34 Rat glyphosate decreases expression EXP 6480464 Glyphosate results in decreased expression of LRRC34 mRNA CTD PMID:38314887 Lrrc34 Rat lipopolysaccharide decreases expression ISO LRRC34 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of LRRC34 mRNA CTD PMID:35811015 Lrrc34 Rat lipopolysaccharide multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of LRRC34 mRNA; [S-(1,2-dichlorovinyl)cysteine more ... CTD PMID:35811015 Lrrc34 Rat mercury dibromide decreases expression ISO LRRC34 (Homo sapiens) 6480464 mercuric bromide results in decreased expression of LRRC34 mRNA CTD PMID:26272509 Lrrc34 Rat mercury dibromide multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Lrrc34 Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of LRRC34 mRNA CTD PMID:30047161 Lrrc34 Rat methylmercury chloride decreases expression ISO LRRC34 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of LRRC34 mRNA CTD PMID:28001369 Lrrc34 Rat nickel atom decreases expression ISO LRRC34 (Homo sapiens) 6480464 Nickel results in decreased expression of LRRC34 mRNA CTD PMID:24768652 Lrrc34 Rat ozone multiple interactions ISO Lrrc34 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... CTD PMID:34911549 Lrrc34 Rat p-chloromercuribenzoic acid decreases expression ISO LRRC34 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in decreased expression of LRRC34 mRNA CTD PMID:26272509 Lrrc34 Rat p-chloromercuribenzoic acid multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Lrrc34 Rat PCB138 multiple interactions ISO Lrrc34 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Lrrc34 Rat phenylmercury acetate decreases expression ISO LRRC34 (Homo sapiens) 6480464 Phenylmercuric Acetate results in decreased expression of LRRC34 mRNA CTD PMID:26272509 Lrrc34 Rat phenylmercury acetate multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Lrrc34 Rat pirinixic acid increases expression ISO Lrrc34 (Mus musculus) 6480464 pirinixic acid results in increased expression of LRRC34 mRNA CTD PMID:20813756 Lrrc34 Rat rotenone decreases expression ISO LRRC34 (Homo sapiens) 6480464 Rotenone results in decreased expression of LRRC34 mRNA CTD PMID:29955902 Lrrc34 Rat S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of LRRC34 mRNA; [S-(1,2-dichlorovinyl)cysteine more ... CTD PMID:35811015 Lrrc34 Rat SB 431542 multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Lrrc34 Rat sodium arsenite increases expression ISO Lrrc34 (Mus musculus) 6480464 sodium arsenite results in increased expression of LRRC34 mRNA CTD PMID:37682722 Lrrc34 Rat sodium arsenite decreases expression ISO LRRC34 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of LRRC34 mRNA CTD PMID:39719251 Lrrc34 Rat sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of LRRC34 mRNA CTD PMID:30047161 Lrrc34 Rat sulforaphane increases expression ISO Lrrc34 (Mus musculus) 6480464 sulforaphane results in increased expression of LRRC34 mRNA CTD PMID:30529165 Lrrc34 Rat temozolomide decreases expression ISO LRRC34 (Homo sapiens) 6480464 Temozolomide results in decreased expression of LRRC34 mRNA CTD PMID:31758290 Lrrc34 Rat titanium dioxide affects expression ISO Lrrc34 (Mus musculus) 6480464 titanium dioxide affects the expression of LRRC34 mRNA CTD PMID:23557971 Lrrc34 Rat Tributyltin oxide decreases expression ISO Lrrc34 (Mus musculus) 6480464 bis(tri-n-butyltin)oxide results in decreased expression of LRRC34 mRNA CTD PMID:25270620 Lrrc34 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of LRRC34 mRNA CTD PMID:33387578 Lrrc34 Rat trichostatin A increases expression ISO LRRC34 (Homo sapiens) 6480464 trichostatin A results in increased expression of LRRC34 mRNA CTD PMID:24935251 Lrrc34 Rat trichostatin A multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Lrrc34 Rat trichostatin A decreases expression ISO LRRC34 (Homo sapiens) 6480464 trichostatin A results in decreased expression of LRRC34 mRNA CTD PMID:26272509 Lrrc34 Rat valproic acid increases expression ISO Lrrc34 (Mus musculus) 6480464 Valproic Acid results in increased expression of LRRC34 mRNA CTD PMID:21427059 Lrrc34 Rat valproic acid decreases expression ISO Lrrc34 (Mus musculus) 6480464 Valproic Acid results in decreased expression of LRRC34 mRNA CTD PMID:21427059 Lrrc34 Rat valproic acid increases expression ISO LRRC34 (Homo sapiens) 6480464 Valproic Acid results in increased expression of LRRC34 mRNA CTD PMID:24935251 Lrrc34 Rat valproic acid decreases expression ISO LRRC34 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of LRRC34 mRNA CTD PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369 Lrrc34 Rat valproic acid multiple interactions ISO LRRC34 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386