Lrriq1 (leucine-rich repeats and IQ motif containing 1) - Rat Genome Database

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Gene: Lrriq1 (leucine-rich repeats and IQ motif containing 1) Rattus norvegicus
Analyze
Symbol: Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
RGD ID: 1564903
Description: Predicted to act upstream of or within several processes, including apoptotic process; ectopic germ cell programmed cell death; and single fertilization. Predicted to be active in microtubule cytoskeleton. Orthologous to human LRRIQ1 (leucine rich repeats and IQ motif containing 1); INTERACTS WITH bisphenol A; Cuprizon; endosulfan.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat and IQ domain-containing protein 1; LOC299759; RGD1564903; similar to leucine-rich repeats and IQ motif containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8740,211,036 - 40,296,374 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl740,070,408 - 40,296,479 (-)EnsemblGRCr8
mRatBN7.2738,317,259 - 38,409,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl738,192,759 - 38,409,901 (-)EnsemblmRatBN7.2
Rnor_6.0745,084,697 - 45,187,614 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl745,056,399 - 45,185,690 (-)Ensemblrn6Rnor6.0
Rnor_5.0745,175,173 - 45,207,553 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4741,318,759 - 41,350,194 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera735,143,752 - 35,358,905 (-)NCBICelera
Cytogenetic Map7q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lrriq1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8740,211,036 - 40,296,374 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl740,070,408 - 40,296,479 (-)EnsemblGRCr8
mRatBN7.2738,317,259 - 38,409,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl738,192,759 - 38,409,901 (-)EnsemblmRatBN7.2
Rnor_6.0745,084,697 - 45,187,614 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl745,056,399 - 45,185,690 (-)Ensemblrn6Rnor6.0
Rnor_5.0745,175,173 - 45,207,553 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4741,318,759 - 41,350,194 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera735,143,752 - 35,358,905 (-)NCBICelera
Cytogenetic Map7q21NCBI
LRRIQ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381285,036,351 - 85,272,805 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1285,036,314 - 85,264,457 (+)Ensemblhg38GRCh38
GRCh371285,430,129 - 85,638,883 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361283,954,230 - 84,163,014 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341283,932,566 - 84,021,104NCBI
Celera1285,093,691 - 85,302,430 (+)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1282,487,346 - 82,696,101 (+)NCBIHuRef
CHM1_11285,395,055 - 85,603,840 (+)NCBICHM1_1
T2T-CHM13v2.01285,015,741 - 85,253,151 (+)NCBIT2T-CHM13v2.0
Lrriq1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910102,880,238 - 103,072,236 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10102,881,892 - 103,072,183 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810103,044,377 - 103,236,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10103,046,031 - 103,236,322 (-)Ensemblmm10GRCm38
MGSCv3710102,525,832 - 102,698,956 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610102,574,485 - 102,663,841 (-)NCBIMGSCv36mm8
Celera10105,008,554 - 105,182,213 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1053.65NCBI
Lrriq1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540523,004,726 - 23,215,249 (+)Ensembl
ChiLan1.0NW_00495540523,004,726 - 23,245,774 (+)NCBIChiLan1.0ChiLan1.0
LRRIQ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21093,085,333 - 93,315,243 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11293,081,731 - 93,311,641 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01282,555,266 - 82,784,679 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11285,658,124 - 85,867,199 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1285,657,812 - 85,901,943 (+)EnsemblpanPan2panpan1.1
LRRIQ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11526,616,783 - 26,829,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1526,616,853 - 26,824,249 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1527,056,389 - 27,271,168 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01527,226,697 - 27,442,047 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1527,226,743 - 27,435,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11526,577,826 - 26,792,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01526,618,110 - 26,833,093 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01526,867,009 - 27,081,833 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrriq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494533,477,168 - 33,657,990 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365072,582,197 - 2,740,155 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365072,577,493 - 2,740,266 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRIQ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl596,801,327 - 96,993,094 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1596,801,180 - 97,093,718 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25101,859,890 - 101,956,006 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRIQ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11180,450,758 - 80,679,685 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1180,452,888 - 80,660,167 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037164,655,068 - 164,883,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Lrriq1
732 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:59
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000031320, ENSRNOT00000071306
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 7 10 145 49 48 17 17 17 1 132 49 9 128 55 87 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000071306   ⟹   ENSRNOP00000067860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl740,078,821 - 40,296,479 (-)Ensembl
mRatBN7.2 Ensembl738,192,759 - 38,409,901 (-)Ensembl
Rnor_6.0 Ensembl745,056,399 - 45,185,690 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111314   ⟹   ENSRNOP00000077587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl740,078,821 - 40,295,487 (-)Ensembl
mRatBN7.2 Ensembl738,192,759 - 38,409,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145532   ⟹   ENSRNOP00000103380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl740,186,914 - 40,296,479 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148069   ⟹   ENSRNOP00000099406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl740,070,408 - 40,295,560 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150529   ⟹   ENSRNOP00000100849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl740,092,808 - 40,295,560 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157295   ⟹   ENSRNOP00000099182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl740,075,063 - 40,296,479 (-)Ensembl
RefSeq Acc Id: XM_063264416   ⟹   XP_063120486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8740,211,036 - 40,296,374 (-)NCBI
RefSeq Acc Id: XM_063264417   ⟹   XP_063120487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8740,213,342 - 40,296,374 (-)NCBI
RefSeq Acc Id: XM_063264418   ⟹   XP_063120488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8740,263,944 - 40,296,374 (-)NCBI
Ensembl Acc Id: ENSRNOP00000067860   ⟸   ENSRNOT00000071306
Ensembl Acc Id: ENSRNOP00000077587   ⟸   ENSRNOT00000111314
RefSeq Acc Id: XP_063120486   ⟸   XM_063264416
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120487   ⟸   XM_063264417
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120488   ⟸   XM_063264418
- Peptide Label: isoform X3
- UniProtKB: A6IGB2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103380   ⟸   ENSRNOT00000145532
Ensembl Acc Id: ENSRNOP00000099182   ⟸   ENSRNOT00000157295
Ensembl Acc Id: ENSRNOP00000100849   ⟸   ENSRNOT00000150529
Ensembl Acc Id: ENSRNOP00000099406   ⟸   ENSRNOT00000148069

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDZ6-F1-model_v2 AlphaFold M0RDZ6 1-1551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564903 AgrOrtholog
BioCyc Gene G2FUF-34211 BioCyc
Ensembl Genes ENSRNOG00000004564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071306.4 UniProtKB/TrEMBL
  ENSRNOT00000111314 ENTREZGENE
  ENSRNOT00000111314.2 UniProtKB/TrEMBL
  ENSRNOT00000145532 ENTREZGENE
  ENSRNOT00000145532.1 UniProtKB/TrEMBL
  ENSRNOT00000148069.1 UniProtKB/TrEMBL
  ENSRNOT00000150529.1 UniProtKB/TrEMBL
  ENSRNOT00000157295.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.190 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  SDS22/Internalin_LRR UniProtKB/TrEMBL
NCBI Gene 299759 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
PhenoGen Lrriq1 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004564 RatGTEx
SMART LRR_SD22 UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A0A8I5ZJI9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDB9_RAT UniProtKB/TrEMBL
  A0ABK0LDN7_RAT UniProtKB/TrEMBL
  A0ABK0LHQ0_RAT UniProtKB/TrEMBL
  A0ABK0LIN0_RAT UniProtKB/TrEMBL
  A6IGB2 ENTREZGENE, UniProtKB/TrEMBL
  M0RDZ6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Lrriq1  leucine-rich repeats and IQ motif containing 1  RGD1564903_predicted  similar to leucine-rich repeats and IQ motif containing 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564903_predicted  similar to leucine-rich repeats and IQ motif containing 1 (predicted)  LOC299759  similar to leucine-rich repeats and IQ motif containing 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299759  similar to leucine-rich repeats and IQ motif containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL